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Brains for Dementia Research: The Importance of Cohorts in Brain Banking

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Neuroscience Bulletin 2019年第2期35卷 289-294页

作者： Paul T.francis Gillian m.Hayes Helen Costello David R.Whitfield Wolfson Centre for Age-Related Diseases King's College London

Background:The Historical Importance of Studies of Human Brain in Dementia Research The collection of brain and related tissue has a long history(1)In terms of dementia,a more systematic examination of the relationship between brain pathology and clinical symptoms can be traced to Alois Alzheimer’s group in munich in the early 1900s(2)The use of human brain tissue is essential to increase our understanding of dementia as it gives us the gold standard of disease pathogenesis and clues as to the molecular mechanisms that underpin the various diseases and conditions.

关键词： Importance of Cohorts Dementia Research mechanisms

Screening of tall fescue genotypes for relative water content and osmotic potential under drought stress

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Grassland Research 2022年第2期1卷 84-93页

作者： francis m.Kirigwi malay C.Saha The Noble Research Institute ArdmoreOklahomaUSA Bayer Crop Science WinnipegManitobaCanada

Background:Tall fescue(Festuca arundinacea Schreb.)is an important coolseason perennial *** persistence and forage yield can be severely affected by drought stresses during the hot,dry summers of the southern ***:One thousand tall fescue genotypes were evaluated in the greenhouse for high relative water content(RWC)and low cell sap osmotic potential(OP).Fifty contrasting genotypes for the two traits were identified and used in further greenhouse and field *** genotypes were also screened with 30%*** and shoot characteristics were studied in 10 ***:The genotypes differed for RWC(33.7%–97.3%,mean:79.7%)and had an almost fivefold difference in OP(−0.5 to−2.4 mPa,mean:−1.2 mPa).Significant variation(pmain effects of environment and genotypes was found for RWC and *** from the greenhouse trial,no correlation was found between RWC and OP,indicating that differences in RWC might have been due to factors other than osmotic *** with either long roots or high root weights,and high root/shoot ratios demonstrated high RWC and low ***:Genotypes with consistently high RWC and low OP were identified and used for the development of mapping populations and transcriptome studies.

关键词： drought tolerance osmotic potential relative water content root/shoot ratio tall fescue

Petroleum waste biodegradation with porous biomass support system (PBSS) on rotating biological contactor

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Journal of Environmental Sciences 1991年第1期3卷 11-28页

作者： Tran T.francis Chowdhury A.K.m.m Asian Institute of Technology Bangkok Thailand.Asian Institute of Technology Bangkok Thailand.

A laboratory scale study was conducted to assess the feasibility of the new coupling of rotating biological contactor (RBC) plus porous biomass support system (PBSS) using polyurethane foam as porous support media to biodegrade petroleum refinery wastewater. Polyurethane foam was attached on disks of two four-stage laboratory scale cascade connected RBC *** two RBC units were operated simultaneously at different but constant, flowrates giving hydraulic loading rates of 0.01, 0.02, 0.03, 0.04 m3/m2/d in two runs keeping the same rotational speed 10 r/min throughout. Organic loading was a less controllable factor in this *** all of the hydraulic loadings, it was found that the removal efficiency of total chemical oxygen demand (TCOD) and oil were above 80 percent. Ammonia nitrogen and phenol removal were above 90 and 80 percent respectively. The maximum biomass concentration within polyurethane foam was about 30 g/m2 in the first stage for 0.03 m3/m2/d hydraulic *** results show that this new technology can be applied effectively for practical purposes with moderate hydraulic loading rates.

关键词： petroleum waste biodegradation rotating biological contactor.

Detection of Different Stages of Alzheimer’s Disease Using CNN Classifier

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Computers, materials & Continua 2023年第9期76卷 3933-3948页

作者： S m Hasan mahmud md mamun Ali mohammad Fahim Shahriar Fahad Ahmed Al-Zahrani Kawsar Ahmed Dip Nandi francis m.Bui Department of Computer Science American International University-Bangladesh(AIUB)Dhaka1229Bangladesh Centre for Advanced machine Learning and Applications(CAmLAs) DhakaBangladesh Department of Software Engineering Daffodil International UniversityDhakaBangladesh Department of Computer Engineering Umm Al-Qura UniversityMecca24381Saudi Arabia Department of ECE University of SaskatchewanSaskatoonSK S7N5A9Canada Group of Biophotomatiχ Department of ICTMBSTUSantoshTangail1902Bangladesh

