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Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate,BMS-753493,in CD2F1 mice after systemic administration

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Acta Pharmaceutica Sinica B 2016年第5期6卷 460-467页

作者： Hong Shen Lifei Wang Weiqi Chen Krista Menard yang Hong yuan Tian Samuel J.Bonacorsi W.Griffith Humphreys francis y.lee Jinping Gan Pharmaceutical Candidate Optimization Bristol-Myers Squibb Research & Development Discovery Oncology Bristol-Myers Squibb Research & Development Chemistry Bristol-Myers Squibb Research & Development

To assess targeting of an epothilone folate conjugate(BMS-753493) to the folate receptor(FR)-overexpressed tumor in mice bearing both FRt and FR– tumors,a series of experiments were conducted by quantitative whole-body autoradiography(QWBA) and LC–MS/MS following *** of BMS-753493 or its active moiety,BMS-748285 in mice bearing FRt(98M109) and FR–(M109) *** showed [3H]BMS-753493–derived radioactivity was extensively distributed to various *** FR over-expressing 98M109 tumors showed consistently higher level of radioactivity than FR-negative tumors(i.e.,M109 tumors) up to 48 h post dose of [3H]BMS-753493,despite the magnitude of difference between the tumors is relatively small(generally 3 5-fold).The radioactivity level in 98M109 tumors was 2 12-fold of normal tissues except intestine/content at 48 h post *** selective radioactivity uptake into 98M109 tumors over M109 or normal tissues was observed after *** of the active epothilone,[3H]***–MS/MS measurements demonstrated that the concentrations of BMS-748285,presumably from hydrolysis of the folate conjugate,in 98M109 tumors were greater than those in M109 tumors after *** of BMS-753493(2–3-fold) whereas no differential uptake in the tumors following BMS-748285 *** data were consistent with radioactivity *** results demonstrated that the folate conjugation in BMS-753493 enabled moderately preferential distribution of the active epothilone to FR overexpressing 98M109 tumors,thereby supporting targeted delivery of cytotoxics through the folate receptor.

关键词： Folate receptor Tumor selective targeting Folate receptor–expressing tumor Epothilone folate conjugate Tissue distribution Tumor uptake

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Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERKl/2 aggravates cancer-induced bone destruction

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Bone Research 2021年第4期9卷 557-570页

作者： Jungho Back Minh Nam Nguyen Lu Li Saelim lee Inkyu lee Fancheng Chen Lauren Gillinov yeon-Ho Chung Kareme D.Alder Hyuk-Kwon Kwon Kristin E.yu Christopher M.Dussik Ziehen Hao Michael J.Flores yoseph Kim Izuchukwu K.Ibe Alana M.Munger Sung Wook Seo francis y.lee Department of Orthopaedics&Rehabilitation Yale UniversitySchool of MedicineNew HavenCTUSA Research Center for Genetics and Reproductive Health School of MedicineVietnam National University Ho Chi Minh CityLinh Trung WardThu Due DistrictHo Chi Minh CityVietnam Department of Rehabilitation Medicine Renji HospitalSchool of MedicineShanghai JiaoTong UniversityShanghaiChina College of Medicine Dankook UniversityCheonanRepublic of Korea Department of Life Science Chung-Ang UniversitySeoulRepublic of Korea Shanghai Medical College Fudan UniversityShanghai CityChina Department of Emergency&Trauma Changhai HospitalNavy Medical UniversityShanghaiChina Biomedical Engineering Johns Hopkins UniversityBaltimoreMDUSA Department of Orthopedic Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulGangnam-guRepublic of Korea

Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation,thereby predisposing patients to pathological fracture and cancer *** of osteoblast function induces skeletal diseases due to the disruption of bone *** observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer *** confirmed that osteolytic breast cancers with high expression of pERK1/2 disrupt bone homeostasis via osteoblastic ERK1/2 activation at the bone-breast cancer *** process of inflammatory osteolysis modulates ERK1/2 activation in osteoblasts and breast cancer cells through dominant-negative MEK1 expression and constitutively active MEK1 expression to promote cancer growth within ***,an FDA-approved MEK inhibitor,not only reduced breast cancer-induced bone destruction but also dramatically reduced cancer growth in bone by inhibiting the inflammatory skeletal *** together,these findings suggest that ERK1/2 activation in both breast cancer cells and osteoblasts is required for osteolytic breast cancer-induced inflammatory osteolysis and that ERK1/2 pathway inhibitors may represent a promising adjuvant therapy for patients with aggressive osteolytic breast cancers by altering the shared cancer and bone microenvironment.

