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Nrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphaneNrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphane

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Journal of Chinese Pharmaceutical Sciences 2016年第8期25卷 559-569页

作者： francisco Fuentes Yury Gomez Ximena Paredes-gonzalez Avantika Barve Sujit Nair Siwang Yu Constance Lay Lay Saw Ah-Ng Tony Kong Facultad de Agronomia e Ingenieria Forestal Pontificia Universidad Cato1ica de Chile Casilla 306-22 Santiago Chile Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey New Jersey 08854 USA Novartis Institutes for Biomedical Research East Hanover NJ-07470 USA Amrita Cancer Discovery Biology Laboratory Amrita Vishwa Vidyapeetham University Amritapuri Clappana P.O. Kollam Kerala-690525 India School of Pharmaceutical Sciences Peking University Health Science Center Beo'ing 100191 China

The dietary phytochemicals curcumin(CUR) and sulforaphane(SFN) have shown remarkable cancer chemopreventive effects in many model systems. This study was designed to investigate the induction of Nrf2-mediated antioxidant enzymes by combining doses of CUR and SFN and the effect of their combination on the Nrf2-ARE(antioxidant response element) response in Hep G2-C8 cells. We hypothesized that the combination of the polyphenol CUR and the isothiocyanate SFN could enhance the induction of AREs and Nrf2-target enzymes. Hep G2-C8 cells were treated with a combination of low doses of CUR, SFN or both. The induction of Nrf2-mediated antioxidant and phase II detoxifying enzymes–heme oxygenase-1(HO-1) and UDP-glucuronosyltransferase-1A(UGT1A)–was measured by real-time RT-PCR and western blotting. ARE-luciferase activity was also quantified. Low doses of CUR(10 μM) and SFN(12.5 μM) significantly induced the expression of HO-1 and UGT1A1 proteins. Through the use of chemical inhibitors of mR NA and protein synthesis, the combination of CUR and SFN was shown to affect the transcriptional regulation of both HO-1 and UGT1A1. Additionally, the combination of CUR and SFN synergistically induced the expression of Nrf2- and ARE-luciferase activity in Hep G2-C8 cells. Thus, CUR and SFN at low concentrations augment therapeutic effects in Hep G2-C8 cells. The enhanced ARE-luciferase activity of combined CUR and SFN treatment could partly explain the significant induction of the Nrf2-target enzymes HO-1 and UGT1A1. Taken together, our results suggest that combining low doses of CUR and SNF could be a promising strategy for cancer chemoprevention in humans.

关键词： Antioxidant response element, Curcumin, HepG2-C8 cell-s, HO-1, Nrf2, Sulforaphane, UGT 1A1

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3D printed tacrolimus suppositories for the treatment of ulcerative colitis

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Asian Journal of Pharmaceutical Sciences 2021年第1期16卷 110-119页

作者： Iria Seoane-Viano Jun Jie Ong Asteria Luzardo-Alvarez Miguel gonzalez-Barcia Abdul W.Basit francisco J.Otero-Espinar Alvaro Goyanes Department of Pharmacology Pharmacy and Pharmaceutical TechnologyFaculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmaceutics UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Pharmacy Department University Clinical Hospital Santiago de Compostela(SERGAS)(CHUS)Santiago de Compostela 15706Spain FabRx Ltd. AshfordKent TN240RWUK Departamento de Farmacologia Farmacia y Tecnologia FarmaceuticaI+D Farma Group(GI-1645)Universidade de Santiago de CompostelaSantiago de Compostela 15782Spain

