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Current treatment landscape for oligometastatic non-small cell lung cancer

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World Journal of Clinical Oncology 2022年第6期13卷 485-495页

作者： javier Garde-noguera Margarita martín-martín Andres Obeso Miriam López-Mata Inigo Royo Crespo Lira Pelari-Mici O Juan Vidal Xabier Mielgo-Rubio Juan Carlos Trujillo-reyes Felipe Couñago Department of Medical Oncology Hospital Arnau de VilanovaValencia 46015Spain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Thoracic Surgery Hospital Clínico Universitario de Santiago de CompostelaVigo 15706Spain Department of Radiation Oncology Hospital Clínico Universitario Lozano BlesaZaragoza 50009Spain Department of Thoracic Surgery Hospital Universitari Vall d’HebronBarcelona 08035Spain Department of Medical Oncology Hospital Universitario y Politécnico La FeValencia 46026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónAlcorcón 28922MadridSpain Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Medicine Department School of Biomedical SciencesUniversidad Europea de MadridVillaviciosa de Odón 28670MadridSpain

The management of patients with advanced non-small cell lung carcinoma(nSCLC)has undergone major changes in recent *** the one hand,improved sensitivity of diagnostic tests,both radiological and endoscopic,has altered the way patients are *** the other hand,the arrival of new drugs with antitumoral activity,such as targeted therapies or immunotherapy,has changed the prognosis of patients,improving disease control and prolonging ***,the development of radiotherapy and surgical and interventional radiology techniques means that radical ablative treatments can be performed on metastases in any location in the *** of these advances have impacted the treatment of patients with advanced lung cancer,especially in a subgroup of these patients in which all of these treatment modalities *** poses a challenge for physicians who must decide upon the best treatment strategy for each patient,without solid evidence for one optimal mode of treatment in this patient *** aim of this article is to review,from a practical and multidisciplinary perspective,published evidence on the management of oligometastatic nSCLC *** evaluate the different alternatives for radical ablative treatments,the role of primary tumor resection or radiation,the impact of systemic treatments,and the therapeutic *** short,the present document aims to provide clinicians with a practical guide for the treatment of oligometastatic patients in routine clinical practice.

关键词： Oligometastatic non-small cell lung carcinoma non-small cell lung cancer Oligometastasis

Conservative management of perforated duodenal diverticulum: A case report and review of the literature

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World Journal of Gastroenterology 2008年第12期14卷 1949-1951页

作者： David martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate javier Briceo Delgado francisco javier Padillo Pedro López-Cillero Sebastián Rufián Pea Hospital Universitario Reina Sofia Av. Menendez Pidal sn. 14005. Córdoba Spain. Clínica Universitaria de navarra Avenida de Pio XII 36 Pamplona 31008 Spain.

Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs.

关键词： Duodenal diverticula Perforation Conservativemanagement

Oral Pharmacokinetics of Mirodenafil in Mexican Healthy Volunteers

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Pharmacology & Pharmacy 2014年第1期5卷 112-116页

作者： Miriam del Carmen Carrasco-Portugal francisco javier Flores-Murrieta Juan Gerardo reyes-García noemí Santos-Caballero Landsteiner Scientific S.A. de C.V. México DF México Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México DF México Unidad de Investigación en Farmacología Insituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” México DF México Unidad de Investigación en Farmacología Insituto Nacional de Enfermedades Respiratorias “Ismael Cosio Villegas” México DF México Sección de Estudios de Posgrado e Investigación Escuela Superior de Medicina Instituto Politécnico Nacional México DF México

Mirodenafil is a 5-phosphodiesterase inhibitor that is currently marketed in Korea for the treatment of erectile dysfunction;however, no information in other populations is available. It has been described that Mirodenafil is metabolized by CYP3A4, a metabolic pathway in which interethnic differences have been reported. The purpose of this study was to characterize the oral pharmacokinetics of Mirodenafil in Mexicans. Seventeen male healthy volunteers were enrolled in this study. After an overnight fast, volunteers received an oral 100 mg dose and blood samples were collected at selected times during 24 h. Plasma was stored frozen and analyzed by an HPLC method. Pharmacokinetic parameters obtained were: Cmax 331.129 ± 32.689 ng/mL, tmax 1.574 ± 0.293 h, AUC24h 883.293 ± 104.088 ng·h/mL, AUC￥ 976.477 ± 108.812 ng·h/mL and t1/2 1.807 ± 0.171 h. Parameter values observed in this study are similar to those reported in Koreans. Since efficacy and safety studies of Mirodenafil have been conducted in Koreans, it is expected that dosage regime to employ in Mexicans should be similar to the approved for Korean population.

