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Intrahepatic flow diversion prior to segmental Yttrium-90 radioembolization for challenging tumor vasculature

Journal of Interventional Medicine 2022年第2期5卷 79-83页

作者： Lindsay B.Young Marcin Kolber Michael J.King Mona Ranade Vivian L.Bishay Rahul s.Patel francis s.nowakowski Aaron M.Fischman Robert A.Lookstein Edward Kim Icahn school of Medicine at Mount sinai Deparmnent of Dignostc Molecular and lterventionl RadiologyOne Gustave L.Levry Place Box 1234NY100296574New YorkUSA University of Teras southwestem Medical Center Division of Vascular and Inerentional Radiology5323 Hary Hines BhvdTx753909316DallasUSA David Geffen school of Medicine at the Univerity of Calfornia-Los Angeles Deparment of Itrentionol Radiology27235 Toumey RoadSuite 1500Califormia91355ValenciaUSA

Background: Hepatic tumors with complex vascular supply or poor relative perfusion are prone to decreased rates of objective response. This is compounded in the setting of Yttrium-90(Y90) transarterial radioembolization(TARE), which is minimally embolic and flow-dependent, relying on high threshold dose for complete ***: We describe our experience with intrahepatic flow diversion(FD) prior to TARE of hepatocellular carcinoma(HCC) with challenging vascular *** and methods: Between April 2014 and January 2020, 886 cases of coinciding MAA or TARE and bland embolization or temporary occlusion were *** embolizations performed for more routine purposes were excluded. FD was performed by bland embolization or temporary occlusion of vessels supplying non-malignant parenchyma in cases where flow was not preferential to target tumor. Lesion characteristics, vascular supply, treatment approach, angiography, and adverse events(AEs) were reviewed. Radiographic response was assessed using mRECIsT ***: 22 cases of FD of focal HCC were identified. Embolics included calibrated microspheres(n = 11), microcoils(n = 4), gelfoam(n = 3), temporary balloon occlusion(n = 2) and temporary deployment of a microvascular plug(n = 1). Post-treatment sPECT-CT dosimetry coverage was concordant with target lesions in all cases. Mean follow-up was 16.7 months(1.4–45 mos). Tumor-specific response per m RECIsT was 41% complete response, 50% objective response, and 59% disease control rate. No major adverse events or grade 3/4 hepatotoxicity were ***: Our findings suggest that FD prior to TARE is safe and potentially effective in treating HCC with complex vascular supply or poor tumor perfusion.

关键词： embolization routine balloon

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Uncertainty, certainty, and relativity(Invited Paper)

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Chinese Optics Letters 2016年第1期14卷 2-6页

作者： francis T.s.Yu Department of Electrical Engineering Penn State University

One of the most fascinating principles in quantum mechanics must be Heisenberg＇s uncertainty principle, which can be briefly stated as follows： every physicM observation cannot be precisely determined without some degree of error or uncertainty. And it is by no means can one use the principle within the limit of certainty region, as will be shown in this Letter. Two of the most important pillars in modern physics must be Einstein＇s relativity theory and schrsdinger＇s contribution to quantum mechanics. Yet, there is a profound connection between these discoveries by means of the uncertainty relationship, in which we shown that the observation of a high-speed object is conceivable if the speed of the observer keeps up with object＇s speed.

关键词： and relativity certainty Uncertainty

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Complex role for the immune system in initiation and progression of pancreatic cancer

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World Journal of Gastroenterology 2014年第32期20卷 11160-11181页

作者： Kristin s Inman Amanda A francis Nicole R Murray Department of Cancer Biology Mayo Clinic Jacksonville FL 32224United States

The immune system plays a complex role in the development and progression of pancreatic cancer. Inflammation can promote the formation of premalignant lesions and accelerate pancreatic cancer development. Conversely, pancreatic cancer is characterized by an immunosuppressive environment, which is thought to promote tumor progression and invasion. Here we review the current literature describing the role of the immune response in the progressive development of pancreatic cancer, with a focus on the mechanisms that drive recruitment and activation of immune cells at the tumor site, and our current understanding of the function of the immune cell types at the tumor. Recent clinical and preclinical data are reviewed, detailing the involvement of the immune response in pancreatitis and pancreatic cancer, including the role of specific cytokines and implications for disease outcome. Acute pancreatitis is characterized by a predominantly innate immune response, while chronic pancreatitis elicits an immune response that involves both innate and adaptive immune cells, and often results in profound sys-temic immune-suppression. Pancreatic adenocarcinoma is characterized by marked immune dysfunction driven by immunosuppressive cell types, tumor-promoting immune cells, and defective or absent inflammatory cells. Recent studies reveal that immune cells interact with cancer stem cells and tumor stromal cells, and these interactions have an impact on development and progression of pancreatic ductal adenocarcinoma(PDAC). Finally, current PDAC therapies are reviewed and the potential for harnessing the actions of the immune response to assist in targeting pancreatic cancer using immunotherapy is discussed.