Ulcerative colitis is a global health problem,affecting millions of individuals *** an inflammatory condition localised in the large intestine,rectal delivery of immunosuppressive therapies such as tacrolimus is a promising strategy to maximise drug concentration at the site of action whilst minimising systemic side ***,for the first time,self-supporting 3D-printed tacrolimus suppositories were prepared without the aid of moulds using a pharmaceutical semi-solid extrusion(SSE)3D *** suppositories were printed vertically in three different sizes using combinations of two lipid pharmaceutical excipients(Gelucire 44/14 or Gelucire 48/16)and coconut *** both suppository formulations had the appropriate viscosity characteristics for printing,the Gel 44 formulation required less energy and force for extrusion compared to the Gel 48 *** Gel 44 disintegrated more rapidly but released tacrolimus more slowly than the Gel 48 *** the tacrolimus release profiles were significantly different,both suppository systems released more than 80% drug within 120 *** and XRD analysis was inconclusive in determining the solid-state properties of the drug in the *** summary,this article reports on the fabrication of 3D printed selfsupporting suppositories to deliver personalised doses of a narrow therapeutic index drug,with potential benefits for patients with ulcerative colitis.

关键词： 3D printed drug products Semi-solid extrusion 3D printing Inflammatory bowel disease Suppository drug delivery Pressure assisted syringe M3dimaker

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Cardiometabolic risk through an integrative classification combining physical activity and sedentary behavior in European adolescents:HELENA study

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Journal of Sport and Health Science 2019年第1期8卷 55-62页

作者： Carlos Cristi-Montero Palma Chillón Idoia Labayen José A.Casajus Marcela gonzalez-Gross Jérémy Vanhelst Yannis Manios Luis A.Moreno francisco B.Ortega Jonatan R.Ruiz IRyS Group Physical Education School Pontificia Universidad Cato?lica de Valparai?o PROmoting FITness and Health through physical activity research group (PROFITH) Department of Physical Education and SportsFaculty of Sport Sciences University of Granada Department of Nutrition and Food Science University of the Basque Country Department of Health and Human Performance School of Health Sciences University of Zaragoza ImFine Research Group Facultad de Ciencias de la Actividad Física y del Deporte-INEF Universidad Politcnica de Madrid Lille Inflammation Research International Center University of Lille Department of Nutrition and Dietetics Harokopio University

Purpose: This study aims to compare adolescents' cardiometabolic risk score through an integrative classification of physical activity(PA),which involves the combination of moderate-to-vigorous physical activity(MVPA) and sedentary behavior(SB).Methods: A cross-sectional study derived from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study database(2006-2008) was conducted in adolescents(n = 548; boys, 47.3%; 14.7 ± 1.2 years) from 10 European cities. MVPA and SB were objectively measured using accelerometry. Adolescents were divided into 4 categories according to MVPA(meeting or not meeting the international recommendations) and the median of SB time(above or below sex-and age-specific median) as follows: High-SB & Inactive, Low-SB & Inactive,High-SB & Active, and Low-SB & Active. A clustered cardiometabolic risk score was computed using the homeostatic model assessment, systolic blood pressure, triglycerides, total cholesterol/high-density lipoprotein cholesterol, sum 4 skinfolds, and cardiorespiratory fitness(CRF).Analyses of covariance were performed to discern differences on cardiometabolic risk scores among PA categories and each health ***: The cardiometabolic risk score was lower in adolescents meeting the MVPA recommendation and with less time spent in SB in comparison to the high-SB & Inactive group(p < 0.05). However, no difference in cardiometabolic risk score was established between High-SB or Low-SB groups in inactive adolescents. It is important to note that CRF was the only variable that showed a significant modification(higher)when children were compared from the category of physically inactive with "active" but not from high-to ***: Being physically active is the most significant and protective outcome in adolescents to reduce cardiometabolic risk. Lower SB does not exhibit a significant and extra beneficial difference.

