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二肽基肽酶-4抑制剂沙格列汀和西格列汀对高脂喂食的链脲酶素注射小鼠的胰岛Beta细胞质量的保护

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二肽基肽酶-4抑制剂沙格列汀和西格列汀对高脂喂食的链脲酶素注射...

Quality Assurance in SPECT/CT for Radionuclide Therapy with Lutetium-177

中华医学会第十一次全国内分泌学学术会议

作者： S.m.Poucher J.francis S.Vickers S.Cheetham G.Birmingham K.Dickinson B.Zinker A.Bellamine m.Kirby Cardiovascular Discovery Department AstraZeneca PharmaceuticalsMacclesfieldUK ASTL AstraZeneca PharmaceuticalsCharnwoodUK

背景和目的:沙格列汀(SAXA)是一个强效的选择性二肽基肽脢-4(DPP-4)抑制剂,具有为延长对DPP-4的抑制特殊设计。肠促胰素能刺激葡萄糖依赖的胰岛素分泌,而DPP-4可使肠促胰素失去活性。SAXA作用机制可能与保护肠促胰素被DPP-4的降解,进而...

背景和目的:沙格列汀(SAXA)是一个强效的选择性二肽基肽脢-4(DPP-4)抑制剂,具有为延长对DPP-4的抑制特殊设计。肠促胰素能刺激葡萄糖依赖的胰岛素分泌,而DPP-4可使肠促胰素失去活性。SAXA作用机制可能与保护肠促胰素被DPP-4的降解,进而改善β细胞应激状态下β细胞的量存。本研究评估了SAXA和西格列汀(SITA)这些DPP-4抑制剂在其相似功效的处理下其对β细胞的保护作用。

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International Journal of medical Physics, Clinical Engineering and Radiation Oncology 2022年第1期11卷 60-76页

作者： Olivia Adu-Poku Eric Kotei Addison Bright Kwakye-Awuah Stephen Inkoom francis Hasford Cletus Ahadzie Joseph Adom Isaac Kojo Wilson Department of Physics Kwame Nkrumah University of Science and Technology Kumasi Ghana Komfo Anokye Teaching Hospital Oncology Directorate Department of Medical Physics Kumasi Ghana Department of medical Physics Graduate School of Nuclear and Allied Sciences University of Ghana Accra Ghana Radiation Protection Institute Ghana Atomic Energy Commission Accra Ghana Nuclear Regulatory Authority Ghana Atomic Energy Commission Accra Ghana

This study was done to quality assure the Hawkeye SPECT/CT at the St. Olav’s hospital and create a clinical method for doing individual dosimetry with 177Lu-octreotate in targeted radionuclide therapy for neuroendocrine tumors. Various quality control parameters were performed on Infinia Hawkeye SPECT/CT. A calibration dose of 160% ± 2% mBq was ordered and first calibrated for all the dose calibrators. The uniformity test was obtained using a 40 mBq Tc-99m point source positioned 2.5 m away from the two detectors. A 200 mBq Tc-99m was diluted in 70 ml of water, dispersed in six syringes for the registration test. A Lu-177 point source was placed in front of the detectors, one at a time, to check the energy peaks. The Jaczczak phantom with a hollow sphere set (volumes: 0.5, 1, 2, 4, 8, and 16) ml with an additional 60 ml sphere was used for the 3D sensitivity and recovery with Lu-177. Total activity of 945.3 mBq was added to 160 ml of water yielding an activity concentration of 5.908 mBq/ml in the spheres. The phantom was then scanned at various time intervals. A cylindrical phantom with a volume of 6283 ml was also used to obtain the cross-calibration measurement (cps/mBq). Total activity of 995.6 mBq was added and the phantom was scanned at days 0, 6, 13 and 23. The dose calibration factor was changed from 762 to 760 to achieve correct doses. The 2D mean sensitivity factor was 5.56 cps/mBq. Uniformities for both detectors were approved after iteration calibration of the Pm tubes. The X-ray to SPECT registration was found to be accurate and within specifications. The energy peak test revealed off-centered 208 keV energy peaks for the two detectors. Quality assurance of imaging devices using radiation is essential for radiation protection and ensures a high-quality image.

关键词： Lutetium-177 Activity Concentration Dose Calibrator SPECT/CT

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眼球摘除手术中用台盼蓝作Tenon囊的染色

丛书名：黑色+蓝色法国新侦探小说

2003年

作者：（法）弗朗西斯·密西奥（francis mizio）徐爽译

承蒙作家张炜推荐，山东文艺出版社接决定翻译出版我的三本小说，得此消息，我高兴不已。我在 1999 年 10 月海南岛一次笔会上认识张炜，他的推荐是对我的厚爱。作家的最大荣耀莫过于见到自己的作品越过原籍国境线。

ISBN: (数字)753292095X

ISBN: (纸本)753292095X

关键词：长篇小说法国当代

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美国医学会眼科杂志（中文版） 2006年第1期18卷 46-46,45页

