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How does stiffness of trabecular meshwork affect outflow resistance in human eyes?

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医用生物力学 2013年第S1期28卷 86-88页

作者： Fan Yuan Lucinda j.Camras W.Daniel Stamer David Epstein Pedro gonzalez Department of Biomedical Engineering Duke University Department of Ophthalmology Duke University

Purpose Ocular hypertension is the primary risk factor for development of glaucoma and the only modifiable endpoint[1,2].Clinical trials involving thousands of patients have shown consistently that lowering intraocular pressure（IOP）in those with glaucoma,whether or not their IOP is above normal,slows vision *** elevation is the result of diminished outflow facility in the conventional outflow pathway;and the highest resistance to aqueous humor outflow resides in the juxtacanalicular tissue（jCT）layer of trabecular meshwork（TM）and the inner wall of Schlemm’s canal（SC）.However,mechanisms of outflow facility decrease in glaucomatous eyes remain to be determined.

关键词： outflow trabecular glaucoma intraocular facility consistently stiffness canal lowering endpoint

Are Ni/and Ni5Fe1/biochar catalysts suitable for synthetic natural gas production?A comparison with g-Al2O3 supported catalysts

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Green Energy & Environment 2023年第3期8卷 744-756页

作者： M.gonzalez-Castano C.Morales j.C.Navarro de Miguel j.H.Boelte O.Klepel j.I.Flege H.Arellano-García Department of Process and Plant Technology Brandenburg University of Technology(BTU)Cottbus-SenftenbergPlatz der Deutschen 1Cottbus03046Germany Applied Physics and Semiconductor Spectroscopy Brandenburg University of Technology Cottbus-SenftenbergKonrad-Zuse-Strasse 1Cottbus03046Germany Department of Inorganic Chemistry Institute of Materials Science of SevilleConsejo Superior de Investigaciones Cientificas(CSIC)Universidad de Sevilla(US)Avenida Americo Vespucio 49Seville41092Spain Institute of Materials Chemistry Brandenburg University of Technology Cottbus–SenftenbergUniversitatsplatz 1SenftenbergD-01968Germany

Among challenges implicit in the transition to the post-fossil fuel energetic model,the finite amount of resources available for the technological implementation of CO_(2) revalorizing processes arises as a central *** development of fully renewable catalytic systems with easier metal recovery strategies would promote the viability and sustainability of synthetic natural gas production circular *** Ni and NiFe catalysts supported over g-Al_(2)O_(3) oxide as reference materials,this work evaluates the potentiality of Ni and NiFe supported biochar catalysts for CO_(2) *** development of competitive biochar catalysts was found dependent on the creation of basic sites on the catalyst *** lower Turn Over Frequencies than Ni/Al catalyst,the absence of basic sites achieved over Ni/C catalyst was related to the depleted catalyst *** NiFe catalysts,analogous Ni_(5)Fe_(1) alloys were constituted over both alumina and biochar *** highest specific activity of the catalyst series,exhibited by the NiFe/C catalyst,was related to the development of surface basic sites along with weaker NiFe-C interactions,which resulted in increased Ni0:NiO surface populations under reaction *** summary,the present work establishes biochar supports as a competitive material to consider within the future low-carbon energetic panorama.

关键词： Biochar catalysts Carbon catalysts Ni catalysts NiFe alloy Bimetallic catalysts Synthetic natural gas CO_(2)methanation

Forecasting the effects of EU policy measures on the nitrate pollution of groundwater and surface waters

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journal of Environmental Sciences 2010年第6期22卷 872-877页

作者： Ralf Kunkel Peter Kreins Bjrn Tetzlaff frank Wendland Research Centre jülich Institute of Chemistry and Dynamics of the Geosphere Institute of Rural Studies Federal Agricultural Research Centre