Alzheimer’s disease(AD)is a neurodevelopmental impairment that results in a person’s behavior,thinking,and memory *** common symptoms ofADare losingmemory and early *** addition to these,there are several serious impacts ***,the impact ofADcanbemitigatedby early-stagedetection though it cannot be cured ***-stage detection is the most challenging task for controlling and mitigating the impact of *** study proposes a predictive model to detect AD in the initial phase based on machine learning and a deep learning approach to address the *** build a predictive model,open-source data was collected where five stages of images of AD were available as Cognitive Normal(CN),Early mild Cognitive Impairment(EmCI),mild Cognitive Impairment(mCI),Late mild Cognitive Impairment(LmCI),and *** stage of AD is considered as a class,and then the dataset was divided into three parts binary class,three class,and five *** this research,we applied different preprocessing steps with augmentation techniques to efficiently *** integrates a random oversampling technique to handle the imbalance problem from target classes,mitigating the model overfitting and *** three machine learning classifiers,such as random forest(RF),K-Nearest neighbor(KNN),and support vector machine(SVm),and two deep learning methods,such as convolutional neuronal network(CNN)and artificial neural network(ANN)were applied on these *** analyzing the performance of the used models and the datasets,it is found that CNN with binary class outperformed 88.20%*** result of the study indicates that the model is highly potential to detect AD in the initial phase.

关键词： Alzheimer’s disease early detection convolutional neural network data augmentation random oversampling machine learning

Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches

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World Journal of Clinical Oncology 2016年第1期7卷 15-26页

作者： Paul L Swiecicki Kelly m malloy francis P Worden Division of Hematology/Oncology Department of Internal Medicine University of Michigan Comprehensive Cancer Center Department of Otolaryngology University of Michigan Health System University of michigan Comprehensive Cancer Center

Oropharyngeal cancer accounts for approximately 2.8% of newly cancer cases. Although classically a tobacco related disease, most cases today are related to infection with human papilloma virus(HPV) and present with locally advanced tumors. HPV related tumors have been recognized as a molecularly distinct entity with higher response rates to therapy, lower rates of relapse, and improved overall survival. Treatment of oropharyngeal cancer entails a multi-disciplinary approach with concomitant chemoradiation. The role of induction chemotherapy in locally advanced tumors continues to be controversial however large studies have demonstrated no difference in survival or time to treatment failure. Surgical approaches may be employed with low volume oropharyngeal cancers and with development new endoscopic tools, more tumors are able to be resected via an endoscopic approach. Given advances in the understanding of HPV related oropharyngeal cancer, ongoing research is looking at ways to minimize toxicities via de-intensification of therapy. Unfortunately, some patients develop recurrent or metastatic disease. Novel therapeutics are currently being investigated for this patient population including immunotherapeutics. This review discusses the current understanding of the pathogenesis of oropharyngeal cancer and treatment. We also discuss emerging areas of research as it pertains to de-intensification as well novel therapeutics for the management of metastatic disease.

关键词： Oropharyngeal cancer Human papilloma virus Transoral robotic surgery Immunotherapy metastatic head and neck squamous cell carcinoma

mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease

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World Journal of Gastroenterology 2006年第35期12卷 5680-5686页

作者： Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger m francis Nick P Thompson musculoskeletal unit Freeman HospitalNewcastle-upon-Tyne United Kingdom Department of Biochemistry Freeman Hospital Newcastle-upon-Tyne United Kingdom Regional medical Physics Department Newcastle General Hospital United Kingdom Dept of Statistics University of Newcastle upon Tyne United Kingdom musculoskeletal unit Freeman Hospital Newcastle-upon-Tyne United Kingdom Department of medicine Freeman Hospital Newcastle-upon-Tyne United Kingdom

AIm: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. mETHODS: Two hundred and fifty-eight unselected patients (92 m, 166 F) with CD were studied. Bone mineral density (BmD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score mbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P mbar spine or hip were a low body mass index (P male sex (P mbined accounted for 23% and 37% of the reduction in BmD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BmD can be attributed to risk factors such as corticosteroid use and low BmI and therefore remains unexplained.

