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Journal of Otology 2023年第1期18卷 26-32页

作者： francisco javier gonzalez eslait Paola Andrea Escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Objective:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center ***:This is a retrospective descriptive *** included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular *** were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ***:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

Vertical Displacement Measurement in a Slow-Moving Sinkhole Using BOTDA

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Photonic Sensors 2024年第1期14卷 23-39页

作者： Pascual SEVILLANO javier PRECIADO-GARBAYO Jorge SEVIL francisco GUTIERREZ Juan JMARTiNEZ Sonia MARTiN-LOPEZ Miguel gonzalez-HERRAEZ Aragon Institute of Engineering Research(I3A) Universidad de ZaragozaZaragoza 50018Spain Electronic Enginering and Communicaton Dpartment EINAUniversidad de ZaragzaZaragza 50018Spain Aragon Photonics Labs. Zaragoza 50009Spain Department of Earth Sciences Universidad de ZaragozaZaragoza 50009Spain Department of Electronics Escuela Politecnica SuperiorUniversidad de AlcalaMadrid 28805Spain

The effectiveness of monitoring and early-warning systems for ground deformation phenomena,such as sinkholes,depends on their ability to accurately resolve the ongoing ground displacement and detect the subtle deformation preceding catastrophic *** sinkholes with a slow subsidence rate and diffuse edges pose a significant challenge for subsidence monitoring due to the low deformation rates and limited lateral strain *** this work,we satisfactorily illustrate the practicality of the Brillouin optical time domain analysis(BOTDA)to measure the spatial-temporal patterns of the vertical displacement in such challenging slow-moving sagging *** assess the performance of the approach,we compare the strain recorded by the distributed optical fiber sensor with the vertical displacement measured by high-precision *** results show a good spatial correlation with the ability to identify the maximum subsidence *** is also a good temporal correlation with the detection of an acceleration phase in the subsidence associated with a flood event.

关键词： Distributed fiber optic sensing(DFOS) vertical displacement measurement slow subsidence rate sinkhole hazard early-warning system

Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

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Nano Research 2023年第5期16卷 7784-7791页

作者： Laura Perez-Garrido Mariano Ortega-Muñoz Fernando Hernandez-Mateo F.javier Lopez-Jaramillo francisco Santoyo-gonzalez Department of Organic Chemistry Biotechnology InstituteSchool of SciencesCampus Fuentenueva snUniversity of Granada18071-GranadaSpain

Selenium(Se)has been defined as the“Janus element”,with one face showing antioxidant activity and the other pro-oxidant *** biological effect of Se depends on both dose and *** nanoparticles are attracting major interest,although their large-scale preparation for biomedical applications is not *** hypothesize that acid anhydride-coated carbon dots(AACD)are an attractive platform for preparing nanoparticles containing chemically defined *** reaction of AA-CD with 3-selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups(CD-SeCN)that allow for tuning the ***-SeCN has a Se content of 0.36μmol per mg of nanoparticles,they show the typical photoluminescence of carbon *** selenocyanate groups(SeCN)exhibited glutathione peroxidase-like activity and *** show that antioxidant behavior differs between normal and tumor cells,the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose,time,intracellular glutathione(GSH)*** toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis,indicating that CD-SeCN is ***,high levels of intracellular GSH exert a protective *** results support a pharmacological potential in cancers with low levels of intracellular *** use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems.

关键词： selenium nanoparticles carbon dots glutathione peroxidase-like activity Janus element nanomedicine

NADPH Thioredoxin Reductase C Controls the Redox Status of Chloroplast 2-Cys Peroxiredoxins in Arabidopsis thaliana

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Molecular Plant 2009年第2期2卷 298-307页

作者： Kerstin Kirchsteiger Pablo Pulido Maricruz gonzalez francisco javier Cejudo Instituto de Bioquimica Vegetal y Fotosintesis Universidad de Sevilla and CSIC Avda Americo Vespucio 49 41092-Sevilla Spain

