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Marfan Syndrome Complicated by Aortic Arch Aneurysm and Aortic Dissection: A Case Report from Congo

World Journal of Cardiovascular Diseases 2022年第10期12卷 463-471页

作者： Solange Flore Ngamami Mongo Christian Michel Kouala Landa franck yannis kouikani Kivié Mou-Moué Ngolo Letomo Rogue Pattern Bakekolo Bertrand Fikahem Ellenga Mbolla Department of Cardiology University Hospital of Brazzaville Brazzaville Republic of the Congo Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Context and Aim: Marfan syndrome is a transmissible genetic disease of the connective tissue that is rarely encountered in Congo and in sub-Saharan African countries. Its cardiovascular complications can be life frightening. The management of that disease is still limited in our country because of a lack of technical capacity in cardiovascular surgery. The aim of this clinical report is to show the interest of echocardiography and especially angioscanner as the main technique in the diagnosis of the severity of this disease, elaborate a literature review, but also to highlight the difficulties encountered in the management of that affection in our countries. Observation: The authors report the medical observation of a 48-year-old adult with a history of cataract of the left eye and a subluxation of the lens for which he underwent surgery in 2016, without any etiology being found. He is a smoker at a rate of 6 packs yearly. He consulted for progressively worsening dyspnea and constrictive mediosternal pain. The clinical examination revealed a moderate alteration of the general state, apyrexia, a blood pressure of 140/90 mmHg, a SPO2 of 97% in ambient air, a respiratory frequency of 32 cycles/min, signs of left ventricular insufficiency, a diastolic murmur of aortic insufficiency of intensity 4/6th, a long-limbed morphotype with a wingspan superior to the height and a kyphoscoliosis. Chest X-ray showed cardiomegaly with a cardiothoracic ratio of 58%, a highly dilated and uncoiled aorta, convexity of the left inferior arch, and venocapillary hypertension and a quiet alveolar-interstitial pulmonary oedema. The ECG was in sinus rhythm and showed a poor R-wave progression in anteroseptal leads. Echocardiography showed significant aortic root dilatation up to 72.6 mm and aortic regurgitation grade IV. Angioscanner showed a dissected aortic aneurysm and areas of emphysema located in the lungs. The medical treatment was palliative with beta blocker and angiotensin

关键词： Marfan Syndrome Heart Failure Aortic Aneurysm Aortic Dissection Congo

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Papulosa Nigra Dermatosis Another Factor Associated with Cardio-Vascular Diseases?

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World Journal of Cardiovascular Diseases 2023年第12期13卷 819-826页

作者： Solange Flore Ngamami Mongo Bani Aloise Macaire franck yannis kouikani Kivié Mou-Moué Ngolo Letomo Bayonne S. E. Kombo Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo General Hospital of Loandjili Pointe Noire Republic of Congo

Objectives: To determine the correlation between dermatosis papulosa nigra (DPN) and cardiovascular disease (CVD). Patients and Method: A retrospective study was conducted between April 2022 and March 2023 in cardiology at Loandjili General Hospital. Were included all adult patients older than 18 years of age presenting with DPN, and divided into two groups according to the presence of CVD. Hypertension (HT), endomyocardial fibrosis, dilated and restrictive cardiomyopathy, chronic pulmonary heart, ischemic heart disease, stroke, and valvular heart disease were retained as CVD. Pregnant women, Peutz Jeghers syndrome and all dermatosis with cardiovascular manifestations were excluded. Studied variables were clinico-demographic, hereditary and behavioral. Results: A total of 55 patients were selected. There were 40 patients with CVD, 15 patients without CVD, 43 women (78.1%) and 12 men (21.8%). Mean age was 52 ± 12.6 years (extremes: 22 - 85 years). There was a significant difference between age and sex (P 0.05). There were 34 hypertensive patients, 10 patients with diabetes mellitus, 7 strokes, 2 endomyocardial fibrosis and 2 ischemic heart diseases. Periorbital location was representative was frequently found in the group with CVD. Hereditary and behavioral factors were involved in the development of DPN and CVD. There was a significant correlation between DPN and onset in childhood (P 0.05), between hypertension and use of medication (P 0.05), and between onset in childhood (P 0.05) and use of mercury containing soap (P 0.05). Conclusion: DPN predominates in young women. The occurrence of CVD depends on DPN location. Hereditary and behavioral factors associated with development of DPN are CVD factor risks.

关键词： Papulosa Nigra Cardiovascular Disease Correlation Pointe Noire

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Epidemiological and Clinical Profile of Hypertensive Patients with Obstructive Sleep Apnea at CHU-B

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World Journal of Cardiovascular Diseases 2023年第10期13卷 664-673页

作者： Solange Flore Ngamami Mongo Kivie Mou-Moue Ngolo Letomo Arnold Sem Nguia Vel Christian Kouala Landa franck yannis kouikani Rogue Pattern Bakekolo Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Adolphe Cissé Emergency Department Pointe Noire Republic of Congo

