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Regulatory T cell Itch reins in Th2 inflammation

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Cellular & Molecular Immunology 2014年第2期11卷 126-128页

作者： Benjamin DSinger franco RD'Alessio Johns Hopkins University Division of Pulmonary and Critical Care Medicine Baltimore USA

Type 2 T helper （Th2） inflammation underlies common clinical disor-ders such as asthma, eczema and other atopic diseases. CD4＋ regulatory T cells （Tregs） suppress over-exuberant immune responses in a variety of inflammatory microenvironments, including Th2 con- ditions. The transcription factor fork- head box protein 3 （Foxp3） controls Treg development, function and main- tenance; however,

关键词： Regulatory reins inflammation

Fluidization: An Important Process in the Formation of the Qiyugou Au-bearing Breccia Pipes in Central China

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Acta Geologica Sinica(english edition) 2007年第2期81卷 226-238页

作者： ZHANG Yuanhou ZHANG Shihong franco PIRAJNO College of earth Sciences Jilin University Changchun Jilin 130061 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China Geological Survey of Western Australia 100 Plain Street Perth WA6004 Australia

Fluidization processes based on experiments are reviewed to gain some useful insights and comparisons with those that occur in hydrothermal systems. Field and petrographic work, and microscope observation were carried out on samples from the Qiyugou Au-bearing breccia pipes from the east Qinling region, Henan Province. evidence from macro- and micro-textures suggests that the style of breccias in the Qiyugou area can be grouped into three types：（1） jigsaw fit-stockwork texture, in which the interval between clasts is marked by fractures or filled with calcite or quartz veins; （2） larger breccias that are supported by smaller breccias, rock flour and alteration materials; in this type clasts moved over short distances, creating open spaces; （3） fluidized texture, where the clasts of different lithologies have rounded shapes. These observations are compared with those resulting from experiments on fluidization processes. The results of this comparison suggest that fluidization is an important geological process in the formation of the Qiyugou Au-bearing breccia pipes and gold mineralization. In addition, fluidization processes such as expansion, bubbling, slugging, channeling and spouting must have contributed to the formation of the pipes and were conducive to the development of gold mineralization. In the Qiyugou breccia pipes, gold mineralization occurs as disseminations, in stockwork veins, and open space infills. The ore zones form subparallel sheets that are nearly perpendicular to the walls of the pipes.

关键词： fluidization breccia pipe gold mineralization Qiyugou Cretaceous Henan Qinling China

Distribution and Abundance of Pelagic Tunicates in the North Yellow Sea

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Journal of Ocean University of China 2014年第5期13卷 782-790页

作者： Pietro franco CHeN Hongju LIU Guangxing Key Laboratory of Marine environment and ecology Ministry of Education Ocean University of China College of environmental Science and engineering Ocean University of China

In this paper, the distribution patterns and abundance of pelagic tunicates in the North Yellow Sea of China during the period 2006-2007 were analyzed. Zooplankton samples were obtained with vertical towing from bottom to surface using a WP2 plankton net(200 μm mesh size; mouth area: 0.25 m2). Five species belonging to two classes were identified: Oikopleura dioica, O. longicauda and Fritillaria borealis belonging to class Appendicularia; Salpa fusiformis and Doliolum denticulatum of class Thaliacea. O. dioica and O. longicauda were the dominant species, occurring in the samples of all four seasons, with different distribution patterns. Their maximum abundance were 1664.7 ind. m-3(spring) and 1031.7 ind. m-3(spring) respectively. Following Oikopleura spp. were D. denticulatum, which was found only in autumn with an average abundance of 149.6 ind. m-3, and S. fusiformis, which was detected all the year long except for autumn with low abundance(max. abundance 289.4 ind. m-3 in summer). Only a very small amount of F. borealis was detected in summer samples, with an average abundance of 2.7 ind. m-3. The relationship between tunicates abundances and the environmental factors was analyzed using the stepwise regression model for each species. The variation of appendicularian abundance showed a significant correlation with the surface water temperature and with the concentration of Chl-a. No relationship was found between tunicates abundance and salinity, likely due to the slight changes in surface salinity of the studied area during the four seasons. Salps abundance and that of doliolids were significantly correlated to bottom water temperature, indicating that these two species(S. fusiformis and D. denticulatum) migrate vertically in the water column. In particular D. denticulatum, known to be a warm water species, showed not only an important correlation with water temperature, but also a spatial distribution connected to the warm currents in the North Yellow Sea. The o

关键词： North Yellow Sea pelagic tunicates abundance distribution sea surface temperature

SHRIMP Zircon U-Pb Dating of Alkaline Dykes in the Pobei Area,Beishan Rift,Xinjiang Autonomous Region,China:Implications for Tectonic Setting and Mantle Plume events

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Acta Geologica Sinica(english edition) 2012年第4期86卷 879-884页

作者： MAO Jingwen franco PIRAJNO ZHANG Zuoheng WAN Yusheng MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences Geological Survey of Western Australia 100 Plain StreetEast PerthWA 6004Australia MLR key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological Sciences Institute of Geology Chinese Academy of Geological Sciences

