检索结果-南通市图书馆

Extracellular vesicles in liver disease and beyond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第40期24卷 4519-4526页

作者： Laura Morán francisco javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain

Extracellular vesicles(EVs) are membrane-derived vesicles which can be released by different cell types, including hepatocytes, hepatic stellate cells and immune cells in normal and pathological conditions. EVs carry lipids, proteins, coding and non-coding RNAs and mitochondrial DNA causing modifications on the recipient cells. These vesicles are considered potential biomarkers and therapeutic agents for human diagnostic and prognostic due to their function as intercellular mediators of cell-cell communication within the liver and between other organs. However, the development and optimization of methods for EVs isolation is required to characterize their biological functions as well as their potential as a treatment option in the clinic. Nevertheless, many questions remain unanswered related to the function of EVs under physiological and pathological conditions. In the current editorial, the results obtained in different studies that investigated the role of intrahepatic EVs during liver diseases, including drug-induced liver injury, non-alcoholic fatty liver, nonalcoholic steatohepatitis, alcoholic liver disease and hepatocellular carcinoma and extrahepatic EVs in remote organs during pathological events such as pulmonary disease, cardiovascular diseases, neurodegenerative disorders e.g., Alzheimer's disease, Parkinson's disease and multiple sclerosis as well as in immunopathological processes, are discussed. Although much light needs to be shed on the mechanisms of EVs, these membranederived vesicles represent both a novel promising diagnostic, and a therapeutic tool for clinical use that we emphasize in the current editorial.

关键词： Extracellular vesicles microRNA Hepatocytes Drug-induced liver injury Alcoholic liver disease Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Hepatocellular carcinoma

The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第12期10卷 1951-1952页

作者： Gervasio Martín-Partido javier francisco-Morcillo Departamento de Biología Celular Facultad de CienciasUniversidad de Extremadura

Many blinding diseases,such as retinitis pigmentosa,age-related macular degeneration,and glaucoma involve the permanent loss of retinal neurons,especially photoreceptors or the centrally projecting retinal ganglion **... 详细信息

关键词： cell RGCs The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina

Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

Post-transcriptional regulation of seed dormancy and germination: Current understanding and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2021年第4期2卷 1-22页

作者： Rocío Soledad Tognacca javier francisco Botto Consejo Nacional de Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de FisiologíaBiología Molecular y Neurociencias(IFIBYNE)Facultad de Ciencias Exactas y NaturalesCP1428 Buenos AiresArgentina Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y TécnicasInstituto de Investigaciones Fisiològicas y Ecològicas Vinculadas a la Agricultura(IFEVA)Facultad de AgronomíaCP1417 Buenos AiresArgentina

Seed dormancy is a developmental checkpoint that prevents mature seeds from germinating under conditions that are otherwise favorable for *** and light are themost relevant environmental factors that regulate seed dormancy and *** environmental cues can trigger molecular and physiological responses including hormone signaling,particularly that of abscisic acid and *** balance between the content and sensitivity of these hormones is the key to the regulation of seed *** and light tightly regulate the transcription of thousands of genes,as well as other aspects of gene expression such asmRNAsplicing,translation,and *** remodeling determines specific transcriptional outputs,and alternative splicing leads to different outcomes and produces transcripts that encode proteins with altered or lost *** regulation of chromatin remodeling and alternative splicing may be highly relevant to seed ***,microRNAs are also critical for the control of gene expression in *** review aims to discuss recent updates on post-transcriptional regulation during seed maturation,dormancy,germination,and post-germination *** propose future prospects for understanding howdifferent post-transcriptional processes in crop seeds can contribute to the design of genotypes with better performance and higher productivity.