Objectives: To detect obstructive sleep apnea syndrome (OSAS) in a population of hypertensive patients, using the Berlin questionnaire and to establish the epidemiological and clinical profile of patients. Patients and Method: This was a cross-sectional and analytical study, carried out from March to August 2019 at the CHU Brazzaville. Included are hypertensive patients followed as outpatients. The diagnosis of the OSAS was based on the answers to the Berlin questionnaire. Results: A total of 315 patients were included, including 210 women (64.9%). Prevalence of OSAS was 75.8% (n = 239). The average age of patients with sleep apnea was 58.5 ± 12.4 years with female predominance (64.9%). In the mixed analysis, the factors associated with (OSAS) were: occupation OR (2.56) 95% CI (1.15 - 5.69), obesity OR 7.50 (1.60 - 35.1) and abdominal obesity OR 2.36 CI 95% (1.36 - 4.08). Living standards were high in 59 cases (18.7 per cent). The medical history of previous hospitalization was present in 209 cases (66.3%), diabetes 95 (30.2%), and heart failure 57 cases (18.1%). Lifestyle patterns were: sedentary (n = 181;57.5%) alcohol consumption (n = 97;30.8%). On physical examination, overweight was noted in 96 cases (30.5%) and obesity in 91 cases (28.8%). The anomalies in the Berlin questionnaire were: snoring (n = 197;62.5%), waking fatigue (n = 127;40.3%), fatigue during the day (n = 97;30.8%). Conclusion: The prevalence of obstructive sleep apnea syndrome is high during arterial hypertension in our setting. Hence the need for sleep exploration through polysomnography, and prevention through the fight against the associated risk factors.

关键词： Hypertension Obstructive Sleep Apnea Syndrome Brazzaville

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Arterial Hypertension and Pregnancy about 72 Cases

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World Journal of Cardiovascular Diseases 2023年第12期13卷 870-878页

作者： Solange Flore Ngamami Mongo Kivié Mou-Moué Ngolo Letomo Christian Michel Kouala Landa Rode Vaclair Kibongui Massinssa Rogue Pattern Bakekolo franck yannis kouikani Bani Aloise Macaire Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Hô pital général de Loandjili Pointe Noire République du Congo

Background: Hypertension is the leading cause of cardiovascular disease worldwide. Hypertensive disorders in pregnancy also constitute a major global health threat. There are different types of hypertension that can occur during pregnancy;with different mechanisms and consequences for mother and fetus. Objectives: To determine the frequency of hypertension (hypertension) during pregnancy. Document the risk factors for pregnancy-related hypertension. Review the material and fetal complications which determine the prognosis. Methods and Patients: This was a retrospective cross-sectional study from January 1 to June 30, 2022 in the Obstetrics and Gynecology Department of the Brazzaville Hospital and University Center. We noted 72 cases of hypertension among 1188 births admitted during the reference period. Hypertension was defined as blood pressure 40/90mmHg. Results: Hypertension was observed in 6% of those giving birth. The average age of the patients was 28 ± 8 years (range 15 to 39 years). The age group of 15 to 34 years was the most affected, 56 cases (778%). The risk factors were young age (15 - 34 years), late transfer of women in labor, 49 cases (68%). Primiparity, 33 cases (45.8%), absence of prenatal consultation, 7 cases (9.7%), hypertension, 8 cases (11%), twinning, 4 cases (5%), fetal macrosomia, one case (1.3%). Maternal complications recorded were: 21 cases of eclampsia (29%), 6 cases of left ventricular failure (8.3%), 5 cases of anemia (6.9%), 2 cases of retroplacental hematoma (2.8%), 1 case of HELLP syndrome, as much renal failure. Fetal and neonatal complications were 23 cases of prematurity (32%), 10 cases of acute fetal distress (14%), 4 cases of hypotrophy (5.6%). Eleven cases of death (15.3%) were: 3 in utero. B in the neonatal period.

关键词： Hypertension Pregnancy Pre-Eclampsia Complications

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Marfan Syndrome Complicated by Aortic Arch Aneurysm and Aortic Dissection:A Case Report from Congo

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World Journal of Cardiovascular Diseases（心血管病） 2022年第10期

作者： solange flore ngamami mongo christian michel kouala landa franck yannis kouikani kivié mou-moué ngolo letomo rogue pattern bakekolo bertrand fikahem ellenga mbolla

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Papulosa Nigra Dermatosis Another Factor Associated with Cardio-Vascular Diseases?

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World Journal of Cardiovascular Diseases（心血管病） 2023年第12期

作者： Solange Flore Ngamami Mongo Bani Aloise Macaire franck yannis kouikani Kivié Mou-Moué Ngolo Letomo Bayonne S. E. Kombo Bertrand Fikahem Ellenga Mbolla

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Epidemiological and Clinical Profile of Hypertensive Patients with Obstructive Sleep Apnea at CHU-B

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World Journal of Cardiovascular Diseases（心血管病） 2023年第10期

作者： Solange Flore Ngamami Mongo Kivie Mou-Moue Ngolo Letomo Arnold Sem Nguia Vel Christian Kouala Landa franck yannis kouikani Rogue Pattern Bakekolo Bertrand Fikahem Ellenga Mbolla

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Arterial Hypertension and Pregnancy about 72 Cases

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World Journal of Cardiovascular Diseases（心血管病） 2023年第12期

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