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Identifying disappeared historic buildings of port of Callao using georeferencing

Built Heritage 2023年第4期7卷 1-15页

作者： Diego javier Celis Estrada francisco Felipe Quiroz Chueca Ruth Aracelis Manzanares Grados Faculty of Architecture and Design Universidad Privada del NorteLimaPeru Research Group GIADIPS Faculty of Architecture and DesignUniversidad Privada del NorteLimaPeru Department of History Universidad Nacional Mayor de San MarcosLima15081Peru Directorate for Research Innovation and Social ResponsibilityUniversidad Privada del NorteLimaPeru

The port of Callao is important for its varied historical and archaeological heritage,which includes several military buildings that were the main actors and witnesses of the colonial era of Peru(from the 16th century to the country’s independence from Spain early in the 19th century).Despite the studies that have been carried out on the basis of documents and some eventual archaeological excavations,the port’s main monument,namely,the Real Felipe Fortress,continues to hide very important information that could be used to understand the role that the fortress played in numerous historical events throughout the *** main contribution of this study is the use of photogrammetry software and a Geographic Information System(GIS)to examine the Real Felipe *** this way,the nature of the atypical construction within the fortress is *** a result,it is possible to accurately establish the location of the defensive wall that surrounded the ancient city of Callao,as well as its first churches,whose records were lost after being destroyed by the 1746 earthquake and tsunami in Lima,the worst cataclysm registered in the history of Peru and South *** a result,this study demonstrates that technology can be successfully used to establish and validate with great precision the existence of the location of churches that have been built in the port of Callao since the founding of Lima in the 16th *** identification allows architects,engineers and students who are interested in the history of monuments to discover hidden structures and buildings and carry out the necessary restoration and archaeological works,with the aim of recovering the history of the colonial architecture of Callao and other similar cities and ports worldwide.

关键词： georeferencing Viceroyalty of Peru church military buildings port of Callao cultural heritage

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The Quaternary Structure of NADPH Thioredoxin Reductase C Is Redox-Sensitive

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Molecular Plant 2009年第3期2卷 457-467页

作者： Juan Manuel Pérez-Ruiz Maricruz Gonzalez Maria Cristina Spinola Luisa Maria Sandalio francisco javier Cejudo Instituto de Bioqulmica Vegetal y Fotoslntesis Universidad de Sevilla y CSIC Avda Américo Vespucio 49 41092-Sevilla Spain Present address: Plant Biology Laboratory The Salk Institute 10010 N. Torrey Pines Rd La Jolla CA 92037 USA Estacion Experimental del Zaidin CSIC C/Prof Albareda 1 18008-Granada Spain

NADPH thioredoxin reductase C （NTRC） is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase （NTR） and thioredoxin （TRX） activities for the efficient reduction of 2-Cys peroxiredoxin （2-Cys PRX）. Because NADPH can be produced in chloroplasts during darkness, NTRC plays a key role for plant peroxide detoxification during the night. Here, it is shown that the quaternary structure of NTRC is highly dependent on its redox status. In vitro, most of the enzyme adopted an oligomeric state that disaggregated in dimers upon addition of NADPH, NADH, or DTT. Gel filtration and Western blot analysis of protein extracts from Arabidopsis chloroplast stroma showed that native NTRC forms aggregates, which are sensitive to NADPH and DTT, suggesting that the aggregation state might be a significant aspect of NTRC activity in vivo. Moreover, the enzyme is localized in clusters in Arabidopsis chloroplasts. NTRC triple and double mutants, A164G- V182E-R183F and A164G-R183F, replacing key residues of NADPH binding site, showed reduced activity but were still able to dimerize though with an increase in intermediary forms. Based on these results, we propose that the catalytically active form of NTRC is the dimer, which formation is induced by NADPH.

关键词： Abiotic/environmental stress oxidative and photo-oxidative stress photosynthesis Arabidopsis rice.

