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Evidences on adaptive mechanisms for cardiorespiratory diseases regarding extreme temperatures and air pollution:A comparative systematic review

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Geography and Sustainability 2021年第3期2卷 182-194页

作者： Helena Madureira Maria Pacheco Carlos Sousa Ana Monteiro francesca de’-donato Manuela de-Sario department of Geography University of PortoCEGOTPorto 4150-564Portugal Faculty of Arts and Humanities University of PortoPorto 4150-564Portugal department of Geography University of PortoCEGOTCITTAPorto 4150-564Portugal department of Epidemiology Lazio Regional Health ServiceRome 00147Italy

The negative cardiorespiratory health outcomes due to extreme temperatures and air pollution are widely stud-ied,but knowledge about the effectiveness of the implementation of adaptive mechanisms remains *** objective of this paper is to explore the evidence of adaptive mechanisms for cardiorespiratory diseases regard-ing extreme temperatures and air pollution by comparing the results of two systematic literature review(SLR)processes sharing the same initial research question but led by two research groups with different academic back-grounds working in the same multidisciplinary *** start by presenting the methodological procedures and the results of the SLR triggered by the research group mainly composed by researchers with a background in ge-ography(named geographical strategy).We then compare these results with those achieved in the SLR led by the research group with a background in epidemiology(named epidemiological strategy).Both SLR were developed under the EU Horizon 2020 Project“EXHAUSTION”.The results showed:1)the lack of evidence regarding the effectiveness of adaptation measures,namely due to the limited number of studies about the topic,the prepon-derance of studies dedicated to heat extremes or the unbalance between different adaptation measures;2)that the choice of search terms in the geographical strategy,despite being more comprehensive at first sight,ended up retrieving less results,but it brought new studies that can complement the results of the epidemiological ***,it is suggested that to strengthen the empirical evidence of the effectiveness of adaptation measures,powerful multidisciplinary teams should work together in the preparation of SLR in topics of great complexity,such as the one presented in this paper.

关键词： Cardiopulmonary diseases Extreme temperatures Air pollution Adaptation Planning Systematic literature review(SLR)

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Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors:A case report and literature analysis

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World Journal of Gastroenterology 2024年第9期30卷 1253-1256页

作者： francesca Colapietro Nicola Pugliese Antonio Voza Alessio Aghemo Stella de Nicola department of Biomedical Sciences Humanitas UniversityMilan 20072Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Research HospitalMilan 20089Italy department of Emergency Humanitas Research HospitalMilan 20089Italy

Hepatitis B virus(HBV)reactivation(HBVr)represents a severe and potentially life-threatening condition,and preventive measures are available through blood test screening or prophylactic therapy *** assessment of HBVr traditionally considers factors such as HBV profile,including hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen,along with type of medication(chemotherapy;immunomodulants).Nevertheless,consideration of possible patient’s underlying tumor and the specific malignancy type(solid or hematologic)plays a crucial role and needs to be assessed for decision-making process.

关键词： Chronic hepatitis B Reactivation Nucleoside analogue Tyrosine kinase inhibitors Onco-hematology

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Cholesterol business:lifeor death byrust

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1247-1248页

作者： Shubhangi Gavalil francesca Maremonti Andreas Linkermann Division of Nephrology Department of Internal Medicine 3University Hospital Carl Gustav Carus at the Technische Universitat DresdenDresdenGermany Division of Nephrology Department of MedicineAlbert Einstein College of MedicineBronxNYUSA

In two recent manuscripts published in Nature,the cholesterol-synthesis pathway was identified as a master regulator of ferroptosis sensitivity and therefore as a novel therapeutic target.1,2 Ferroptosis does not only represent one way to eliminate cancer cells,but also contributes to acute organ damage in the kidney,heart,brain,and liver,and it kills tissues during the process of organ *** term“ferroptosis”should be defined as a cellular process of iron-catalyzed lipid peroxidation-mediated rupture of the plasma membrane.

关键词： rupture death damage

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Extracellular polymeric substances as paper coating biomaterials derived from anaerobic granular sludge

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Environmental Science and Ecotechnology 2024年第5期21卷 178-186页

作者： Cuijie Feng Lorenzo Bonetti Hui Lu Zhongbo Zhou Tommaso Lotti Mingsheng Jia Giacomo Rizzardi Luigi de Nardo francesca Malpei department of Civil and Environmental Engineering Politecnico di MilanoPiazza Leonardo da Vinci3220133MilanItaly School of Civil Engineering Sun Yat-sen University519082ZhuhaiChina department of Chemistry Materials and Chemical Engineering“G.Natta”Politecnico di MilanoVia Mancinelli720131MilanItaly School of Environmental Science and Engineering Sun Yat-sen University510275GuangzhouChina Southwest University College of Resources and EnvironmentTiansheng Road 2Beibei District400716ChongqingChina Civil and Environmental Engineering department University of FlorenceVia di Santa Marta 350139FlorenceItaly Center for Microbial Ecological and Technology(CMET) Ghent UniversityCoupure Links 653GentBelgium

