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Pre-malignant processes of smoking-induced lung adenocarcinoma development: A conceptual biological model

Advances in Lung Cancer 2013年第2期2卷 32-53页

作者： frank tobin Gregory Vuillaume Marja Talikka Gaelle Diserens Gaelle Diserens Manuel C. Peitsch Julia Hoeng Philip Morris International R&D Philip Morris Products S.A. Neuchatel Switzerland tobin Consulting LLC Newton Square PA USA

Chronic exposure to cigarette smoke is the leading cause of human lung cancer and its most prevalent form, adenocarcinoma. However, the mechanisms by which smoking induces adenocarcinoma are largely inferred from the analysis of fully developed tumors. The current work focuses on the early events that precede the existence of clinically detectable tumors and where the progressive mechanisms are believed to be different from the ones driving established tumor growth. Biological information was drawn from the literature and generalized into a conceptual model, or framework, which describes and integrates the main processes involved in the early stages of smoking-induced lung adenocarcinoma development. No such integrative representation currently exists. The biological framework presented here is based on the “field of injury” of the lung. It covers the smoking-induced stepwise transition of unexposed (naive) lung tissue to the first appearance of neoplastic cells through defined tissue states referred to as pre-field and field. Each tissue state exhibits its own formalized characteristics (or phenotype properties), which evolve as a result of the combined effects of smoking, the interactions between the different tissue properties, and the local environment represented in the framework as lung inflammation and immune surveillance. The resulting network of influences between the lung tissue states and properties provides a good understanding of the early events involved in lung adenocarcinoma triggered by smoking. The resulting conceptual model—an integrative mechanistic hypothesis—can explain a broad range of cigarette smoking and smoking cessation scenarios.

关键词： Lung Adenocarcinoma Cigarette Smoke Field Cancerization

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Experimental qualification and sensitivity study of antipodal patch antenna structures for orientation independent detection of partial discharges

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High Voltage 2024年第3期9卷 674-684页

作者： Kerstin Friebe frank Jenau TU Dortmund University Institute of High Voltage EngineeringDortmundGermany

Partial discharge diagnosis is an important part of monitoring and diagnosing compo-nents of the power transmission *** different patch antenna structures for the detection of partial discharges are *** patch antennas,which are realisable in a variety of geometric structures,are already the subject of *** offer the advantage of contactless detection without intervention in the test object or the measuring circuit,and also offer the possibility of alignment independent detection compared to directional ***,it is important and required to examine different structures extensively at the same measurement setup and to compare their *** achieve this,four different configurations of patch antenna structures based on basic geometries all in antipodal design are realised:a logarithmic periodic structure,a Hilbert fractal structure and two tapered slot *** are exposed to the same conditions on a special and unique measurement *** the main aspect,the performance of orientation independent detection of partial discharges patch antennas with varying distance and rotation in relation to the partial discharge source as well as the operating bandwidth is *** rate the structures,an evaluation scheme is created and a sensitivity matrix is generated.

关键词： antenna patch structures

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Solving traffic data occlusion problems in computer vision algorithms using DeepSORT and quantum computing

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 1-15页

作者： frank Ngeni Judith Mwakalonge Saidi Siuhi Department of Engineering South Carolina State UniversityOrangeburgSC 29117USA

Inaccuracies of traffic sensors during traffic counting and vehicle classification have persisted as transportation agencies have been prompted to calibrate sensors *** of multiple objects,heavy occlusions,and similar appearances in congested places are some causes of computer vision model *** paper used the YOLOv5 model for detection and the DeepSORT model for tracking *** to the nature of the reported problem caused by many misses and mismatches,the power of quantum computing with the alternating direction method of multipliers(ADMM)optimizer was leveraged.A basic Kalman filter and the Hungarian algorithm features were used in combination with a quantum optimizer to present robust multiple object tracking(MOT)*** hybrid combination of the classical and quantum model has fastened learning the occludes during frame matching of tracks and detections by generating minimum quantum cost function *** with the existing models indicated a significant increase in the primary MOT metric multiple object tracking accuracy(MOTA)by 16%more than the regular YOLOv5-DeepSORT model when using a quantum ***,a 6%multiple object tracking precision(MOTP)increases and a 6%identification metrics(F_(1))score increase were observed using the quantum optimizer with identity switching reduced from 6 to *** model is expected to assist transportation officials in improving the accuracy of traffic counts and vehicle classification and reduce the need for regular computer vision software calibration.

