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Journal of Otology 2021年第1期16卷 6-11页

作者： Pedro Salvador francisco Moreira da Silva Rui Fonseca Department of Otorhinolaryngology Hospital Senhora da OliveiraGuimaraesPortugal

Objectives:To evaluate hearing outcome of salvage treatment with intratympanic steroids(ITS)in idiopathic sudden sensorineural hearing loss(ISSNHL)refractory to initial systemic steroid(SS)*** and methods:A retrospective medical chart review was conducted on 54 consecutive patients with ISSNHL refractory to *** treatment with a low dose intratympanic dexamethasone(4 mg/ml)was offered after one week of primary *** were divided into two groups:25 patients accepted ITS(treatment group)and 29 patients did not undergo additional treatment(control group).A pure tone average(PTA)gain of at least 10 dB was considered hearing ***:Hearing improvement rate was higher in ITS group compared to control group(40%vs.13.8%,p=0.035).A mean PTA improvement of 8.6±9.8 dB was observed in the ITS group and,whereas the control group had an average hearing gain of 0.7±2 dB(p<0.001).Audiometric analysis revealed a significant hearing gain in ITS group at all tested frequencies compared to control group(p<0.05).Analysis of the selected variables,identified intratympanic steroid treatment as the only independent prognostic factor for hearing improvement(OR=4.2,95%CI:1.1e15.7;p=0.04).Conclusion:Intratympanic low dose dexamethasone is effective in patients with incomplete hearing recovery after primary systemic steroid treatment.

关键词： Intratympanic Steroids Salvage Sudden sensorineural hearing loss Idiopathic

Does wetland watershed land use influence amphibian larval development? A relevant effect of agriculture on biota

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Journal of Oceanology and Limnology 2019年第1期37卷 160-168页

作者： GARCíA-MU?OZ Enrique GUERRERO francisco ARECHAGA Garbi?e PARRA Gema Departamento de Biología Animal Biología Vegetal y Ecología Campus de las Lagunillas Centro de Estudios Avanzados en Ciencias de la Tierra Campus de las Lagunillas Departamento de Ciencias de la Salud Campus de las Lagunillas

Agriculture practices have been widely proposed as the major cause of amphibian population decline. However, the majority of these results have been based on laboratory experiments. The present study was conducted to test the repercussion of wetland sediment provenance on amphibian larval *** bufo larvae were used in two dif ferent treatments in an outdoor experiment, the ?rst one using sediment from one wetland surrounded by intensive agricultural practices, and the second using sediment with no record of agrochemical uses. A negative ef fect was observed in the agricultural treatment, from subcellular to individual level. The results showed that the sediment from agricultural practices watershed generates a reduction in survival. Furthermore, individuals that developed under this treatment showed a lower total length and a delay in the time necessary to complete metamorphosis; these features are connected with recruitment success. In the same way, biochemical analysis showed high values of lipid peroxidation in metamorphs developing in sediments from an agricultural area. Finally, the results obtained highlight the importance of considering the sediments, not only the water, as origin treatment, allowing us to understand the consequences on amphibian populations that inhabit areas af fected by intensive agriculture.

关键词： amphibian decline Bufo bufo survival ecotoxicology agricultural practices

francisco Goya, 1746-1828

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Francisco Goya, 1746-1828

Predicting EHL film thickness parameters by machine learning approaches

作者： Hagen Rose-Marie. (1928-)Hagen Rainer (1746-1828.)Goya francisco

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Friction 2023年第6期11卷 992-1013页

作者： Max MARIAN Jonas MURSAK Marcel BARTZ francisco J.PROFITO Andreas ROSENKRANZ Sandro WARTZACK Department of Mechanical and Metallurgical Engineering School of EngineeringPontificia Universidad Católica de ChileSantiago6904411Chile Engineering Design Friedrich-Alexander-University Erlangen-Nuremberg(FAU)Erlangen91058Germany Department of Mechanical Engineering Polytechnic School of the University of São PauloSão Paulo05508-030Brazil Department of Chemical Engineering Biotechnology and Materials(DIQBM)FCFMUniversidad de ChileSantiago8370456Chile

