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Effect of Cellulose Microfibers from Sugar Beet Pulp By-product on the Reinforcement of HDPE Composites Prepared by Twin‐screw Extrusion and Injection Molding

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journal of Bionic Engineering 2023年第1期20卷 349-365页

作者： Abdelghani Boussetta Anass Ait Benhamou francisco j.Barba Nabil Grimi Mario j.Simirgiotis Amine Moubarik Laboratory of Chemical Processes and Applied Materials Poly Disciplinary FacultySultan Moulay Slimane UniversityBP 592Beni-MellalMorocco Materials Science Energy and Nanoengineering(MSN)DepartmentMohammed VI Polytechnic UniversityLot 660-Hay Moulay Rachid43150Ben GuerirMorocco Materials Science and Process Optimization Laboratory Faculty of Science SemlaliaCadi Ayyad University40000MarrakechMorocco Nutrition and Food Science Area Preventive Medicine and Public HealthFood ScienceToxicology and Forensic Medicine DepartmentFaculty of PharmacyUniversitat de ValènciaAvda.Vicent Andrés Estelléss/n46100BurjassotValènciaSpain Sorbonne Université Universitéde Technologie de CompiègneLaboratoire Transformations Intégrées de La Matière Renouvelable(UTC/ESCOMEA 4297 TIMR)Centre de recherches RoyallieuCS 6031960203Compiègne CedexFrance Campus Isla Teja Institute of PharmacyFaculty of SciencesUniversidad Austral de Chile5090000ValdiviaChile

The aims of this work turn towards the valorization of the underutilized Raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of High-Density Polyethylene(HDPE)*** CMFs were first obtained by subjecting raw SBP to alkali and bleaching *** characterization techniques were performed to confirm the successful removal of the amorphous compounds from the surface of individual fibers,including SEM,XRD,TGA,and FT-IR *** CMF loadings(5–10 wt%)were incorporated as bio-fillers into HDPE polymer to evaluate their reinforcing ability in comparison to raw and alkali-treated SBP using twin-screw extrusion followed by injection ***–(Ethylene–Butene)–Styrene Three-Block Co-Polymer Grafted with Maleic Anhydride was used as a compatibilizer to improve the interfacial adhesion between fibers and the ***,mechanical,and rheological properties of the produced composite samples were *** was found that the Young’s modulus were gradually increased with increasing of fibers loadings,with a maximum increase of 30%and 26%observed for composite containing 10 wt%of CMFs and raw SBP,respectively,over neat ***,the use of coupling agent enhances the ductile behavior of the *** was also found that all fiber improves the hardness and toughness behavior of all reinforced composites as well as the complex modulus particularly at 10 wt%.The thermal stability slightly increases with the addition of *** study demonstrates a new route for the valorization of SBP *** fibers can be considered as a valuable bio-fillers candidate for the development of composite materials with enhanced properties.

关键词： Sugar beet pulp By-product-Cellulose HDPE Coupling agent Composite Mechanical and rheological properties

History of pseudomyxoma peritonei from its origin to the first decades of the twenty-first century

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World journal of Gastrointestinal Surgery 2019年第9期11卷 358-364页

作者： francisco j Morera-Ocon Clara Navarro-Campoy Department of General Surgery Hospital General de RequenaValencia 46340Spain Department of Gynecology and Obstetrics Hospital 9 OctubreValencia 46340Spain

Pseudomyxoma peritonei(PMP)is a disease surrounded by misunderstanding and *** about the etymology of pseudomyxoma is useful to remove the ambiguity around that *** word pseudomyxoma derives from pseudomucin,a type of *** was first described in a case of a woman alleged to have a ruptured pseudomucinous cystadenoma of the ovary,a term that has disappeared from today’s classifications of cystic ovarian *** is known today that in the majority of cases,the origin for PMP is an appendiceal neoplasm,often of low histological ***,ovarian tumors are wrongly being considered a significant recognized etiology of *** classification continues to be under discussion,and experts’panels strive for *** is also under discussion,and it is shown in this review that there is a long-standing historical reason for *** is the main tool in the treatment armamentarium for PMP,and the only therapy with potential curative option.