关键词： Traffic classification Traffic counting DeepSORT YOLOv5 Quantum computing

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Antiviral factors and their counteraction by HIV-1: many uncovered and more to be discovered

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Journal of Molecular Cell Biology 2024年第2期16卷 1-10页

作者： Dorota Kmiec frank Kirchhoff Institute of Molecular Virology Ulm University Medical Center89081 UlmGermany

Extensive studies on HIV-1 have led to the discovery of a variety of structurally and functionally diverse innate defense factors that target various steps of the retroviral replication *** of them,such as APOBEC3,tetherin,and SERINC5,are well *** importance is evident from the fact that HIV-1 uses its accessory proteins Vif,Vpu,and Nef to counteract ***,the list of antiviral factors is constantly increasing,and accumulating evidence suggests that innate defense mechanisms,which restrict HIV-1 and/or are counteracted by viral proteins,remain to be *** antiviral factors are relevant to diseases other than HIV/AIDS,since they are commonly active against various viral *** this review,we provide an overview of recently reported antiretroviral factors and viral countermeasures,present the evidence suggesting that more innate defense mechanisms remain to be discovered,and discuss why this is a challenging but rewarding task.

关键词： HIV-1 restriction factors viral antagonists interferon-stimulated genes antiviral factors

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Guaranteed Cost Attitude Tracking Control for Uncertain Quadrotor Unmanned Aerial Vehicle Under Safety Constraints

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1447-1457页

作者： Qian Ma Peng Jin frank L.Lewis School of Automation Nanjing University of Science and TechnologyNanjing 210094China UTA Research Institute University of Texas at ArlingtonFort WorthTexas 76118 USA IEEE

In this paper,guaranteed cost attitude tracking con-trol for uncertain quadrotor unmanned aerial vehicle(QUAV)under safety constraints is ***,an augmented system is constructed by the tracking error system and reference *** transformation aims to convert the tracking control prob-lem into a stabilization control ***,control barrier function and disturbance attenuation function are designed to characterize the violations of safety constraints and tolerance of uncertain disturbances,and they are incorporated into the reward function as penalty *** on the modified reward function,the problem is simplified as the optimal regulation problem of the nominal augmented system,and a new Hamilton-Jacobi-Bellman equation is ***,critic-only rein-forcement learning algorithm with a concurrent learning tech-nique is employed to solve the Hamilton-Jacobi-Bellman equa-tion and obtain the optimal *** proposed algorithm can not only ensure the reward function within an upper bound in the presence of uncertain disturbances,but also enforce safety *** performance of the algorithm is evaluated by the numerical simulation.

关键词： Attitude tracking control quadrotor unmanned aerial vehicle(QUAV) reinforcement learning safety constraints uncertain disturbances.

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Seed-assisted growth for high-performance perovskite solar cells:A review

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Journal of Energy Chemistry 2024年第9期96卷 588-610页

作者： Zhimin Fang Ting Nie Jianning Ding Shengzhong(frank)Liu Institute of Technology for Carbon Neutralization Yangzhou UniversityYangzhou 225127JiangsuChina Dalian National Laboratory for Clean Energy iChEMDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119ShaanxiChina

