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e.hance. Me.ahe.ristics with Trust Aware.Route.Se.e.tion for Wire.e.s Se.sor Ne.works

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Compute. Syste.s Scie.ce.& e.gine.ring 2023年第8期46卷 1431-1445页

作者： A.francis Saviour De.araj T.Satyanarayana Murthy Fayadh Ale.e.i e.Laxmi Lydia Mohamad Adzhar Md Zawawi Mohamad Khairi Ishak De.artme.t of IT The University of Technology and Applied Sciences-IbriPO Box:466IbriPostal Code:516Sultanate of Oman Chaitanya Bharathi Institute.of Te.hnology HyderabadTelanganaIndia De.artme.t of e.e.trical e.gine.ring College of EngineeringJouf UniversitySaudi Arabia De.artme.t of Compute. Scie.ce.and e.gine.ring Vignan’s Institute of Information TechnologyVisakhapatnam530049India School of e.e.trical and e.e.tronic e.gine.ring Engineering CampusUniversiti Sains MalaysiaNibong Tebal14300PenangMalaysia

Re.e.tly,a trust syste. was introduce. to e.hance.se.urity and coope.ation be.we.n node. in wire.e.s se.sor ne.works(WSN).In routing,the.trust syste. include. or avoids node. re.ate. to the.e.timate. trust value. in the.routing *** article.introduce. e.hance. Me.ahe.ristics with Trust Aware.Se.ure.Route.Se.e.tion Protocol(e.TA-SRSP)for *** pre.e.te. e.TA-SRSP te.hnique.majorly involve. the.optimal se.e.tion of route. in *** accomplish this,the.e.TA-SRSP te.hnique.involve. the.de.ign of an oppositional Aquila optimization algorithm to choose.safe.route. for data *** the.cluste.ing proce.s,the.node. with maximum re.idual e.e.gy will be.conside.e. cluste. he.ds(CHs).In addition,the.OAOA te.hnique.ge.s e.e.ute. to choose.optimal route. base. on obje.tive.functions with multiple.parame.e.s such as e.e.gy,distance.and trust *** e.pe.ime.tal validation of the.e.TA-SRSP te.hnique.is te.te.,and the.re.ults e.hibite. a be.te. pe.formance.of the.e.TA-SRSP te.hnique.ove. othe. approache..

关键词： Se.urity wire.e.s se.sor ne.works trust factor routing protocol privacy

LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. Mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

phytoche.ical analysis and in vitro antioxidant acitivity of hydroalcoholic se.d e.tract of Nymphae. nouchali Burm.f.

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Asian Pacific Journal of Tropical Biome.icine 2013年第11期3卷 887-895页

作者： Mabe. Parimala francis Gricilda Shoba P.G.& Re.e.rch De.artme.t of Zoology Voorhees College

Obje.tive.To e.aluate.the.phytoche.ical constitue.ts and the.antioxidant activity of hydroalcoholic e.tract of Nymphae. nouchali se.d locally pre.cribe. as a die. for diabe.e. ***:The.antioxidant and fre. radical scave.ging activity of hydroalcoholic e.tract of the.plant was asse.se. against 1,1 diphe.yl-2-picryl hydrazyl(DPPH),nitric oxide.and lipid pe.oxidation using standard *** phe.olics,flavonoids and tannins we.e.also ***:Phytoche.ical analysis re.e.le. the.pre.e.ce.of phe.ols,flavone.,tannins,prote.n,re.ucing sugars,glycoside.,saponins,alkaloids and *** activitie. of plant e.tract against DPPH,nitric oxide.and lipid pe.oxidation was conce.tration de.e.de.t with IG_(50)value.of42.82,23.58 and 54.65μg/mL *** total antioxidant capacity was high with 577.73 mg vitamin e.g of the.e.tract and showe. a mode.ate.y high vitamin C conte.t of 197.22 mg/*** total tannin conte.t of hydroalcoholic se.d e.tract was high(195.84 Ge.g),followe. by phe.olics(179.56 Ge.g)and flavonoids(23.55 Qe.g).Conclusion:Our findings provide.e.ide.ce.that the.crude.e.tract of Nymphae. nouchali is a pote.tial source.of natural antioxidants and this justifie. its use.in folkloric me.icine.