Non-dimensional similarity groups and analytically solvable proximity equations can be used to estimate integral fluid film parameters of elastohydrodynamically lubricated(EHL)*** this contribution,we demonstrate that machine learning(ML)and artificial intelligence(AI)approaches(support vector machines,Gaussian process regressions,and artificial neural networks)can predict relevant film parameters more efficiently and with higher accuracy and flexibility compared to sophisticated EHL simulations and analytically solvable proximity equations,*** this purpose,we use data from EHL simulations based upon the full-system finite element(FE)solution and a Latin hypercube *** verify that the original input data are required to train ML approaches to achieve coefficients of determination above *** is revealed that the architecture of artificial neural networks(neurons per layer and number of hidden layers)and activation functions influence the prediction *** impact of the number of training data is exemplified,and recommendations for a minimum database size are *** ultimately demonstrate that artificial neural networks can predict the locally-resolved film thickness values over the contact domain 25-times faster than FE-based EHL simulations(R^(2) values above 0.999).We assume that this will boost the use of ML approaches to predict EHL parameters and traction losses in multibody system dynamics simulations.

关键词： machine learning elastohydrodynamic lubrication film thickness support vector machine Gaussian process regression artificial neural network

Fetkin-hydro,a new thermo-hydrological algorithm for low-temperature thermochronological modeling

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Geoscience Frontiers 2021年第3期12卷 186-200页

作者： francisco Sánchez Andres Barrea Federico M.Dávila Andres Mora Centro de Investigaciones en Ciencias de la Tierra(CICTERRA) CONICET-UNCFCEFyNCiudad UniversitariaAv.Vélez Sarsfield 16115000 CórdobaArgentina Facultad de Matemática AstronomíaFísica y Computación(FAMAF)Ciudad UniversitariaAv.Medida Allende 21445000 CórdobaArgentina Ecopetrol BotafogoRio de JaneiroBrazil

Despite two decades of major advances in the field of thermochronological modeling,state-of-the-art numerical implementations still rely mostly on burial and exhumation processes to explain radiometric *** though such an approach has proved valuable,failing to account for other first-order geological variables has led to misinterpretations and therefore,calls for a *** this study a new version of the Fetkin(finite element temperature kinematics,Ecopetrol)program is *** new algorithm couples time-dependent hydrological and thermal calculations,thus rendering thermochronological ages that,instead of being solely dependent on the kinematical evolution of a system,conditioning by the fluid flow is also *** contrast with previous thermochronological models,this work considers the influence of effective stress on rock properties(porosity and permeability)and therefore,in thermal *** analyses addressing relevant geological questions show not only the versatility of the code but also,new perspectives on forward low-temperature thermochronological *** circulation through pure-sandstone settings produce colder thermal architectures than those obtained in impermeable *** in cooling ages from models with and without fluid circulation are up to 5 Myr.A 4-fold variation in thrusting rates(0.5 km/Myr to 2 km/Myr)produces a 15-Myr difference in cooling ages in models with fluid flow,which contrasts to much lower differences,only 2 Myr,in domains without(or minimal)fluid circulation.2D thermal solutions in fold-bend-fold thrust belts composed of sandstones remain static despite substantial relief development by kinematic folding.A case-study from Western Argentina,in the Andean Precordillera,confirms the plausibility of the numerical algorithm here posed and raises new questions on the first-order thermal controls in settings under deformation.

关键词： Thermochronology Hydrogeology Fluid flow Numerical modeling

Resampling in neural networks with application to spatial analysis

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Geo-Spatial Information Science 2022年第3期25卷 413-424页

作者： Bruno Póvoa Rodrigues Vinicius francisco Rofatto Marcelo Tomio Matsuoka Talita Teles Assunção Graduate Program in Agriculture and Geospatial Information Federal University of UberlândiaMonte CarmeloBrazil Institute of Geography Federal University of UberlândiaMonte CarmeloBrazil

In developing Artificial Neural Networks(ANNs),the available dataset is split into three categories:training,validation and ***,an important problem arises:How to trust the predic-tion provided by a particular ANN?Due to the randomness related to the network itself(architecture,initialization and learning procedure),there is usually no best *** this issue,we provide a framework,which captures the randomness related to the network *** idea is to perform several training and test trials based on the Jackknife resampling *** consists of iteratively deleting a single observation each time from the sample and recomputing the ANN on the rest of the sample ***,interval prediction is available instead of point *** proposed method was applied and tested using pH,Ca and P data obtained by analyzing 118 georeferenced soil *** results,based on the dataset size simulation,showed that 60%reduction in available dataset offers compatible accuracy in relation to full dataset,and therefore a higher cost of sampling in the field would not be *** re-sampling method spatially characterizes the points of greater or lesser accuracy and *** re-sampling method increased the success rate by using interval prediction instead of using the mean as the most probable *** we restrict it to the regression neural network model,the resampling method proposed can also be extended to other modern statistical tools,such as Kriging,Least Squares Collocation(LSC),Convolutional Neural Network(CNN),and so on.

