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中华内科杂志 2014年第1期53卷 5-8页

作者： frank b.hu HarvardSchoolofPublicHealth HarvardMedicalSchool

中国正处于一个向西方饮食与城市化生活方式转型的阶段，随之而来的是肥胖和2型糖尿病患病率的大幅上升，正确了解我国肥胖患病现状、健康危害、相关危险因素及其可能的预防措施对于肥胖和糖尿病的预防与控制具有重要的意义。

关键词： 2型糖尿病肥胖发病趋势中国糖尿病患病率相关危险因素生活方式患病现状

Precision Nutrition in Obesity and Diabetes Prevention and Treatment

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Precision Nutrition in Obesity and Diabetes Prevention and T...

第五届两岸四地营养改善学术会议

作者： frank b.hu Nutrition and Epidemiology Harvard T.H.Chan School of Public Health Medicine Harvard Medical School and Brigham and Women’s Hospital

Obesity and type 2 diabetes arise from the complex interplay of genetic and environmental *** the past several years,we have seen considerable progress in the use of genomics and metabolomics in investigating the role of diet and nutrition in the etiology of obesity and cardiometabolic disease,enabling the application of the precision medicine concept in preventing and managing chronic *** work suggests that the adverse effect of several obesity loci especially FTO can be modified by dietary and lifestyle *** particular,our results have

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咖啡,茶,酒精饮料及其保健效果

咖啡,茶,酒精饮料及其保健效果

中国女性被动吸烟与外周血管病和缺血性脑卒中关系的流行病学研究

饮料摄入与健康学术研讨会

作者： frank b.hu Professor of Nutrition Epidemiologyand Medicine

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中国女性被动吸烟与外周血管病和缺血性脑卒中关系的流行病学研究

Optimization of chemistry and process parameters for control of intermetallic formation in Mg sludges

履约控烟创建无烟环境——第14届全国控制吸烟学术研讨会暨中国控烟高级研讨班

作者：何耀林大庆姜斌王洁赛晓勇范利李晓鹰秦银河 frank b.hu 解放军总医院老年医学研究所香港大学公卫学院暨社会医学系解放军总医院针灸科

背景:被动吸烟(亦称吸二手烟)与外周血管病和脑卒中的关系尚不明确。方法:以北京城市社区无吸烟史老年妇女为研究对象,分析了从不吸烟的中国女性中二手烟和心血管病尤其是外周血管病和脑卒中的关系。被动吸烟的暴露定义为:过去10年中在...

背景:被动吸烟(亦称吸二手烟)与外周血管病和脑卒中的关系尚不明确。方法:以北京城市社区无吸烟史老年妇女为研究对象,分析了从不吸烟的中国女性中二手烟和心血管病尤其是外周血管病和脑卒中的关系。被动吸烟的暴露定义为:过去10年中在家庭或工作场所吸入其他人吸烟产生的烟雾。心血管事件包括冠心病、脑卒中和外周血管病;其中,外周血管病以世界卫生组织ROSE问卷测量的间歇性跛行和踝臂指数<0.9为诊断标准。

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Journal of Magnesium and Alloys 2024年第4期12卷 1431-1448页

作者： Y.Fu G.G.Wang A.hu Y.Li K.b.Thacker J.P.Weiler H.hu Department of Mechanical Automotive and Materials EngineeringUniversity of Windsor401 Sunset AveWindsorOntario N9B 3P4Canada Global Technology Centre Meridian Lightweight Technologies25 MacNab AveStrathroyOntario N7G 4H6Canada