The rapid increase in the power conversion efficiency(PCE)of perovskite solar cells(PSCs)is closely related to the development of deposition techinique for perovskite *** high-quality perovskite film enables efficient charge transportation and less trap states,which are eventually translated into enhanced device ***-assisted growth(SAG)is a potential technique for depositing highly-crystallized perovskite films with preferential crystal orientation among the numerous approaches related to crystallization *** this review,we summarize the recent advances in the SAG technique for both one-step and two-step processed perovskite ***,seeding at the buried interface and on the top surface are also *** present different seeds and their corresponding seeding mechanism in detail,such as inorganic nanomaterials,organic ammoniums,alkali metal halides,and perovskite ***,challenges and perspectives are proposed to investigate the potential expansion of seeding engineering in high-performance PSCs,particularly large-area devices.

关键词： Perovskite solar cell Seed Crystallization Efficiency

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Monitoring and evaluation of the water quality of the Lower Neches River, Texas, USA

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Water Science and Engineering 2024年第1期17卷 21-32页

作者： Qin Qian Mengjie He frank Sun Xinyu Liu Department of Civil and Environmental Engineering Lamar UniversityBeaumontTX 77710USA Department of Industry Engineering Lamar UniversityBeaumontTX 77710USA Department of Computer Science Lamar UniversityBeaumontTX 77710USA

Increasing bacteria levels in the Lower Neches River caused by Hurricane Harvey has been of a serious *** study is to analyze the historical water sampling measurements and real-time water quality data collected with wireless sensors to monitor and evaluate water quality under different hydrological and hydraulic *** statistical and Pearson correlation analysis on historical water samples determines that alkalinity,chloride,hardness,conductivity,and pH are highly correlated,and they decrease with increasing flow rate due to *** flow rate has positive correlations with Escherichia coli,total suspended solids,and turbidity,which demonstrates that runoff is one of the causes of the elevated bacteria and sediment loadings in the *** correlation between *** and turbidity indicates that turbidity greater than 45 nephelometric turbidity units in the Neches River can serve as a proxy for *** to indicate the bacterial outbreak.A series of statistical tools and an innovative two-layer data smoothing filter are developed to detect outliers,fill missing values,and filter spikes of the sensor *** correlation analysis on the sensor data illustrates that the elevated sediment/bacteria/algae in the river is either caused by the first flush rain and heavy rain events in December to March or practices of land use and land ***,utilizing sensor measurements along with rainfall and discharge data is recommended to monitor and evaluate water quality,then in turn to provide early alerts on water resources management decisions.

关键词： Water quality Pearson correlation analysis Lower Neches River YSI wireless sensors Non-point pollution

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Spatially resolved investigation of flame particle interaction in a two dimensional model packed bed

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Particuology 2024年第2期85卷 167-185页

作者： Mohammadhassan Khodsiani Reza Namdar Fathollah Varnik frank Beyrau Benoit Fond Institute of Fluid Dynamics and Thermodynamics Universitaetsplatz 2Magdeburg39106Saxony-AnhaltGermany Interdisciplinary Centre for Advanced Materials Simulation(ICAMS) Ruhr-University BochumBochum44801Germany ONERA The French Aerospace Lab Department of AerodynamicsAeroelasticity and Acoustics(DAAA)Paris-Saclay UniversityMeudon92190France

This study investigates the interaction between a premixed methane-air flame and particles inside a model packed *** opacity of the spherical packed beds to visible light poses a major barrier to the implementation of highly resolved optical diagnostics,so that no detailed experimental data were so far available for the validation of numerical ***,a two-dimensional cylindrical packed bed design is set up,which enables direct line-of-sight optical measurements without loss of spatial reso-lution over the fluid region between the *** this study,the case of cold metallic cylindrical particles(T=377 K)relevant to start-up of a reactor is investigated using internal particle cooling,which also allows cylinder specific heat transfer rate measurements by differential temperature measurements on the coolant *** two dimensional assumption is first verified by measuring the inflow ve-locity and cylinder temperature profile along the *** imaging is then per-formed using a telecentric lens to observe the position and geometry of the two-dimensional flame front with respect to the surrounding cylinders without loss of ***,the cylinder-specific flame to cylinder heat transfer rates and cylinder surface temperature are *** the flame is closely surrounded by the three cooled cylinders,intense heat transfer is observed in this region corresponding to 25±2.5%of the flame thermal *** were stabilised at different positions depending on inflow velocity and equivalence ratio,and a direct correlation between flame to cylinder stand-off distance and the heat transfer rate normalised to the flame thermal power was found for both top and side ***,sidewall quenching distances to the curved cylinder surfaces were evaluated,and seem to be influenced by the presence of a warm recirculation zone behind the *** investigation provides fully resolved flame front position and heat tra

