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Epidemiology of liver diseases:global disease burden and forecasted research trends

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Science China Life Sciences 2024年

作者： Jia Xiao Fei Wang Yuan Yuan Jinhang Gao Lu Xiao Chao Yan Feifei Guo Jiajun Zhong Zhaodi Che Wei Li Tian Lan frank Tacke Vijay h.Shah Cui Li hua Wang Erdan Dong Division of Gastroenterology and hepatology Mayo Clinic Department of health Sciences National Natural Science Foundation of China Department of Oncology The First Affiliated Hospital Institute for Liver Diseases of Anhui Medical University Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Medical University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third Hospital State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Gastroenterology Qingdao Central Hospital University of Health and Rehabilitation Sciences Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai Hospital Affiliated with Jinan University Division of Gastroenterology Seventh Affiliated Hospital of Sun Yat-sen University School of Biological Sciences Jinan University Aier Institute of Ophthalmology Central South University Lab of Gastroenterology and hepatology West China Hospital Sichuan University Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Faculty of Pharmaceutical Sciences Toho University Department of hepatology and Gastroenterology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum and Campus Charité Mitte

We assessed the global incidence, mortality, and disability-adjusted life years(DALYs) associated with various liver diseases, including alcohol-related liver disease(ALD), hepatitis B/C virus infections(hBV or hCV), liver cancer, metabolic dysfunction-associated steatotic liver disease(MASLD), and other chronic liver diseases, from the 2019 Global Burden of Disease study. Additionally, we analyzed the global trends in hepatology research and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and other liver diseases, while they decreased for hBV, hCV, and liver cancer. Countries with a high socio-demographic index(SDI) exhibited the lowest mortality rates and DALYs. The burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD,along with hepatobiliary cancer, showed highest increase in funding in hepatology research. Globally, the major research categories in hepatology papers from 2000 to 2019 were cancer, pathobiology, and MASLD. The United States(U.S.) was at the forefront of hepatology research, with China gradually increasing its influence over time. hepatologists worldwide are increasingly focusing on studying the communication between the liver and other organs, while underestimating the research on ALD. Cancer, hCV, and MASLD were the primary diseases targeted for therapeutic development in clinical trials. however, the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S., China, Japan, and the European Union. Notably, there were no approved drug for the treatment of ALD in the world.

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Effect of nocturia in patients with different severity of obstructive sleep apnea on polysomnography: A retrospective observational study

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Asian Journal of Urology 2024年第3期11卷 486-496页

作者： Chin-heng Lu hung-Min Chang Kuang-hsi Chang Yen-Chuan Ou Chao-Yu hsu Min-Che Tung frank Cheau-Feng Lin Stella Chin-Shaw Tsai Division of Urology Department of SurgeryTungs’Taichung Metroharbor HospitalTaichungTaiwanChina Rong hsing Research Center for Translational Medicine Chung Hsing UniversityTaichungTaiwanChina College of Life Sciences Chung Hsing UniversityTaichungTaiwanChina Department of Otolaryngology Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina Department of Medical Research Tungs’Taichung Metroharbor HospitalTaichungTaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichungTaiwanChina Department of Post-Baccalaureate Medicine College of MedicineChung Hsing UniversityTaichungTaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoliTaiwanChina Department of Surgery Chung Shan Medical UniversityTaichungTaiwanChina College of Medicine Chung Shan Medical UniversityTaichungTaiwanChina