关键词： Crohn's disease Osteoporosis Osteopenia Bone mineral density

Post-Traumatic Stress Disorder among Defence and Security Forces in Northern Benin (2023)

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Open Journal of Psychiatry 2024年第2期14卷 142-161页

作者： Ireti Nethania Elie Ataigba Guy Gérard Aza Gnandji David Sinet Koivogui Dalmace Fauste Adjaho Eurydice Elvire Djossou Anselme Djidonou francis Tognon Tchegnonsi Prosper Gandaho Josiane Ezin Houngbe Faculté de médecine & Institut de Formation en Soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin Service de Psychiatrie Centre Hospitalier Universitaire Départemental du Borgou Alibori Parakou Bénin Organisation Non Gouvernementale de Soutien Réhabilitation Insertion et Réinsertion (SouRIR ONG) Parakou Bénin Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Centre Nationale Hospitalier Universitaire Hubert Koutoucou maga de Cotonou Cotonou Bénin Faculté des Sciences et Techniques de Santé Université Gamal Abdel Nasser de Conakry Conakry Guinée

Introduction: Post-traumatic stress disorder (PTSD) is defined as “actual exposure to death or the threat of death, serious injury or sexual violence”, either directly or indirectly, resulting in a symptomatic procession of repetition, avoidance, neurovegetative hyperactivity and individualized symptoms, with or without negative cognitive and mood changes. It therefore goes without saying that the defence and security forces constitute a high-risk population in need of attention. Objective: To study post-traumatic stress disorder in defence and security forces in the city of Parakou in 2023. methods: Descriptive cross-sectional study conducted from December 2022 to July 2023. The study population consisted of active military, republican police and firefighters in the city of Parakou in 2023. Non-proportional stratified sampling was used, given the inaccessibility of the source population size for national security reasons. Post-traumatic stress disorder was assessed using the “post-traumatic stress disorder checklist-5 (PCLS-5) scale. Results: A total of 305 subjects participated in the survey. males dominated 90.2%. The most represented corps was the Republican Police (41.6%), most of whom were non-commissioned officers (46.6%). The majority count between 11 and 20 years of service (48.9%), with 2 to 5 missions completed (67.5%). The calculated prevalence of post-traumatic stress disorder was 11.8%, based on the post-traumatic stress disorder checklist-5 (PCL-5). Of the 36 respondents with post-traumatic stress disorder, 20 (55.6%) had experienced an armed attack, 25 (69.4%) had witnessed a violent death, 18 (50.0%) had witnessed the agony of a colleague, 15 (41.7%) had been exposed to a fire or explosion, while 26 (72.2%) had been traumatized by physical and/or verbal aggression. 5 (13.9%) had consulted a specialist psychiatrist, while 6 (16.7%) were on medication and 26 (72.2%) used sport as a means of maintaining physical and mental health. Respectively 22 (61.1

关键词： Post-Traumatic Stress Disorder Forces Defence Security Benin 2023

Eating Disorders among Students in Northern Benin (2023)

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Open Journal of Psychiatry 2024年第1期14卷 11-28页

作者： Ireti Nethania Elie Ataigba Guy Gérard Aza-Gnandji David Sinet Koïvogui Wifrieda Aguidissou Eurydice Elvire Djossou Anselme Djidonou francis Tognon Tchegnonsi Prosper Gandaho Josiane Ezin Houngbe Institut de Formation en Soins Infirmiers et Obstétricaux Faculté de Médecine Université de Parakou Parakou Bénin Service de Psychiatrie Centre Hospitalier Universitaire Départemental du Borgou Alibori Parakou Bénin Organisation Non Gouvernementale de Soutien Réhabilitation Insertion et Réinsertion (SouRIR ONG) Parakou Bénin Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Service de Psychiatrie Centre National Hospitalier Universitaire Hubert Koutoucou Maga de Cotonou Cotonou Bénin Faculty of Health Sciences and Techniques Université Gamal Abdel Nasser de Conakry Conakry Guinée