关键词： Accelerometry Cardiovascular disease Exercise Metabolic disease Sedentary lifestyles

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Cardiac monitoring for patients with palpitations

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World Journal of Cardiology 2021年第11期13卷 608-627页

作者： Jaume francisco-Pascual Javier Cantalapiedra-Romero Jordi Pérez-Rodon Begoña Benito Alba Santos-Ortega Jenson Maldonado Ignacio Ferreira-gonzalez Nuria Rivas-Gándara Unitat d'Arritmies Servei de CardiologiaHospital Universitari Vall d'HebronVall d’Hebron Institut de Recerca(VHIR)Vall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain Facultat de Medicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Enfermedades Cardiovasculares(CIBERCV) Instituto de Salud Carlos IIIMadrid 28029Spain

Palpitations are one of the most common reasons for medical consultation. Theytend to worry patients and can affect their quality of life. They are often asymptom associated with cardiac rhythm disorders, although there are otheretiologies. For diagnosis, it is essential to be able to reliably correlate the symptomswith an electrocardiographic record allowing the identification or rulingout of a possible rhythm disorder. However, reaching a diagnosis is not alwayssimple, given that they tend to be transitory symptoms and the patient isfrequently asymptomatic at the time of assessment. In recent years, electrocardiographicmonitoring systems have incorporated many technical improvements thatsolve several of the 24-h Holter monitor limitations. The objective of this review isto provide an update on the different monitoring methods currently available,remarking their indications and limitations, to help healthcare professionals toappropriately select and use them in the work-up of patients with palpitations.

关键词： Palpitation Cardiac monitoring Electrocardiogram Loop recorder

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Epidemiological Investigation and Genetic Characterization of Type 2 PCV2 （Type 2 Porcine Circovirus） in Mexican Commercial Herds

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Journal of Agricultural Science and Technology(A) 2012年第3期2卷 363-372页

作者： francisco Robles-gonzalez Edgar Diaz Jean Claude Cheve Ricardo Angulo Carlos Gonzfilez Research and Development Department Boehringer Ingelheim Vetmedica S.A. de C. K Guadalajara Jalisco 44940 Mexico Technical Services Boehringer Ingelheim Vetmedica S.A. de C. V. Guadalajara Jalisco 44940 Mexico Boehringer Ingelheim Vetmedica Inc. St. Joseph Missouri 6450 USA

PCV2 (Porcine circovirus type 2) is considered as the essential infectious agent of PMWS (post weaning multisystemic wasting syndrome) in pigs. Serological studies have shown that the virus is ubiquitous. Currently, there are many reports about the epidemiology and genetic characteristics of this virus around the world, but in Mexico it has not been studied. More than 3,500 samples of serum, rectal swabs, tissues and semen of 34 Mexican porcine farms from 10 important producer regions were analyzed by PCR. Results show that 97% of the farms were positive. Both genotypes, PCV2a and PCV2b were detected. It also found that the most prevalent genotype in Mexico is PCV2b. Regarding to amino acid sequence; three major heterogenic regions were present in the positions 59-91, 123-136 and 185-210.

关键词：猪2型圆环病毒流行病学调查遗传特性 PCV2 墨西哥断奶多系统衰竭综合征猪圆环病毒2型类型

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正癸烷+正戊醇,+1-己醇,+庚醇二元混合物在293.15到363.15K和大气压力下的密度和粘度（英文）

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Chinese Journal of Chemical Engineering 2015年第3期23卷 559-571页

作者： Alejandro Estrada-Baltazar Micael Gerardo Bravo-Sanchez Gustavo Arturo Iglesias-Silva Juan francisco Javier Alvarado Edgar Omar Castrejon-gonzalez Mariana Ramos-Estrada Department of Chemical Engineering Instituto Tecnologico de Celaya Faculty of Chemical Engineering Universidad Michoacana de San Nicolas de Hidalgo

Densities(ρ) and dynamic viscosities(η) for three binary mixtures of n-decane with 1-pentanol,1-hexanol and1-heptanol are presented at temperatures from 293.15 to 363.15 K and atmospheric pressure over the entire composition *** density and viscosity are measured using a vibrating tube densimeter and a cylindrical Couette type rotating viscometer,*** molar volumes(V^E),viscosity deviations(△η) and excess Gibbs energy of activation of viscous flow(△G^(*E)) are calculated from the experimental *** and structural interactions are indicated by the sign and magnitude of these *** molar volumes and infinity dilution molar partial volumes are also calculated for each binary *** results are correlated using Redlich-Kister type equations.