关键词： pERK1/2 breast homeostasis

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Hole-Selective Contact with Molecularly Tailorable Reactivity for Passivating High-Performing Inverted Perovskite Solar Cells

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CCS Chemistry 2024年第7期6卷 1654-1661页

作者： Wenlin Jiang yingie Hu Fengzhu Li francis R.Lin Alex K-y.Jen Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong China 999077 Department of Chemistry City University of Hong KongKowloonHong Kong China 999077 Hong Kong Institute for Clean Energy City University of Hong KongKowloonHong Kong China 999077 State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong China 999077

The precisely customizable attributes of self-assembled monolayers(SAMs)molecules at the atomic level hold the potential to facilitate efficient hole selection and interface passivation ***,the correlation between the exposure of passivating groups on the surface and device performance remains ***,we introduce two newly designed SAM molecules,Cbz2S and Cbz2SMe,incorporating cyclic disulfide or two flanking thiomethyls by modifying the 4,5-position of carbazole to adjust the Lewis basicity of the SAM-modified *** possessing suitable energetic alignment,Cbz2S with more-exposed sulfur atoms exhibited inferior device performance due to excessive reactivity,leading to an overpopulation of PbI2 crystallites at the buried perovskite *** contrast,the screening effect from the methyl groups of Cbz2SMe optimized SAM reactivity,exquisitely integrating buried interface passivation and hole selection ***,the champion inverted perovskite solar cell(PSC)employing Cbz2SMe achieved an impressive power conversion efficiency of 24.42%,accompanied by prolonged *** work demonstrates the feasibility of incorporating Lewis-basic passivation groups into SAM molecules and elucidates the relationship between the reactivity of SAM passivation groups and device *** findings provide valuable insights for the design of novel multifunctional SAM molecules,further advancing the performance of PSCs.

关键词： self-assembled monolayer perovskite solar cell hole-selective layer carbazole derivatives defect passivation

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DNA Barcoding of Insects and Its Direct Application for Plant Protection

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Open Journal of Applied Sciences 2024年第3期14卷 676-686页

作者： Peter Quandahor Iddrisu yahaya francis Kusi Issah Sugri Julius yirzagla Abdul Karim Alhassan Jerry A. Nboyine George y. Mahama Godwin Opoku Mohammed Mujitaba Dawuda Asieku yahaya Theophilus Kwabla Tengey Rofela Combey John Abraham CSIR-Savanna Agricultural Research Institute Tamale Ghana Faculty of Agriculture Food and Consumer Science University for Development Studies Tamale Ghan Department of Conservational Biology and Entomology School of Biological Sciences University of Cape Coast Ghana

The introduction of invasive insect pests across national borders has become a major concern in crop production. Accordingly, national plant protection organizations are challenge to reinforce their monitoring strategies, which are hampered by the weight and size of inspection equipment, as well as the taxonomic extensiveness of interrupted species. Moreover, some insect pests that impede farmer productivity and profitability are difficult for researchers to address on time due to a lack of appropriate plant protection measures. Farmers’ reliance on synthetic pesticides and biocontrol agents has resulted in major economic and environmental ramifications. DNA barcoding is a novel technology that has the potential to improve Integrated Pest Management decision-making, which is dependent on the ability to correctly identify pest and beneficial organisms. This is due to some natural traits such as phenology or pesticide susceptibility browbeaten by IPM strategies to avert pest establishment. Specifically, Deoxyribonucleic acid (DNA) sequence information was applied effectively for the identification of some micro-organisms. This technology, DNA barcoding, allows for the identification of insect species by using short, standardized gene sequences. DNA barcoding is basically based on repeatable and accessible technique that allows for the mechanisation or automation of species discrimination. This technique bridges the taxonomic bio-security gap and meets the International Plant Protection Convention diagnostic standards for insect identification. This review therefore discusses DNA barcoding as a technique for insect pests’ identification and its potential application for crop protection.