In the Beishan rift in the eastern Tianshan orogen, Xinjiang Province, a N-S-trending dyke swarm is present in the Pobei area. The swarm cuts through the 270-290 Ma mafic-ultramafic intrusions associated with Ni-Cu sulphide mineralization. These mafic-ultramafic intrusions are typically found along e-W major faults in the Tianshan orogenic belts. We report SHRIMP U-Pb dating of zircons from a dyke of alkaline composition, which yielded a mean age of 252~9 Ma. Alkaline dykes of the same age are found in the Altay region of Siberia. This age is younger than the 270-290 Ma intraplate magmatic events that produced the mafic-ultramafic intrusions in the region, but in general agreement with the 250-260 Ma Permian plume event that gave rise to the Siberian traps and the emeishan flood basalts in SW China. We suggest that there is a link between the emeishan event and the dyke swarm in the Beishan rift and that the intraplate magmatism at 270-290 Ma reflects an early stage of mantle plume activity. The N-S trending dyke swarm in the Beishan rift may represent a later stage in the evolution of mantle plume activity in the NW and SW of China. We also speculate that in Beishan rift and possibly elsewhere in the Tianshan region, the dykes fed basaltic volcanism, whose products have since been eroded due to the strong uplift of the Tianshan orogen as a result of the Indiaeurasia collision in the Cenozoic.

关键词： Alkaline dykes SHRIMP tectonic setting mantle plume China

Mucosal biomarkers in inflammatory bowel disease:Key pathogenic players or disease predictors?

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World Journal of Gastroenterology 2010年第21期16卷 2616-2625页

作者： franco Scaldaferrii Carmen Correale Antonio Gasbarrini Silvio Danese Department of Internal Medicine Catholic University of Rome00168 RomeItaly Division of Gastroenterology IRCCSIstituto Clinico Humanitas20089 RozzanoMilanItaly

Inflammatory bowel diseases(IBDs) are chronic inflammatory disorders of the bowel,including ulcerative colitis and Crohn's disease.A single etiology has not been identified,but rather the pathogenesis of IBD is very complex and involves several major and minor contributors,employing different inflammatory pathways which have different roles in different *** new and powerful medical treatments are available,many are biological drugs or immunosuppressants,which are associated with significant side effects and elevated *** a result,the need for predicting disease course and response to therapy is *** attempts have been made at identifying clinical characteristics,concurrent medical therapy,and serological and genetic markers as predictors of response to biological *** few reports exist on how mucosal/tissue markers are able to predict clinical behavior of the disease or its response to *** aim of this paper therefore is to review the little information available regarding tissue markers as predictors of response to therapy,and reevaluate the role of tissue factors associated with disease severity,which can eventually be ranked as "tissue factor predictors".Five main categories are assessed,including mucosal cytokines and chemokines,adhesion molecules and markers of activation,immune and non-immune cells,and other mucosal *** in the design and specificity of clinical studies are mandatory to be able to classify tissue markers as predictors of disease course and response to specific therapy,obtain the goal of achieving "personalized pathogenesisoriented therapy" in IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course predictors Cytokines Chemokines Intestinal mucosa

Prediction of the Resonance Characteristics of Combustion Chambers on the Basis of Large-eddy Simulation

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Journal of Thermal Science 2005年第2期14卷 156-161页

作者： franco MAGAGNATO Balázs PRITZ Horst BCHNeR Martin GABI Department of Fluid Machinery University of Karlsruhe GermanyDepartment of Fluid Machinery University of KarlsruheGermanyEngler-Bunte-Institute/Division for Combustion Technology University of KarlsruheGermanyDepartment of Fluid Machinery University of KarlsruheGermany

In the last few years intensive experimental investigations were performed at the University of Karlsruhe to develop an analytical model for the Helmholtz resonator-type combustion system. In the present work the resonance characteristics of a Helmholtz resonator-type combustion chamber were investigated using large-eddy simulations (LeS), to understand better the flow effects in the chamber and to localize the dissipation. In this paper the results of the LeS are presented, which show good agreement with the experiments. The comparison of the LeS study with the experiments sheds light on the significant role of the wall roughness in the exhaust gas pipe.

关键词： compressible large-eddy simulation combustion instabilities oscillating flow damping ratio.