关键词：振动管密度计二元混合物动态粘度大气压力正戊醇正癸烷温度庚醇

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Blood Flow-Restricted Training in Older Adults:A Narrative Review

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Journal of Science in Sport and Exercise 2020年第1期2卷 25-37页

作者： Abel Plaza-Florido Jairo H.Migueles Antonio Piepoli Pablo Molina-Garcia Maria Rodriguez-Ayllon Cristina Cadenas-Sanchez Jose Mora-gonzalez Irene Esteban-Cornejo francisco B.Ortega PROFITH"PROmoting FITness and Health Through Physical Activity"Research Group Sport and Health University Research Institute(iMUDS)Department of Physical and Sports EducationFaculty of Sport SciencesUniversity of GranadaCarretera de Alfacars/nCP 18071 GranadaSpain Department of Health Sciences Faculty of Health SciencesUniversity of JaénResearch Group CTS-026:Study Group on Physical ActivityPhysiotherapy and HealthJaénSpain Department of Rehabilitation Sciences KU Leuven-University of LeuvenLeuvenBelgium Department of Psychology Center for Cognitive and Brain HealthNortheastern UniversityBostonMAUSA

Background Low-intensity resistance training(LI-RT)combined with blood flow restriction(BFR)is an alternative to traditional moderate-high-intensity resistance training to increase strength and muscle ***,the evidence about the efficacy of this novel training method to increase strength and muscle mass in healthy and older adults with patholo-gies is ***,the possible risk and adverse effects with BFR training methodology in older adults should be ***(1)To summarize the current evidence on training with BFR strategies in older adults aiming to improve strength and to increase muscle mass;and(2)to provide recommendations for resistance and aerobic training with BFR in older adults based on the studies *** Studies that investigated the chronic responses to resistance training or aerobic training with BFR related to strength and muscle mass changes in older adults were *** independent researchers conducted the search in PubMed,Web of Science,and Google Scholar databases from their inception up to November 1,*** Seventeen out of 35 studies,which performed resistance or aerobic training with BFR in older adults focused on strength and muscle mass outcomes,were included in this *** performing resistance and aerobic train-ing with BFR found better improvements in strength and higher increase in muscle mass compared to non-BFR groups that performed the same training ***-intensity resistance training(HI-RT)without BFR provided greater improvements in strength and a similar increase in muscle mass compared to light-intensity resistance training(LI-RT)with *** Current evidence suggests that LI-RT and/or aerobic training with BFR improves strength and increases muscle mass in older ***-intensity training without BFR would normally not obtain such ***,LI-RT and aerobic training with BFR is an alternative to traditional methods to improve strength an

关键词： Hyertroply Strength Vascular oclusion Reistance raining Elderly aduts

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An Ant Colony Optimization Algorithm for Quadratic Assignment Problem

An Ant Colony Optimization Algorithm for Quadratic Assignmen...

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The Twelfth Asia Pacific Industrial Engineering ＆ Management Systems Conference(APIEMS 2011)

作者： Kun-Chih Wu Ching-Jung Ting Lionel francisco Casanova gonzalez Department of Industrial Engineering and Management Yuan Ze University 135 Yuan Tune Road.Chune-Li.Taiwan 32003China

＜正＞The Quadratic Assignment Problem（QAP） is a well-known and important NP-hard *** optimization problems are related to QAP,such as facilities layout problem,airport gate assignment problem,and backboard wiring *** QAP considers assigning N facilities to N locations,where the cost function is composed by the multiplications of the distance between two locations and flow between two *** objective is to find the minimum total *** this paper,we develop an Ant Colony Optimization（ACO） to solve the problem,in which a specific heuristic information and local search are both well *** test the efficiency and effectiveness of our ACO,we run the ACO on the benchmark instances for facilities location problem obtained from the QAPLIB web *** experiment results show that our ACO can achieve the competing results on the benchmark instances.