关键词： Nymphae. ste.lata Phytoche.ical Antioxidant Scave.ging Fre. radicals DPPH Nitric oxide Lipid pe.oxidation Phe.ols Flavonoids

Farming Familie. and Climate.Change.Issue. in Nige. De.ta Re.ion of Nige.ia: e.te.t of Impact and Adaptation Strate.ie.

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Agricultural Scie.ce. 2014年第12期5卷 1140-1151页

作者： Michae. e. Ike.i francis M. Onu Flore.ce.O. Ife.nyie.e.Patrick S. Paradang Agricultural Unit Department of Vocational Teacher Education University of Nigeria Nsukka Nigeria De.artme.t of Agriculture.e.ucation Federal College of Education Pankshin Nigeria

The.study focuse. on the.impacts of climate.change.on the.farme. and the.farming familie. in Nige. De.ta Re.ion of Nige.ia. The.study spe.ifically e.aluate. the.pe.ce.ve. re.ultant situations attribute. to climate.change.to de.e.mine.the.e.te.t of impacts of climate.change.on the.farme. and the.farming familie. and also e.plore. adoptable.strate.ie. for coping with the.situations. The.study adopte. de.criptive.surve. re.e.rch de.ign. Two re.e.rch que.tions and two hypothe.e. guide. the.study. The.population for the.study was 246,909 re.ponde.ts made.up of farme.s and e.te.sion worke.s who are.re.iste.e. with the.State.Ministrie. of Agriculture. Out of the.nine.Nige. De.ta state., Baye.sa and De.ta state. we.e.randomly chose. for the.study. Proportionate.stratifie. random sampling te.hnique.was use. to se.e.t a sample.size.of 5,038 re.ponde.ts. Structure. que.tionnaire.and inte.vie. we.e.use. to colle.t data. The.instrume.ts we.e.validate. by thre. e.pe.ts. Cronbach Alpha me.hod was use. to de.e.mine.the.inte.nal consiste.cy of the.que.tionnaire.ite.s which yie.de. a coe.ficie.t of 0.81. The.Statistical Product and Se.vice.Solutions (SPSS v 20.0) was e.ploye. for data analysis. The.statistical tools use. for data analysis we.e.we.ghte. me.n to answe. re.e.rch que.tions and standard de.iation to validate.the.close.e.s of the.re.ponde.ts from the.me.n and from e.ch othe. in the.r re.ponse. while.t-te.t was use. to te.t the.null hypothe.e.. The.findings of the.study re.e.le. that the.e.te.t of impacts of climate.change.on farme.s and the.farming familie. in Nige. De.ta re.ion of Nige.ia are.mode.ate. Findings furthe. re.e.le. that climate.change.has le. to incre.se. pove.ty le.e. and raise. cost of production (input and labour cost) as indicate. by the.farme.s. The.study re.omme.ds that farme.s in the.re.ion should be.e.courage. by providing ince.tive. and subsidizing inputs for the. by Fe.e.al and State.gove.nme.ts as we.l as othe. non-gove.nme.tal organizations, as th

关键词： Climate Change Farming Familie. Impacts Flooding Se. Le.e. Rise Adaptation Te.pe.ature

De.th to the.appare.t re.ox pote.tial discontinuity(aRPD)as a parame.e. of inte.e.t in marine.be.thic habitat quality mode.s

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Inte.national Journal of Se.ime.t Re.e.rch 2018年第2期33卷 149-156页

作者： Travis G.Ge.wing Kie.an Cox Alyssa M.Alle. Ge.wing Charmaine.N.Carr-Harris Sarah e.Dudas francis Juane. e.osyste. Scie.ce.and Manage.e.t Program University of Northern British Columbia De.artme.t of Biology University of Victoria Ske.na Fishe.ie. Commission 4. De.artme.t of Biology Vancouver Island University

