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Present concepts in management of atrial fibrillation:From drug therapy to ablation

World Journal of Cardiology 2009年第1期1卷 11-22页

作者： Giovanni B Forleo Luca Santini francesco romeo Division of Cardiology Department of Internal MedicineUniversity of Rome "Tor Vergata"Viale Oxford8100133 RomeItaly

Atrial fibrillation(AF) management requires knowledge of its pattern of presentation,underlying conditions,and decisions about restoration and maintenance of sinus rhythm,control of the ventricular rate,and antithrombotic *** of sinus rhythm is a desirable goal in AF patients because the prevention of recurrence may improve cardiac function,relieve symptoms and reduce the likelihood of adverse ***-arrhythmic drug therapy is the first-line treatment for patients with paroxysmal and persistent AF based on current ***,currently used drugs have limited efficacy and cause cardiac and extracardiac ***,there is a continued need to develop new drugs,device and ablative approaches to rhythm ***,simpler and safer stroke prevention regimens are needed for AF patients on life-long anticoagulation,including occlusion of the left atrial *** results of the Randomized Evaluation of Long-Term Anticoagulant Therapy study are encouraging in these *** on the pathophysiology of AF is rapidly expanding and identification of focally localized triggers has led to the development of new treatment options for this ***,the clinical decision whether to restore and maintain sinus rhythm or simply control the ventricular rate has remained a matter of intense *** the minority of patients in whom AF cannot be adequately managed by pharmacological therapy,the most appropriate type of non-pharmacological therapy must be selected on an individualized *** treatment of AF with catheter ablation is now a legitimate option for a large number of *** evolution of hybrid therapy,in which two or more different strategies are employed in the same patient,may be an effective approach to management of *** any case,planning a treatment regimen for AF should include evaluation of the risks inherent in the use of various drugs as well as more invasive strategies.

关键词： Antiarrhythmic medications Atrial fibrillation Catheter ablation

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Percutaneous assist devices in acute myocardial infarction with cardiogenic shock: Review, meta-analysis

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World Journal of Cardiology 2016年第1期8卷 98-111页

作者： francesco romeo Maria Cristina Acconcia Domenico Sergi Alessia romeo Simona Francioni Flavia Chiarotti Quintilio Caretta Department of Cardiovascular Disease University of Rome-Tor Vergata Department of Cardiovascular Disease University of Rome-La Sapienza Center for Biomedical Technology and Integrated Department Services to Education University of Florence Department of Cell Biology and Neuroscience Italian National Institute of Health Department of Experimental and Clinical Medicine University of Florence

AIM: To assess the impact of percutaneous cardiac support in cardiogenic shock(CS) complicating acute myocardial infarction(AMI), treated with percutaneous coronary intervention. METHODS: We selected all of the studies published from January 1st, 1997 to May 15 st, 2015 that compared the following percutaneous mechanical support in patients with CS due to AMI undergoing myocardial revascularization:(1) intra-aortic balloon pump(IABP) vs Medical therapy;(2) percutaneous left ventricular assist devices(PLVADs) vs IABP;(3) complete extracorporeal life support with extracorporeal membrane oxygenation(ECMO) plus IABP vs IABP alone; and(4) ECMO plus IABP vs ECMO alone, in patients with AMI and CS undergoing myocardial revascularization. We evaluated the impact of the support devices on primary and secondary endpoints. Primary endpoint was the inhospital mortality due to any cause during the same hospital stay and secondary endpoint late mortality at 6-12 moof follow-up. RESULTS: One thousand two hundred and seventytwo studies met the initial screening criteria. After detailed review, only 30 were selected. There were 6 eligible randomized controlled trials and 24 eligible observational studies totaling 15799 patients. We found that the inhospital mortality was:(1) significantly higher with IABP support vs medical therapy(RR = +15%, P = 0.0002);(2) was higher, although not significantly, with PLVADs compared to IABP(RR = +14%, P = 0.21); and(3) significantly lower in patients treated with ECMO plus IABP vs IABP(RR =-44%, P = 0.0008) or ECMO(RR =-20%, P = 0.006) alone. In addition, Trial Sequential Analysis showed that in the comparison of IABP vs medical therapy, the sample size was adequate to demonstrate a significant increase in risk due to IABP. CONCLUSION: Inhospital mortality was significantly higher with IABP vs medical therapy. PLVADs did not reduce early mortality. ECMO plus IABP significantly reduced inhospital mortality compared to IABP.

