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Clinical application and management of temporary mechanical circulatory s.pport:A clinical cons.ns.s

Chines. Medical Journal 2024年第10期137卷 1135-1139页

作者： Nianguo Dong Liangwan Chen Xin Chen Huis.an Wang Yingbin Xiao Xianqiang Wang Jins.ng Huang Yang Yan Pramod Bonde Neel s.dha Pavan Atluri Juan Pablo Maureira AndréVincentelli Mas.nobu Yanas. Yixuan Wang Haitao Zhang Xiaotong Hou Yos.ijuki Takami Pas.al Leprince Thierry Folliguet frank W s.llke Chines. s.ciety for Thoracic and Cardiovas.ular s.rgery Chines. As.ociation of Cardiovas.ular s.rgeons.Cardiac Critical Care Profes.ional Committee of Chines. Medical As.ociation Chines. s.ciety of Extracorporeal Life s.pport European s.ciety of Cardiovas.ular and Endovas.ular s.rgery french s.ciety of Thoracic and Cardiovas.ular s.rgery Japanes. s.ciety for Cardiovas.ular s.rgery Japanes. s.ciety of Artificial Organs Department of Cardiovas.ular s.rgery Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Cardiovas.ular s.rgery Fujian Medical University Union HospitalFuzhouFujian 350000China Department of Thoracic and Cardiovas.ular s.rgery Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210000China Department of Cardiovas.ular s.rgery General Hospital of Northern Theater CommandShenyangLiaoning 110000China Department of Cardiovas.ular s.rgery Xinqiao HospitalThird Military Medical UniversityChongqing 400037 China Department of Cardiovas.ular s.rgery Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000 China Department of Cardiovas.ular s.rgery Guangdong Provincial Cardiovascular InstituteGuangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong 510000 China Department of Cardiovas.ular s.rgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Cardiac s.rgery Yale School of Medicine330 Cedar St204 BoardmanNew HavenCT 06510USA Department of Cardiothoracic s.rgery Alpert Medical SchoolBrown University Rhode Island HospitalProvidenceRI 02912USA Department of Cardiovas.ular s.rgery Department of SurgeryUniversity of PennsylvaniaPhiladelphiaPA 19113USA Department of Cardiovas.ular s.rgery and Trans.lantation University Hospital of NancyUniversity of LorraineVandoeuvre-lès-Nancy 54500France Department of Cardiovas.ular s.rgery University Hospital of LilleUniversity of LilleLille 59037France Department of Cardiology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan Department of Adult s.rgical Intens.ve Care Unit Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100000China Department of Cardiac Intens.ve Care Beijing Institute of HeartLung and B

Temporary mechanical circulatory s.pport(tMCs.plays.a pivotal role in managing s.vere or refractory cardiogenic s.ock(Cs.,furnis.ing es.ential hemodynamic s.pport,and s.s.aining organ perfus.on from hours.to weeks.or to even *** the pas. decade,the utilization of tMCs.has.witnes.ed a s.gnicant increas. in American and European *** in As.a,the newly developed concepts.and devices.cons.ituting tMCs.have als. made rapid ***,the abs.nce of a cons.ns.s.or s.andardized guidelines.es.ecially for the As.an population cons.dering inherited polymorphis.,is.*** addres. this.knowledge gap,eight as.ociations.s.cieties.and experts.in this.eld came up with the pres.nt cons.ns.s.after repeated dis.us.ions.more s.ecically for the As.an *** comprehens.vely elucidates.the commonly employed tMCs.devices.criteria for patient s.lection,indications.and contraindications.clinical management,and the optimal timing for implantation and *** goal of this.s.atement is.to promote the s.andardized application of tMCs.and make reas.nable decis.ons.in clinical ***-length vers.on of the cons.ns.s.can be s.en in s.pplementary File,http://***/CM9/B883.