Recovering extracellular polymeric substances(EPS)from waste granular sludge offers a cost-effective and sustainable approach for transforming wastewater resources into industrially valuable ***,the application potential of these EPS in real-world scenarios,particularly in paper manufacturing,remains *** we show the feasibility of EPS-based biomaterials,derived from anaerobic granular sludges,as novel coating agents in paper *** systematically characterised the rheological properties of various EPS-based *** applied as surface sizing agents,these EPS-based biomaterials formed a distinct,ultra-thin layer on paper,as evidenced by scanning electron microscopy.A comprehensive evaluation of water and oil penetration,along with barrier properties,revealed that EPS-enhanced coatings markedly diminished water absorption while significantly bolstering oil and grease *** performance was observed in EPS variants with elevated protein and hydrophobic contents,correlating with their superior rheological *** enhanced water-barrier and grease resistance of EPS-coated paper can be attributed to its non-porous,fine surface structure and the functional groups in EPS,particularly the high protein content and hydrophobic humic-like *** research marks the first demonstration of utilizing EPS from anaerobic granular sludge as paper-coating biomaterials,bridging a critical knowledge gap in the sustainable use of biopolymers in industrial applications.

关键词： Anaerobic granular sludge Extracellular polymeric substances(EPS) Resource recovery Paper coating

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Is GDNF to Parkinson’s disease what BDNF is to Huntington’s disease?

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Neural Regeneration Research 2024年第5期19卷 973-974页

作者： francesca R.Fusco Emanuela Paldino Laboratory of Neuroanatomy Fondazione Santa Lucia IRCCS HospitalRomeItaly

Neurotrophic factors,or neurotrophins,are a group of molecules supporting the growth,survival,and differentiation of developing and mature *** their role in the survival of neurons,and often of specific subsets of bra... 详细信息

关键词： Huntington supporting degenerative

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Isochronous singing in 3 crested gibbon species(Nomascus spp.)

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Current Zoology 2024年第3期70卷 291-297页

作者： Chiara de Gregorioa Teresa Raimondi Valeria Bevilacqua Chiara Pertosa Daria Valente Filippo Carugati francesca Bandoli Livio Favaro Brice Lefaux Andrea Ravignani Marco Gamba department of Life Sciences and Systems Biology University of Turinvia Accademia Albertina 13Torino 10125Italy department of Biology University of PaduaVia VIII Febbraio2Padova 35122Italy Giardino Zoologico di Pistoia Via Pieve a Celle160/APistoia 5110Italy Botanical and Zoological Garden of Mulhouse 11 Av.de la 1ère Division BlindéeMulhouse 68100France Comparative Bioacoustics Group Max Planck Institute for PsycholinguisticsWundtlaan 1Nijmegen 6525 XDThe Netherlands Center for Music in the Brain Department of Clinical MedicineAarhus UniversityBuilding 1710Universitetsbyen 38000AarhusDenmark department of Human Neuroscience Sapienza University of RomeViale Regina Elena 334Rome 00185Italy

The search for common characteristics between the musical abilities of humans and other animal species is still taking its frst *** of the most promising aspects from a comparative point of view is the analysis of rhythmic components,which are crucial features of human communicative performance but also well-identifable patterns in the vocal displays of other ***,the study of rhythm is becoming essential to understand the mechanisms of singing behavior and the evolution of human *** fndings provided evidence that particular rhythmic structures occur in human music and some singing animal species,such as birds and rock hyraxes,but only 2 species of nonhuman primates have been investigated so far(Indri indri and Hylobates lar).Therefore,our study aims to consistently broaden the list of species studied regarding the presence of rhythmic *** investigated the temporal organization in the singing of 3 species of crested gibbons(Nomascus gabriellae,Nomascus leucogenys,and Nomascus siki)and found that the most prominent rhythmic category was ***,we found slight variation in songs’tempo among species,with *** and *** singing with a temporal pattern involving a gradually increasing tempo(a musical accelerando),and *** with a more regular ***,we show how the prominence of a peak at the isochrony establishes itself as a shared characteristic in the small apes considered so far.