关键词： Immune system Pancreatitis Pancreatic ductal adenocarcinoma Immunosuppression Immunotherapy Inflammation

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Anomalies in(semi)-leptonic B decays B~±→τ~±ν,B~±→Dτ~±ν and B~±→D~*τ~±ν,and possible resolution with sterile neutrino

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Chinese Physics C 2017年第11期41卷 14-27页

作者： Gorazd Cveti francis Halzen C.s.Kim sechul Oh Department of Physics Universidad Tcnica Federico Santa María Wisconsin Ice Cube Particle Astrophysics Center and Department of Physics University of Wisconsin Department of Physics and IPAP Yonsei University University College Yonsei University

The universality of the weak interactions can be tested in semileptonic b→c transitions,and in particular in the ratios R（D＊） ≡ Γ（B → D（＊）τν）/Γ（B → D＊lν）（where 1 = μ or e）.Due to the recent differences between the experimental measurements of these observables by Ba Bar,Belle and LHCb on the one hand and the standard Model predicted values on the other hand,we study the predicted ratios R（D＊）=Γ（B→D＊τ＋＂missing＂）/Γ（B→D（＊）lν）in scenarios with an additional sterile heavy neutrino of mass ～1 Ge ***,we evaluate the newly defined ratio R（0）≡Γ（B→τ＋＂missing＂）/Γ（B→μν） in such scenarios,in view of the future possibilities of measuring the quantity at Belle-Ⅱ.

关键词： sterile neutrino lepton universality semileptonic B decays

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Determination of contact parameters for discrete element method simulations of granular systems

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Particuology 2008年第6期6卷 521-528页

作者： Kevin francis Malone Institute of Particle science and Engineering University of Leeds

Both linear-spring-dashpot （LsD） and non-linear Hertzian-spring-dashpot （HsD） contact models are commonly used for the calculation of contact forces in Discrete Element Method （DEM） simulations of granular systems. Despite the popularity of these models, determination of suitable values for the contact parameters of the simulated particles such as stiffness, damping coefficient, coefficient of restitution, and simulation time step, is not altogether obvious. In this work the relationships between these contact parameters for a model system where a particle impacts on a flat base are examined. Recommendations are made concerning the determination of these contact parameters for use in DEM simulations.

关键词： Discrete Element Method (DEM) Linear-spring--dashpot model Non-linear Hertzian-spring-dashpot model Contact parameters

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Neutrino astronomy： An update

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Frontiers of physics 2013年第6期8卷 759-770页

作者： francis Halzen Wisconsin IceCube Particle Astrophysics Center (WIPAC) and Department of Physics University of Wisconsin Madison WI 53706 USA

Detecting neutrinos associated with the still enigmatic sources of cosmic rays has reached a new watershed with the completion of IceCube, the first detector with sensitivity to the anticipated fluxes. In this review, we will briefly revisit the rationale for constructing kilometer-scale neutrino detectors and summarize the status of the field.

关键词： neutrinos cosmic rays astrophysics

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No country is an island in regulating food safety:How the WTO monitors Chinese food safety laws through the Trade Policy Review Mechanism(TPRM)

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Journal of Integrative Agriculture 2015年第11期14卷 2142-2156页

作者： francis snyder Northwest A&F University school of Transnational Law Peking University Shenzhen Graduate School College of Europe

Established within the framework of the World Trade Organization （WTO）, the Trade Policy Review Mechanism （TPRM） reviews periodically the trade policies of all WTO Members. The review includes many aspects of food safety regulation. China＇s trade policy is reviewed every two years. This paper analyses in detail the reviews of China＇s trade policy in 2006, 2008, 2010, 2012 and 2014. It focuses in particular on food safety laws and types of standards, alignment of domestic standards with international standards, the role of different domestic institutions, transparency and notification of food safety measures under the WTO agreements on sanitary and Phytosanitary Measures （sPs） and on Technical Barriers to Trade （TBTAgreement）, import and export, and geographical indications （GIs）. It concludes that the WTO TPRM can contribute, within its mandate, to reform of Chinese food safety laws and improvement of food safety in China. it notes that China has already undertaken substantial reforms of its system for regulating food safety. It recommends that China should continue to participate actively in the TPRM, follow its own path with regard to alignment and learn selectively from other WTO Members.