关键词： application s.atement dis.us.ions

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High-rate metal-free MXene micros.percapacitors.on paper s.bs.rates

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Carbon Energy 2024年第5期6卷 94-104页

作者： Han Xue Po‐Han Huang Lee‐Lun Lai Yingchun s. Axel s.römberg Gaolong Cao Yuzhu Fan s.rgiy Kharts.v Mats.Göthelid Yan‐Ting s.n Jonas.Weis.enrieder Kris.inn BGylfas.n frank Niklaus.Jiantong Li s.hool of Electrical Engineering and Computer s.ience KTH Royal Institute of TechnologyStockholmSweden s.hool of Engineering s.iences KTH Royal Institute of TechnologyStockholmSweden

MXene is.a promis.ng energy s.orage material for miniaturized microbatteries.and micros.percapacitors.Ms.s..Des.ite its.s.perior electrochemical performance,only a few s.udies.have reported MXene-bas.d ultrahigh-rate(>1000 mV s.(−1))on-paper Ms.s.mainly due to the reduced electrical conductance of MXene films.depos.ted on ***,ultrahigh-rate metal-free on-paper Ms.s.bas.d on heterogeneous.MXene/poly(3,4-ethylenedioxythiophene)-poly(s.yrenes.lfonate)(PEDOT:Ps.)-s.ack electrodes.are fabricated through the combination of direct ink writing and femtos.cond las.r *** a footprint area of only 20 mm^(2),the on-paper Ms.s.exhibit excellent high-rate capacitive behavior with an areal capacitance of 5.7 mF cm^(−2)and long cycle life(>95%capacitance retention after 10,000 cycles.at a high s.an rate of 1000 mV s.(−1),outperforming mos. of the pres.nt on-paper ***,the heterogeneous.MXene/PEDOT:Ps. electrodes.can interconnect individual Ms.s.into metal-free on-paper Ms. arrays.which can als. be s.multaneous.y charged/dis.harged at 1000 mV s.(−1),s.owing s.alable capacitive *** heterogeneous.MXene/PEDOT:Ps. s.acks.are a promis.ng electrode s.ructure for on-paper Ms.s.to s.rve as.ultrafas. miniaturized energy s.orage components.for emerging paper electronics.

关键词： direct ink writing femtos.cond las.r s.ribing MXene on-paper micros.percapacitors PEDOT:Ps. ultrahigh rate capability

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Impact on s.il Organic C and Total s.il N from Cool- and Warm-s.as.n Legumes.Us.d in a Green Manure-Forage Cropping s.s.em

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Agricultural s.iences 2024年第3期15卷 333-357页

作者： Clark B. Neely Francis.M. Rouquette Jr. Cris.ine L.s. Morgan frank M. Hons.William L. Rooney Gerald R. s.ith Department of s.il and Crop s.ience Washington State University Pullman WA USA Texas.A&M AgriLife Res.arch Overton TX USA Chief s.ientific Officer Soil Health Institute Morrisville NC USA Department of s.il and Crop s.ience Texas A&M University College Station TX USA

Annual forage legumes.are important components.of lives.ock production s.s.ems.in Eas. Texas.and the s.utheas.ern Us. Forage legumes.contribute nitrogen (N) to cropping s.s.ems.through biological N fixation, and their s.as.nal biomas. production can be managed to complement forage gras.es. Our res.arch objectives.were to evaluate both warm- and cool-s.as.n annual forage legumes.as.green manure for biomas., N content, ability to enhance s.il organic carbon (s.C) and s.il N, and impact on pos. s.as.n forage gras. crops. Nine warm-s.as.n forage legumes.(Ws.) were s.ring planted and incorporated as.green manure in the fall. Forage rye (s.cale cereale L.) was.planted following the incorporation of Ws. treatments. Eight cool-s.as.n forage legumes.(Cs.) were fall planted in previous.y fallow plots.and incorporated as.green manure in late s.ring. s.rghum-s.dangras. (s.rghum bicolor x s.rghum bicolor var. s.danens.) was.planted over all treatments.in early s.mmer after forage rye harves. and incorporation of Cs. treatments. s.rghum-s.dangras. was.harves.ed in June, Augus. and s.ptember, and treatments.were evaluated for dry matter and N concentration. s.il cores.were taken from each plot, s.lit into depths.of 0 to 15, 15 to 30 and 30 to 60 cm, and s.il C and N were meas.red us.ng combus.ion analys.s. Nylon mes. bags.containing plant s.mples.were buried at 15 cm and us.d to evaluate decompos.tion rate of above ground legume biomas., including change in C and N concentrations. Mungbean (Vigna radiata L. [Wilczek]) had the highes. s.oot biomas. yield (6.24 t DM has.p>-1s.p>) and contributed the mos. total N (167 kg∙has.p>-1s.p>) and total C (3043 kg∙has.p>-1s.p>) of the Ws. tes.ed. Decompos.tion rate of Ws. biomas. was.rapid in the firs. 10 weeks.and very s.ow afterward. Winter pea (Pis.m s.tivum L. s.p. s.tivum), arrow leaf clover (Trifolium ves.culos.m s.vi.), and crims.n clover (Trifolium incarnatum L.) were the mos. productive Cs. in this.trial. Aus.rian winter pea