关键词： DNA Barcoding Integrated Pest Management Taxonomy Biosecurity Crop Protection

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用于PJMIF的超快气阀性能表征

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应用物理 2024年第6期14卷 508-521页

作者：景原通刘延斌 y. C. francis Thio 张德雨袁东方张晓兵上海科技大学终极能源中心上海

上海科技大学正在研发第三代用于PJMIF的同轴等离子体枪STG1以及配套超快气阀。STG1的超快气阀需要在百微秒(~100 μs)的开关时间内注入0~30 mg的均匀气体。超快气阀利用j × B电磁力驱动金属飞盘控制气路开关,检测气阀结构中金属飞盘... 详细信息

上海科技大学正在研发第三代用于PJMIF的同轴等离子体枪STG1以及配套超快气阀。STG1的超快气阀需要在百微秒(~100 μs)的开关时间内注入0~30 mg的均匀气体。超快气阀利用j × B电磁力驱动金属飞盘控制气路开关,检测气阀结构中金属飞盘弹射时的运动轨迹可以直接体现气阀的稳定性和开关性能。针对两种结构的超快气阀搭建实验平台,采用激光三角测距法对气阀的金属飞盘的位移进行检测,获得金属飞盘在两种结构下的位移曲线,以及新型结构的气阀在不同电压下的开关时间,并通过有限元分析法对飞盘弹射过程中的振动现象进行验证。研究结果表明,金属飞盘在弹射过程中会产生中心振动,新型弹簧和短翼无孔飞盘组合下的新型结构相比于传统结构具有更高的重复性,可以通过改变电压的方式可以有效的将气阀的开关时间控制在0~300 μs。

关键词： PJMIF 超快气阀三角激光测距法飞盘

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Lower Extremity Arterial Disease in Patients with Type 2 Diabetes: Prevalence and Associated Factors at the Libreville University Hospital Center

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World Journal of Cardiovascular Diseases 2024年第5期14卷 295-308页

作者： Allognon Mahutondji Christian Ayo Bivigou Elsa Ntoutoume Mvé Dylan Anthony N’nang Jean-Fidel Kinga Armel Mpori Jamila Myrtille Akagah Kondé Christelle Ndoume Obiang francis yékini Carole Fadylath Ndjibah Alakoua Cajole Ludvine Babongui Boussougou Latifah Mipinda Jean-Bruno Moubamba Franck Ecke Nzengue Jean-Emmanuel Houenassi Dèdonougbo Martin Boguikouma Jean-Bruno Department of Medicine and Medical Specialties Health Sciences University (USS) Libreville Gabon Cardiology Service Libreville University Hospital Center (CHUL) Libreville Gabon Department of Physiology Health Sciences University Libreville Gabon Amissa Bongo Regional Hospital Franceville Gabon Mother-Child Hospital Center Jeanne Ebori Foundation Libreville Gabon Medicine Service Owendo University Hospital Center Owendo Gabon