关键词： food safety food standards public health consumer welfare China Chinese food safety laws World Trade Organization WTO law Trade Policy Review Mechanism (TPRM) sPs Agreement TBT Agreement

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Evaluation of High-Resolution WRF Model simulations of surface Wind over the West Coast of India

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Atmospheric and Oceanic science Letters 2014年第5期7卷 458-463页

作者： s. VIsHNU P. A. francis Indian National Centre for Ocean Information services Ministry of Earth Sciences Hyderabad-500090 India

This paper presents results from a statistical validation of the hindcasts of surface wind by a high-reso-ution-mesoscale atmospheric numerical model Advanced Research WRF （ARW3.3）, which is set up to force the operational coastal ocean forecast system at Indian Na- tional Centre for Ocean Information services （INCOIs）. Evaluation is carried out based on comparisons of day-3 forecasts of surface wind with in situ and remote-sensing data. The results show that the model predicts the surface wind fields fairly accurately over the west coast of India, with high skill in predicting the surface wind during the pre-monsoon season. The model predicts the diurnal variability of the surface wind with reasonable accuracy. The model simulates the land-sea breeze cycle in the coastal region realistically, which is very clearly observed during the northeast monsoon and pre-monsoon season and is less prominent during the southwest monsoon season.

关键词： WRF Arabian sea surface wind field valida- tion land-sea breeze

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Topological studies of Three-dimensional Flows in a High Pressure Compressor stator Blade Row without and with Boundary Layer Aspiration

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Chinese Journal of Aeronautics 2011年第5期24卷 541-549页

作者： Ankit sACHDEVA francis LEBOEUF Laboratoire de Mécanique des Fluides et d'Acoustique Ecole Centrale de Lyon

This paper presents a numerical study of the flow topologies of three-dimensional （3D） flows in a high pressure compressor stator blade row without and with boundary layer aspiration on the hub wall. The stator blade is representative of the first stage operating under transonic inlet conditions and the blade design encourages development of highly complex 3D flows. The blade has a small tip clearance. The computational fluid dynamics （CFD） studies show progressive increase of hub corner stall with the increase in incidence. Aspiration is implemented on the hub wall via a slot in the comer between the hub wall and the suction surface. The CFD studies show aspiration to be sensitive to the suction flow rate; lower rate leads to very complex flow struc- tures and increased level of losses whereas higher rate renders aspiration effective for control of hub comer separation. The flow topologies are studied by trace of skin friction lines on the walls. The nature of flow can be explained by the topological rules of closed separation. Furthermore, a deeper analysis is done for a particular case with advanced criterion to test the non-degeneracy of critical points in the flow field.

关键词： high pressure compressor flow topologies three-dimensional flows boundary layer aspiration tip clearance

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Implementing the Node Based smoothed Finite Element Method as User Element in Abaqus for Linear and Nonlinear Elasticity

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Computers, Materials & Continua 2019年第8期61卷 481-502页

作者： s.Kshrisagar A.francis J.J.Yee s.Natarajan C.K.Lee Integrated Modelling and simulation Lab Department of Mechanical EngineeringIndian Institute of Technology MadrasChennai600036India The Department of Architectural Engineering Dong-A UniversityS04-0302Engineering 237Nakdongdaero 550beon-gilSaha-guBusan49315Korea National Research Center for Disaster-free&safe Ocean City Dong-A UniversityS04-0311-3Engineering 237Nakdong-daero 550beon-gilSaha-guBusan49315Korea

In this paper,the node based smoothed-strain Abaqus user element(UEL)in the framework of finite element method is *** basic idea behind of the node based smoothed finite element(NsFEM)is that finite element cells are divided into subcells and subcells construct the smoothing domain associated with each node of a finite element cell[Liu,Dai and Nguyen-Thoi(2007)].Therefore,the numerical integration is globally performed over smoothing *** is demonstrated that the proposed UEL retains all the advantages of the NsFEM,i.e.,upper bound solution,overly soft stiffness and free from locking in compressible and nearly-incompressible *** this work,the constant strain triangular(CsT)elements are used to construct node based smoothing domains,since any complex two dimensional domains can be discretized using CsT *** additional challenge is successfully addressed in this *** efficacy and robustness of the proposed work is obtained by several benchmark problems in both linear and nonlinear *** developed UEL and the associated files can be downloaded from https://***/nsundar/NsFEM.

关键词： smoothed finite element method(sFEM) node based sFEM(NsFEM) linear and nonlinear elasticity Abaqus UEL(user elements) compressible and nearlyincompressible materials

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