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Optical coherence tomography angiography in retinal cavernous hemangioma

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1945-1946页

作者： Gilda Cennamo francesca Amoroso Domenico Solari Mariacristina Alfier Giuseppe de Crecchio Eye Clinic Department of Public HealthUniversity of Naples Fedefico IINaples 80100Italy Eye Clinic Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy Division of Neurosurgery Department of NeurosciencesReproductive Sciences and DentistryUniversity of Naples Federico IINaples 80100Italy UOC Ophthalmology Pellegrini Hospital Naples 80100Italy

Citation： Cennamo G, Amoroso F, Solari D, Alfieri MC, de Crecchio G. Optical coherence tomography angiography in retinal cavernous hernangioma, lnt J Ophthalmol 2017; 10（12）： 1945-1946

关键词： Figure Optical coherence tomography angiography in retinal cavernous hemangioma

Membraneless organelles restructured and built by pandemic viruses:HIV-1 and SARS-CoV-2

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Journal of Molecular Cell Biology 2021年第4期13卷 259-268页

作者： Viviana Scoca francesca Di Nunzio Advanced Molecular Virology and Retroviral Dynamics Group Department of VirologyPasteur InstituteParisFrance BioSPC Doctoral School Universite de ParisParisFrance

Viruses hijack host functions to invade their target cells and spread to new ***,viruses learned to usurp liquid-liquid phase separation(LLPS),a newly exploited mechanism,used by the cell to concentrate enzymes to accelerate and confine a wide variety of cellular *** gives rise to actual membraneless organelles(MLOs),which do not only increase reaction rates but also act as a filter to select molecules to be retained or to be excluded from the liquid *** is exactly what seems to happen with the condensation of SARS-CoV-2 nucleocapsid protein to favor the packaging of intact viral genomes,excluding viral subgenomic or host cellular *** older pandemic virus,HIV-1,also takes advantage of LLPS in the host cell during the viral *** discoveries highlighted that HIV-1 RNA genome condensates in nuclear MLOs accompanied by specific host and viral proteins,breaking the dogma of retroviruses that limited viral synthesis exclusively to the cytoplasmic *** fundamental properties of viral/host LLPS remain still *** studies will contribute to deeply understanding the role of pathogen-induced MLOs in the epidemic invasion of pandemic viruses.

关键词： LLPS MLO HIV-1 SARS-CoV-2

Compliant semiconductor scaffolds: building blocks for advanced neural interfaces

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Neural Regeneration Research 2015年第11期10卷 1741-1742页

作者： francesca Cavallo Center for High Technology Materials University of New Mexico

Neuroscience,neuroprosthetics and neural regeneration would benefit from more adequate interfacing *** understand how neurons communicate,process information and control behavior,researchers need to monitor nerve cell activity with high specifity and high spatio-temporal *** prostheses require minimally invasive-implantable devices to re- place lost function, and bypass dysfunctional pathways in the nervous system. devices built to repair damaged nerves have to support and promote regeneration of host neurons through an injured area. Finally, as neuromodulation is being elevated from last resort to first choice treatment for an increasing number of conditions, implantable devices able to perform targeted regu- lation of neural activity are needed. Recent advances in device miniaturization, materials engineering, and nanotechnology are enabling development of an increasing number of devices that effectively interface with neural circuits. Wireless spinal cord and deep brain stimulators, retinal and cochlear implants, high density electrodes arrays for neural recording have already proven to significantly impact fundamental research in neuro- science, as well as individuals＇ quality of life.

关键词： high building blocks for advanced neural interfaces Compliant semiconductor scaffolds

Unsteady Inflow Effects on the Wake Shed from a High-Lift LPT Blade Subjected to Boundary Layer Laminar Separation

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Journal of Thermal Science 2012年第2期21卷 97-108页