Introduction: Lower extremity arterial disease in diabetic patients has distinct characteristics. Objectives: To study the hospital frequency of lower extremity arterial disease and identify associated factors in diabetic patients at the Libreville University Hospital Center (CHUL). Materials and Methods: This was a cross-sectional study conducted from July 1, 2023, to January 31, 2024, in the endocrinology department of the CHUL. All patients with type 2 diabetes over the age of 18 admitted to this department, regardless of the reason for hospitalization, who provided informed consent, were included. Socio-demographic data and cardiovascular risk factors were recorded. Personal and family cardiovascular history and functional symptoms were investigated. The physical examination included measuring blood pressure, heart rate, and the ankle-brachial index in all patients. Results: A total of 219 patients were included, of whom 75 had lower extremity arterial disease, representing a prevalence of 34.24%. It was compensated in 28 cases (37.33%) and decompensated in 39 patients (52%). In eight cases (10.67%), there was critical chronic ischemia. Cardiovascular risk factors associated with diabetes were physical inactivity (89.5%), hypertension (55.25%), overweight (49.77%), obesity (22.84%), and smoking (10.04%). In multivariate analysis, only hypertension (OR = 2.09;95% CI: 1.05 - 4.17;p = 0.035) and LDL cholesterol (OR = 2.75;95% CI: 1.10 - 6.85;p = 0.03) were significantly associated with lower extremity arterial disease in diabetics at the University Hospital of Libreville. Conclusion: Lower extremity arterial disease is common in diabetic patients at the University Hospital of Libreville. It is often asymptomatic, thus requiring systematic screening.[-rId11-]

关键词： Lower Extremity Arterial Disease Diabetes Hypertension Ankle-Brachial Index Gabon

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Selenium-fused y6 derivatives and their derived polymerized small molecule acceptors for efficient organic solar cells

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Science China Chemistry 2023年第3期66卷 615-619页

作者： Qunping Fan francis RLin Wei Ma Alex K.-y.Jen State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Department of Chemistry City University of Hong KongKowloon 999077Hong KongChina Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina Hong Kong Institute for Clean Energy City University of Hong KongKowloon 999077Hong KongChina Department of Materials Science and Engineering University of WashingtonSeattleWashington 98195-2120USA

Before 2015,only few organic solar cells(OSCs)obtained power conversion efficiencies(PCEs)over 10%because the commonly used fullerene derivatives as acceptors have narrow absorption,low extinction coefficient,and are difficult to adjust energy *** overcome these shortcomings,in 2015,Zhan et al.[1]developed acceptor(A)-donor(D)-A-type fused-ring small-molecule acceptors(SMAs)with good planarity and strong intramolecular charge transfer(ICT)effect to fulfill both broad absorption and high extinction coefficient,offering the revolutionary PCEs of 13%–15%.In 2019,another milestone SMA(y6)with A-DA′D-A structure was developed by Zou et al.

关键词： fused extinction absorption

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Sequence assembly using next generation sequencing data —challenges and solutions

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Science China(Life Sciences) 2014年第11期57卷 1140-1148页

作者： CHIN francis y.L. LEUNG Henry C.M. yIU S.M. Department of Computer Science The University of Hong Kong

Sequence assembling is an important step for bioinformatics *** the help of next generation sequencing(NGS)technology,high throughput DNA fragment(reads)can be randomly sampled from DNA or RNA molecular ***,as the positions of reads being sampled are unknown,assembling process is required for combining overlapped reads to reconstruct the original DNA or RNA *** with traditional Sanger sequencing methods,although the throughput of NGS reads increases,the read length is shorter and the error rate is *** introduces several problems in ***,paired-end reads instead of single-end reads can be sampled which contain more *** existing assemblers cannot fully utilize this information and fails to assemble longer *** this article,we will revisit the major problems of assembling NGS reads on genomic,transcriptomic,metagenomic and metatranscriptomic *** will also describe our IDBA package for solving these *** package has adopted several novel ideas in assembling,including using multiple k,local assembling and progressive depth *** with existence assemblers,IDBA has better performance on many simulated and real sequencing datasets.