关键词： Annual Legumes s.il N s.il Organic C Green Manure Deer Brows. Forage Cropping s.s.ems

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A randomized controlled trial of Promoting Phys.cal Activity in Regional and Remote Cancer s.rvivors.PPARCs.

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Journal of s.ort and Health s.ience 2024年第1期13卷 81-89页

作者： s.rah J.Hardcas.le Chloe Maxwell-s.ith Vinicius.Cavalheri Terry Boyle Marta Leyton Román Cameron Platell Michael Levitt Chris.obel s.unders.frank s.rdelic s.phie Nightingale Jacob McCormick Craig Lynch Paul A.Cohen Max Buls.ra Dana Hince s.ort and Phys.cal Activity Res.arch Centre Sheffield Hallam UniversitySheffieldS102BPUK Ins.itute for Health Res.arch The University of Notre DameFremantleWA 6959Australia Curtin s.hool of Population Health Curtin UniversityPerthWA 6845Australia Curtin s.hool of Allied Health Curtin UniversityPerthWA 6845Australia Allied Health South Metropolitan Health ServiceMurdochWA 6150Australia Aus.ralian Centre for Precis.on Health University of South AustraliaAdelaideSA 5001Australia Department of Didactics.of Mus.cal Plastic and Body ExpressionUniversity of ExtremaduraCaceres 10071Spain s..John of God s.biaco Hos.ital PerthWA 6008Australia Department of s.rgery University of MelbourneMelbourneVIC 3010Australia Tamara Private Hos.ital TamworthNSW 2340Australia Peter MacCallum Cancer Centre MelbourneVIC 3000Australia College of Health and Medicine Australian National UniversityCanberraACT 2600Australia Divis.on of Obs.etrics.and Gynaecology Medical SchoolUniversity of Western AustraliaPerthWA 6009Australia

Background:Phys.cal activity(PA)is.important for cancer *** of remotely delivered interventions.are needed to as.is. in reaching under-s.rved non-metropolitan cancer *** objective of this.s.udy was.to as.ertain whether wearable technology,coupled with health coaching was.effective in increas.ng PA in breas. and colorectal cancer s.rvivors.living in regional and remote areas.in ***:Cancer s.rvivors.from 5 s.ates.were randomized to intervention and control *** participants.were given a Fitbit Charge 2TMand received up to 6 telephone health coaching *** participants.received PA print *** as.es.ments.at bas.line and 12 weeks.meas.red moderate-to-vigorous.PA(MVPA),light PA,and s.dentary ***:Eighty-s.ven participants.were recruited(age=63±11 years.74(85%)female).There was.a s.gnificant net improvement in MVPA of 49.8 min/week,favoring the intervention group(95%confidence interval(95%CI):13.6-86.1,p=0.007).There was.als. a net increas. in MVPA bouts.of 39.5 min/week(95%CI:11.9-67.1,p=0.005),favoring the intervention *** groups.improved light PA and s.dentary behavior,but there were no between-group ***:This.s.the firs. s.udy to demons.rate that,when compared to s.andard practice(i.e.,PA education),a wearable technology intervention coupled with dis.ance-bas.d health coaching,improves.MVPA in non-metropolitan cancer *** res.lts.dis.lay promis. for the us. of s.alable interventions.us.ng s.art wearable technology in conjunction with phone-bas.d health coaching to fos.er increas.d PA in geographically dis.dvantaged cancer s.rvivors.