关键词： Intra-aortic balloon pump Impella Tandem Heart Extracorporeal membrane oxygenation Cardiogenic shock Meta-analysis

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The Effect of Bergamot-Derived Polyphenolic Fraction on LDL Small Dense Particles and Non Alcoholic Fatty Liver Disease in Patients with Metabolic Syndrome

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Advances in Biological Chemistry 2014年第2期4卷 129-137页

作者： Micaela Gliozzi Cristina Carresi Vincenzo Musolino Ernesto Palma Carolina Muscoli Cristiana Vitale Santo Gratteri Giuseppe Muscianisi Elzbieta Janda Saverio Muscoli francesco romeo Salvatore Ragusa Rocco Mollace Ross Walker James Ehrlich Vincenzo Mollace Interregional Research Centre for Food Safety & Health University “Magna Graecia” of Catanzaro Catanzaro Italy San Raffaele IRCCS Rome Italy University of Rome “Tor Vergata” Rome Italy

The occurrence of Metabolic Syndrome (MS) represents an independent risk factor for developing cardiovascular disease states in patients suffering from type 2 diabetes mellitus. Moreover, both the size of LDL particles and liver dysfunction identified as non alcoholic fatty liver disease (NAFLD) represent important biomarkers for the development of cardiometabolic risk in patients with MS. Here we studied the effect of bergamot polyphenolic fraction (BPF) in patients with MS and NAFLD. 107 patients were enrolled at the San Raffaele IRCCS (Rome). All of them showed ultrasonografic evidences of NAFLD and at least three out of five previous identified criteria for the diagnosis of MS. Patients were divided into two groups: one receiving placebo and the second receiving BPF 650 mg twice a day for 120 consecutive days. In the group receiving BPF 650 mg twice a day, a significant reduction of fasting plasma glucose, serum LDL cholesterol and triglycerides alongside with an increase of HDL cholesterol was found. This effect was accompanied by significant reduction of both ultrasonographic and metabolic biomarkers of NAFLD. Moreover, a significant reduction of small dense LDL particles, as detected via proton NMR Spectroscopy, was found after BPF treatment. In conclusion, our data confirm the beneficial effect of bergamot-extract in patients with MS an effect highlighted by significant reduction of small dense LDL particles and by improvement of NAFLD biomarkers. This suggests a potential preventive role of bergamot derivatives in reducing cardiometabolic risk.

关键词： Metabolic Syndrome Non Alcoholic Fatty Liver Disease Cardiometabolic Risk Bergamot Polyphenolic Fraction

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Role of genomics in cardiovascular medicine

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World Journal of Cardiology 2010年第12期2卷 428-436页

作者： Giuseppe Novelli Irene M Predazzi Ruggiero Mango francesco romeo Jawahar L Mehta Department of Biopathology and Diagnostic Imaging Section of Medical Genetics School of MedicineTor Vergata University Department of Internal Medicine University of Arkansas for Medical Sciences Centro Neurolesi"Bonino Pulejo" 98100 Messina Italy Department of Internal Medicine University of Rome Tor Vergata

As all branches of science grow and new experimental techniques become readily accessible,our knowledge of medicine is likely to increase exponentially in the coming *** developed technologies have revolutionized our analytical capacities,leading to vast knowledge of many genes or genomic regions involved in the pathogenesis of congenital heart diseases,which are often associated with other genetic syndromes,coronary artery disease and non-ischemic cardiomyopathies and *** knowledge-base of the genesis of cardiovascular diseases is likely going to be further revolutionized in this new era of genomic ***,we review the advances that have been made over the last several years in this field and discuss different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases.

关键词： Genomics Polymorphisms Mutations Complex diseases Atherosclerosis

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Environmental factors determining growth of salamander larvae： A field study

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Current Zoology 2015年第3期61卷 421-427页

作者： Laura LIMONGI Gentile francesco FICETOLA Giuseppe romeo Raoul MANENTI Dipartimento di Bioscienze Universita degli Studi di Milano Via Celoria 26 20133 Milano Italy Dipartimento di Scienze dell'Ambiente e del Territorio e di Scienze della Terra UniversitA degli Studi di Milano-Bicocca. Piaz- za della Scienza 1 20126 Milano Italy Laboratoire d'Ecologie Alpine (LECA) Universit6 Grenoble Alpes F-38000 Grenoble France CNRS LECA F-38000 Grenoble France

Larval growth and survival of organisms are strongly influenced by abiotic and biotic factors, as demonstrated by ex- perimental studies performed under controlled laboratory or semi-natural conditions. Even if they have many advantages, ex- periments cannot cover the full complexity of natural conditions and field studies are needed for a better understanding of how environmental variation determines growth and development rate. Fire salamander Salamandra salamandra females give birth to larvae in a variety of habitats, both epigean and subterranean. In caves, salamander larvae successfully grow and metamorphose, but their growth is more than three times longer than in epigean streams and factors determining these differences require inves- tigation. We performed a field study to understand the factors related to the growth of fire salamander larvae in different envi- ronmental conditions, evaluating the relationship between environmental features and larval growth and differences between caves and epigean spring habitats. Both caves and epigean larvae successfully grew. Capture-mark-recapture allowed to individu- ally track individuals along their whole development, and measure their performance. Growth rate was significantly affected by environmental variables： larvae grew faster in environments with abundant invertebrates and few conspeciflcs. Taking into ac- count the effect of environmental variables, larval growth was significantly lower in caves. Food availability plays a different ef- fect in the two environments. Larval growth was positively related to the availability of invertebrates in epigean sites only. The development rate of hypogeous populations of salamanders is slower because of multiple parameters, but biotic factors play a much stronger role than the abiotic ones