关键词： Erectile Dysfunction Healthy Volunteers Mexican Mirodenafil Pharmacokinetic

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer MSilvia Román-Azcona javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-martínez Irene Miguel-Escalada Jorge Ferrer Jfrancisco nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera Department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBCnatal-Barcelona Center for Maternal–Fetal and neonatal Medicine(Hospital Clínic and Hospital Sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de Cirugía Cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TnF-α.notably,these effects were associated with a decrease in the mRnA and protein levels of FOS and the DnA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac

Isolation and Characterization of 26 Microsatellite Loci for the Shortfin Silverside Fish <i>Chirostoma humboldtianum</i>Valenciennes1835 (Atherinopsidae: Menidiinae) Derived from next Generation Sequencing and Their Cross-Amplification in Central Mexican Atherinopsids

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Open Journal of Genetics 2014年第5期4卷 355-361页

作者： Barriga-Sosa Irene de los Angeles Rosa María García-martínez Jhoana Díaz-Larrea Oscar Adrián Lozano Garza francisco javier García-De-León Departamento de Hidrobiología Universidad Autónoma Metropolitana Iztapalapa México D.F. México Laboratorio de Genética y Biología Molecular Planta Experimental de Producción Acuícola Departamento de Hidrobiología Universidad Autónoma Metropolitana Iztapalapa México D.F. México Laboratorio de Genéticapara la Conservación Centro de Investigaciones Biológicas del Noroeste Instituto Politécnico Nacional La Paz México

The endemic silverside fish C. humboldtianum is of great ichtyologycal, economical and cultural relevance in central Mexico and it has been suggested that it is among a group of other “peces blancos”, the most ancestral species. Here we characterized a set of 26 microsatellite loci from the species in order to further assess population and phylogeographic issues that aid in evaluating their highly impacted populations. From 58 primer pairs tested on specimens from Villa Victoria dam (Rio Balsas Basin), 26 loci positively amplified on the species and cross-primed on specimens of the closely related and threatened Poblana alchichica, C. promelas and C. riojai. Loci resolved medium and high genetic variation (mean nA = 14.3, SD = 9.38;mean HO & HE = 0.47, SD = 0.32 and 0.58, SD = 0.32, respectively) and it is expected that these polymorphic loci are also useful in studing threatened atherinopsid species.

关键词： Endemic Polymorphism Villa Victoria Poblana alchichica C. promelas C. riojai

Forecast of the Luminescent Phenomena of Silicon Rich Oxide Films off Stoichiometry by Means of the Global Reaction Model

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Journal of Modern Physics 2015年第11期6卷 1679-1694页

作者： néstor David Espinosa-Torres José álvaro David Hernández de la Luz José francisco javier Flores-Gracia José Alberto Luna-López javier martínez-Juárez Gregorio Flores-Carrasco IC-CIDS Benemérita Universidad Autónoma de Puebla Puebla México Ex Graduate Research Trainee at Plasma Processing Laboratory Chemical Engineering Department McGill University Montreal Canada Department of Materials Science and Engineering and Chemical Engineering University Carlos III of Madrid and IAAB Madrid Spain

The Global Reaction Model describes a set of chemical reactions that can potentially occur during the process of obtaining silicon rich oxide (SRO) films, regardless of the technique used to grow such films which are an outside stoichiometry material. Particularly, chemical reactions that occur during the process of growing of SRO films by LPCVD technique are highlighted in this model. We suggest and evaluate either some types of molecules or resulting nanostructures and we predict theoretically, by applying the density functional theory, the contribution that they may have to the phenomenon of luminescence which is measured in SRO films. Also, we have calculated the opto-electronic properties of SRO films. The suggested model provides enough information required to identify the molecular structures resulting from the presence of defects in SRO films and also those corresponding to charged structures. It is also possible to detect the molecular structures which are modified due to the effect of heat treatment, and identify the presence of different oxidation states inclusive the formation of siloxanes.