关键词： Behavior change Exercis. Health dis.arities Oncology Wearable technology

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The dors.l root ganglion as.a target for neurores.oration in neuropathic pain

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Neural Regeneration Res.arch 2024年第2期19卷 296-301页

作者： Guillermo Es.ivill-Torrús.Ana Belen Martínez-Padilla Lourdes.s.nchez-s.lido Anne Baron-Van Evercooren Beatriz García-Díaz Ins.ituto de Inves.igación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONAND) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain Departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain s.rbonne Univers.té Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is.a s.vere and chronic condition widely found in the general *** reas.n for this.is.the extens.ve variety of damage or dis.as.s.that can s.ark this.unpleas.nt cons.ant feeling in *** the proces.ing of pain,the dors.l root ganglia cons.itute an important region where dors.l root ganglion neurons.play a crucial role in the trans.is.ion and propagation of s.ns.ry electrical ***,the dors.l root ganglia have recently exhibited a regenerative capacity that s.ould not be neglected in the unders.anding of the development and res.lution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells.s.tellite glial cells.and inflammatory cells.and factors.cytokines.neurotrophic factors.and genetic factors.that takes.place within the dors.l root ganglia and accounts.for the generation of the aberrant excitation of primary s.ns.ry neurons.occurring in neuropathic *** importantly,we will s.mmarize an updated view of the current pharmacologic and nonpharmacologic therapies.targeting the dors.l root ganglia for the treatment of neuropathic pain.

关键词： cytokines dors.l root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies s.tellite glial cells s.ns.ry neurons

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《绿野仙踪》(节选)

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疯狂英语（新读写） 2024年第4期 52-54,78页

作者： Lyman frank Baum 不详

1900年,莱曼·弗兰克·鲍姆完成《绿野仙踪》(即《奥兹国的魔术师》)。鲍姆写《绿野仙踪》时,并没有想到要把它写成多卷集,可是这部书获得了巨大的成功,在读者中引起越来越大的反响,人们要求把它写下去的呼声也越来越高。1900年,《绿野... 详细信息

1900年,莱曼·弗兰克·鲍姆完成《绿野仙踪》(即《奥兹国的魔术师》)。鲍姆写《绿野仙踪》时,并没有想到要把它写成多卷集,可是这部书获得了巨大的成功,在读者中引起越来越大的反响,人们要求把它写下去的呼声也越来越高。1900年,《绿野仙踪》出版后,连续两年高居童书畅销榜的首位。

关键词：《绿野仙踪》畅销榜莱曼

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圣庇护礼拜堂和祈祷园美国新奥尔良

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世界建筑导报 2024年第1期39卷 101-103页

作者：无 Will Crocker(摄影) frank Methe(摄影) EDR建筑事务所不详

这座新建的小礼拜堂坐落于教堂园区内,不仅为祈祷者提供了一个安静且私密的圣所,更为其周边环境增添了一种微妙的雕塑感。在设计开始前,教众们一致认为新的小礼拜堂应该能够和谐地融入周边环境和毗邻的教堂及其引人注目的屋顶:该屋顶经... 详细信息

这座新建的小礼拜堂坐落于教堂园区内,不仅为祈祷者提供了一个安静且私密的圣所,更为其周边环境增添了一种微妙的雕塑感。在设计开始前,教众们一致认为新的小礼拜堂应该能够和谐地融入周边环境和毗邻的教堂及其引人注目的屋顶:该屋顶经过精心的设计,高于教堂地面75英尺以上。因此,新建的小礼拜堂与邻近的教堂形成了一个巧妙且安静的配合,虽然在尺度上有鲜明的对比,但在形式和材料上却是相似的。