关键词： Pseudomyxoma peritonei Pseudomucin Appendiceal neoplasm Hyperthermic intraperitoneal chemotherapy

Testing the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective disorder:A prospective study

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World journal of Psychiatry 2020年第11期10卷 260-271页

作者： Dulcinea Vega francisco j Acosta Pedro Saavedra Department of Psychiatry University of Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35016Las PalmasThe Canary IslandsSpain Department of Psychiatry Insular University Hospital Department of Mental Health General Management of Healthcare Programs Canary Islands Health ServiceLas Palmas de Gran Canaria 35004Las PalmasThe Canary IslandsSpain Research Network on Health Services for Chronic Conditions(REDISSEC) Carlos III Health InstituteMadrid 28029Spain Department of Mathematics University of Las Palmas de Gran CanariaLas Palmas de Gran Canaria 35016Las PalmasThe Canary IslandsSpain

BACKGROUND Nonadherence is a major problem in the treatment of psychotic *** has been hypothesized that nonadherent patients with schizophrenia are not a homogeneous population and subtypes of nonadherence might exist,but this hypothesis has not been specifically *** To test the hypothesis of subtypes of nonadherence in schizophrenia and schizoaffective *** This prospective study included 110 consecutively admitted patients diagnosed with schizophrenia or schizoaffective *** were performed at baseline and at 6 mo follow-up after ***,clinical,psychopathological and treatment-related variables were *** was defined as the concurrence of adherence to antipsychotic treatment and outpatient follow-up during the six-month *** to antipsychotic treatment was defined as the concurrence of objective and subjective ***-four patients(58%)fulfilled nonadherence criteria at the end of the followup period and were categorized according to their subtype of *** In nonadherent patients(n=64),32(50%)fulfilled criteria of intentional nonadherence,and 32(50%)of unintentional nonadherence(UNA).Unintentional nonadherent patients,as compared to intentional nonadherent patients,are characterized by older age,lower educational level,worse cognitive and negative symptoms,greater severity,worse knowledge of their treatment regimen,greater prevalence of supervision of the treatment,lower number of prior hospitalizations and greater use of nonpsychiatric treatment,anticholinergics and *** educational level(OR=26.1;95%CI:2.819-241),worse treatment knowledge at six months(OR per unit=0.904;95%CI:0.853-0.957)and nonpsychiatric treatment at six months(OR=15.8;95%CI:1.790-139)were independently associated to *** Differentiated subtypes of nonadherence according to intentionality seem to exist in patients with schizophrenia and schizoaffective ***

关键词： Adherence Hospitalization Psychosis Hypothesis Unintentional nonadherence Intentional nonadherence

GSTARS computer models and their applications, Part Ⅱ: Applications

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International journal of Sediment Research 2008年第4期23卷 299-315页

作者： francisco j.M.SIM■ES Chih Ted YANG Research Hydrologist US Geological Survey Geomorphology and Sediment Transport Laboratory4620 Technology Drive Suite 400 Golden CO 80403 USA Borland Prof. of Water Resources and Director of Hydroscience and Training Center Department of Civil and Environmental Engineering Colorado State UniversityFort Collins CO 80523-1372 USA

In part 1 of this two-paper series, a brief summary of the basic concepts and theories used in developing the Generalized Stream Tube model for Alluvial River Simulation (GSTARS) computer models was presented. Part 2 provides examples that illustrate some of the capabilities of the GSTARS models and how they can be applied to solve a wide range of river and reservoir sedimentation problems. Laboratory and field case studies are used and the examples show representative applications of the earlier and of the more recent versions of GSTARS. Some of the more recent capabilities implemented in GSTARS3, one of the latest versions of the series, are also discussed here with more detail.

关键词： Computer model Reservoir River Sediment transport Unit stream power

HER2-low metastatic breast cancer: molecular insights and therapeutic strategies

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journal of Cancer Metastasis and Treatment 2023年第1期9卷 541-547页

作者： francisco j.Esteva Shabnam jaffer Division of Hematology and Medical Oncology Lenox Hill HospitalNew YorkNY 10065USA Department of Pathology Lenox Hill HospitalNew YorkNY 10065USA

The identification of HER2-low metastatic breast cancer as a novel subgroup with therapeutic implications underscores the intricacies in breast cancer *** subset,comprising 45%-60%of breast cancer cases,presents a challenge due to its heterogeneous nature,characterized by varying HER2 protein expression *** heterogeneity complicates diagnosis and treatment *** advent of trastuzumab deruxtecan(T-DXd),a second-generation antibody-drug conjugate(ADC),instills renewed hope for HER2-low breast cancer patients,having demonstrated effectiveness in clinical *** article also explores the evolution of HER2 testing guidelines,notably the 2023 ASCO/CAP guidelines that acknowledge the potential benefits of HER2-targeted therapies for this *** summary,this article emphasizes the significance of collaborative efforts between Pathologists and Oncologists in the era of precision *** also highlights the potential for innovative,tailored therapies for HER2-low breast cancer,promising enhanced treatment outcomes and a broader range of therapeutic options.

