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仿生人字形小肋阵列对压气机叶栅角区分离的控制

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航空动力学报 2024年第3期39卷 182-193页

作者：张鹏李永宏程日新中国民航大学航空工程学院天津300300

通过数值模拟的方法探究了一种新型被动控制结构——仿生人字形小肋阵列,对压气机叶栅角区分离的控制效果及作用机理。人字形小肋阵列被布置在叶栅前缘端壁处,并探究了肋条高度和偏转角对角区分离控制效果的影响规律。研究表明:人字形... 详细信息

通过数值模拟的方法探究了一种新型被动控制结构——仿生人字形小肋阵列,对压气机叶栅角区分离的控制效果及作用机理。人字形小肋阵列被布置在叶栅前缘端壁处,并探究了肋条高度和偏转角对角区分离控制效果的影响规律。研究表明:人字形小肋阵列在叶栅整个稳定工作范围内均能有效改善角区的流动,高度仅为0.08附面层厚度且偏转角为30°的小肋阵列,最高可以使总压损失降低9.89%,静压系数提升12.27%。流场细节表明:小肋通道内的小尺度涡流可以通过积聚效应,在下游形成紧贴附面层底部的高强度大尺度涡流,相较于传统微型涡流发生器有效降低了附加损失;诱导涡增强了附面层与主流的掺混,抑制端壁附面层内低能流体的横向迁移,进而延缓了分离涡的形成,消除了端壁角区的涡环,有效改善了叶栅角区的流动。

关键词：压气机叶栅角区分离人字形小肋阵列被动控制附加损失

Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan Yue Gao Pengfei Zhao Guomin Xie Yanying Zhou Xiao Yang Xuan li Shuaishuai Zhang frank JGonzalez Aijuan Qu Min Huangb Huichang Bi NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.Yes-associated protein(YAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated YAP signaling by suppressing its K48-linked ubiquitination,promoting its K63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the YAP-TEAD *** inhibition of YAP-TEAD interaction using verteporfin or suppression of YAP using AAV Yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MYC,KRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the YAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy liver regeneration YAP TEAD Ubiquitination

半干旱草原大中型土壤动物在畜粪分解中的作用

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生物多样性 2022年第12期30卷 61-71页

作者：程建伟王亚东王桠楠李莹郭颖白正刘新民李永宏太原师范学院地理科学学院山西晋中030619 内蒙古大学生态与环境学院蒙古高原生态学与资源利用教育部重点实验室/省部共建草地生态学国家重点实验室培育基地呼和浩特010021 内蒙古师范大学生命科学与技术学院呼和浩特010022

土壤动物是陆地生态系统的重要组分,在有机质分解过程中具有重要作用。目前有关土壤动物在生态系统分解中的作用研究主要聚焦于植物凋落物的分解,而对动物粪便分解的研究稀少。本研究在内蒙古典型草原设置了马粪和牛粪分解原位实验,使... 详细信息

土壤动物是陆地生态系统的重要组分,在有机质分解过程中具有重要作用。目前有关土壤动物在生态系统分解中的作用研究主要聚焦于植物凋落物的分解,而对动物粪便分解的研究稀少。本研究在内蒙古典型草原设置了马粪和牛粪分解原位实验,使用不同孔径的金属隔离网排除不同体型大小的土壤动物,通过测定大中型土壤动物对畜粪分解过程中质量损失、碳氮含量和微生物呼吸以及土壤养分动态变化的影响,解析其在分解中的作用。设置5个处理,即CK,仅土壤,无粪;T0,粪添加+0.425 mm隔离网(排除了粪居型和掘洞型粪金龟和中型土壤动物);T1,粪添加+1 mm隔离网(排除了粪居型和掘洞型粪金龟);T2,粪添加+2 mm隔离网(排除了掘洞型粪金龟);T3,仅粪添加(不排除土壤动物)。结果表明:(1)在畜粪分解60天内,土壤动物对畜粪的干质量损失没有显著的促进作用(P>0.05);相反,在畜粪分解360天,不隔离土壤动物处理(T3)显著地提高了牛粪干质量损失(P0.05)。研究表明,分解初期粪金龟的取食和活动会改变畜粪的理化性质,进而影响分解后期土壤生物在畜粪分解中的作用。