Intermetallic formation in sludge during magnesium(Mg)melting,holding and high pressure die casting practices is a very important ***,very often it is overlooked by academia,original equipment manufacturers(OEM),metal ingot producers and even die *** aim of this study was to minimize the intermetallic formation in Mg sludge via the optimization of the chemistry and process *** Al8Mn5 intermetallic particles were identified by the microstructure analysis based on the Al and Mn *** design of experiment(DOE)technique,Taguchi method,was employed to minimize the intermetallic formation in the sludge of Mg alloys with various chemical compositions of Al,Mn,Fe,and different process parameters,holding temperature and holding *** sludge yield(SY)and intermetallic size(IS)was selected as two *** optimum combination of the levels in terms of minimizing the intermetallic formation were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,690℃ for the holding temperature and holding at 30 mins for the holding time,*** best combination for smallest intermetallic size were 9 wt.%Al,0.15 wt.%Mn,0.001 wt.%(10 ppm)Fe,630℃ for the holding temperature and holding at 60 mins for the holding time,*** groups of sludge factors,Chemical Sludge(CSF),Physical Sludge(PSF)and Comprehensive Sludge Factors(and CPSF)were established for prediction of sludge yields and intermetallic sizes in Al-containing Mg *** CPSF with five independent variables including both chemical elements and process parameters gave high accuracy in prediction,as the prediction of the PSF with only the two processing parameters of the melt holding temperature and time showed a relatively large deviation from the experimental *** Chemical Sludge Factor was primarily designed for small ingot producers and die casters with a limited melting and holding capacity,of which process parameters could be fixed *** Physical Sludge Factor could be used f

关键词： Magnesium sludge Al-Mn intermetallic Optimization Taguchi method Sludge factor Chemical composition Process parameter

东风-同济队列研究：研究方法及调查对象基线和第一次随访特征

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中华流行病学杂志 2016年第4期37卷 480-485页

作者：何美安张策朱江姚平李秀楼袁晶王峰刘跃伟陈卫红闵新文韩煦关蕾王静方为民梁渊王友洁魏晟刘继纯司文虎缪小平李东风郑建如张晓敏郭欢杨汉东 frank b.hu 邬堂春华中科技大学同济医学院公共卫生学院教育部环境与健康重点实验室武汉430030 东风汽车公司东风总医院十堰442008 社保中心哈佛公共卫生学院营养学系美国波士顿02115

目的探讨环境、职业因素、个人生活方式、遗传因素和遗传-环境交互作用对某职业人群的主要慢性病发生和发展的影响。方法东风-同济队列研究为一项建立有生物样本库的前瞻性开放式队列研究。2008-2009年对湖北省十堰市东风汽车公司退... 详细信息

目的探讨环境、职业因素、个人生活方式、遗传因素和遗传-环境交互作用对某职业人群的主要慢性病发生和发展的影响。方法东风-同济队列研究为一项建立有生物样本库的前瞻性开放式队列研究。2008-2009年对湖北省十堰市东风汽车公司退休职工进行基线调查,包括问卷调查、体格检查、生化指标检查和血液样本采集。计划每5年随访一次。2013年4-10月完成了第一次随访,再次进行了问卷调查、体格检查、生化指标检查和血液样本采集。结果基线调查共邀请了31000名东风汽车公司退休职工,其中27009名（占87%）退休职工同意参加并提供了流行病学调查信息和基线血液样本。东风-同济队列研究入选人群的基线平均年龄为63.6岁,其中男性占44.6%。2013年第一次随访共纳入了38295名退休职工,男性占44.7%。在2013年第一次随访研究人群中,40.5%的参与者为高中及以上学历。队列人群男性和女性的现在吸烟率分别为33.6%和2.0%,饮酒率分别为39.9%和10.6%;38295人群中流行病学调查自我报告的慢性疾病患病率分别为高血压41.1%、高脂血症24.3%、糖尿病13.9%、冠心病16.7%、中风5.1%、慢性支气管炎12.7%和哮喘4.0%;男性高血压和中风的自我报告患病率高于女性。2008年基线人群中,共有25978人随访到相关信息,2008年基线人群第一次的随访率为96.2%。结论东风-同济队列的建立为研究遗传、环境及遗传-环境交互作用对慢性病发生和发展提供了重要资源。

关键词：慢性病队列研究职业人群生物样本库

Mapping out the reaction network of humin formation at the initial stage of fructose dehydration in water

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Green Energy & Environment 2024年第6期9卷 1016-1026页

作者： Xing Fu Yexin hu Ping hu hui Li Shuguang Xu Liangfang Zhu Changwei hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengduSichuan610064China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengduSichuan611137China