关键词： accelerando isochrony music rhythm singing primates song tempo

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A novel low-cost visual ear tag based identification system for precision beef cattle livestock farming

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Information Processing in Agriculture 2024年第1期11卷 117-126页

作者： Andrea Pretto Gianpaolo Savio Flaviana Gottardo francesca Uccheddu Gianmaria Concheri department of Civil Environmental and Architectural EngineeringUniversity of PaduaItaly department of Animal Medicine Production and HealthUniversity of PadovaItaly department of Industrial Engineering University of PadovaItaly

The precision livestock farming(PLF)has the objective to maximize each animal's performance while reducing the environmental impact and maintaining the quality and safety of meat *** the PLF techniques,the personalised management of each individual animal based on sensors systems,represents a viable *** is worth noting that the implementation of an effective PLF approach can be still expensive,especially for small and medium-sized farms;for this reason,to guarantee the sustainability of a customized livestock management system and encourage its use,plug and play and cost-effective systems are *** this context,we present a novel low-cost method for identifying beef cattle and recognizing their basic activities by a single surveillance *** leveraging the current state-of-the-art methods for real-time object detection,(i.e.,YOLOv3)cattle's face areas,we propose a novel mechanism able to detect the ear tag as well as the water ingestion state when the cattle is close to the *** cow IDs are read by an Optical Character Recognition(OCR)algorithm for which,an ad hoc error correction algorithm is here presented to avoid numbers misreading and correctly match the IDs to only actually present *** to the detection of the tag position,the OCR algorithm can be applied only to a specific region of interest reducing the computational cost and the time *** times for the areas are outputted as cattle activity recognition *** results demonstrate the effectiveness of our proposed method,showing a mAP@0.50 of 89%.

关键词： Precision livestock farming deep learning Cattlei dentification Low-cost sensors Computer vision

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Primary sclerosing cholangitis and cholangiocarcinoma:the 2023 practice guidance and future perspectives

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 172-175页

作者： francesca Saffioti Vasileios K.Mavroeidis department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxfordUK UCL Institute for Liver and Digestive Health University College LondonLondonUK department of HPB Surgery University Hospitals Bristol&Weston NHS Foundation TrustBristol Royal InfirmaryBristolUK department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristolUK

The 2023 practice guidance on primary sclerosing cholangitis(PSC)and cholangiocarcinoma(CCA)of the American Association for the Study of Liver Diseases(AASLD)came as a needful update to the previous 2010 guidelines on PSC,with a first-time inclusion of dedicated guidance on the diagnosis and management of CCA(1,2).This data-supported approach developed by consensus of an expert panel,provides guidance statements based on analytical review of the relevant literature.

关键词： American Association for the Study of Liver Diseases(AASLD) guidelines primary sclerosing cholangitis(PSC) liver cancer biliary cancer

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Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： Rodrigo V.Motta francesca Saffioti Vasileios K Mavroeidis Translational Gastroenterology and Liver Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic *** disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic *** classifications have aimed at providing useful insight of clinically relevant aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious *** comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liver transplant Paediatric

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Genome-resolved metagenomics of Venice Lagoon surface sediment bacteria reveals high biosynthetic potential and metabolic plasticity as successful strategies in an impacted environment

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Marine Life Science & Technology 2024年第1期6卷 126-142页

作者： Elisa Banchi Erwan Corre Paola del Negro Mauro Celussi francesca Malfatti National Institute of Oceanography and Applied Geophysics OGS TriesteItaly FR2424 Station Biologique de RoscoffPlateforme ABiMS(Analysis and Bioinformatics for Marine Science)Sorbonne Universite CNRS29680 RoscoffFrance department of Life Sciences University of TriesteTriesteItaly

Bacteria living in sediments play essential roles in marine ecosystems and deeper insights into the ecology and biogeochemistry of these largely unexplored organisms can be obtained from‘omics’***,we characterized metagenome-assembled-genomes(MAGs)from the surface sediment microbes of the Venice Lagoon(northern Adriatic Sea)in distinct sub-basins exposed to various natural and anthropogenic *** were explored for biodiversity,major marine metabolic processes,anthropogenic activity-related functions,adaptations at the microscale,and biosynthetic gene *** from 126 MAGs,a non-redundant dataset of 58 was compiled,the majority of which(35)belonged to(Alpha-and Gamma-)*** the broad microbial metabolic repertoire(including C,N,and S metabolisms)the potential to live without oxygen emerged as one of the most important *** was also found as a successful *** analysis showed that different MAGs encoded the same metabolic patterns(e.g.,C fixation,sulfate oxidation)thus suggesting metabolic *** and toxic compounds resistance genes were coupled,a condition that could promote the spreading of these genetic *** showed a high biosynthetic potential related to antimicrobial and biotechnological classes and to organism defense and interactions as well as adaptive strategies for micronutrient uptake and cellular *** results highlighted that bacteria living in an impacted environment,such as the surface sediments of the Venice Lagoon,may benefit from metabolic plasticity as well as from the synthesis of a wide array of secondary metabolites,promoting ecosystem resilience and stability toward environmental pressures.

关键词： Antibiotic resistance PAHs Biosynthetic gene clusters Microscale Mobilome Resistome

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