Introduction: From their earliest hours, human beings are able to identify a source of food and to feed themselves. Feeding is therefore one of the most instinctive human functions. It is regulated by several factors (physiological, psycho-affective and environmental) whose disruption can lead to eating disorders. Objective: The aim of this study was to investigate eating disorders among students in the town of Parakou in 2023. method: Descriptive cross-sectional study conducted from January to July 2023 in various universities in the city of Parakou, Benin. The study population consisted of all students in grades 1 to 7 at these universities. A two-stage non-proportional stratified sampling technique combined with a simple random draw was adopted. The Eating Attitude Test-26, Bulimia Inventory Test Edinburgh and a set of questions focusing on the diagnostic criteria for pica were used to screen for pica and other disorders such as anorexia, bulimia nervosa and binge eating disorder. Data were analyzed using SPSS (Statistical Package for Social Sciences) version 25. Results: A total of 607 students were surveyed, 323 of whom had eating disorders. A prevalence of 53.21% of students at risk of eating disorders was found. In relation to the total population, the prevalences of anorexia, bulimia nervosa, binge eating disorder and pica were 45.96%, 0.82%, 15.48% and 12.68% respectively. In multivariate analysis, seven factors explained the risk to develop at least one eating disorder among the students surveyed. These were: urban area of residence (OR (95% CI) = 5.059 (1.75 - 14.65);p = 0.003);year of study (OR (95% CI) = 0.47 (0.28 - 0.79);p = 0.035);type of university attended (private university: OR (95% CI) = 1.63 (1.08 - 2.44);p = 0.019);parents’ marital status (couple or not) (OR (95% CI) = 1.50 (1.01 - 2.24);p = 0.046);father’s level of education: secondary (OR (CI 95%) = 3.85 (1.96 - 7.54);p 0.001)/higher (OR (CI 95%) = 2.83 (1.36 - 5.86);p = 0.005);mother’s one:

关键词： Eating Disorders Benin 2023

Sexual Assault and Its Psychopathological Repercussions in the Life of Female Students in Northeastern Benin (2023)

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Open Journal of Psychiatry 2024年第3期14卷 163-178页

作者： Ireti Nethania Elie Ataigba Djibrilla moussa Oumou Ousseyni Zika Fidélia Dotou Coovi Ignace Tokpanoude Anselme Djidonou Djibo Douma maiga francis Tognon Tchegnonsi Prosper Gandaho Josiane Ezin Houngbe Faculté de médecine & Institut de Formation en Soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin Service de Psychiatrie Départemental du Borgou Alibori Centre Hospitalier Universitaire Parakou Bénin Organisation Non Gouvernementale de Soutien de Réhabilitation d’Insertion et de Réinsertion (SouRIR ONG) Parakou Bénin Faculté des Sciences de la Santé Université André Salifou de Zinder Zinder Niger Service de Psychiatrie H?pital National de Zinder Zinder Niger Faculté des Sciences de la Santé Université Abdou Moumouni de Niamey Niamey Niger Service de Psychiatrie H?pital National de Niamey Niamey Niger Faculté des Sciences de la Santé de Cotonou Université d’Abomey-Calavi Abomey-Calavi Bénin Service de Psychiatrie Centre National Hospitalier Universitaire - Hubert Koutoucou Maga de Cotonou Cotonou Bénin

Objective: The aim of the present study was to investigate the psychic repercussions of sexual assault among female students in Parakou in 2023. methods: Descriptive cross-sectional study conducted from December 2022 to July 2023 among all students at the University of Parakou. The sampling technique was stratified non-proportional at two levels. The dependent variable was self-reported sexual assault. The psychopathological repercussions linked to sexual assault and explored in these students were: post-traumatic stress disorder assessed with the Post Traumatic Stress Disorder Checklist-5 (PCL-5) scale;and current depression screened with the Patient Health Questionnaire-9 (PHQ-9) scale. Results: A total of 376 female students from the University of Parakou meeting the inclusion criteria were surveyed. The average age of the subjects surveyed was 20.56 ± 2.46 years, with extremes of 16 and 32 years. A predominance of subjects under 25 was observed. The prevalence of sexual assault among female students at the University of Parakou was 10.63%. The types of aggression suffered were mostly rape (18 people;45%) and sexual touching (16 people;40%), and the aggressors were mainly friends/boyfriends (13;32.5%), family members (12;30.0%) and people from the house/neighborhood (9;22.5%). Psychological repercussions included depression in 72.5% (29) of cases, with mild depression in 30% (12), moderate depression in 37.5% (15) and severe depression in 5% (2). Anxiety disorders were present in 27.50% (11) of victims. The risk factors associated with sexual assault in these students were gravidity (p = 0.014;OR = 15.32), unhappy life events (p = 0.01;OR = 17.24), and age of first sexual intercourse (p = 0.016;OR = 4.608). Conclusion: One in ten female students in Parakou has been sexually assaulted. Once again, preventive action through effective sex education is a means of fighting the problem that should be prioritized for every girl and boy from an early age. Psychological s

关键词： Sexual Assault Psychopathological Repercussions Benin 2023