关键词：土壤动物粪分解养分释放微生物呼吸地球化学

A unique subseafloor microbiosphere in the Mariana Trench driven by episodic sedimentation

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Marine life Science & Technology 2024年第1期6卷 168-181页

作者： Jiwen liu Da-Wei li Xinxin He Ronghua liu Haojin Cheng Chenglong Su Mengna Chen yonghong Wang Zhongsheng Zhao Hanyue Xu Zhangyu Cheng Zicheng Wang Nikolai Pedentchouk David J.Lea-Smith Jonathan D.Todd Xiaoshou liu Meixun Zhao Xiao-Hua Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine Life SciencesOcean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Laoshan LaboratoryQingdao 266237China Institute of Evolution and Marine Biodiversity Ocean University of ChinaQingdao 266003China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education/College of Marine GeosciencesOcean University of ChinaQingdao 266100China Key Laboratory of Physical Oceanography Ministry of Education/Research Vessel CentreOcean University of ChinaQingdao 266100China School of Environmental Sciences University of East AngliaNorwich NR47TJUK School of Biological Sciences University of East AngliaNorwich NR47TJUK

Hadal trenches are characterized by enhanced and infrequent high-rate episodic sedimentation events that likely introduce not only labile organic carbon and key nutrients but also new microbes that significantly alter the subseafloor ***,the role of high-rate episodic sedimentation in controlling the composition of the hadal subseafloor microbiosphere is ***,analyses of carbon isotope composition in a~750 cm long sediment core from the Challenger Deep revealed noncontinuous deposition,with anomalous ^(14)C ages likely caused by seismically driven mass transport and the funneling effect of trench *** community composition and diverse enzyme activities in the upper~27 cm differed from those at lower depths,probably due to sudden sediment deposition and differences in redox condition and organic matter *** lower depths,microbial population numbers,and composition remained relatively constant,except at some discrete depths with altered enzyme activity and microbial phyla abundance,possibly due to additional sudden sedimentation events of different *** is provided of a unique role for high-rate episodic sedimentation events in controlling the subsurface microbiosphere in Earth’s deepest ocean floor and highlight the need to perform thorough analysis over a large depth range to characterize hadal benthic *** depositional processes are likely crucial in shaping deep-water geochemical environments and thereby the deep subseafloor biosphere.

关键词： Hadal subseafloor Deep water sediment Mariana Trench Radiocarbon Microbial community Redox potential

High-rate metal-free MXene microsupercapacitors on paper substrates

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Carbon Energy 2024年第5期6卷 94-104页

作者： Han Xue Po‐Han Huang Lee‐Lun Lai Yingchun Su Axel Strömberg Gaolong Cao Yuzhu Fan Sergiy Khartsev Mats Göthelid Yan‐Ting Sun Jonas Weissenrieder Kristinn BGylfason frank Niklaus Jiantong li School of Electrical Engineering and Computer Science KTH Royal Institute of TechnologyStockholmSweden School of Engineering Sciences KTH Royal Institute of TechnologyStockholmSweden

MXene is a promising energy storage material for miniaturized microbatteries and microsupercapacitors(MSCs).Despite its superior electrochemical performance,only a few studies have reported MXene-based ultrahigh-rate(>1000 mV s^(−1))on-paper MSCs,mainly due to the reduced electrical conductance of MXene films deposited on ***,ultrahigh-rate metal-free on-paper MSCs based on heterogeneous MXene/poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)(PEDOT:PSS)-stack electrodes are fabricated through the combination of direct ink writing and femtosecond laser *** a footprint area of only 20 mm^(2),the on-paper MSCs exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles)at a high scan rate of 1000 mV s^(−1),outperforming most of the present on-paper ***,the heterogeneous MXene/PEDOT:PSS electrodes can interconnect individual MSCs into metal-free on-paper MSC arrays,which can also be simultaneously charged/discharged at 1000 mV s^(−1),showing scalable capacitive *** heterogeneous MXene/PEDOT:PSS stacks are a promising electrode structure for on-paper MSCs to serve as ultrafast miniaturized energy storage components for emerging paper electronics.