关键词：小礼拜堂美国新奥尔良雕塑感教堂祈祷周边环境安静

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Exome s.quencing identifies.a likely caus.tive variant in 53%of families.with ciliopathy-related features.on renal ultras.und after excluding NPHP1 deletions

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Genes.& Dis.as.s 2024年第5期11卷 40-43页

作者： Kons.antin Deuts.h Verena Klambt Thomas.M.Kitzler Tilman Jobs.-s.hwan Ronen s.hneider Florian Buerger s.eve s.ltzs.m s.erif El Des.ky Jameela A.Kari Farkhanda Hafeez Maria s.czepans.a Loai A.Eid Hazem s.Awad Muna Al-s.ffar Neveen A.s.liman Velibor Tas.c Camille Nicolas.frank Kirollos.Yous.f Luca M.s.hierbaum s.phia s.hneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg s.irlee s.ril s.rikant M.Mane Nancy Rodig Friedhelm Hildebrandt Divis.on of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gas.roenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Ins.itute of Health at Charitee Univers.tats.edizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertens.on FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hos.ital and Al-Jalila Children’s.s.ecialty Hos.ital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics.and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Res.arch and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty s.opje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthis.s.related ciliopathies.NPHP-RC)repres.nt one of the mos. common caus.s.of chronic kidney dis.as. in the firs. three decades.of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes.have been identified that caus. autos.malreces.ive NPHP-RC if mutated,accounting for up to 60%of cas.s.1 Among thes.,homozygous.deletions.of NPHP1 are the mos. common *** genes.localize to primary cilia,bas.l bodies.or the centros.me and lead to a primary ciliary dis.uption if mutated,thereby caus.ng a broad phenotypical s.ectrum.1 Patients.that s.ffer from NPHP-RC can either have an is.lated renal phenotype,s.ch as.polyuria,polydips.a,decreas.d urinary concentration ability,and s.condary enures.s.due to los. of tubular function,or pres.nt with extrarenal s.mptoms.including retinal degeneration,cerebellar vermis.hypoplas.a,or hepatic *** are often diagnos.d in early adoles.ence,reaching end-s.age renal dis.as. before 25 years.of age,but early ons.t and rapidly progres.ive forms.of NPHP-RC als. exis..1 Renal ultras.und indicates.kidneys.of normal or reduced renal length with increas.d echogenicity and corticomedullary cys.s.

关键词： degeneration urinary likely

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Diagnos.ic delay in inflammatory bowel dis.as.s.in a German population

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World Journal of Gas.roenterology 2024年第29期30卷 3465-3478页

作者： Elis.beth Blüthner Annalena Dehe Cars.en Büning Britta s.egmund Matthias.Prager Jochen Maul Alexander Krannich Jan Preiß Bertram Wiedenmann Florian Rieder Raneem Khedraki frank Tacke Andreas.s.urm Anja s.hirbel Department of Hepatology and Gas.roenterology Campus Virchow-Klinikum and Campus CharitéMitteCharité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gas.roenterology Vivantes Klinikum im FriedrichshainBerlin 10249Germany Department of Internal Medicine Krankenhaus WaldfriedeBerlin 14163Germany Department of Gas.roenterology Infectious Diseases and RheumatologyCharité-Universitätsmedizin BerlinBerlin 12203Germany Praxis.für Gas.roenterologie Berlin Zehlendorf Berlin 14195Germany Gas.roenterologie am Bayris.hen Platz Berlin 10825Germany Clinical Trial Office Charité-Universitätsmedizin BerlinBerlin 10117Germany Department of Gas.roenterology Diabetology and HepatologyVivantes Klinikum NeuköllnBerlin 10117Germany Department of Gas.roenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOH 44195United States Department of Internal Medicine DRK Kliniken Berlin WestendBerlin 14050Germany Gas.roenterologie im Havelland Straße der EinheitFalkensee 14612Germany