The.use.ulne.s of the.appare.t re.ox pote.tial discontinuity(aRPD) in asse.sme.ts of marine.be.thic habitat quality was e.plore. at two inte.tidal mudflats along the.north Pacific coast of Canada. Two transe.ts we.e.e.tablishe. at e.ch inte.tidal site. with thre. se.ime.t bioge.che.istry core. colle.te. from e.ch transe.t four time. ove. the.summe. of 2016. Me.sure.e.ts of the.se.ime.t pore.wate. dissolve. oxyge.(DO) conte.t and re.ox(e.) conditions we.e.take. at the.surface.of the.core.me.sure. ve.tically), as we.l as at incre.sing de.ths(1 cm be.we.n re.dings) into the.se.ime.t(me.sure. horizontally through pre.rille. hole. in the.bioge.che.istry core.). While.oxic, anoxic, oxidize., and re.uce. se.ime.t pore.wate. was obse.ve. above.and be.ow the.aRPD, in ge.e.al, se.ime.t above.the.aRPD had highe. DO conte.t, and highe. e. value. than se.ime.t be.ow the.aRPD. The.e.ore. the.aRPD de.th can be.use. as a re.ative.indicator of se.ime.t pore.wate. DO and e. conditions: se.ime.t with a de.pe. aRPD de.th has more.available.DO, and the.pore.wate. has highe. e. value.(more.oxidize. or le.s re.uce.) than se.ime.t with a shallowe. aRPD de.th. As such, the.aRPD de.th is a use.ul parame.e. to include.in mode.s that asse.s the.quality of marine.be.thic habitats.

关键词： Anoxia Appare.t re.ox pote.tial discontinuity(aRPD) Dissolve. oxyge. Habitat quality Hypoxia Inte.tidal Marine.be.thos Se.ime.t pore.wate.

e.fe.ts of Foliar Fe.tilize. Application on Quality of Te. (<I>Came.lia sine.sis</I>) Grown in the.Ke.yan Highlands

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Ame.ican Journal of Plant Scie.ce. 2014年第18期5卷 2707-2715页

作者： Rachae. Nje.i e. Njogu David K. Kariuki David M. Kamau francis N. Wachira De.artme.t of Che.istry University of Nairobi Nairobi Kenya Te. Re.e.rch Foundation of Ke.ya Kericho Kenya

In Ke.ya, foliar fe.tilize.s have.not found use.in te. production de.pite.the.r nume.ous advantage. as e.hibite. in othe. crops. A fe.tilize. trial te.t was e.tablishe. in thre. site. of the.major te. growing re.ions, with 36 plots pe. site.to de.e.mine.the.e.fe.ts of foliar fe.tilize. application on te. quality. Two foliar fe.tilize.s we.e.te.te.;foliar fe.tilize. 1 (FF1) and foliar fe.tilize. 2 (FF2), with a positive.control of soil fe.tilize. (SF) and a blank. Two le.ve. and a bud te. sample. we.e.colle.te. e.e.y two we.ks afte. e.ch foliar fe.tilize. application. The.e.we.e.the. analyze. for te. quality (total polyphe.ols, TP), nutrie.t re.idue. for the.diffe.e.t clone. and ge.graphical locations. The.TP conte.ts for clone.TRFK 31/8 we.e.as follows: FF1 = 17.8%, FF2 = 17.9%, SF = 16.56% and Ze.o = 17.4%. Tuke.-Krame. pair wise.comparison te.t re.ults be.we.n the.foliar fe.tilize.s and SF showe. that the.FF1 (HSD = 4.78) and FF2 (HSD = 5.27) fe.tilize.s had significantly (P e. le.e.s of TP conte.t as compare. to control SF fe.tilize.. Nutrie.ts analyze. had ave.age.me.ns as follows: N = 4% - 5%, P = 0.25% - 0.28%, K = 1.35% - 1.69%, Ca = 0.3 - 0.5 ppm, Mg = 0.19 - 0.27 ppm, Mn = 0.05 - 0.13 ppm, Zn = 25 - 40.5 ppm, Cu = 11 - 17 ppm and Fe.= 72 - 122 ppm. The.nutrie.t re.idue.le.e.s had non-significantly statistical diffe.e.ce. at P e.e. be.we.n pairs of ze.o applie. plots and the.FF1, FF2 and SF applie. plots re.pe.tive.y. It was conclude. that the.foliar fe.tilize.s incre.se. the.TP conte.t in te.te. te. sample. and the.nutrie.ts analyze. we.e.all within the.die.ary re.e.e.ce.intake.(DRI) le.e.s for SF, FF1 and FF2. Ove.all, the.foliar fe.tilize. incre.se. the.quality of the.te.te. te. sample..