Patients with suspected OSA were examined using *** were divided into two groups based on the presence of *** was defined as a patient who needed to void at least *** index(AhI)was employed to classify patients according to degrees of severity:AhIh,5 events/hAhIh,15 events/hAhIh,and AhI30 events/h,defined as normal,mild OSA,moderate OSA,and severe OSA,*** variables,PSG parameters,International Prostate Symptom Scores(IPSSs),and quality of life scores due to urinary symptoms were ***:In total 140 patients,114 patients had OSA(48 had mild OSA;34 had moderate OSA;and 32 had severe OSA)and 107 patients had *** total IPSS was significantly higher in nocturia patients in all groups except the group of severe OSA *** the increasing severity of OSA,more correlated factors related to nocturia were *** mild OSA patients,nocturia related to increased age(p=0.025),minimum arterial blood oxygenation saturation(p=0.046),and decreased AhI of non-rapid eye movement(p=0.047),AhI of total sleep time(p=0.010),and desaturation index(p=0.012).In moderate OSA patients,nocturia related to increased age(pheight(p=0.044),weight(p=0.025),and sleep efficiency(p=0.003).In severe OSA patients,nocturia related to increased weight(p=0.011),body mass index(p=0.009),awake time(p=0.008),stage 1 sleep(p=0.040),arousal number(p=0.030),arousal index(p=0.013),periodic limb movement number(p=0.013),and periodic limb movement index(p=0.004),and decreased baseline arterial blood oxygenation saturation(p=0.046).Conclusion:Our study revealed that there were more correlated factors related to nocturia with increasing severity of *** study helps in clinical education and treatment for OSA patients with different severity.

关键词： Nocturia Obstructive sleep apnea Polysomnography Apneaehypopnea index International Prostate Symptom Score

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计量软件溯源中的TraCIM软件认证系统

工具技术 2017年第12期51卷 118-121页

作者：汤洁 frank h.rtig 石照耀北京工业大学北京市精密测控技术与仪器工程技术研究中心 Physikalisch-Technische Bundesanstalt Braunschweig und Berlin(PTB)

工业计量领域、校准实验室和计量研究机构均需要一致的计算溯源框架以对计量软件进行溯源。计量软件溯源主要是对其算法进行溯源,并与其特定的计算目标相关联。德国国家计量院(PTB)推出了国际计量软件认证系统(TraCIM)实施计量软件溯源... 详细信息

工业计量领域、校准实验室和计量研究机构均需要一致的计算溯源框架以对计量软件进行溯源。计量软件溯源主要是对其算法进行溯源,并与其特定的计算目标相关联。德国国家计量院(PTB)推出了国际计量软件认证系统(TraCIM)实施计量软件溯源,国际软件认证包括高斯(Gauss)软件认证、切比雪夫(Chebyshev)软件认证和比对(Comparison)软件认证。TraCIM计量软件认证通过在专用网络平台上实施"认证用户—服务器"间的应用来实现。认证流程主要包括索要标准输入数据、提交结果和获得认证报告。计量领域企业三丰(Mitutoyo)、蔡司(Zeiss)均实施并通过认证。

关键词：软件认证 TraCIM 软件溯源国际比对标准数据

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Efficacy of chlorfenapyr against adult Tribolium castaneum exposed on concrete＂ effects of exposure interval, concentration and the presence of a food source after exposure

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Insect Science 2009年第2期16卷 157-163页

作者： frank h. Arthur USDA-ARS Grain Marketing and Production Research Center Manhattan Kansas USA

Chlorfenapyr, an insecticidal pyrrole, was applied to concrete arenas at concentrations of 1. 1, 0.825, 0.55, and 0.275 g of active ingredient [AI]/m^2. Adult Tribolium castaneum （herbst）, the red flour beetle, were exposed for 2, 4, or 8 h at each concentration, then removed and held either with or without food （wheat flour） for 7 days. Survival was assessed when the beetles were removed fi＇om the exposure arenas and daily during the post- exposure period. In the presence of food, survival was high regardless of concentration and the day on which post-treatment survival was assessed, but survival did decrease as the exposure period increased from 4 to 8 h. When the beetles were not given food after exposure, survival at each concentration and exposure period declined during the 1-week post- exposure assessments. This pattern of decrease could be described by linear and non-linear equations. Results show the presence of food material greatly compromised effectiveness of the insecticide, and emphasize the importance of cleaning and sanitation in conjunction with insecticide treatments.