关键词： direct ink writing femtosecond laser scribing MXene on-paper microsupercapacitors PEDOT:PSS ultrahigh rate capability

Multifunctional SnO_(2) QDs/MXene Heterostructures as Laminar Interlayers for Improved Polysulfide Conversion and lithium Plating Behavior

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Nano-Micro Letters 2024年第11期16卷 156-169页

作者： Shungui Deng Weiwei Sun Jiawei Tang Mohammad Jafarpour frank Nüesch Jakob Heier Chuanfang Zhang College of Materials Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China Laboratory for Functional Polymers Swiss Federal Laboratories for Materials Science and Technology(EMPA)Überlandstrasse 1298600 DübendorfSwitzerland Institute of Materials Science and Engineering Ecole Polytechnique Fédérale de Lausanne(EPFL)Station 121015 LausanneSwitzerland Key Laboratory of Quantum Materials and Devices of Ministry of Education School of PhysicsSoutheast UniversityNanjing 211189People’s Republic of China SEU‑FEI Nano‑Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096People’s Republic of China

Poor cycling stability in lithium–sulfur(li–S)batteries necessitates advanced electrode/electrolyte design and innovative interlayer *** catalysis has emerged as a promising approach,leveraging the adsorption and catalytic performance on lithium polysulfides(liPSs)to inhibit liPSs shuttling and improve redox *** this study,we report an ultrathin and laminar SnO_(2)@MXene heterostructure interlayer(SnO_(2)@MX),where SnO_(2) quantum dots(QDs)are uniformly distributed across the MXene *** combined structure of SnO_(2) QDs and MXene,along with the creation of numerous active boundary sites with coordination electron environments,plays a critical role in manipulating the catalytic kinetics of sulfur *** li–S cell with the SnO_(2)@MX-modified separator not only demonstrates superior electrochemical performance compared to cells with a bare separator but also induces homogeneous li deposition during *** a result,an areal capacity of 7.6 mAh cm^(-2) under a sulfur loading of 7.5 mg cm^(-2) and a high stability over 500 cycles are *** work demonstrates a feasible strategy of utilizing a laminar separator interlayer for advanced li–S batteries awaiting commercialization and may shed light on the understanding of heterostructure catalysis with enhanced reaction kinetics.

关键词： lithium-sulfur battery Heterogeneous catalysis Heterostructure Redox kinetics lithium dendrites

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微生物合成阿魏酸的研究进展

中国生物工程杂志 2024年第9期44卷 113-125页

作者：李园子谢琴廖永红王凤寰北京工商大学轻工科学与工程学院北京100048

阿魏酸是一种来源于植物的酚酸,具有抗氧化、降血脂、抗癌等药理作用,被广泛应用于医药、化妆品和食品行业。从植物中提取和化学合成阿魏酸存在提取效率低、催化成本高、产量低及环境污染严重等问题。微生物合成法具有高效、经济和环保... 详细信息

阿魏酸是一种来源于植物的酚酸,具有抗氧化、降血脂、抗癌等药理作用,被广泛应用于医药、化妆品和食品行业。从植物中提取和化学合成阿魏酸存在提取效率低、催化成本高、产量低及环境污染严重等问题。微生物合成法具有高效、经济和环保等优势,将成为未来制备阿魏酸的一种趋势。综述了阿魏酸的微生物合成研究进展,讨论了改造底盘菌株、构建异源路径、筛选和优化关键酶、供应和循环辅因子、提高菌株稳定性、细胞共培养、优化发酵条件等提高产量的策略,并就未来的发展趋势提出展望。