关键词： Te. Total Polyphe.ols Nutrie.t Re.idue Foliar Fe.tilize.

Uncoupling prote.n 1 ablation in mice.Physiological and pathological conse.ue.ce. highlighte. by comparative.prote.mics

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Uncoupling protein 1 ablation in mice:Physiological and path...

Mitochondrial prote.me.plasticity of live. in re.ponse.to obe.ity in mouse.and to chronic poisoning by me.hylme.cury in ze.rafish.

中国药理学会第十次全国学术会议

作者： francis e.SLUSe

The.mitochondrial uncoupling prote.n(UCP-1) pre.e.t in the.inne. mitochondrial me.brane.of mammalian brown adipose.tissue.BAT) ge.e.ate. he.t(non-shive.ing the.moge.e.is) by consuming the.proton e.e.troche.ical gradie.t cre.te. by *** proce.s prote.ts against cold and re.ulate. e.e.gy *** studie. of UCP-1 ablate. mice.made.at normothe.my(20℃) faile. to e.ide.ce.an obe.oge.ic e.fe.t of the.***-

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Mitochondrial proteome plasticity of liver in response to ob...

Role.of hypoxia inducible.factor 1α in cobalt nanoparticle.induce. cytotoxicity of human THP-1 macrophage.

药学发展前沿论坛及药理学博士论坛

作者： francis e.Sluse Laboratory of Bioe.e.ge.ics and Ce.lular Physiology Chemistry InstituteLiege University

Ste.tosis e.compasse. the.accumulation of drople.s of fats into *** pe.forme. a comparative.analysis of mitochondrial prote.n patte.ns found in wild-type.and ste.tosis- affe.te. live. (ob/ob mice. using the.te.hnique.two-dime.sional diffe.e.tial in-ge. e.e.trophore.is (2D-DIGe..A total of 56 prote.ns e.hibiting significant diffe.e.ce.in the.r abundance.we.e.unambiguously ***,major prote.ns that re.ulate.ge.e.ation and consumption of the.ace.yl-CoA pool we.e.dramatically change. during *** prote.ns involve. in the.re.ponse.to oxidative.stre.s we.e.also affe.te..

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Biomate.ials Translational 2021年第2期2卷 143-150页

作者： We.dy Rache. francis Zhao Liu Sian e.Owe.s Xiao Wang Huaming Xue.Ale. Lord Ve.kate.warlu Kanamarlapudi Zhidao Xia Ce.tre.for Nanohe.lth Swansea University Medical SchoolSwanseaUK De.artme.t of Orthopae.ic Surge.y Orthopaedic InstituteThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina De.artme.t of Orthopae.ic Surge.y Johns Hopkins School of MedicineBaltimoreMDUSA De.artme.t of Orthopae.ics Yangpu Hospital affiliated to Tongji University School of MedicineShanghaiChina.

Cobalt is one.of the.main compone.ts of me.al hip prosthe.e. and cobalt nanoparticle.(CoNPs)produce. from we.r cause.inflammation,bone.lyse. and cytotoxicity at high *** ions mimic hypoxia in the.pre.e.ce.of normal oxyge. le.e.s,and activate.hypoxic signalling by stabilising hypoxia inducible.transcription factor 1α(HIF1α).This study aime. to asse.s in vitro the.functional role.of HIF1αin CoNP induce. ce.lular ***1α,lysosomal pH,tumour ne.rosis factorαand inte.le.kin 1βe.pre.sion we.e.analyse. in THP-1 macrophage. tre.te. with CoNP(0,10 and 100μg/mL).HIF1αknock out assays we.e.pe.forme. using small inte.fe.ing RNA to asse.s the.role.of HIF1αin CoNP-induce. *** CoNP conce.tration incre.se. lysosomal activity and acidity in THP-1 *** dose. of CoNP significantly re.uce. ce.l viability,stimulate. caspase.3 activity and *** HIF1αactivity incre.se. the.pro-inflammatory activity of tumour ne.rosis factorαand inte.le.kin 1β,but had no significant impact on ce.lular *** sugge.ts that whilst CoNP promote. cytotoxicity and ce.lular inflammation,the.apoptotic me.hanism is not de.e.de.t on HIF1α.

关键词： cobalt nanoparticle cytotoxicity hypoxia inducible.factor macrophage. TNFα