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In advanced gastric cancer:Prognosis and treatment of patients with positive peritoneal cytology

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World Journal of Gastrointestinal Surgery 2013年第5期5卷 135-137页

作者： francesco frattini Stefano Rausei Corrado Chiappa Francesca Rovera Luigi Boni Gianlorenzo Dionigi Department of Surgical Sciences University of Insubria School of Medicine

Positive peritoneal cytology in gastric cancer is classified as M1 disease by the 7thEdition of American Joint Committee on Cancer staging *** the introduction of laparoscopy and peritoneal washing cytology in the staging of gastric cancer a new category of patients has been *** are patients with no macroscopic peritoneal metastases but with peritoneal cytology positive(P0C1).Prognosis and treatment of such patientsrepresent a controversial *** evaluate the state of the art of staging system in gastric cancer and discusss tandardisation in staging and treatment *** is still a lack of uniformity in the use of laparoscopy with peritoneal cytology in clinical decision making and in the surgical treatment for gastric *** of this patient subset remains *** therapies and new therapeutic strategies are required to improve the survival of these patients.

关键词： Advanced gastric cancer Peritoneal washing cytology Staging laparoscopy Reverse transcription-polymerase chain reaction

A decade in gastric cancer curative surgery:Evidence of progress(1999-2009)

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World Journal of Gastrointestinal Surgery 2012年第3期4卷 45-54页

作者： Stefano Rausei Gianlorenzo Dionigi Francesca Rovera Luigi Boni Caterina Valerii Luisa Giavarini francesco frattini Renzo Dionigi Department of Surgical Sciences University of Insubria

To investigate the progress in evidence-based surgical treatment of non-metastatic gastric cancer,we re- viewed the last ten years'*** data used in this review were identified by searches made on MED-LINE,Current Contents,PubMed,and other references taken from relevant original articles(on prospective and retrospective studies)concerning gastric cancer *** papers published in English between January 1999 and December 2009 were *** from ongoing studies were obtained in December 2009, from the trials registry of the United States National Institutes of Health(http://***).The citations list was presented according to evidence based relevance(i.e.,randomized controlled trials,pro- spective studies,retrospective series).In the last ten years,many challenges have been faced relating to the extension of gastric resection and nodal dissection as well as surgical timing,but we found only limited evidence,regardless of latitude of *** ongoing phase-Ⅲ trials may provide answers that will be valid for the coming decades,and which may bring definitive answers for the currently unresolved questions.

关键词： Gastric cancer Evidence-based surgery D2 lymphadenectomy Laparoscopic gastrectomy Endo-scopic treatment Neoadjuvant therapy

Multimodal treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2014年第4期6卷 55-58页

作者： Ilaria Proserpio Stefano Rausei Sabrina Barzaghi francesco frattini Federica Galli Domenico Iovino Francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti Department of Oncology Ospedale di Circolo and University of Insubria Department of Surgery Ospedale di Circolo and University of Insubria

Gastric cancer is the second leading cause of death from malignant disease *** complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage *** improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and *** clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative ***,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric *** this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients.

关键词： Gastric cancer Gastrectomy Lymphadenectomy Multimodal treatment Adjuvant therapy Neoadjuvant therapy Chemotherapy Radiotherapy Targeted therapy

Single-cell pan-omics, environmental neurology, and artificial intelligence:the time for holistic brain health research

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Neural Regeneration Research 2025年第6期20卷 1703-1704页

作者： Paolo Abondio francesco Bruno IRCCS Istituto delle Scienze Neurologiche di Bologna BolognaItaly Association for Neurogenetic Research(ARN) Lamezia TermeCatanzaroItaly

The brain,with its trillions of neural connections,different cellular types,and molecular complexities,presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural *** traditional methods have provided valuable insights,emerging technologies offer unprecedented opportunities to delve deeper into the underpinnings of brain *** the everevolving landscape of neuroscience,the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks.

关键词： function artificial landscape

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic International Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： francesco Ferrini Esri H.Juárez Adalberto Merighi Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei Xiu Jiafeng Wang Tianle Cheng Dong He Qiang Sun Xuhang Ma francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Nickle oxide Magnetron sputter Defect Stability Perovskite solar cell

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

A new three-dimensional finite-volume non-hydrostatic shock-capturing model for free surface flow

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Journal of Hydrodynamics 2017年第4期29卷 552-566页

作者： francesco Gallerano Giovanni Cannata francesco Lasaponara Chiara Petrelli Department of Civil Constructional and Environmental Engineering Sapienza University of Rome

In this paper a new finite-volume non-hydrostatic and shock-capturing three-dimensional model for the simulation of wave-structure interaction and hydrodynamic phenomena（wave refraction, diffraction, shoaling and breaking） is proposed. The model is based on an integral formulation of the Navier-Stokes equations which are solved on a time dependent coordinate system： a coordinate transformation maps the varying coordinates in the physical domain to a uniform transformed space. The equations of motion are discretized by means of a finite-volume shock-capturing numerical procedure based on high order WENO reconstructions. The solution procedure for the equations of motion uses a third order accurate Runge-Kutta（SSPRK） fractional-step method and applies a pressure corrector formulation in order to obtain a divergence-free velocity field at each stage. The proposed model is validated against several benchmark test cases.

关键词： Three-dimensional simulation non-hydrostatic wave-structure interaction flow-structure interaction shock-capturing