关键词： Artificial Neural Network(ANN) data splitting resampling delete-1 Jackknife spatial analysis

Moving toward an understanding of the metastatic process in hepatocellular carcinoma

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World Journal of Gastroenterology 2001年第6期7卷 777-778页

作者： W.Michael Korn Division of Gastroenterology and Comprehensive Cancer Canter,University of California San francisco,San francisco,CA 94143-0128,USA Division of Gastroenterology and Comprehensive Cancer Center University of California San Francisco 94143-0128 USA. mkorn@cc.ucsf.edu

INTRODUCTIONClinical factors contributing to the therapeutic challenge of hepatocellular carcinoma (HCC) are manifold :tumors arise often in patients with compromised liver function ,therefore limiting therapeutic options ;symptoms develop only at later stages of tumor progression ,and tumors tend to invade normal stuctures or occur in multiple locations simultaneously.

关键词： Animals Carcinoma, Hepatocellular Humans Liver Neoplasms Neoplasm Metastasis

Do biometric payment systems work during the COVID-19 pandemic?Insights from the Spanish users’viewpoint

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Financial Innovation 2022年第1期8卷 770-794页

作者： francisco Liébana-Cabanillas francisco Muñoz-Leiva Sebastián Molinillo Elena Higueras-Castillo Department of Marketing and Market Research Faculty of Economics and Business AdministrationUniversity of Granada18011 GranadaSpain Faculty of Economics and Business Department of Business ManagementUniversity of MálagaCampus El Ejido29013 MálagaSpain

Technological developments are changing how users pay for goods and *** the context of the COVID-19(coronavirus disease 2019)pandemic,new payment systems have been established to reduce contact between buyer and *** addition to the pandemic,the future is payment processing is also uncertain due to the new EU security regulations of the Payment Services Directive(PSD2).Biometric payments one option that would guarantee the security of transactions and reduce the risk of *** research analyses the intention to recommend the use of the mobile phone as a tool for collecting payments in a shop using iris reading as a biometric measure of the *** moderating effect of the fear of contagion in the proposed relationships was also *** online survey was carried out,which yielded a sample of 368 *** results indicate that the main antecedents of intention to use,which precedes intention to recommend,are perceived trust,habit,personal innovativeness and comfort of ***,the moderating effect of COVID-19 was checked among users with a higher perception of *** results obtained have interesting implications for purchase management among manufacturers and retailers.

关键词： Biometric payment systems Intention to recommend COVID-19 Fear

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小型水坝安全管理现状(英文)

岩土工程学报 2008年第11期30卷 1713-1721页

作者： Joao francisco Alves Silveira Technical Director SBB Engenharia Ltda 1265 Miguel Petroni St - Sao Carlos S.P. Brazil

提出了关于小型水坝安全管理的一些见解,并尝试区分小坝与大坝之间的主要特征。小型水坝的安全管理包括一些政策、程序和现场监测,目的在于将水坝风险最小化。有关设计标准、材料参数和小坝降等原始资料的仔细检查,小坝巡视检查表,水坝... 详细信息

提出了关于小型水坝安全管理的一些见解,并尝试区分小坝与大坝之间的主要特征。小型水坝的安全管理包括一些政策、程序和现场监测,目的在于将水坝风险最小化。有关设计标准、材料参数和小坝降等原始资料的仔细检查,小坝巡视检查表,水坝监测指导性文件和对小型坝按安全进行分级都是本文阐述的主要内容。

关键词：安全监测巡视检查小型水坝

Novel preoperative strategies to improve hepatocellular carcinoma resectability

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 140-141页

作者： francisco Tustumi Fabricio Ferreira Coelho Paulo Herman Department of Gastroenterology Universidade de São PauloSao PauloBrazil Department of Surgery Hospital Israelita Albert EinsteinSao PauloBrazil

Peng et al.(1)performed a pretty interesting article,reporting the proposal of a new strategy to improve resectability for hepatocellular carcinoma(HCC).Their findings are *** strategies to improve liver resection are methods for promoting future liver remnant(FLR)growth in a timely manner before cancer *** main strategies are portal vein embolization(PVE)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).

关键词： hepatocellular liver