关键词： alternative splicing chromatin remodeling dormancy germination microRNA(miRNA) seeds

Feeding on clean food?Potential effects of electric organ discharges by Torpedo spp.(Torpediniformes:Torpedinidae)on their trophically transmitted parasites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2022年第2期17卷 234-245页

作者： Jaime PENADÉS-SUAY Tania REGACHO francisco javier AZNAR Marine Zoology Unit Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of ValenciaValènciaSpain LAMNA Association for the study of elasmobranchs from the Valencian Community ValènciaSpain

Members of the Torpedinidae(torpedoes)and Hypnidae(coffin ray)use electric organ discharges(EOD)to stun or kill their prey before *** investigated whether EOD could also negatively affect the helminth larvae infecting these preys through a surrogate model:we applied electric discharges to individuals of blue whiting,Micromesistius poutassou,that harbored live larvae of *** mortality throughout a 6-h period was significantly higher in the treatment group,suggesting that EODs could significantly hamper helminth *** then tested whether torpedinids and hypnids(“strong-EOD”families)harbored species-poor helminth(cestode)assemblages compared with“weak-EOD”Torpediniformes(Narcidae and Narkidae)and other *** on comparisons on estimated species diversity and mean species richness of tapeworms at host individual level we found that(i)Torpediniformes had the lowest tapeworm diversity of all Batoidea orders;(ii)Torpedo *** had the lowest mean cestode richness at host individual level,and this could not be related to other host factors influencing cestode diversity in chondrichthyans,that is body size,trophic level or dietary ***,a preliminary comparison between“strong-EOD”and“weak-EOD”Torpediniformes did not detect clear differences of cestode ***,evidence supporting an unambiguous contribution of EODs to depauperate cestode assemblages requires further research.

关键词： Anisakis Batoidea cestode EOD behavior Torpediniform Torpedo

Transverse　Dimension　of　R^n　Actions　on　Compact　Foliated　Manifolds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Quarterly Journal of Mathematics 1995年第4期10卷 86-97页

作者： francisco javier Geometria Y

Consider a foliate Rn-action on a compact connected foliated manifold (M,F). Let mand r be the codimension of F and the (transverse)rank of (M,F)respectively. Suppose r<*** this paper we prove that either there exists an orbit of the Rn-action of transverse dimension< (m + r)/2 or F can be arbitrarily approached by foliations with rank≥r+1. Moreover weshow that this kind of orbits exists in the following three cases: if F is Riemannian ;when all itsleaves are closed or if X(M)≠0(then r=0).On the other hand all foliate Rn-action on (S3,F) has a fixed leaf if dimF=*** result generalies a well known Lima's theorem about Rn-actions on surfaces.

关键词： transverse action foliation

2-Cys Peroxiredoxins Participate in the Oxidation of Chloroplast Enzymes in the Dark

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2018年第11期11卷 1377-1388页

作者： Valle Ojeda Juan Manuel Perez-Ruiz francisco javier Cejudo Instituto de Bioquimica Vegetaly Fotosintesis Universidad de Sevilla and Consejo Superior de lnvestigaciones CientificasAvenida Americo Vespucio 4941092SevillaSpain

Most redox-regulated chloroplast enzymes are reduced during the day and oxidized during the *** the reduction mechanism of light-dependent enzymes is well known,the mechanism mediating their oxidation in the dark remains *** thiol-dependent peroxidases,2-Cys peroxiredoxins (Prxs),play a key role in light-dependent reduction of chloroplast *** transfer reducing equivalents of thiols to hydrogen peroxide,suggesting the participation of these peroxidases in enzyme oxidation in the ***,we have addressed this issue by analyzing the redox state of well-known redox-regulated chloroplast enzymes in response to darkness in Arabidopsis thaliana mutants deficient in chloroplastlocalized Prxs (2-Cys Prxs A and B,Prx ⅡE,and Prx Q).Mutant plants lacking 2-Cys Prxs A and B,and plants overexpressing NADPH-dependent thioredoxin (Trx) reductase C showed delayed oxidation of chloroplast enzymes in the *** contrast,the deficiencies of Prx ⅡE or Prx Q exerted no *** vitro assays allowed the reconstitution of the pathway of reducing equivalents from reduced fructose 1,6-bisphosphatase to hydrogen peroxide mediated by Trxs and 2-Cys *** together,these results suggest that 2-Cys Prxs participate in the short-term oxidation of chloroplast enzymes in the dark.