关键词： genomic assembling de Bruijn graph paired-end reads next generation sequencing

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Bacteria may contribute to distant species recognition in ant-aphid mutualistic relationships

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Insect Science 2017年第2期24卷 278-284页

作者： Christophe y. Fischer Claire Detrain Philippe Thonart Eric Haubruge Frederic francis Francois J. Verheggen Georges C. Lognay Laboratory of Analytical Chemistry University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Unit of Social Ecology Universite Libre de Bruxelles CP231 50 avenue F. Roosevelt B-1050 Brussels Walloon Center of Industrial Biology University of Liege B40 Sart-Tilman 4000 Liege 4Functional and Evolutionary Entomology University of Liege Gembloux Agro-Bio Tech Passage des Deportes 2 5030 Gembloux Belgium

Mutualistic interactions between ant and aphid species have been the subject of considerable historical and contemporary investigations, the primary benefits being clean- ing and protection for the aphids and carbohydrate-rich honeydew for the ants. Questions remained, however, as to the volatile semiochemical factor influencing this relationship. A recent study highlighted the role of bacterial honeydew volatile compounds in ant at- traction. Here, ant＇s ability to distantly discriminate 2 aphid species was investigated based on bacterial honeydew semiochemicals emissions using a two-way olfactometer. Both the mutualistic aphid Aphis fabae L. and the nonmyrmecophilous aphid Acyrthosiphon pisum Harris were found to be attractive for the ant Lasius niger L. The level of attraction was similar in both assays （control vs. one of the aphid species）. However, when given a choice between these 2 aphid species, ants showed a significant preference for Aphis fabae. Honeydew volatiles, mostly from bacterial origins, are known to be a key element in ant attraction. Using the same olfactometry protocol, the relative attractiveness of volatiles emitted by honeydews collected from each aphid species and by bacteria isolated from each honeydew was investigated. Again, ants significantly preferred volatiles released by Aphis fabae honeydew and bacteria. This information suggests that microbial honeydew volatiles enable ants to distantly discriminate aphid species. These results strengthen the interest of studying the occurrence and potential impact of microorganisms in insect symbioses.

关键词： ant aphid bacteria honeydew mutualism recognition VOC

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Broadband photomultiplication-type polymer photodetectors and its application in light-controlled circuit

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Science China Chemistry 2022年第8期65卷 1642-1649页

作者： Ming Liu Qunping Fan Kaixuan yang Zijin Zhao Xingchao Zhao Zhengji Zhou Jian Zhang francis Lin Alex K.-y.Jen Fujun Zhang Key Laboratory of Luminescence and Optical Information Ministry of EducationBeijing Jiaotong UniversityBeijing 100044China Department of Chemistry City University of Hong KongHong Kong 999077China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China Key Lab for Special Functional Materials Ministry of EducationNational and Local Joint Engineering Research Center for High-Efficiency Display and Lighting Technologyand School of MaterialsHenan UniversityKaifeng 475004China Guangxi Key Laboratory of Information Materials School of Material Science and TechnologyGuilin University of Electronic TechnologyGuilin 541004China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering University of WashingtonWashington 98195-2120United States Hong Kong Institute for Clean Energy City University of Hong KongHong Kong 999077China

Photomultiplication-type polymer photodetectors(PM-PPDs)were achieved with polymer P3HT as donor and Py3Se-1V as acceptor based on structure of ITO/PEDOT:PSS/active layer/*** optimal weight ratio of P3HT to Py3Se-1V is about 100:*** of isolated electron traps are formed with Py3Se-1V surrounded by P3HT due to rather less content of Py3Se-1V in active layers and about 0.94 e V energy offset between the lowest unoccupied molecular orbitals(LUMO)of P3HT and *** optimal PM-PPDs exhibit broad spectral response from 350 to 950 nm and external quantum efficiency(EQE)values of68,200%at 360 nm,26,400%at 630 nm and 19,500%at 850 nm under-15 V *** working mechanism of PM-PPDs is attributed to the interfacial trap-assisted hole tunneling injection from external *** performance of PM-PPDs can be further improved by incorporating appropriate PMBBDT with high hole mobility as the third *** EQE values of optimal ternary PM-PPDs are increased to 105,000%at 360 nm,40,000%at 630 nm and 31,800%at 850 nm under-15 V bias,benefiting from the enhanced hole transport in ternary active *** optimal ternary PM-PPDs were successfully applied in a light-controlled circuit to turn on or turn off light emitting diode(LED).

关键词： polymer photodetectors photomultiplication external quantum efficiency broadband

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