作者： Leanne m. Cheung Geoffrey A. Wilcsek lan C. francis minas T. Coroneo 王静波（译）惠延年（校）

重要的台盘蓝染色一直广泛的应用于眼外科手术中，我们描述了在眼球摘除手术时台盘蓝Tenon囊染色的一项新的眼外使用方法。台盘蓝前Tenon囊染色最常见的临床用途是在摘除白色或成熟的白内障。时以帮助囊膜切开术的完成．台盘蓝也一直用... 详细信息

重要的台盘蓝染色一直广泛的应用于眼外科手术中，我们描述了在眼球摘除手术时台盘蓝Tenon囊染色的一项新的眼外使用方法。台盘蓝前Tenon囊染色最常见的临床用途是在摘除白色或成熟的白内障。时以帮助囊膜切开术的完成．台盘蓝也一直用于在深板层角膜成型术中在后基质纤维层的染色。，在切削过程中染色内界膜。以厦有助于完全地切除增殖性玻璃体视网膜病变．

关键词： Tenon囊眼球摘除蓝染色手术中增殖性玻璃体视网膜病变台盼蓝囊膜切开术临床用途板层角膜眼外科

Visualization of Activated BAT in mice,with FDG-PET and Its Relation to UCP1

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Advances in molecular Imaging 2013年第3期3卷 19-22页

作者： Christian Jeanguillaume Gilles metrard Daniel Ricquier Pierre Legras francis Bouchet Franck Lacoeuille Francois Hindre Olivier morel Herve Rakotonirina Service de medecine Nucleaire CHU d’AngersAngersFrance LISA ISTIA Universite d’AngersAngersFrance Service de medecine Nucleaire CHR d’OrleansOrleansFrance Universite Paris Descartes Institut CochinParisFrance Service Commun d’Animalerie Hospitalo Universitaire(SCAHU)AngersFrance Unite Inserm U646 AngersFrance Service de médecine Nucléaire ICOPaul PapinAngersFrance

The visualization of symmetric structure by [18F]-FluoroDeoxyGlucose-Positron Emission Tomography (FDG-PET), corresponding to adipose density in computed tomography (CT), has led to the idea that Brown Adipose Tissue (BAT) could be present in adult human. This article studies the FDG uptake in a mice model deficient on Uncoupling Protein 1 (UCP1), in a simple thermal activation protocol. methods: FDG were injected in mice, control and knock out (K.O.) for the UCP1. Before imaging mice were placed either in cold or warm environment. BAT uptake was evaluated by ratio named RISC. Results: In warm condition, mean value of the Ratio of Inter-Scapular uptake (RISC) was 1.34 +/﹣ 0.27. After cold exposure, RISC increased 2 fold for control mice, male K.O. did not increase their RISC, female K.O. increased their RISC up to 2.45. Conclusion: Our study brought a further confirmation that FDG-PET visualised activated Brown Adipose Tissue. It gives a direct proof of the role of UCP1 in this process. The FDG uptake by cold female K.O. mice was unexpected.

关键词： FDG PET Brown Adipose Tissue Uncoupling Protein 1 mice

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本草医案

移植于裸鼠的人鼻咽癌细胞DNA合成生物节律的初步研究

丛书名：黑色+蓝色法国新侦探小说

2003年

作者：（法）弗朗西斯·密西奥（francis mizio）傅杰译

a两棵濒临灭绝的小树，突然身价暴涨；科学巨骗信口开河，于是商人追名逐利；环保卫士不甘寂寞；私家侦探大展身手……逸趣横生而环环相扣的情节，波诡云谲。

ISBN: (数字)7532920968

ISBN: (纸本)7532920968

关键词：长篇小说法国当代

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癌症 2001年第2期20卷 128-130页

作者：孙健冼励坚曹弃元叶燕丽 LIU Xu-hui LI Xiao-mei francis Lé vi 中山医科大学肿瘤研究所广东广州510060 Labortoire Rythmes Bioloques et Chronothé rapeutique Institute du Cancer et d' Immunogé né tique H pital Paul Brousse Villejuif France

目的:探索鼻咽癌细胞DNA合成的生物节律为临床制订鼻咽癌时辰化疗方案提供必要的参数。方法:BALB/C裸小鼠15只,置于程控的独立光照系统中(12h光照,12h黑暗)中同步化至少3周。然后双侧腋下接种人鼻咽低分化鳞癌细胞裸小鼠移植瘤CNE2,... 详细信息