We used the interdisciplinary model network REGFLUD to predict the actual mean nitrate concentration in percolation water at the scale of the Weser river basin （Germany） using an area differentiated （100 m × 100 m） approach. REGFLUD combines the agro-economic model RAUMIS for estimating nitrogen surpluses and the hydrological models GROWA/DENUZ for assessing the nitrate leaching from the soil. For areas showing predicted nitrate concentrations in percolation water above the European Union （EU） groundwater quality standard of 50 mg NO3-N/L, effective agri-environmental reduction measures need to be derived and implemented to improve groundwater and surface water quality by 2015. The effects of already implemented agricultural policy are quantified by a baseline scenario projecting the N-surpluses from agricultural sector to 2015. The REGFLUD model is used to estimate the effects of this scenario concerning groundwater and surface water pollution by nitrate. From the results of the model analysis the needs for additional measures can be derived in terms of required additional N-surplus reduction and in terms of regional prioritization of measures. Research work will therefore directly support the implementation of the Water Framework Directive of the European Union in the Weser basin.

关键词： catchment management diffuse source pollution mitigation methods river basin management Water Framework Directive

Determination of nitrogen reduction levels necessary to reach groundwater quality targets in Slovenia

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journal of Environmental Sciences 2014年第9期26卷 1806-1817页

作者： Miso Andelov Ralf Kunkel jo?e Uhan frank Wendland Slovenian Environment Agency Hydrogeological Analysis DivisionVojkova 1bSI-1000 LjubljanaSlovenia Forschungszentrum jülich (FZj) Institute of Bio- and Geosciences (IBG)Institute 3: Agrosphere52425 JuelichGermany

Within a collaborative project between Slovenian Environment Agency （ARSO） and Research Center jfilich （FZj）, nitrogen reduction levels necessary to reach groundwater quality targets in Slovenia were assessed. For this purpose the hydrological model GROWA- DENUZ was coupled with agricultural N balances and applied consistently to the whole territory of Slovenia in a spatial resolution of 100 x 100 m. GROWA was used to determine the water balance in Slovenia for the hydrologic period 1971-2000. Simultaneously, the displaceable N load in soft was assessed from agricultural Slovenian N surpluses for 2011 and the atmospheric N deposition. Subsequently, the DENUZ model was used to assess the nitrate degradation in soil and, in combination with the percolation water rates from the GROWA model, to determine nitrate concentration in the leachate. The areas showing predicted nitrate concentrations in the leachate above the EU groundwater quality standard of 50 mg NO3/L have been identified as priority areas for implementing nitrogen reduction measures. For these ＂hot spot＂ areas DENUZ was used in a backward mode to quantify the maximal permissible nitrogen surplus levels in agriculture to guarantee a nitrate concentration in percolation water below 50 mg NO3/L. Model results indicate that additional N reduction measures should be implemented in priority areas rather than area-covering. Research work will directly support the implementation of the European Union Water Framework Directive in Slovenia, e.g., by using the maximal permissible nitrogen surplus levels as a framework for the derivation of regionally adapted and hence effective nitrogen reduction measures.

关键词： EU Water Framework DirectiveGroundwater quality targetsNitrate pollutionReactive nitrate transport modeling

Impact of age on transcatheter aortic valve implantation outcomes：a comparison of patients aged≤ 80 years versus patients ＆gt; 80 years

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journal of Geriatric Cardiology 2016年第1期13卷 31-36页

作者： frank van der Kley Philippe j van Rosendael Spyridon Katsanos Vasileios Kamperidis Nina A Marsan Ioannis Karalis Arend de Weger Meindert Palmen jeroen j Bax Martin j Schalij Victoria Delgado Heart Lung Center Leiden University Medical Center Leiden the Netherlands