关键词： HER2-low breast cancer heterogeneity trastuzumab deruxtecan(T-DXd) HER2 testing guidelines precision medicine therapeutic strategies immunohistochemistry in situ hybridization

Multi-objective optimization design of bridge piers with hybrid heuristic algorithms

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第6期13卷 420-432页

作者： francisco j. MARTINEZ-MARTIN Fernando GONZALEZ-VIDOSA Antonio HOSPITALER Víctor YEPES Department of Geotechnical Engineering Universitat Politècnica de València 46022 Valencia Spain Department of Construction Engineering ICITECH Universitat Politècnica de València 46022 Valencia Spain

This paper describes one approach to the design of reinforced concrete (RC) bridge piers, using a three-hybrid multi- objective simulated annealing (SA) algorithm with a neighborhood move based on the mutation operator from the genetic algorithms (GAs), namely MOSAMO1, MOSAMO2 and MOSAMO3. The procedure is applied to three objective functions: the economic cost, the reinforcing steel congestion and the embedded CO 2 emissions. Additional results for a random walk and a descent local search multi-objective algorithm are presented. The evaluation of solutions follows the Spanish Code for structural concrete. The methodology was applied to a typical bridge pier of 23.97 m in height. This example involved 110 design variables. Results indicate that algorithm MOSAMO2 outperforms other algorithms regarding the definition of Pareto fronts. Further, the proposed procedure will help structural engineers to enhance their bridge pier designs.

关键词： Bridge piers Concrete structures Multi-objective optimization Simulated annealing (SA) Structural design

Thermo-electro-mechanical microstructural interdependences in conductive thermoplastics

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npj Computational Materials 2023年第1期9卷 955-965页

作者： javier Crespo-Miguel Sergio Lucarini Angel arias Daniel Garcia-Gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911 LeganésMadridSpain Department of Civil and Environmental Engineering Imperial College of LondonSouth Kensington CampusLondon SW72AZUK

Additive manufacturing has enabled the design of thermoplastic components that provide structural support,electrical conductivity and heat generation modulated by mechanical *** mechanisms and interplays that govern the material response at the microstructural level remain,however,***,we develop an experimental method to characterise conductive filaments from a combined mechanical,electrical and thermal *** approach is used to unravel exciting material interplays of conductive polylactic *** overcome experimental limitations that prevent a complete microstructural analysis of the problem,we develop a full-field homogenisation framework and implement it for finite *** framework accounts for viscoplasticity,electrical and thermal conduction,convection and heat generation via joule effect,as well as for the interdependences between *** experimental validation,the framework is applied to virtually optimise fabrication requirements to obtain desired properties in final products,i.e.,stiffer products,filaments with higher conductivities or with better sensing capabilities.

关键词： conductive electrical overcome

Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy

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World journal of Gastroenterology 2006年第37期12卷 6032-6036页

作者： RN Zárate R F arias E Bandres E Cubedo R Malumbres j García-Foncillas Laboratory of Biotechnology and Pharmacogenomics Center for Applied Medical Research University Clinic of Navarra 36 Pio XII Ave Pamplona 31008 Spain Navarra Hospital center s/n Irunlarrea Street Pamplona 31008 Spain

AIM: To evaluate the potential association of xeroderma pigmentosum group D (XPD) codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer. METHODS: We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage Ⅲ (48%) and Ⅳ (20%) gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy. RESULTS: Statistical analysis showed that 75% (12 of 16) of relapse patients showed Lys/Lys genotype more frequently (P = 0.042). The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis (HR: 3.07, 95% CI: 1.07-8.78, P = 0.036) and Kaplan-Meir test (P = 0.027, log-rank test). CONCLUSION: XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients.

关键词： Xeroderma pigmentosum group D gene Polymorphism Gastric cancer Radiotherapy

Agglomerate behavior in a recirculating fluidized bed with sheds： Effect of ring baffles

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Particuology 2018年第3期16卷 143-151页

作者： francisco j. Sanchez Careaga Cedric Briens Franco Berruti jennifer McMillan Murray Gray Institute for Chemicals and Fuels from Alternative Resources Western University 22312 Wonderland Rd. Hderton ON NO M2AO Canada Edmonton Research Centre Syncrude Canada Ltd 9421 17th Ave Edmonton AB T6N 1H4 Canada The Petroleum Institute PO Box 2533 Abu Dhabi UAE

The radioactive particle tracking technique was used to study the effect of internal ring baffles on wet agglomerate motion inside a cold flow recirculating fluidized bed. The study found that using such a baffle on its own or above the regular sheds helps reduce the fouling of the stripper section by increasing the residence time that the agglomerates spend above the baffle, thereby reducing the release of the vapors below the baffles that cause fouling of the sheds. Adding down-comers, or flux tubes, to the ring baffles degrades the performance of the baffles, Reducing the length of the flux tubes, so that they do not reach the bottom of the baffle lip results in a further degradation in baffle performance.

关键词： Radioactive particle tracking Fluidized bed Fluid coker Baffles