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Oral pharmacological treatment for patent ductus arteriosus in premature neonates with hemodynamic repercussions

Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1080-1083页

作者： Clarissa de Albuquerque Botura Bruno Ambrósio da Rocha Thiely Balensiefer franciele queiroz ames Ciomar Aparecida Bersani-Amado Roberto Kenji Nakamura Cuman Department of Medicine Faculdade Uningá Department of Pharmacology and Therapeutics State University of Maringá Hospital Pharmacy at Santa Rita Hospital

Objective: To evaluate the efficacy of oral indomethacin, ibuprofen, and paracetamol in oral dosage form on patent ductus arteriosus(PDA) in premature neonates with significant clinical and hemodynamic repercussions(CHRs) and to determine the effect of these respective treatments on renal ***: A retrospective study of cases of PDA in premature neonates in the Neonatal Intensive Care Unit was conducted. The treatments consisted of indomethacin[0.2 mg/(kg$d), 3-day cycle], ibuprofen [10 mg/(kg$d) followed by 5 mg/(kg$d), 3-day cycle], and paracetamol(15 mg/kg every 6 h, 5-day cycle). The drugs were administered as an oral solution. The following variables were considered: gestational age,newborn weight at birth, Apgar score, diuresis, serum creatinine and urea levels, and serum electrolyte levels(sodium and potassium).Results: Treatment with indomethacin presented efficacy of 87.5% in closure of the ductus with a mean outcome period of 3.5 d. In premature neonates with CHRs and contraindications for indomethacin, the initial treatment with either ibuprofen or paracetamol failed to close the ductus. However, when this treatment was followed by indomethacin, closure occurred in 66.7% of the neonates, with an outcome period of9.66 d. The initial treatment with one cycle of ibuprofen followed by one or two cycles of paracetamol failed to close the ***: Oral indomethacin was effective for closure of the PDA in premature neonates with severe CHRs. Oral paracetamol or ibuprofen for PDA closure in premature neonates with severe CHRs and contraindications for indomethacin was ***, results in clinical improvements of neonates allowed the subsequent use of indomethacin and successful closure of the ductus. A significant reduction of diuresis occurred in neonates who were treated with indomethacin, either as a first-line treatment or after the failure of ibuprofen or paracetamol.

关键词： Patent ductus arteriosus Premature neonatal Indomethacin Ibuprofen Paracetamol

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A single administration of fish oil inhibits the acute inflammatory response in rats

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 830-837页

作者： Laura Licia Milani de Arruda franciele queiroz ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Department of Pharmacology and Therapeutics State University of MaringaMaringa-PRBrazil Department of Chemistry State University of MaringaMaringa-PRBrazil

Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein.

关键词： Omega-3 fatty acid Polyunsaturated fatty acid Pleurisy Leukocyte migration EPA DHA

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Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y strain

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 838-843页

作者： áurea Regina Telles Pupulin Lívia Bracht Márcia Machado de Oliveira Dalalio Francielli Maria de Souza Silva-Comar Bruno Ambrósio da Rocha franciele queiroz ames Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado Laboratory of Parasitology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Hepatic Metabolism Department of BiochemistryState University of Maringá-PR Laboratory of Immunology Department of Basic Sciences of HealthState University of Maringá-PR Laboratory of Inflammation Department of Pharmacology and TherapeuticState University of Maringá-PR

Objective:To identify whether Canova medication changes TNF-α and IL-10 serum levels in mice infected with Trypanosoma cruzi Y ***:Animals were divided into five groups:non-treated infected animals(I); benznidazole-treated infected animals(Bz; 100 mg/kg body weight,single daily dose by gavage); Canova medication(CM) treated infected animals(CM;0.2 mL/animal,single daily dose by gavage); benznidazole- and Canova medication–treated infected animals with the above-mentioned dose(Bz+CM);and non-infected animals(C).TNF-α and IL-10 levels were determined in serum aliquots after 4,7,10,13,and 29 days of *** ELISA technique was employed with R&D System *** ***:A high increase in TNF-α and IL-10 levels occurred in the infected and CM-treated groups within the treatment employed on the 10 th day after infection,coupled with a IL-10 decrease on the 13 th day after infection when compared with the other experimental ***:CM may change the balance between plasma cytokine levels(TNF-α and IL-10) in mice infected with Y strain ***,with important consequences leading towards a more severe infection.

关键词： Trypanosoma cruzi Canova medication Cytokines

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 248-253页

作者： Ana Beatriz Boamorte Cortela franciele Silva Bernardo Marcos Tadao Kavanishi Vilmar queiroz de Menezes Nivaldo Cortela Faculty of Medicine Centro Universitario de Varzea Grande Varzea Grande 78110-000 Brazil Faculty of Medicine Universidade do Estado de Mato Grosso Caceres 78200-000 Brazil Hospital Regional de Caceres Dr. Antonio Fontes Universidade do Estado de Mato Grosso Caceres 78200-000 Brazil

First described in Hiroshima City Hospital in 1990, Takotsubo Cardiomyopathy emerged as an important differential diagnosis for acute coronary syndrome, since this disease mimics some commemoratives presentations of acute coronary syndrome such as chest symptoms, electrocardiographic changes and cardiac injury biomarker alteration. Also, it＇s important to emphasize that, although it commonly occurs among woman, TCC can happen in males, as demonstrated in other studies which 10% of the cases occurred in male sex. In this way, this study shows the importance of Takotsubo Cardiornyopathy as a differential diagnosis for acute coronary syndrome.

关键词： Takotsubo cardiomyopathy apical ballooning broken-heart syndrome

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PROD and BROD Modulation in Nile Tilapia after Exposure to 17 β-estradiol

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Journal of Life Sciences 2011年第4期5卷 287-290页

作者： franciele Bitencourt Rosa Toyoko Shiraishi Frighetto Julio Ferraz de queiroz Marcos Eliseu Losekann Alffedo Jose Barreto Luiz Eduardo Alves de Almeida Departament of Chemistry and Environmental Sciences （IBILCE） S~o Paulo State University S6o Jos~ do Rio Preto S6o Paulo15054-000 Brazil The Brazilian Agricultural Research Corporation （EMBRAPA） S~o Paulo 13820-000 Brazil

The activities of 7-ethoxyresorufin-O-deetylase （EROD）, 7-benzyloxyresorufin-O-debenzylase （BROD）, 7-pentoxyresorufin-O-depentilase （PROD）, and glutathione S-transferase （GST） were measured in Nile tilapias exposed for 7 days of 5 and 15μg/L 17 β-estradiol. EROD and GST activities were unchanged. PROD activity increased in animals exposed to the higher dose of the hormone, while BROD was increased after 7 exposure days to both doses of the compound. These results indicate the usefulness of these enzymes as biomarkers for 17 β-estradiol exposure.

关键词： EROD PROD BROD 17 β-estradiol biomarker Nile ti|apia.

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