Chloroplast 2-Cys peroxiredoxins （2-Cys Prxs） are efficiently reduced by NADPH Thioredoxin reductase C （NTRC）. To investigate the effect of light/darkness on NTRC function, the content of abundant plastidial enzymes, Rubisco, glutamine synthetase （GS）, and 2-Cys Prxs was analyzed during two consecutive days in Arabidopsis wild-type and ntrc mutant plants. No significant difference of the content of these proteins was observed during the day or the night in wildtype and mutant plants. NTRC deficiency caused a lower content of fully reduced 2-Cys Prxs, which was undetectable in darkness, suggesting that NTRC is the most important pathway for 2-Cys Prx reduction, probably the only one during the night. Arabidopsis contains two plastidial 2-Cys Prxs, A and B, for which T-DNA insertion lines were characterized showing the same phenotype as wild-type plants. Two-dimensional gel analysis of leaf extracts from these mutants allowed the identification of basic and acidic isoforms of 2-Cys Prx A and B. In-vitro assays and mass spectrometry analysis showed that the acidic isoform of both proteins is produced by overoxidation of the peroxidatic Cys residue to sulfinic acid. 2-Cys Prx overoxidation was lower in the NTRC mutant. These results show the important function of NTRC to maintain the redox equilibrium of chloroplast 2-Cys Prxs.

关键词： Chloroplast peroxiredoxin NADPH thioredoxin reductase C overoxidation thioredoxin Arabidopsis.

Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： francisco javier Pérez Lara Rogelio Zubizarreta Jimenez Tatiana Prieto-Puga Arjona Pilar Gutierrez Delgado Juan Manuel Hernández Carmona Jose Manuel Hernández gonzalez Maria Pitarch Martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive *** approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is *** To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic *** For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to *** Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was *** difference was statistically ***,the insertion of mesh did not improve results for the non-accessible *** For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for *** parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

ON CONSERVATIVE APPROXIMATION BY LINEAR POLYNOMIAL OPERATORS AN EXTENSION OF THE BERNSTEIN'S OPERATOR

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Analysis in Theory and Applications 1995年第1期11卷 62-71页

作者： francisco-javier Munoz-Delgado Victoriano Ramirez-gonzalez Paul Sablonniere Universidad de Jaen SpainUniversidad de Granada SpainInstitut National des Sciences Appliquees France

In this work we slwly linear polynomial operators preserving some consecutive i-convexities and leaving in-verant the polynomtals up to a certain degree. First we study the existence of an incompatibility between the conservation of cenain i-cotivexities and the invariance of a space of polynomials. Interpolation properties are obtained and a theorem by Berens and DcVore about the Bernstein's operator ts extended. Finally, from these results a genera'ized Bernstein's operator is obtained.

关键词： LPO ON CONSERVATIVE APPROXIMATION BY LINEAR POLYNOMIAL OPERATORS AN EXTENSION OF THE BERNSTEIN’S OPERATOR

The Quaternary Structure of NADPH Thioredoxin Reductase C Is Redox-Sensitive

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Molecular Plant 2009年第3期2卷 457-467页

作者： Juan Manuel Pérez-Ruiz Maricruz gonzalez Maria Cristina Spinola Luisa Maria Sandalio francisco javier Cejudo Instituto de Bioqulmica Vegetal y Fotoslntesis Universidad de Sevilla y CSIC Avda Américo Vespucio 49 41092-Sevilla Spain Present address: Plant Biology Laboratory The Salk Institute 10010 N. Torrey Pines Rd La Jolla CA 92037 USA Estacion Experimental del Zaidin CSIC C/Prof Albareda 1 18008-Granada Spain

NADPH thioredoxin reductase C （NTRC） is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase （NTR） and thioredoxin （TRX） activities for the efficient reduction of 2-Cys peroxiredoxin （2-Cys PRX）. Because NADPH can be produced in chloroplasts during darkness, NTRC plays a key role for plant peroxide detoxification during the night. Here, it is shown that the quaternary structure of NTRC is highly dependent on its redox status. In vitro, most of the enzyme adopted an oligomeric state that disaggregated in dimers upon addition of NADPH, NADH, or DTT. Gel filtration and Western blot analysis of protein extracts from Arabidopsis chloroplast stroma showed that native NTRC forms aggregates, which are sensitive to NADPH and DTT, suggesting that the aggregation state might be a significant aspect of NTRC activity in vivo. Moreover, the enzyme is localized in clusters in Arabidopsis chloroplasts. NTRC triple and double mutants, A164G- V182E-R183F and A164G-R183F, replacing key residues of NADPH binding site, showed reduced activity but were still able to dimerize though with an increase in intermediary forms. Based on these results, we propose that the catalytically active form of NTRC is the dimer, which formation is induced by NADPH.