ObjectiveTo investigate the procedural outcomes and the long-term survival of patients undergoing transcatheter aortic valve implantation （TAVI） and compare study results of patients≤ 80 years and patients ＆gt; 80 years *** total of 240 patients treated with TAVI were divided into two groups according to age≤ 80 years （n = 105; 43.8%） and ＆gt; 80 years （n= 135; 56.2%）. The baseline characteristics and the pro-cedural outcomes were compared between these two groups of *** the exception of peripheral artery disease and hypercho-lesterolemia, which were more frequently observed in the older age group, baseline characteristics were comparable between groups. Complica-tion rates did not differ significantly between patients≤ 80 years and patients ＆gt; 80 years. There were no differences in 30-day mortality rates be-tween patients aged≤ 80 years and patients ＆gt; 80 years old （9.5%vs. 7.4%, respectively;P = 0.557）. After a median follow-up of 28 months （in-terquartile range： 16-42 months）, 50 （47.6%） patients aged≤ 80 years died compared to 57 （42%） deaths in the group of patients ＆gt; 80 years old （P= 0.404）.ConclusionThe results of the present single center study showed that age did not significantly impact the outcomes of TAVI.

关键词： Age Survival rate Transcatheter aortic valve implantation

Effects of Adrenalectomy and Corticosterone on Hippocampal Lesions Induced by Trimethyltin

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Biomedical and Environmental Sciences 1989年第1期2卷 54-64页

作者： LOUIS W.CHANG AUBREY j. HOUGH frank G. BIVINS DAVID COCKERILL Department of Pathology University of Arkansas for Medical Sciences 4301 West Markham Little Rock Arkansas 72205

The effects of adrenalectomy and corticosterone supplementation on the neurotoxicity of trimethyltin (TMT) were tested. CD-1 mice with or without adrenalectomy were injected with TMT at a dose of 3.0mg/kg body wt. At 48h post-TMT administration, the animals were killed for pathological examination. It was found that the adrenalectomized animals developed even more severe lesions in the hippocampal formation (fascia dentata granule cells) than the intact animals. When animals were given a supplement of corticosterone pellets at doses of 0.15, 1.5, and 7.5mg, there was a reduction of lesion development. Total alleviation of pathology was seen at the two higher doses of supplementation. Our present investigation strongly indicates that there may be a close and important interrelationship between TMT-induced neurotoxicity and adrenal function. 1989 Academic Press, Inc.

关键词： dentata administration granule intact hippocampal fascia killed adrenal doses injected

用简版烧伤专用健康量表评估影响患者重新工作的因素

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中华烧伤杂志 2010年第6期26卷 416-419页

作者： Deborah j Dowda frank Li 2139 New South Wales State-wide Burn Injury Service Concord Repatriation General HospitalSydneyAustralia

目的评估影响烧伤患者出院后重新工作的因素.方法选择2007年3月1日-2009年2月28日笔者单位收治的18岁以上、烧伤总面积大于或等于10%TBSA的住院患者24例.于患者出院时及出院后3个月与6个月,采用简版烧伤专用健康量表以问卷方式调告有... 详细信息

目的评估影响烧伤患者出院后重新工作的因素.方法选择2007年3月1日-2009年2月28日笔者单位收治的18岁以上、烧伤总面积大于或等于10%TBSA的住院患者24例.于患者出院时及出院后3个月与6个月,采用简版烧伤专用健康量表以问卷方式调告有关其身心健康状况的9项内容：手功能、简单活动能力、热敏感、治疗反感、外貌、性能力、人际关系、情感问题与重新工作能力,进行相关分析.对患者一般情况与重新工作能力进行相关性分析,数据进行配对t检验或皮尔森相关性检验.结果出院后3、6个月分别有19、16例患者寄回合格问卷.患者出院时与出院后3个月相比,有关身心健康状况的各项目得分差异均无统计学意义（t=-4.87～-2.16,P值均大于0.05）;出院后6个月重新工作能力得分较出院时显著增高[（9±5）分与（6±3）分,t=-4.87,P＜0.001].重新工作能力与热敏感、治疗反感、外貌和情感问题均呈明显的正相关（r值分别为0.9256、0.8891、0.7502、0.6022,P值均小于0.05）,与住院时间、烧伤总面积和工伤补偿额度呈负相关（r值分别为-0.7000、-0.6844、-0.8003,P值均小于0.05）.结论烧伤患者重新工作能力与热敏感、治疗反感、外貌、情感问题以及住院时间、烧伤总面积、工伤补偿额度相关,医疗工作者应为患者提供持续教育和必要信息,帮助他们重新工作.