The formation of humins hampers the large-scale production of 5-hydroxymethylfurfural(HMF)in ***,a detailed reaction network of humin formation at the initial stage of fructose-to-HMF dehydration in water is delineated by combined experimental,spectroscopic,and theoretical *** bimolecular reaction pathways to build up soluble humins are *** is,the intermolecular etherification of β-furanose at room temperature initiates the C12 path,whereas the C-C cleavage of a-furanose at 130-150℃ leads to C11 path,and that of open-chain fructose at 180℃ to C11' *** successive intramolecular dehydrations and condensations of the as-formed bimolecular intermediates lead to three types of soluble *** show that the C12 path could be restrained by using HCl or AlCl_(3) catalyst,and both the C12 and C110 paths could be effectively inhibited by adding THF as a co-solvent or accelerating heating rate via microwave heating.

关键词： Carbohydrates 5-hydroxymethylfurfural Reaction network Soluble humins Tautomer

Multi-Axis Attention With Convolution Parallel block for Organoid Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1295-1297页

作者： Pengwei hu Xun Deng Feng Tan Lun hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830011 University of Chinese Academy of Sciences Beijing 100049 Xinjiang Laboratory of Minority Speech and Language Information Processing Urumqi 830011China Merck KGaA Darmstadt 64293Germany

Dear Editor,This letter presents an organoid segmentation model based on multi-axis attention with convolution parallel *** adeptly captures dynamic dependencies within bright-field microscopy images,improving global ... 详细信息

关键词： letter convolution organo

Rational modulation of electronic structure in PtAuCuNi alloys boosts efficient electrocatalytic ethanol oxidation assisted with energy-saving hydrogen evolution

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Journal of Energy Chemistry 2024年第6期93卷 557-567,I0014页

作者： hu Yao Yinan Zheng Xin Yu Songjie hu baolian Su Xiaohui Guo Key Lab of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education The College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069ShaanxiChina Department of Inorganic Chemistry University of NamurBruxellesB-5000 NamurBelgium

Compared to conventional electrocatalytic water splitting,electrocatalytic ethanol oxidation reaction(EOR)along with hydrogen production is considered a more energy-efficient ***,we prepared a type of novel quaternary alloy catalyst(PtAuCuNi@NF)that exhibits excellent activity for EOR(0.215 V at 10 mA cm^(-2))and hydrogen evolution reaction(HER)(7 mV at 10 mA cm^(-2)).Experimental results demonstrated that both Cu and Ni modulated the electronic environment around Pt and *** electron-rich active center facilitates the rapid adsorption and dissociation of reactants and intermediates for both EOR and ***,in the ethanol-assisted overall water splitting(E-OWS),a current density of 10 mA cm^(-2)was achieved at 0.28 ***,an advanced acid-base self-powered system(A-bsps)that can achieve a self-powered voltage of 0.59 V was ***,the self-driven hydrogen production with zero external power supply was realized by integrating A-bsps with the E-OWS *** interesting results can provide a feasible strategy for designing and developing advanced nanoalloy-based materials for clean energy integration and use in various fields.

关键词： Pt-based alloy Electronic structure Ethanol oxidation Self-powered system Overall water splitting

Total synthesis of a putative yuzurimine-type Daphniphyllum alkaloid C_(14)–epi-deoxycalyciphylline H

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Chinese Chemical Letters 2024年第4期35卷 336-339页

作者： Jingping hu Jing Xu Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhen 518055China

One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contiguous stereogenic centers, and vicinal all-carbon quaternary centers make these alkaloids formidable challenge for synthetic chemists. Recently, synthesis of these alkaloids has received extensive attention from our community. Herein, we wish to report the total synthesis of C_(14)–epideoxycalyciphylline H, a putative member of yuzurimine-type alkaloid subfamily. Key transformations employed in our approach include an intramolecular Prins reaction and a Pd-catalyzed enyne cycloisomerization. In addition, synthesis of a daphnezomine L-type alkaloid, paxdaphnidine A, was also studied.

关键词： Total synthesis Daphniphyllum alkaloids Yuzurimine-type alkaloids Prins reaction Enyne cycloisomerization