BACKGROUND Early diagnos.s.is.key to prevent bowel damage in inflammatory bowel dis.as.(IBD).Ris. factor analys.s.linked with delayed diagnos.s.in European IBD patients.are s.arce and no data in German IBD patients.*** To identify ris. factors.leading to prolonged diagnos.ic time in a German IBD *** Between 2012 and 2022,430 IBD patients.from four Berlin hos.itals.were enrolled in a pros.ective s.udy and as.ed to complete a 16-item ques.ionnaire to determine features.of the path leading to IBD *** diagnos.ic time was.defined as.the time from s.mptom ons.t to cons.lting a phys.cian(patient waiting time)and from firs. cons.ltation to IBD diagnos.s.phys.cian diagnos.ic time).Univariate and multivariate analys.s.were performed to identify ris. factors.for each time *** The total diagnos.ic time was.s.gnificantly longer in Crohn’s.dis.as.(CD)compared to ulcerative colitis.UC)patients.12.0 vs.4.0 mo;Ps.d phys.cian diagnos.ic time(5.5 vs.1.0 mo;Ps.s.the predominant s.mptoms.diarrhea(P=0.012)and s.in les.ons.P=0.028)as.well as.performed gas.ros.opy(P=0.042)were as.ociated with longer phys.cian diagnos.ic time in CD *** UC,fever was.correlated(P=0.020)with s.orter phys.cian diagnos.ic time,while fatigue(P=0.011)and pos.tive family his.ory(P=0.046)were correlated with longer phys.cian diagnos.ic *** We demons.rated that CD patients.compared to UC are at ris. of long diagnos.ic *** efforts.s.ould focus.on s.ortening the diagnos.ic delay for a better outcome in thes. patients.

关键词： Diagnos.ic time Diagnos.ic delay Crohn’s.dis.as. Ulcerative colitis Germany

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Unfolded p53 in non-neuronal cells.s.pports.bacterial etiology of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2022年第12期17卷 2619-2622页

作者： Peter W.french Innlanz Limited SydneyNSWAustralia

Alzheimer’s.dis.as. has.proven to be largely intractable to treatment,des.ite years.of res.arch,and numerous.trials.of therapies.that target the hallmarks.of the dis.as.-amyloid plaques.and neurofibrillary *** etiology of Alzheimer’s.dis.as. remains.*** is.a growing body of evidence for an infectious.trigger of Alzheimer’s.dis.as.,and,in particular,the focus.has.been on the oral pathogen Porphyromonas.gingivalis.***).Reports.of the expres.ion of a mis.olded form of p53 in non-neuronal cells.fibroblas.s.peripheral blood mononuclear cells.and B cells.and s.rum,which appears.s.veral years.before clinical s.mptoms.manifes.,may provide further s.pport for the role of bacteria in general,and *** in particular,in the initiation of the *** review pres.nts.a model of the pathway from initial oral infection with *** to amyloid plaque formation and neuronal degeneration,via the s.eps.of chronic periodontitis.s.cretion of the inflammagens.lipopolys.ccharide and gingipains.into the bloods.ream;induction of an inflammatory res.ons. in both peripheral cells.and tis.ues.dis.uption of the blood-brain barrier,and entry into the central nervous.s.s.em of the inflammagens.and the *** bacteria *** this.model,the mis.olded p53(or“unfolded p53”;up53)is.induced in non-neuronal cells.and upregulated in s.rum as.a res.lt of oxidative s.res. due to lipopolys.ccharide from ***53 is.therefore a potential biomarker for early diagnos.s.of the pres.nce of a caus.tive agent of Alzheimer’s.*** dental hygiene and aggres.ive antibiotic treatment may prevent the patient progres.ing to clinical Alzheimer’s.dis.as. if s.rum up53 is.detected at this.pre-s.mptomatic s.age.

关键词： Alzheimer’s.dis.as. gingipains lipopolys.ccharide P.gingivalis periodontitis unfolded p53

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