关键词： Quadratic Assignment Problem Ant Colony Optimization Heuristics

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Diabetic Renal-Retinal Syndrome and Inflammatory Markers of Acute Phase

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Journal of Diabetes Mellitus 2014年第3期4卷 194-201页

作者： francisco Jesus Sepulveda-Canamar Raul Trevino Hernandez Joaquin Dario Trevino Baez Jesus H.gonzalez Cortes Ophtalmology and Nephrology Services Unidad Medica de Atencion AmbulatoriaInstituto Mexicano del Seguro SocialSan Pedro Garza GarciaMexico Universidad Juarez del Estado de Durango DurangoMexico Ophtalomology Department of Universidad Autonoma de Nuevo Leon San Nicolas de los GarzaMexico

Objective: To determine the association between the acute inflammatory markers and Diabetic Renal-Retinal Syndrome in our patients. Methods: A total of 44 patients were included in this transverse (cross sectional), observational, analytical, and comparative study. Two groups of patients were created. Results: In patients with chronic renal failure, stages 3, 4, or 5 (scale 1 to 5) were identified and divided into two groups: Group I (Patients with concomitant diabetic retinopathy stabilized with photocoagulation) 22 patients. Group II (Patients with progression of retinopathy, after photocoagulation, in the form of intraocular bleeding) 22 patients. The number of patients with chronic renal failure in stage 3 was: Group I;16. In Group II;12 patients (OR: 1.0). Stage 4: Group I;4 patients. Group II: 3 patients (OR: 1.0, CI 95%;0.3843 - 2.021). Stage 5: Group I;2 patients. Group II;7 patients (OR: 1.8148, CI 95%;1.0448 - 3.1523;Chi-squared (x2) 2.7450, p = 0.097). t-Test found statistical significance in Erythrocyte Sedimentation Rate (ESR): p < 0.0001 (CI 95%;7.8959 - 23.2515);R = 0.56 p = 0.001;and OR = 1.959 (CI 95%;1.193 - 3.217). By non-parametric tests, C-reactive protein with binomial test showed p < 0.001. ESR showed p < 0.001 with U of Mann Whitney. Conclusions: With this study revealed a possible association of inflammatory markers with Diabetic Renal-Retinal Syndrome.

关键词： Diabetic Renal-Retinal Syndrome Erythrocyte Sedimentation Rate C-Reactive Protein

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Contamination Potential of an Urban Mine Tailings Deposit in Central Mexico—A Preliminary Estimation

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International Journal of Geosciences 2014年第3期5卷 296-312页

作者： Liliana Lizarraga-Mendiola Diana Elizabeth Angeles-Chavez Alberto Blanco-Pinon Marius Ramirez-Cardona francisco Javier Olguin-Coca Maria del Refugio gonzalez-Sandoval Academic Area of Engineering Institute of Basic Sciences and EngineeringAutonomous University of the State of HidalgoPachucaMexico Academic Area of Earth and Materials Sciences Institute of Basic Sciences and EngineeringAutonomous University of the State of HidalgoPachucaMexico

This study consisted of a geochemical analysis of the Dos Carlos tailings’ deposit located in the Mining District of Pachuca-Real del Monte in the state of Hidalgo, Central Mexico. The goal of the study was to determine the potential effects of this deposit on the environment and health of the population of the metropolitan area of Pachuca. Sampling was conducted from the top to the base of two raised sections at opposite ends of the deposit, and macroscopic features (profiles A and B) of these deposits were evaluated. Subsequently, mineralogical analyses of the collected samples were performed using X-ray diffraction and physico-chemical analysis of the leachates. The results were compared with the maximum permissible limits established by different national and international standards for drinking water and hazardous waste. In addition, geochemical modeling was conducted using PHREEQC to calculate the distribution of aqueous species, ionic activities and saturation indices.(For more information, please refer to the PDF.)

关键词： Contamination Dos Carlos Tailings Mining District Pachuca-Real del Monte

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