关键词： chloroplast enzyme oxidation peroxiredoxin thioredoxin hydrogen peroxide darkness

NADPH Thioredoxin Reductase C Controls the Redox Status of Chloroplast 2-Cys Peroxiredoxins in Arabidopsis thaliana

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2009年第2期2卷 298-307页

作者： Kerstin Kirchsteiger Pablo Pulido Maricruz Gonzalez francisco javier Cejudo Instituto de Bioquimica Vegetal y Fotosintesis Universidad de Sevilla and CSIC Avda Americo Vespucio 49 41092-Sevilla Spain

Chloroplast 2-Cys peroxiredoxins （2-Cys Prxs） are efficiently reduced by NADPH Thioredoxin reductase C （NTRC）. To investigate the effect of light/darkness on NTRC function, the content of abundant plastidial enzymes, Rubisco, glutamine synthetase （GS）, and 2-Cys Prxs was analyzed during two consecutive days in Arabidopsis wild-type and ntrc mutant plants. No significant difference of the content of these proteins was observed during the day or the night in wildtype and mutant plants. NTRC deficiency caused a lower content of fully reduced 2-Cys Prxs, which was undetectable in darkness, suggesting that NTRC is the most important pathway for 2-Cys Prx reduction, probably the only one during the night. Arabidopsis contains two plastidial 2-Cys Prxs, A and B, for which T-DNA insertion lines were characterized showing the same phenotype as wild-type plants. Two-dimensional gel analysis of leaf extracts from these mutants allowed the identification of basic and acidic isoforms of 2-Cys Prx A and B. In-vitro assays and mass spectrometry analysis showed that the acidic isoform of both proteins is produced by overoxidation of the peroxidatic Cys residue to sulfinic acid. 2-Cys Prx overoxidation was lower in the NTRC mutant. These results show the important function of NTRC to maintain the redox equilibrium of chloroplast 2-Cys Prxs.

关键词： Chloroplast peroxiredoxin NADPH thioredoxin reductase C overoxidation thioredoxin Arabidopsis.

Simulated predation pressure in Pelobates Cultripes tadpoles modulates morphology at the metamorphic stage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2019年第6期65卷 651-656页

作者： francisco javier ZAMORA-CAMACHO Susana Cortes-MANZANEOUE Pedro ARAGON Museo Nacional de Ciencias Naturales(MNCN-CSIC) MadridSpain

Studies on the impacts of variation of biotic interactions at key life cycle stages are crucial to understand the interface between ecological and developmental *** exert a major impact on prey *** direct consumption entails the greatest effect,predators can affect prey by means of other *** instance,injuries inflicted by failed predation attempts can jeopardize prey fitness,even beyond the *** anuran tadpoles,failed predation typically results in partial tail loss,which is known to reduce swimming ***,the potential consequences of tadpole partial tail loss after metamorphosis remain *** tail materials could be important in conforming metamorph body,we assess the effects of tadpole partial tail loss on metamorph body size in Iberian spadefoot toads Pelobates *** clipped 55%tail length of pre-tail-resorption stage anesthetized tadpoles,and compared their body size as metamorphs with anesthetized and non-anesthetized non-tail-clipped ***,we tested whether tail length correlated with metamorph body size of individuals of the control *** tadpoles produced smaller metamorphs than both controls(the bdy size of metamorphs from both controls was similar),which could incur costs in mid-term survival or time to first *** effect could be particularly important in areas with introduced predators,if autochthonous tadpoles lack defenses against *** suggest that materials resorbed from tadpole tail tissues might be reallocated into metamorph body,according to the negative effect of shorter tails in a correlational analysis,and clipped tails in an experimental test,on metamorph body size.

关键词： amphibian anuran body condition body size failed predation partial tail loss