关键词： Spring Freshwater Cave Amphibians Salamandra Cannibalism

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Radiomics and machine learning applications in rectal cancer:Current update and future perspectives

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World Journal of Gastroenterology 2021年第32期27卷 5306-5321页

作者： Arnaldo Stanzione francesco Verde Valeria romeo Francesca Boccadifuoco Pier Paolo Mainenti Simone Maurea Department of Advanced Biomedical Sciences University of Naples"Federico II"Naples 80131Italy Institute of Biostructures and Bioimaging National Council of ResearchNapoli 80131Italy

The high incidence of rectal cancer in both sexes makes it one of the most common tumors,with significant morbidity and mortality *** define the best treatment option and optimize patient outcome,several rectal cancer biological variables must be ***,medical imaging plays a crucial role in the characterization of this disease,and it often requires a multimodal *** resonance imaging is the first-choice imaging modality for local staging and restaging and can be used to detect high-risk prognostic *** tomography is widely adopted for the detection of distant ***,conventional imaging has recognized limitations,and many rectal cancer characteristics remain assessable only after surgery and histopathology *** is a growing interest in artificial intelligence applications in medicine,and imaging is by no means an *** introduction of radiomics,which allows the extraction of quantitative features that reflect tumor heterogeneity,allows the mining of data in medical images and paved the way for the identification of potential new imaging *** manage such a huge amount of data,the use of machine learning algorithms has been ***,without prior explicit programming,they can be employed to build prediction models to support clinical decision *** this review,current applications and future perspectives of artificial intelligence in medical imaging of rectal cancer are presented,with an imaging modality-based approach and a keen eye on unsolved *** results are promising,but the road ahead for translation in clinical practice is rather long.

关键词： Rectal cancer Radiomics Radiogenomics Artificial intelligence Machine learning Deep learning

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“Tradamixina TP” Compound in Monotherapy for Three Months in Patients with LUTS: Observational Study on Improvement of Urinary Symptoms and Sexual Function in Men

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Health 2019年第6期11卷 621-629页

作者： Trama francesco Riccardo Filippo romeo Giuseppe Ruffo Antonio Department of Urology—University Federico II of Naples Via S. Pansini Naples Italy AORN Cardarelli Napoli Italy

Introduction: Benign Prostatic Hypertrophy (BPH) and Lower Urinary Tract Symptoms (LUTS) frequently affect the male population after the age of 50. Moreover, it is well known that there is a correlation of these symptoms with Erectile Dysfunction (ED) that can reach a frequency of roughly 52% in men aged between 40 and 70 years old. In this study, we aimed at evaluating the effect of a new natural compound “Tradamixina TP” (composed of 80 mg of the algae Ecklonia Bicyclis, 100 mg of Tribulus terrestris and 100 mg of Chitosan Water-soluble oligosaccharide 320 mg of Serenoa repens) in the improvement of Lower Urinary Tract Symptoms (LUTS). Materials & Methods: One-hundred patients with an average age of 64 years old and who were not taking any medication or phytotherapy for prostatic hypertrophy or erectile dysfunction were recruited in the study. All participants were subjected to serum prostate antigen (PSA) and uroflowmetry measuring maximal urine flow/sec (Qmax), at baseline and after 12 weeks. In addition, patients were asked to take the Tradamixina TP for 3 months and to complete at the beginning and end of the treatment the following questionnaires: 1) the IPSS investigating the level of LUTS, and 2) the IIEF-15 investigating the erectile dysfunction. Results: After the treatment, the IPSS scores were lower than those before the treatment. Moreover, a significant effect was found for the IIEF erectile subdomain with scores that were significantly higher at 12 weeks than at baseline. A similar result was found for the IIEF overall subdomain. A decrease of total serum PSA was also observed. Conclusions: After 3 months of daily treatment, the new compound “Tradamixina TP” improved patients’ sexual function, LUTS and led also to a decrease in serum PSA levels.