关键词： Abiotic/environmental stress oxidative and photo-oxidative stress photosynthesis Arabidopsis rice.

Review of incomplete macroscopic resections(R2)in rectal cancer:Treatment,prognosis and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 1062-1072页

作者： francisco javier Pérez Lara Maria Luisa Hebrero Jimenez francisco javier Moya Donoso Jose Manuel Hernández gonzalez Maria Pitarch Martinez Tatiana Prieto-Puga Arjona Department of Surgery Antequera HospitalMálaga 29200Spain Department of Oncologic Radiotherapy Hopital Regional de MálagaMálaga 29010Spain

Colorectal cancer is one of the most prevalent tumours,but with improved treatment and early detection,its prognosis has greatly improved in recent ***,when the tumour is locally advanced at diagnosis or if there is local recurrence,it is more difficult to perform a complete tumour resection,and there may be a residual macroscopic *** this paper,we review the literature on residual macroscopic tumour resections,concerning both locally advanced primary tumours and recurrences,evaluating the main problems encountered,the treatments applied,the prognosis and future perspectives in this field.

关键词： Rectal cancer Surgery Treatment Incomplete resection Local recurrence

Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain

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World Journal of Pediatrics 2020年第6期16卷 629-632页

作者： Pan Roses-Gibert javier Gimeno Castillo Amaia Saenz Aguirre francisco javier De la Torre Gomar Lucia Carnero gonzalez Zurine Martinez de Lagran Alvarez de Arcaya Ricardo gonzalez-Perez Araba University Hospital Francisco Leandro de Viana Street01009 VitoriaSpain

Background To describe the cutaneous acral findings in a pediatric population noticed during this *** A retrospective descriptive study was performed collecting data on 36 patients under 14 years old,presenting suspicious acral skin manifestations for coronavirus disease 2019(COVID-19).Results Patients were mostly male(63.8%).The mean age was 11.11 years.66.67%of patients showed erythematous papules,and 44.44%purpuric *** were aifected in 97.22%of patients and hands in 5.55%.Lesions were asymptomatic in 50%of patients.30.55%of patients showed extracutaneous findings,preceding skin lesions in 12.62 *** patients underwent specific severe acute coronavirus 2(SARS-CoV-2)testing;all of these patients tested *** The association between these symptoms and SARS-CoV-2 remains *** recommend using these manifestations as a sign of SARS-CoV-2 infection in *** could lead to the examination of asymptomatic and mildly symptomatic children so that contagions may be avoided.

关键词： Acral lesions Acute acro-ischemia Chilblain-like COVID-19

Rare earth elements and yttrium in ferromanganese deposits from the South China Sea:distribution,composition and resource considerations

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Acta Oceanologica Sinica 2018年第7期37卷 41-54页

作者： ZHONG Yi CHEN Zhong gonzalez francisco javier ZHENG Xufeng LI Gang LUO Yun MO Aibin XU Antao WANG Shuhong Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Department of Marine Science and Engineering Southern University of Science and Technology of ChinaShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Geological Survey of Spain(IGME) Madrid 28003Spain

Ferromanganese nodules and crusts contain relatively high concentration of rare earth elements（REE） and yttrium（REY）,with a growing interest in exploitation as an alternative to land-based REY *** the basis of comprehensive geochemical approach,the abundance and distribution of REY in the ferromanganese nodules from the South China Sea are *** results indicate that the REY contents in ferromanganese deposits show a clear geographic *** REY contents range from 69.1×10^-6 to 2 919.4×10^-6,with an average value of 1 459.5×10^-***,the enrichment rate of Ce content is high,accounting for almost 60% of the total *** REE enrichment is controlled mainly by the sorption of ferromanganese oxides and clay minerals in the nodules and ***,the total REY are higher in ferromanganese deposits of hydrogenous origin than of diagenetic ***,Light REE（LREE） and heavy REE（HREE） oxides of the ferromanganese deposits in the study area can be classified into four grades： non-enriched type,weakly enriched type,enriched type,and extremely enriched *** to the classification criteria of rare earth resources,the Xisha and Zhongsha platform-central deep basin areas show a great potential for these rare earth metals.

关键词： ferromanganese deposits rare earth elements and yttrium abundance characteristics controlling factors potential source South China Sea