关键词：阿魏酸生物合成代谢工程微生物

青川刨地里地震滑坡发育特征及其成因机制探讨

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地震学报 2024年第3期46卷 514-525页

作者：李均益罗永红周赞南凯成都理工大学环境与土木工程学院成都610059 成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059

以“5·12”汶川地震诱发的青川县刨地里滑坡为例,现场调查了滑坡的地质特征,并基于离散元软件(UDEC)分析了1号滑坡动力响应及变形破坏过程,探讨了滑坡的成因机制。现场调查表明,刨地里1号滑坡具有近水平“上硬下软”的地层结构,其中石... 详细信息

以“5·12”汶川地震诱发的青川县刨地里滑坡为例,现场调查了滑坡的地质特征,并基于离散元软件(UDEC)分析了1号滑坡动力响应及变形破坏过程,探讨了滑坡的成因机制。现场调查表明,刨地里1号滑坡具有近水平“上硬下软”的地层结构,其中石坎断层穿过了滑坡后缘;滑坡堆积体的岩性分带特征表明,刨地里1号滑坡下部千枚岩先于上部硅质岩被破坏,且破坏时间早于2号和3号滑坡;数值模拟研究揭示,峰值加速度放大效应在断层带附近的千枚岩内最强,其放大系数达6.79,导致下层千枚岩首先沿陡倾面产生拉裂破坏,随后上层硅质岩体产生拉裂破坏,结果与现场调查堆积物特征较吻合;断层和上硬下软的地层结构对刨地里滑坡动力响应、变形及破坏起到了控制作用。该研究可为上硬下软且含断层的地震滑坡的评价提供参考。

关键词： “5·12”汶川地震地震滑坡上硬下软地层石坎断层成因机制

基于深度学习与信息融合技术的陶瓷辊道窑温度智能检测方法

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陶瓷学报 2024年第1期45卷 180-190页

作者：朱永红戴晨雨李蔓华景德镇陶瓷大学机械电子工程学院江西景德镇333403

目前,陶瓷辊道窑烧制温度主要通过热电偶检测。由于热电偶容易老化,造成温度检测精度逐渐变低,以致影响陶瓷制品烧成质量。针对此问题,提出将基于深度学习火焰图像特征识别与热电偶点检测数据融合代替热电偶的辊道窑温度智能检测方法。... 详细信息

目前,陶瓷辊道窑烧制温度主要通过热电偶检测。由于热电偶容易老化,造成温度检测精度逐渐变低,以致影响陶瓷制品烧成质量。针对此问题,提出将基于深度学习火焰图像特征识别与热电偶点检测数据融合代替热电偶的辊道窑温度智能检测方法。该方法是针对陶瓷辊道窑火焰图像采用一种基于移位窗口视觉自注意力机制的多尺度特征提取网络,利用卷积神经网络和Transformer分支的局部和远程特征来保留更多图像信息,获得较准确的火焰图像特征,并与热电偶点检测数据融合,从而实现对陶瓷辊道窑温度的精确检测。该多尺度特征提取网络模型首先是采用一种基于多层Transformer的自编码器网络提取出其中的浅层和多尺度深层特征,其次将多个特征融合到Transformer和卷积神经网络中使其获得足够的能力去捕捉特征信息,最后将热电偶点检测获得的数据输入前面的网络中,利用特征级信息融合来是实现火焰图像特征与关键点检测温度数据的融合。实验结果表明,本文提出的融合网路模型比基于卷积神经网络融合方法特征识别平均准确率提高了1.75%,平均误差产生的减少了2.67%,其大多数指标上优于卷积神经网络分支或Transformer分支图像融合,因而本文的方法有效可行。

关键词：陶瓷辊道窑深度学习信息融合智能温度检测