关键词： Lower Urinary Tract Symptoms Benign Prostatic Hyperplasia Tradamixina TP Erectile Dysfunction Tribulus Terrestris Algae Ecklonia Bicyclis Chitosan Water-Soluble Oligosaccharide

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Elastosonographic Changes in Patients with Peyronie's Disease, before and after Treatment with a Compound Based on <i>Ecklonia bicyclis</i>, <i>Tribulus terrestris</i>, and Water-Soluble Chitosan

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Open Journal of Urology 2018年第3期8卷 77-87页

作者： francesco Trama Filippo Riccardo Antonio Ruffo Giuseppe Celentano Giuseppe romeo Antonio Russo Università degli Studi di Napoli Federico II Napoli Italy

Several diagnostic techniques have been proposed during the time for the diagnostic evaluation of Induratio Penis Plastica (IPP), due to poor sensitivity and specificity of standard B-Mode Ultrasonography. Shear-Wave elastosonography (SWE) is a relative new ultrasound technique, already used for several organs, which allows evaluating the rigidity of the tissues. Furthermore, we used a compound consisting of Ecklonia bicyclis, Tribulus terrestris, and Biovis (water-soluble Chitosan) with antifibrotic and antioxidant properties and analyzed the elastosonographic variations following the assumption of the compound. From March 2016 to April 2017, 40 patients were recruited with a mean age of 62. All patients underwent elastosonographic measurements at the start of treatment. Subsequently each patient took 1 tablet of the compound of Ecklonia bicyclis, Tribulus terrestris, and Biovis (water-soluble Chitosan) for 6 months. All patients underwent elastosonographic investigation at the end of treatment. The elastosonographic measurement prior treatment, showed that the average of the three measurements (proximal, medial and distal), was 37.05 KPa ± 7.76 SD and 38.8 KPa ± 10.11 SD for the left and right cavernous body, respectively. The examination at the end of the six months of treatment, with the compound showed that the average values of fibrosity were 31.07 KPa ± 7.5 SD and 30.86 KPa ± 11.4 SD for the left and right cavernous body respectively, demonstrating a decrease in fibrosity that was statistically significant (P < 0.01). Our data demonstrate that taking the compound for six months reduces the stiffness of the corpora cavernosa.

关键词： Peyronie’s Disease Elastosonography Ecklonia bicyclis Soluble Chitosan Tribulus terrestris

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使用意法半导体的TWISTER仿真软件开发基于M0^(TM)固态继电器的汽车系统

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中国集成电路 2015年第7期24卷 56-59页

作者： romeo Letor francesco Giuffre' Alessio Brighina 意法半导体

汽车系统的成本优化和可靠性设计需要对功率电子器件进行复杂的测评。TWISTER是意法半导体开发的一款仿真器,能够精确地预测采用意法半导体智能功率技术的功率电路的特性,并支持电热特性混合式评测模型。Twister开发工具能够有效缩短研... 详细信息

汽车系统的成本优化和可靠性设计需要对功率电子器件进行复杂的测评。TWISTER是意法半导体开发的一款仿真器,能够精确地预测采用意法半导体智能功率技术的功率电路的特性,并支持电热特性混合式评测模型。Twister开发工具能够有效缩短研发周期,因为它能够执行重复性任务,例如,负载兼容性、布线优化、故障状况再现、诊断行为、动静态热性能评测、工艺角参数评测等。

关键词：意法半导体 M0 TM TWISTER 汽车系统固态继电器仿真软件开发功率电子器件功率电路可靠性设计

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Current trends of artificial intelligence in cancer imaging

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Artificial Intelligence in Medical Imaging 2020年第3期1卷 87-93页

作者： francesco Verde Valeria romeo Arnaldo Stanzione Simone Maurea Department of Advanced Biomedical Sciences University of Naples"Federico II"Napoli 80131Italy

In this editorial,we discussed the current research status of artificial intelligence(AI)in Oncology,reviewing the basics of machine learning(ML)and deep learning(DL)techniques and their emerging applications on clinical and imaging cancer *** growing amounts of available“big data”coupled to the increasing computational power have enabled the development of computerbased systems capable to perform advanced tasks in many areas of clinical care,especially in medical *** is a branch of data science that allows the creation of computer algorithms that can learn and make predictions without prior *** is a subgroup of artificial neural network algorithms configurated to automatically extract features and perform high-level tasks;convolutional neural networks are the most common DL models used in medical image *** methods have been proposed in many areas of oncology granting promising results in radiology-based clinical *** detail,we explored the emerging applications of AI in oncological risk assessment,lesion detection,characterization,staging,and therapy *** issues such as the lack of reproducibility and generalizability need to be addressed to fully implement AI systems in clinical ***,AI impact on cancer imaging has been driving the shift of oncology towards a precision diagnostics and personalized cancer treatment.

关键词： Artificial intelligence Machine learning Deep learning Oncology Medical imaging Cancer imaging

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