作者： francesca Satta Marina Ubaldi Pietro Zunino Università degli Studi di Genova

An experimental investigation on the near and far wake of a cascade of high-lift low-pressure turbine blades subjected to boundary layer separation over the suction side surface has been carried out, under steady and unsteady inflows. Two Reynolds number conditions, representative of take-off/landing and cruise operating conditions of the real engine, have been tested. The effect of upstream wake-boundary layer interaction on the wake shed from the profile has been investigated in a three-blade large-scale linear turbine cascade. The comparison between the wakes shed under steady and unsteady inflows has been performed through the analysis of mean velocity and Reynolds stress components measured at midspan of the central blade by means of a two-component crossed miniature hot-wire probe. The wake development has been analyzed in the region between 2% and 100% of the blade chord from the central blade trailing edge, aligned with the blade exit direction. Wake integral parameters, half-width and maximum velocity defects have been evaluated from the mean velocity distributions to quantify the modifications induced on the vane wake by the upstream wake. Moreover the thicknesses of the two wake shear layers have been considered separately in order to identify the effects of Reynolds number and incoming flow on the wake shape. The self-preserving state of the wake has been looked at, taking into account the different thicknesses of the two shear layers. The evaluation of the power density spectra of the velocity fluctuations allowed the study of the wake unsteady behavior, and the detection of the effects induced by the different operating conditions on the trailing edge vortex shedding.

关键词： Wake-wake unsteady interaction high-lift blade profiles low-pressure turbine blade wake.

An unusual case of fatty liver in a patient with desmoid tumor

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World Journal of Gastroenterology 2012年第24期18卷 3173-3176页

作者： francesca de Felice Daniela Musio Rossella Caiazzo Bartolomeo Dipalma Lavinia Grapulin Camilla Proietti Semproni Vincenzo Tombolini department of Radiological Sciences-Oncology and Pathological Anatomy and Department of RadiotherapyUniversity of Rome "La Sapienza"00161 RomeItaly

A desmoid tumor,also known as aggressive fibromatosis,is a rare benign neoplasm that arises from fascial or musculoaponeurotic *** can occur in any anatomical location,most commonly the abdominal wall,shoulder girdle and *** typical clinical presentation is a painless mass with a slow and progressive invasion of contiguous *** is associated with a high local recurrence rate after *** issues regarding the optimal treatment of desmoid tumors remain *** surgical resection with a wide margin(2-3 cm) remains the gold standard treatment with regard to preserving quality of *** alone has been shown to be effective for the control of unresectable or recurrent *** tumors tend to be locally infiltrative,therefore,the fields must be generous to prevent marginal *** radiation dose appropriate for treating desmoid tumors remains *** present a 25-year-old Caucasian man with local recurrence of a desmoid tumor after repeated surgical resection,treated with *** patient achieved complete tumor regression at 4 mo after radiotherapy,and he is clinically free of disease at 12 mo after the end of treatment,with an acceptable quality of *** patient developed short bowel syndrome as a complication of second surgical ***,radiotherapy might have worsened an already present malabsorption and so led to steatohepatitis.

关键词： desmoid tumor Aggressive fibromatosis Fattyliver

New obesity classification criteria as a tool for bariatricsurgery indication

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World Journal of Gastroenterology 2016年第2期22卷 681-703页

作者： Antonino de Lorenzo Laura Soldati francesca Sarlo Menotti Calvani Nicola Di Lorenzo Laura Di Renzo Division of Clinical Nutrition and Nutrigenomic Department of Biomedicine and PreventionUniversity of Tor Vergata00133 RomeItaly department of Internal Medicine UOSD Service of Clinical Nutritionparenteral therapy and anorexia nervosaPoliclinico Tor Vergata00133 RomeItaly department of Health Sciences University of Milan20122 MilanItaly department of Agriculture University of Naples“Federico II” 80055 Portici(NA)Italy department of Surgical Sciences University of Tor VergataPoliclinico Tor Vergata00133 RomeItaly

Obesity plays relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional, and metabolic factors. Due to the role of adipose tissue in lipid and glucose metabolism, and low grade inflammation, it is necessary to classify obesity on the basis of body fat composition and distribution, rather than the simply increase of body weight, and the Body Mass Index. The new term of adiposopathy(‘‘sick fat'') clearly defines the pathogenic role of adipose tissue. Four phenotypes of obese individuals have been described:(1) normal weight obese(NWO);(2) metabolically obese normal weight;(3) metabolically healthy obese; and(4) metabolically unhealthy obese or "at risk" obese. Moreover, sarcopenic obesity has been related to all the phenotypes. The category of normal weight lean, represented by metabolically healthy normal weight has been classified to distinguish from NWO. It is crucial to recommend a bariatric surgery taking into account adiposopathy and sick fat that occurs with the expansion of fat mass, changing the inflammatory and metabolic profile of the patient. Body fat percentage and genetic polymorphism have to be evaluated to personalize the best bariatric surgery intervention.