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Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： francisco javier Pérez Lara Rogelio Zubizarreta Jimenez Tatiana Prieto-Puga Arjona Pilar Gutierrez delgado Juan Manuel Hernández Carmona Jose Manuel Hernández Gonzalez Maria Pitarch Martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive *** approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is *** To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic *** For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to *** Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was *** difference was statistically ***,the insertion of mesh did not improve results for the non-accessible *** For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for *** parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

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mRNA levels of TLR4 and TLR5 are independent of H pylori

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World Journal of Gastroenterology 2008年第34期14卷 5306-5310页

作者： Elvira Garza-González Virgilio Bocanegra-García francisco javier Bosques-Padilla Juan Pablo Flores-Gutiérrez francisco Moreno Guillermo Ignacio Perez-Perez Departmento de Microbiología Facultad de MedicinaUniversidad Autónoma de Nuevo León Departmento de Biología Molecular y Bioingeniería UAM Reynosa Aztlán Universidad Autónoma de Tamaulipas Hospital Universitario "Dr. José Eleuterio González" Universidad Autónoma de Nuevo León Department of Medicine and Microbiology New York University School of Medicine

AIM:To determine if the presence H pylori or its viru- lence affect toll-like receptor 4 (TLR4) and TLR5 mRNA expression levels. METHODS:For the in vivo assays, gastric biopsies were obtained from 40 patients and H pylori status was determined. For the in vitro assays, human gastric adenocarcinoma mucosal cells (AGS) were cultured in the presence or absence of twelve selected H pylori strains. H pylori strains isolated from culture-positive patients and selected strains were genotyped for cagA and vacA. The cDNA was obtained from mRNA extracted from biopsies and from infected AGS cells. TLR4 and TLR5 mRNA levels were examined by real-time PCR. RESULTS: The presence of H pylori did not affect the mRNA levels of TLR4 or TLR5 in gastric biopsies. The mRNA levels of both receptors were not influenced by the vacA status (P > 0.05 for both receptors) andthere were no differences in TLR4 or TLR5 mRNA levels among the different clinical presentations/histological fi ndings (P > 0.05). In the in vitro assay, the mRNA levels of TLR4 or TLR5 in AGS cells were not influenced by the vacAs1 status or the clinical condition as-sociated with the strains (P > 0.05 for both TLR4 and TLR5). CONCLUSION: The results of this study show that the mRNA levels of TLR4 and TLR5 in gastric cells, both in vivo and in vitro, are independent of H pylori colonization and suggest that vacA may not be a significant player in the first step of innate immune recognition mediated by TLR4 or TLR5.

关键词： H pylori Toll-like receptor 4 Toll-likereceptor 5 AGS cells mRNA

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Amyotrophic lateral sclerosis: a complex syndrome that needs an integrated research approach

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Neural Regeneration Research 2019年第2期14卷 193-196页

作者： javier Riancho francisco J.Gil-Bea Ana Santurtun Adolfo López de Munaín Service of Neurology Hospital Sierrallana-Idival CIBERNED (Center for Networked Biomedical Research on Neurodegenerative Diseases Ministry of Economy and Competitiveness Institute Carlos Ⅲ) Neurosciences Area Institute Biodonostia Department of Physiology and Pharmacology University of Cantabria-Idival Department of Neurology University Hospital Donostia Department of Neurosciences University of the Basque Country Universidad País Vasco-Euskal Herria Unibertsitatea

Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, while the vast majority of amyotrophic lateral sclerosis cases are considered to be sporadic, resulting from the interaction between genes and environmental factors in predisposed individuals. During the past few years, dozens of drugs have been postulated as promising strategies for the disease after showing some beneficial effects in preclinical cellular and murine models. However, the translation into clinical practice has been largely unsuccessful and the compounds failed when were tested in clinical trials. This might be explained, at least partially, by the enormous complexity of the disease both from clinico-epidemiological and a pathogenic points of view. In this review, we will briefly comment on the complexity of the disease focusing on some recent findings, and we will suggest how amyotrophic lateral sclerosis research might be reoriented to foster the advance in the diagnostic and therapeutic questions.

关键词： amyotrophic lateral sclerosis ALS environment epidemiology genes phenotype therapy

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Preoperative calculation of angles of vision and working area in laparoscopic surgery to treat a giant hiatal hernia

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1638-1650页

作者： francisco javier Perez Lara Rogelio Zubizarreta Jimenez francisco javier Moya Donoso Jose Manuel Hernández Gonzalez Tatiana Prieto-Puga Arjona Arturo del Rey Moreno Maria Pitarch Martinez Surgery Service Antequera HospitalRincón de la Victoria 29730MálagaSpain DOXA Microfluidics Rincon de la Victoria 29738MálagaSpain