关键词： chlorfenapyr efficacy sanitation Tribolium castaneum

Aerosol distribution and efficacy in a commercial food warehouse

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Insect Science 2008年第2期15卷 133-140页

作者： frank h. Arthur USDA-ARS Grain Marketing and Production Research Center Manhattan Kansas USA

A series of field trials were conducted in a commercial food storage facility to evaluate exposure of stored-product insects to aerosol formulations of synergized pyrethrins and the insect growth regulator methoprene. When adults of Tribolium castaneum （herbst）, the red flour beetle, and Tribolium confusum （Jacqueline DuVal）, the confused flour beetle were exposed with and without a food source to synergized pyrethrin aerosol, there was no difference in adult mortality with respect to availability of food at either 7 or 14 days after exposure （P≥0.05）. however, mortality was lower in T. confusum （40.4% and 79.3% with flour at 7 and 14 days, 38.9% and 84.8% without flour at 7 and 14 days） compared to T. castaneum （96.5% and 99.8% with flour at 7 and 14 days, 91.0% and 98.7% without flour at 7 and 14 days）. Few late-stage larvae and pupae of either species exposed to the pyrethrin aerosol emerged as adults. In tests with methoprene aerosol, adult emergence of exposed 3- and 4-week-old larvae of T. confusum was less than 2%. Only 0.3% of 4-week-old larvae of T. castaneum exposed in open and obstructed areas emerged as adults. Emergence of adults from eggs of Plodia interpunctella （hubner）, the Indianmeal moth, embedded in culture media and exposed to the methoprene aerosol was 13.2%±3.5%. Results show that the aerosols evaluated in our study could give effective control of some of the major storedproduct insect pests in commercial food storage facilities, and may offer an alternative to fumigation.

关键词： aerosols control methoprene Plodia pyrethrin Tribolium

钢悬链线立管全尺寸共振弯曲疲劳试验系统与模态分析

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振动与冲击 2024年第20期43卷 119-127页

作者：徐泽鑫安晨谢智张吉祥林方坚中国石油大学(北京)安全与海洋工程学院北京102249 里约热内卢联邦大学阿尔韦托·路易斯·科英布拉工程研究学院海洋工程系里约热内卢21941-972 2h海洋工程有限公司伦敦GU216HJ

钢悬链线立管(steel catenary riser,SCR)作为支撑海上平台和其他关键设备的重要组成部分,在极端的海洋环境中长时间服役运行时,其结构完整性和安全性至关重要。为确保SCR立管在恶劣环境下的安全运行,对立管进行共振弯曲疲劳试验研究成... 详细信息

钢悬链线立管(steel catenary riser,SCR)作为支撑海上平台和其他关键设备的重要组成部分,在极端的海洋环境中长时间服役运行时,其结构完整性和安全性至关重要。为确保SCR立管在恶劣环境下的安全运行,对立管进行共振弯曲疲劳试验研究成为必要的评估标准,同时也为后续立管疲劳寿命预测和失效分析提供基础。针对两种特定型号的SCR立管,推导并求解不同约束条件下的共振系统的固有频率与振型函数,分析管道长度、管道壁厚、偏心块和配重块质量对共振系统固有频率的影响;在此基础上开展不同特定工况下的全尺寸共振弯曲疲劳试验,同时对SCR立管在全尺寸共振弯曲疲劳试验系统中不同跨距及内压的振动响应特性进行了模拟。结合理论分析、有限元计算和共振弯曲疲劳试验结果,发现管道长度和两端的配重约束是影响共振系统1阶固有频率的重要参数,特别是在管道长度较短和壁厚较薄的情况下,影响更为显著。此外,注水加压和跨距增加会降低共振系统的固有频率,支撑跨距越短,系统的固有频率越大。分析所得结果为SCR立管的共振弯曲疲劳试验系统结构设计和试验方案优化提供了重要的参考依据。

关键词：钢悬链线立管(SCR) 共振弯曲疲劳试验固有频率全尺寸模态特性

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Low-complexity online correction and calibration of pedestrian dead reckoning using map matching and GPS

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Geo-Spatial Information Science 2019年第2期22卷 114-127,I0004页

作者： Fabian hölzke Johann-P.Wolff frank Golatowski Christian haubelt Institute of Applied Microelectronics and CE University of RostockRostockGermany