关键词： Global Reactions Model Silicon Rich-Oxide Defects LPCVD Luminescence

Role of capsule endoscopy in suspected celiac disease: A European multi-centre study

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World Journal of Gastroenterology 2017年第4期23卷 703-711页

作者： Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles javier Garcia-Lledo José-francisco Juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García Juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio López-Higueras noelia Alonso-Lazaro Mileidis Sanjuan-Acosta francisco Sanchez-Ceballos Bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier Federico Argüelles-Arias Juan-Manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-martínez javier Sempere-García-Argüelles Digestive Diseases Unit General University Hospital of Valencia Small Bowel Unit Hospital Morales Meseguer Digestive Diseases Unit General University Gregorio Maranón Unit of Gastroenterology and Endoscopy Complejo Hospitalario de Navarra Center for prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterology and Endoscopy University Hospital Virgen Macarena Gastroenterology department Hospital Virgen de la Arrixaca Department of Gastroenterology Complejo Hospitalario de Toledo Department of Gastroenterology University of Navarra Clinic1 Endoscopy Digestive Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestive Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestive Diseases Unit Clinical Hospital San Carlos1 Digestive Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestive Unit Hospital Clinic de Barcelona

AIMTo analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE).METHODSThis is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were *** overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P nd 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated *** has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.

关键词： Capsule endoscopy Celiac disease Anti-transglutaminase antibodies Gluten-free diet non-celiac gluten sensitivity

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Kfz.385油罐车

模型世界 2018年第2期 79-81页

作者： francisco javier martínez Rodríguez

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK15... 详细信息

这款模型的板件是一款意大利(ITALERI)的老产品了(货号6467.1/35比例),但是适当的进行改造并添加细节后的效果依然非常不错。1我选用了Hauler出品的蚀刻片改件(货号HLU35038)来搭配这套板件。在组装前我先在蚀刻片表面上涂抹了一层AK159金属锈蚀液,从而可以让蚀刻片表面变暗,并且让质感更像是真实的暗色钢制表面。我非常建议在使用任何蚀刻片时候都配合这款溶媒液,因为他同时还可以让漆在蚀刻片表面上有更好的附着力,同时粘贴起来也更方便。

关键词：油罐车油画颜料 Kfz.385 库尔斯克 AK

Identification of Potential Areas for Establishment of Plantations of <i>Agave lechuguilla</i>Torr. in Coahuila, Mexico

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Open Journal of Forestry 2014年第5期4卷 520-526页

作者： David Castillo-Quiroz Oscar Ulises martínez-Burciaga Diana Yemilet ávila-Flores francisco Castillo-reyes Juan David Sánchez-Chaparro national Institute of Forestry Agriculture and Livestock Research (INIFAP) Experimental Station Saltillo Saltillo Mexico

Adverse weather conditions and intensive use for fiber production have caused decline of natural populations of Agave lechuguilla. By these reasons, it is important to develop a sustainable management of this specie to avoid this situation. One of the first steps is to establish forest plantations as an alternative to restore A. lechuguilla habitat and increase its range while at the same time indirectly reducing erosion rates. The aim of this study was to identify the potential areas for establishment of plantations of A. lechuguilla in the State of Coahuila, Mexico. Areas for planting establishment were selected according to multi-criteria analysis using Geographic Information System (GIS) Idrisi32 Ver 2.0 and 3.2 ***. The analysis was based on comparison of climate and soil requirements in contrast to environmental conditions of the tested area. The evaluated variables were: soil type, texture, depth, average annual temperature, annual precipitation, elevation and slope. Results derive in potential area maps, geo-referenced and their distribution by Agricultural Development District. An area of 5 million 159,273 hectares was determined with potential for establishment of A. lechuguilla forest plantations in the State of Coahuila. It was concluded that, use of GIS is a reliable tool to determine potential areas for A. lechuguilla forest plantations, where this specie has higher probability of success in survival and biomass production. This study will support programs aimed to strengthen the economy of rural producers and also recover and preserve the arid state.

关键词： Agave lechuguilla Forest Plantations natural-Fiber Geographical Information Systems