BACKGROUND Giant hiatal hernias still pose a major challenge to digestive surgeons,and their repair is sometimes a highly complex *** is usually performed by laparoscopy,while the role of the thoracoscopic approach has yet to be clearly *** To preoperatively detect patients with a giant hiatal hernia in whom it would not be safe to perform laparoscopic surgery and who,therefore,would be candidates for a thoracoscopic *** In the present study,using imaging test we preoperatively simulate the field of vision of the camera and the working area(instrumental access)that can be obtained in each patient when the laparoscopic approach is *** From data obtained,we can calculate the access angles that will be obtained in a preoperative computerised axial tomography coronal section,according to the location of the *** also provide the formula for performing the angle calculations If the trocars are placed in loss common situations,thus enabling us to determine the visibility and manoeuvrability for any position of the *** The working area determines the cases in which we can operate safely and those in which certain areas of the hernia cannot be accessed,which is when the thoracoscopic approach would be safer.

关键词： Hiatal hernia Angles Approach Laparoscopy Thoracoscopy

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Novel single-ion conducting polymer electrolytes with high toughness and high resistance against lithium dendrites

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Nano Research 2023年第6期16卷 8457-8468页

作者： David Fraile-Insagurbe Nicola Boaretto Itziar Aldalur Iñigo Raposo francisco javier Bonilla Michel Armand María Martínez-Ibañez Centre for Cooperative Research on Alternative Energies CIC energiGUNEBasque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain

Solid-state polymer electrolytes are considered as an alternative to classic liquid electrolytes,particularly for application in highenergy lithium metal *** respect to common dual-ion conductors,single-ion conducting polymer electrolytes(SICPEs)are less affected by lithium dendrites growth and thus are particularly interesting for application in lithium metal *** this work,novel SIC-PEs are developed,based on an ionomer having poly(ethylene-alt-maleimide)backbone and lithium phenylsulfonyl(trifluoromethanesulfonyl)imide pendant moieties,further blended with poly(ethylene oxide)(PEO)and poly(ethylene glycol)dimethyl ether(PEGDME).These SIC-PEs exhibit ionic conductivity around~7×10^(−6)S·cm^(−1) at 70℃,lithium transference number close to unity,and excellent mechanical properties,with fracture toughness over 30 J·cm^(−3).Additionally,the electrolytes show very high resistance against lithium dendrites growth,by cycling for more than 1200 h in Li°symmetric cells at a current density of 0.1 mA·cm^(−2).LiFePO4||Li°cells with these SIC-PEs were cycled at 70℃ and C/10,showing initial capacity of almost 160 mAh·g^(−1)and residual capacity of 45%after 100 *** work shows that single-ion conducting polymer electrolytes based on poly(ethylene-alt-maleimide)backbone are promising materials for application as electrolytes or catholytes in lithium metal polymer batteries.

关键词： single-ion conductors solid-state Li metal batteries polymer electrolytes lithium dendrites transference number mechanical properties

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Microbial Degradation of Organophosphate Pesticides： A Review

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Pedosphere 2018年第2期28卷 190-208页

作者： Shardendu KUMAR Garima KAUSHIK Mohd Ashraf DAR Surendra NIMESH Ulrico javier LOPEZ-CHUKEN Juan francisco VILLARREAL-CHIU Department of Environmental Science School of Earth Sciences Central University of Rajasthan Ajmer 305817 (India) Department of Biotechnology School of Life Sciences Central University of Rajasthan Ajmer 305817 (India) Laboratorio de InvestigaciSn en Ciencias Ambientales Facultad de Cieneias Quimicas Universidad AutSnoma de Nuevo León Nuevo LeSn 66455 (Mexico) Laboratorio de Biotecnologla Facultad de Ciencias Qulmicas Universidad AutSnoma de Nuevo LeSn Nuevo Ledn 66455 (Mexico)

Pesticides have become an inevitable part of the modern environment as they are widely used in agriculture,household,and public health sectors and,hence,are extensively distributed throughout most ***,organophosphate pesticides are the most commercially favored group of pesticides,with large application areas all over the *** on their fate,these organophosphorus compounds may become bioavailable for microbial *** microbes,such as Aspergillus,Pseudomonas,Chlorella,and Arthrobacter,are capable of coupling a variety of physical and biochemical mechanisms for the degradation of organophosphate pesticides,including adsorption,hydrolysis of P–O alkyl and aryl bonds,photodegradation,and enzymatic ***,such as esterase,diisopropyl fluorophosphatase,phosphotriesterase,somanase,parathion hydrolase,and paraoxonase,have been isolated from microbes to study and understand the catabolic pathways involved in the biotransformation of these xenobiotic *** review highlights various aspects of biodegradation of organophosphate pesticides along with biological and molecular characterization of some organophosphate pesticide-degrading bacteria.