Dead Reckoning is a relative positioning scheme that is used to infer the change of position relative to a point of origin by measuring the traveled distance and orientation *** Dead Reckoning(PDR)applies this concept to walking *** method can be used to track someone's movement in a building after a known landmark like the building's entrance is ***,the movement of a foot and the corresponding direction change is measured and summed up,to infer the current *** and integrating the corresponding physical parameters,*** inertial sensors,introduces small errors that accumulate quickly into large distance *** of a buildings geography may reduce these errors as it can be used to keep the estimated position from moving through walls and onto likely *** this paper,we use building maps to improve localization based on a single foot-mounted inertial *** describe our localization method using zero velocity updates to accurately compute the length of individual steps and a Madgwick filter to determine the step *** though the computation of individual steps is quite accurate,small errors still accumulate in the long *** show how correction algorithms using likely and unlikely paths can rectify errors intrinsic to pedestrian dead reckoning tasks,such as orientation and displacement drift,and discuss restrictions and disadvantages of these *** also present a method of deriving the initial position and orientation from GPS *** verify our PDR correction methods analyzing the corrected and raw trajectories of six participants walking four routes of varying length and complexity through an office building,walking each route three *** quantitative results show an endpoint accuracy improvement of up to 60%when using likely paths and 23%when using unlikely ***,both approaches can also decrease accuracy in certain *** identify those scenarios and

关键词： Indoor localization Pedestrian Dead Reckoning(PDR) Inertial Navigation System(INS) map matching Zero Velocity Update(ZUPT)

Efficacy of an esfenvalerate plus methoprene aerosol for the control of eggs and fifth instars of Plodia interpunctella （Lepidoptera： Pyralidae）

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Insect Science 2010年第1期17卷 21-28页

作者： Emily A. Jenson frank h. Arthur James R. Nechols Kansas State University USDA-ARS Grain Marketing and Production Research Center Manhattan KS USA

Aerosol insecticides may provide an alternative to fumigants for control of the Indianmeal moth, Plodia interpunctella （hübner）, the Indianmeal moth, a major insect pest of stored processed food. In this study, eggs and larvae （5th instars） ofP. interpunctella were exposed to aerosol applications of the pyrethroid esfenvalerate and insect growth regulator methoprene, alone and in combination, in open and obstructed positions inside small sheds. When larvae were exposed to methoprene alone, adult emergence from those exposed larvae was 7.1% ± 1.5%. In contrast, adult emergence was 92.5% ± 3.5% when larvae were exposed to esfenvalerate alone. When eggs were exposed to methoprene, adult emergence of those exposed eggs was approximately 75%; however, when eggs were exposed to esfenvalerate, adult emergence was approximately 35%. In the combination treatment of methoprene plus esfenvalerate at their respective label rates, adult emergence following larval exposure was 0.91% ±0.61% compared to 16.3% ± 9.6% when eggs were exposed. Based on our results, methoprene alone is highly effective in reducing adult emergence after larval exposure. however, it is not as effective on eggs as esfenvalerate. A combination treatment of esfenvalerate plus methoprene could be used to control eggs and the wandering-phase larval stages ofP. interpunctella. An economic risk analysis also supports a strategy of combining methoprene and esfenvalerate.

关键词： control Indianmeal moth Plodia interpunctella

From basic properties to the Mott design of correlated delafossites

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npj Computational Materials 2021年第1期7卷 1084-1100页

作者： frank Lechermann European XFEL SchenefeldGermany Center for Computational Quantum Physics Flatiron InstituteNew YorkNYUSA

The natural-heterostructure concept realized in delafossites highlights these layered *** metallic,band-or Mott-insulating character may be associated with individual layers,inter-layer coupling still plays a decisive *** review the correlated electronic structure of PdCoO_(2),PdCrO_(2),and AgCrO_(2),showing that layer-entangled electronic states can deviate from standard classifications of interacting *** finding opens up possibilities for materials design in a subtle Mott-critical *** hidden-Mott physics,correlation-induced semimetallicity,or Dirac/flat-band dispersions in a Mott background are emerging *** with achievements in the experimental preparation,this inaugurates an exciting research field in the arena of correlated materials.

关键词： materials metallic showing