关键词： Obesity Adiposopathy Normal weightlean Normal weight obese Metabolically obese normalweight Metabolically healthy obese Metabolicallyhealthy normal weight Metabolically unhealthy obese Laparoscopic gastric banding Fat mass

Next-generation surgicalmeshes for drug delivery and tissue engineering applications:materials,design and emerging manufacturing technologies

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Bio-design and Manufacturing 2021年第2期4卷 278-310页

作者： francesca Corduas Dimitrios A.Lamprou Elena Mancuso Nanotechnology and Integrated Bio-Engineering Centre(NIBEC) Ulster UniversityJordanstown CampusNewtownabbey BT370QBUK School of Pharmacy Queen’s University BelfastBelfast BT97BLUK

Surgical meshes have been employed in the management of a variety of pathological conditions including hernia,pelvic floor dysfunctions,periodontal guided bone regeneration,wound healing and more recently for breast plastic surgery after *** common pathologies affect a wide portion of the worldwide population;therefore,an effective and enhanced treatment is crucial to ameliorate patients’living conditions both from medical and aesthetic points of *** present,non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia,pelvic floor dysfunctions and guided bone regeneration,with polypropylene and poly tetrafluoroethylene being the most *** prostheses,such as surgical grafts,have been employed mainly for breast plastic surgery and wound healing *** the advantages of mesh implants to the treatment of these conditions,there are still many drawbacks,mainly related to the arising of a huge number of post-operative complications,among which infections are the most *** a mesh that could appropriately integrate with the native tissue,promote its healing and constructive remodelling,is the key aim of ongoing research in the area of surgical mesh *** this end,the adoption of new biomaterials including absorbable and natural polymers,the use of drugs and advanced manufacturing technologies,such as 3D printing and electrospinning,are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical *** aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes,the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations.

关键词： 3D printing Electrospinning Manufacturing technologies Biomaterials Drug delivery Surgical mesh implants

What good is the reserve? A translational perspective for the managing of cognitive decline

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Neural Regeneration Research 2019年第7期14卷 1219-1220页

作者： Laura Serra francesca Gelfo Neuroimaging Laboratory IRCCS Fondazione Santa Lucia department of Clinical and Behavioural Neurology IRCCS Fondazione Santa Lucia department of Human Sciences Guglielmo Marconi University

The concept of reserve appears in the neurological literature in the 1940s arising from the observation that there is no linear relationship between neurological damage and severity of the clinical ***,this concept sustains that the experiences pursued during life-span enrich the brain by making it more resilient to neuronal ***,in the last three decades the reserve concept has become very popular in the scientific field,mainly associated with the pathophysiological mechanisms underlying the Alzheimer’s Disease(AD)(Serra et al.,2018;Stern et al.,2018).

关键词： reserve appears neurological literature reserve concept

Human bocavirus: Current knowledge and future challenges

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World Journal of Gastroenterology 2016年第39期22卷 8684-8697页

作者： Marcello Guido Maria Rosaria Tumolo Tiziano Verri Alessandro Romano francesca Serio Mattia de Giorgi Antonella de Donno Francesco Bagordo Antonella Zizza Laboratory of Hygiene Department of Biological and Environmental Sciences and Technologies Faculty of Sciences University of Salento Institute of Clinical Physiology National Research Council Laboratory of Physiology Department of Biological and Environmental Sciences and Technologies University of Salento Neuropathology Unit Institute of Experimental Neurology and Division of Neuroscience IRCCS San Raffaele Scientific Institute

Human bocavirus(HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate(HBoV 1), namely HBoV 2, HBoV 3 and HBoV 4, have been detected principally in human faeces. HBo Vs are small nonenveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1(NS1) and nuclear phosphoprotein(NP1) and the third the viral capsid proteins 1 and 2(VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBo V infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzymelinked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoV s as true pathogen or innocent bystander is also emphasized.

关键词： Human bocavirus Respiratory virus Molecular tests Gastrointestinal virus Pathogenesis Epidemiology Immunoassay methods