关键词： biodegradation enzymes insecticide metabolic pathways pesticide-degrading bacteria organophosphorus compound xenobiotics

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Agronomic evaluation of eight 41 B×110 richter grapevine genotypes as rootstock candidates for mediterranean viticulture

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Horticultural Plant Journal 2023年第4期9卷 720-728页

作者： Diana Marín Carlos Miranda francisco javier Abad Jorge Urrestarazu Blanca Mayor Ana Villa-Llop Luis Gonzaga Santesteban Department of Agronomy Biotechnology and Food SciencePublic University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for Multidisciplinary Research in Applied Biology(IMAB-UPNA) Public University of NavarreCampus ArrosadiaPamplona 31006NavarraSpain Institute for Agri-food Technology and Infrastructure of Navarre(INTIA) Edificio de PeritosAvda.Serapio Huici 22Villava 31610NavarraSpain

Choosing the most appropriate rootstock(s)is a key decision for the profitability of vineyards;therefore,there must be a sufficient range of rootstocks in the market adapted to different environmental conditions and production ***,rootstock-breeding programs have been scarce in recent decades,and most of the rootstocks used today were bred a century ago,when the needs of the sector were very different from *** this work,we aimed to evaluate new rootstock candidates before their introduction in the *** agronomic evaluation was conducted on eight novel rootstock genotypes obtained from the first generation of the cross-pollination of 41 B Millardet et de Grasset(41 B)and 110 Richter(110 R)grafted with‘Syrah’and‘Tempranillo’and planted in a typical vineyard of the Ebro Valley in *** the four consecutive growing seasons(2016–2019),growth,yield and berry composition parameters at harvest were collected.A linear mixed-effects model was constructed,considering year and block as random *** factor analysis and hierarchical clustering on principal components were performed to establish clusters of genotypes with similar *** rootstock candidates showed a very wide performance range compared to their *** trial allowed us to identify two very promising candidates(RG8 and RG10),whose registration as commercial rootstocks is already in progress.

关键词： Vitis vinifera Graft Phenolic quality Vigour Yield

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Management of recurrent hepatitis C virus after liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16409-16417页

作者： Miguel Jiménez-Pérez Rocío González-Grande francisco javier Rando-Mu?oz Liver transplantation and hepatology unit UGC de Aparato Digestivo Hospital Regional Universitario Department of Abdominal Diseases Hospital Nij Smellinghe Ziekenhuis

Chronic hepatitis C virus (HCV) infection is the leading cause of death from liver disease and the leading indication for liver transplantation (LT) in the United States and Western Europe. LT represents the best therapeutic alternative for patients with advanced chronic liver disease caused by HCV or those who develop hepatocarcinoma. Reinfection by HCV of the graft is universal and occurs in 95% of transplant patients. This reinfection can compromise graft function and patient survival. In a few cases, the histological recurrence is minimal and non-progressive; however, in most patients it follows a more rapid course than in immunocompetent persons, and frequently evolves into cirrhosis with graft loss. In fact, the five-year and ten-year survival of patients transplanted because of HCV are 75% and 68%, respectively, compared with 85% and 78% in patients transplanted for other reasons. There is also a pattern of recurrence that is very severe, but rare (< 10%), called fibrosing cholestatic hepatitis, which often involves rapid graft loss. Patients who present a negative HCV viremia after antiviral treatment have better survival. Many studies published over recent years have shown that antiviral treatment of post-transplant HCV hepatitis carried out during the late phase is the best option for improving the prognosis of these patients. Until 2011, PEGylated interferon plus ribavirin was the standard of care, resulting in a sustained virological response in around 30% of recipients. The addition of protease inhibitors, such as boceprevir or telaprevir, to the standard of care, or the use of other direct-acting antiviral drugs may involve therapeutic changes in the context of HCV recurrence. This may result a better prognosis for these patients, particularly those with severe recurrence or factors predicting rapid progression of fibrosis. However, the use of these agents in LT still requires clarification in terms of safety and efficacy.

关键词： Hepatitis C virus Liver transplantation Recurrence Treatment

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