关键词： Packed beds Flame-particle interaction Optical diagnostics Sidewall quenching

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Error-based adaptive optimal tracking control of nonlinear discrete-time systems

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Science China(Information Sciences) 2024年第1期67卷 154-167页

作者： Chun LI Jinliang DING frank L.LEWIS Tianyou CHAI State Key Laboratory of Synthetical Automation for Process Industries Northeastern University UTA Research Institute The University of Texas at Arlington

In this paper,for the output tracking problem of nonlinear discrete-time systems,a performance index is newly defined using the adaptive dynamic programming(ADP) technique to completely eliminate tracking errors in *** contrast to traditional definitions of performance indices in other ADP-based methods,the proposed performance index is not only designed from the perspective of output tracking errors but also introduced errors of system states and control inputs at adjacent stages,which is suitable for practical situations in many industrial applications,such as the alumina production,the flotation process,and the mineral grinding *** proved that the obtained controller can make the system output fully track the given reference trajectory by applying the iterative criteria of the ADP *** addition,the proposed algorithm was implemented using a data-driven technique and neural networks to avoid analyzing and deducing the complicated dynamics of actual industrial ***,using historical data for a forced-circulation evaporation system in the alumina production process,the effect of the proposed approach was verified through a numerical simulation and compared with that of the proportional-integral controller.

关键词： adaptive dynamic programming iterative criteria performance index tracking errors tracking problem

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Control Policy Learning Design for Vehicle Urban Positioning via BeiDou Navigation

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Journal of Systems Science & Complexity 2024年第1期37卷 114-135页

作者： QIN Yahang ZHANG Chengye CHEN Ci XIE Shengli LEWIS frank L School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of IoT Information Technology Guangzhou 510006China. Center for Intelligent Batch Manufacturing Based on IoT Technology Key Laboratory of Intelligent Detection and The Internet of Things in Manufacturing Ministry of EducationGuangzhou 510006China Guangdong-HongKong-Macao Joint Laboratory for Smart Discrete Manufacturing Guangzhou 510006China Key Laboratory of Intelligent Information Processing and System Integration of IoT Ministry of EducationGuangzhou 510006China. UTA Research Institute The University of Texas at ArlingtonFort WorthTX 76019USA

This paper presents a learning-based control policy design for point-to-point vehicle positioning in the urban environment via BeiDou *** navigating in urban canyons,the multipath effect is a kind of interference that causes the navigation signal to drift and thus imposes severe impacts on vehicle localization due to the reflection and diffraction of the BeiDou ***,the authors formulated the navigation control system with unknown vehicle dynamics into an optimal control-seeking problem through a linear discrete-time system,and the point-to-point localization control is modeled and handled by leveraging off-policy reinforcement learning for feedback *** proposed learning-based design guarantees optimality with prescribed performance and also stabilizes the closed-loop navigation system,without the full knowledge of the vehicle *** is seen that the proposed method can withstand the impact of the multipath effect while satisfying the prescribed convergence rate.A case study demonstrates that the proposed algorithms effectively drive the vehicle to a desired setpoint under the multipath effect introduced by actual experiments of BeiDou navigation in the urban environment.

关键词： BeiDou navigation multipath effect prescribed convergence rate reinforcement learning urban localization.

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