关键词：烧伤康复职业性心理健康量表

Limitations for tungsten as plasma facing material in the diverse scenarios of the European inertial confinement fusion facility HiPER: Current status and new approaches

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Matter and Radiation at Extremes 2020年第5期5卷 52-72页

作者： R.gonzalez-Arrabal A.Rivera j.M.Perlado Instituto de Fusi´on Nuclear Guillermo Velarde y Departamento de Ingenier´ıa Energ´etica ETSII Universidad Polit´ecnica de MadridE-28006 MadridSpain

The high-power laser energy research(HiPER)project was a European project for demonstrating the feasibility of inertial fusion energy based on using direct-drive targets in a shock ignition scheme using a drywall evacuated *** was intended to drive the transition from a scientific proof of principle to a demonstration power plant in *** project was divided into three realistic scenarios(Experimental,Prototype,and Demo)to help identify open problems and select appropriate technologies to solve *** of the problems identified was the lack of appropriate plasma-facing materials(PFMs)for the reaction ***,a major challenge was to develop radiation-resistant materials able to withstand the large thermal loads and radiation in these *** this paper,we describe the main threats that coarse-grained Wwould face in the diverse HiPER *** on purely thermomechanical considerations,theWlifetimes for the HiPER Prototype and Demo scenarios are limited by fatigue to 14000 h and 28 h,*** combined effects of thermal load and atomistic damage significantly reduce these lifetimes to just∼1000 shots for the Experimental scenario and a few minutes and seconds for the Prototype and Demo scenarios,***,coarse-grainedWis not an appropriatePFMfor the Prototype or Demo ***,alternatives to this material need to be ***,we review some of the different approaches that are being investigated,highlight the work done to characterize these new materials,and suggest further experiments.

关键词： diverse purely proof

DNA reveals long-distance partial migratory behavior in a cryptic owl lineage

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Chinese Birds 2015年第4期6卷 235-241页

作者： Keren R.Sadanandan David j.X.Tan Kolbjorn Schjolberg Philip D.Round frank E.Rheindt Department of Biological Sciences National University of Singapore TSG/31 BSP HQ Department of Biology Faculty of ScienceMahidol University

Background: The Brown Hawk Owl complex is said to consist of three species,the Brown Boobook(Ninox scutulata),the Chocolate Boobook(Ninox randi) and the Northern Boobook(Ninox japonica),which includes the nominate migratory lineage Ninox japonica japonica and a mitochondrially distinct lineage of taxonomically uncertain status that has been recorded year-round at least in *** in ranges during migration and morphological similarity have led to difficulties in distinguishing the Brown Boobook from the Northern ***: PCR of cytochrome-b and Sanger sequencing of Ninox samples from Singapore and Brunei were used to determine sample ***: Two out of four Singaporean samples and the Brunei sample were identified as Northern *** is the first official record of this species in Singapore and represents a considerable range extension for the ***,the samples belong to the mitochondrially distinct lineage previously characterized in resident Taiwan Residents populations rather than to the well-known nominate migratory ***: Our data show that the mitochondrial signature previously documented in resident Taiwan Residents populations of the Northern Boobook extends to migratory *** cryptic lineage may be more widespread in its breeding quarters,extending to the Chinese and Russian mainland,in which case the name florensis would apply to *** genetic and bioacoustic investigation is required to resolve the taxonomic status of this lineage.

关键词： Migration Cryptic species Mitochondrial lineage Brown hawk owl Partial migrant