Robot-assisted laparoscopic vs open gastrectomy for gastric cancer:Systematic review and meta-analysis

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World Journal of Clinical Oncology 2017年第3期8卷 273-284页

作者： Stefano Caruso Alberto Patriti franco Roviello Lorenzo De franco franco Franceschini Graziano Ceccarelli Andrea Coratti Department of General Surgery and Surgical Specialties Unit of General Surgery"Santa Maria Annunziata" HospitalLocal Health Unit Center Tuscany Company Department of Surgery Division of General SurgeryHospitals of Pesaro and Fano"Ospedali Riuniti Marche Nord" Hospital Company Department of Medical Surgical and NeuroscienceUnit of General and Minimally Invasive SurgeryUniversity of Siena Department of Medicine and General Surgery Unit of Minimally Invasive and General SurgeryLocal health Unit South-Est Tuscany Company"San Donato" Hospital Division of Oncological and Robotic General Surgery "Careggi" University Hospital

AIM To evaluate the potential effectiveness of robot-assisted gastrectomy(RAG) in comparison to open gastrectomy(OG) for gastric cancer *** A comprehensive systematic literature search using PubM ed,eMBASe,and the Cochrane Library was carried out to identify studies comparing RAG and OG in gastric *** of any age and sex were considered for inclusion in comparative studies of the two techniques independently from type of gastrectomy.A meta-analysis of short-term perioperative outcomes was performed to evaluate whether RAG is equivalent to *** primary outcome measures were set for estimated blood loss,operative time,conversion rate,morbidity,and hospital *** among postoperative complications,wound infection,bleeding and anastomotic leakage were also *** A total of 6 articles,5 retrospective and 1 randomized controlled study,involving 6123 patients overall,with 689(11.3%) cases submitted to RAG and 5434(88.7%) to OG,satisfied the eligibility criteria and were included in the *** was associated with longer operation time than OG(weighted mean difference 72.20 min;P eduction in blood loss and shorter hospital stay(weighted mean difference-166.83 mL and-1.97 d respectively;P erences were found with respect to overall postoperative complications(P = 0.65),wound infection(P = 0.35),bleeding(P = 0.65),and anastomotic leakage(P = 0.06).The postoperative mortality rates were similar between the two *** respect to oncological outcomes,no statistical differences among the number of harvested lymph nodes were found(weighted mean difference-1.12;P = 0.10).CONCLUSION RAG seems to be a technically valid alternative to OG for performing radical gastrectomy in gastric cancer resulting in safe complications.

关键词： Robot-assisted gastrectomy Gastric resection Open gastrectomy Gastric cancer

Haemostatic system in inflammatory bowel diseases:New players in gut inflammation

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World Journal of Gastroenterology 2011年第5期17卷 594-608页

作者： franco Scaldaferri Stefano Lancellotti Marco Pizzoferrato Raimondo De Cristofaro Department of Inter nal Medicine and Medical Specialties Gastroenterology Divi sionCatholic University of Rome00168 RomeItaly Department of Internal Medicine and Medical Specialties Haemostasis Research CenterCatholic University of Rome00168 RomeItaly

Inflammation and coagulation constantly influence each other and are constantly in *** evidence supports this statement in acute inflammatory diseases,such as sepsis,but it also seems to be very important in chronic inflammatory settings,such as inflammatory bowel disease(IBD).Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events,and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels,where most severe inflammatory abnormalities *** aims of this review are to update and classify the type of coagulation system abnormalities in IBD,and analyze the strict and delicate balance between coagulation and inflammation at the mucosal *** studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.

关键词： Activated protein C Coagulation Crohn'sdisease Inflammation Inflammatory bowel disease Platelets Ulcerative colitis

Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients

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World Journal of Gastroenterology 2012年第44期18卷 6398-6408页

作者： Alessandro Cucchetti Matteo Cescon franco Trevisani Antonio Daniele Pinna General Surgery and Transplant Unit Department of General Surgery and Organ TransplantationAlma Mater StudiorumUniversity of Bologna40138 BolognaItaly Department of Clinical Medicine Semeiotica MedicaS.Orsola-Malpighi HospitalAlma Mater StudiorumUniversity of BolognaVia Massarenti 940138 BolognaItaly

Hepatocellular carcinoma(HCC) is one of the most frequent neoplasms worldwide and in most cases it is associated with liver *** resection is considered the most potentially curative therapy for HCC patients when liver transplantation is not an option or is not immediately *** review is aimed at investigating the current concepts that drive the surgical choice in the treatment of HCC in cirrhotic patients;eastern and Western perspectives are *** extensive literature review of the last two decades was performed,on topics covering various aspects of hepatic *** post-operative and long-term outcome measures adopted were firstly analyzed in an attempt to define an optimal standardization useful for research *** need to avoid the development of post-hepatectomy liver failure represents the "conditio sine qua non" of surgical choice and the role of the current tools available for the assessment of liver function reserve were *** of hepatic resection in relationship with tumor burden were compared with those of available competing strategies,namely,radiofrequency ablation for early stages,and trans-arterial chemoembolization for intermediate and advanced ***,the choice for anatomical versus non-anatomical,as well as the role of laparoscopic approach,was *** literature review suggests that partial hepatectomy for HCC should be considered in the context of multi-disciplinary evaluation of cirrhotic *** research on HCC has moved,in recent years,from surgical therapy toward non-surgical approaches and most of the literature regarding topics debated in the present review is represented by observational studies,whereas very few well-designed randomized controlled trials are currently available;thus,no robust recommendations can be derived.

关键词： Hepatocellular carcinoma Hepatic resec-tion Surgical therapy Ablation techniques Transplan-tation Survival Liver failure