目的:探索鼻咽癌细胞DNA合成的生物节律为临床制订鼻咽癌时辰化疗方案提供必要的参数。方法:BALB/C裸小鼠15只,置于程控的独立光照系统中(12h光照,12h黑暗)中同步化至少3周。然后双侧腋下接种人鼻咽低分化鳞癌细胞裸小鼠移植瘤CNE2,成瘤后按灯亮后3、9、15、21h(即3、9、15、21HALO)的时间点取瘤块,制成单个细胞悬液固定,染色后流式细胞仪测DNA含量。用SPSS软件系统ANOVA法检验各期细胞在4个时间点差异的显著性,用Cosinor法考察G1、S、G2/m期细胞在24h的分布是否符合余弦函数。结果:G1、S、G2/m期细胞在3、9、15、21HALO的分布随时间变化有显著性差异,G1、G2/m期细胞变化符合余弦节律。结论:移植于裸鼠的人鼻咽癌细胞的DNA合成随昼夜交替呈节律性变化。

关键词：鼻咽肿瘤 DNA合成生物节律

C-Reactive Protein as a Triage Test in Guiding Who Should Get a Confirmatory Test for Pulmonary Tuberculosis Diagnosis among Adults: A Case-Control Proof-of-Concept Study from Urban Tanzania

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Journal of Tuberculosis Research 2022年第1期10卷 28-44页

作者： Evarist Chiweka Thomas maroa Hosiana Temba Joseph Ponera Sharifa Athumani Lujeko Kamwela mohamed Sasamalo Rastard Naftari mirambi Tito francis mhimbira Jerry Hella Ifakara Health Institute Dar es Salaam Tanzania Nelson mandela African Institution of Science and Technology Arusha Tanzania

Background: The current screening tools for tuberculosis (TB) are inadequate resulting in insufficient TB case detection and continued community transmission of TB. As the world is geared into finding missing TB cases, new strategies are called for to aid in rapid identification of TB cases. This study aimed to evaluate the role C-reactive protein (CRP) in triaging patients to get a definitive test for active pulmonary TB diagnosis in urban Tanzania. methods: A case-control study was conducted among pulmonary TB (PTB) patients and contacts without active PTB. The diagnosis of PTB was performed using GeneXpert mTB/RIF assay and culture. Blood was collected from cases and controls for measuring CRP levels during recruitment. We compared socio-demographic characteristics, clinical and laboratory parameters obtained during recruitment and performed diagnostic accuracy analyses for CRP. Results: Out of all 193 study participants who were involved in final analysis, 147 (76.2%) were males. Pulmonary TB cases had significantly lower median BmI than controls (median 17.4 kg/m2 [IQR: 15.8 - 19.2 kg/m2] vs., 24.9 kg/m2 [IQR: 22.1 - 28.5 kg/m2), p median 67.8 mg/L, [IQR: 36.5 - 116.9 mg/L] vs., 1.55 mg/L, [IQR: 0.59 - 6.0 mg/L], p = 0.003). Furthermore, CRP at cut-off ≥10 mg/L was associated with best combination of sensitivity, specificity and area under the curve of 89.9%, 95% CI: 82.2 - 95.0, 80.9%, CI: 71.4 - 88.2 and 0.85, 95% CI: 0.80 - 0.90 respectively. A multivariate logistic regression model adjusted for fever, night sweats and body mass index showed that CRP above 10 mg/L was significantly associated with PTB, aOR 5.2, 95% CI 1.2 - 22.8. Conclusions: CRP at cut-off ≥10 mg/L can be used to screen pulmonary TB. These findings can be used

关键词： C-Reactive Protein Pulmonary Tuberculosis Screening Temeke Tanzania

CT偶发肾上腺肿块的管理--美国放射学院(ACR)偶发病变委员会白皮书

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放射学实践 2018年第2期33卷 134-140页

作者： William W.mayo-Smith Julie H.Song Giles L.Boland Isaac R.francis Gary m.Israel Peter J.mazzaglia Lincoln L.Berland Pari V.Pandharipande 张惠茅胡道予江新青刘爱连伍兵不详吉林大学第一医院放射科长春华中科技大学同济医学院附属同济医院放射科武汉华南理工大学附属广州市第一人民医院放射科广州大连医科大学附属第一医院放射科大连四川大学华西医院放射科成都

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)针对CT和mRI上偶然发现的肾上腺肿块,提出了新的管理建议。该建议是对美国放射学院杂志(JACR)2010版肾上腺、肾脏、肝脏及胰腺偶发... 详细信息

美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)针对CT和mRI上偶然发现的肾上腺肿块,提出了新的管理建议。该建议是对美国放射学院杂志(JACR)2010版肾上腺、肾脏、肝脏及胰腺偶发病变管理白皮书中肾上腺部分的更新。由腹部放射科医师和1位内分泌外科医生组成的肾上腺亚组委员会制定了该方案。该方案结合已发表的文献和专家意见,经过反复推敲最终达成共识。该方案依据患者的特征和图像的特点对偶然发现的肾上腺肿块进行分类。对于每种特定的组合,总结良性或惰性的特征(足以终止随访),并提出后续管理建议。该方案涵盖了很多、但并非适用于所有的病理及临床情况,旨在通过提供肾上腺偶发肿块的管理意见以提升医疗质量。

关键词：肾上腺结节偶发病变偶发瘤