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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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A novel method to predict static transmission error for spur gear pair based on accuracy grade

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Journal of Central South University 2020年第11期27卷 3334-3349页

作者： LIU Chang SHI Wan-kai francesca Maria CURÀ Andrea MURA State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400044China Department of Mechanical and Aerospace Engineering Politecnico di TorinoTorino 10129Italy

This paper proposes a novel method to predict the spur gear pair’s static transmission error based on the accuracy grade,in which manufacturing errors(MEs),assembly errors(AEs),tooth deflections(TDs)and profile modifications(PMs)are *** the prediction,a discrete gear model for generating the error tooth profile based on the ISO accuracy grade is ***,the gear model and a tooth deflection model for calculating the tooth compliance on gear meshing are coupled with the transmission error model to make the prediction by checking the interference status between gear and *** prediction method is validated by comparison with the experimental results from the literature,and a set of cases are simulated to study the effects of MEs,AEs,TDs and PMs on the static transmission *** addition,the time-varying backlash caused by both MEs and AEs,and the contact ratio under load conditions are also *** results show that the novel method can effectively predict the range of the static transmission error under different accuracy *** prediction results can provide references for the selection of gear design parameters and the optimization of transmission performance in the design stage of gear systems.

关键词： gear transmission error time-varying backlash prediction method accuracy grade

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p-Multigrid Method for Fekete-Gauss Spectral Element Approximations of Elliptic Problems

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Communications in Computational Physics 2009年第2期5卷 667-682页

作者： Richard Pasquetti francesca Rapetti Laboratoire J.A.Dieudonne UMR 6621 CNRSUniversite de Nice Sophia-AntipolisParc Valrose06108 Nice cedex 02France

An efficient p-multigrid method is developed to solve the algebraic systems which result from the approximation of elliptic problems with the so-called FeketeGauss Spectral Element Method,which makes use of the Fekete points of the triangle as interpolation points and of the Gauss points as quadrature points.A multigrid strategy is defined by comparison of different prolongation/restriction operators and coarse grid algebraic *** efficiency and robustness of the approach,with respect to the type of boundary condition and to the structured/unstructured nature of the mesh,are highlighted through numerical examples.

关键词： Spectral elements Fekete points multigrid methods

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Hepatitis B virus and hepatitis C virus dual infection

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World Journal of Gastroenterology 2014年第40期20卷 14559-14567页

作者： Gaia Caccamo francesca Saffioti Giovanni Raimondo Division of Clinical and Molecular Hepatology Department of Internal Medicine University Hospital of Messina 98124 Messina Italy

Hepatitis B virus(HBV)and hepatitis C virus(HCV)share common mode of transmission and both are able to induce a chronic *** HBV/HCV chronic coinfection is a fairly frequent occurrence,especially in high endemic areas and among individuals at high risk of parenterally transmitted *** intracellular interplay between HBV and HCV has not yet been sufficiently clarified,also due to the lack of a proper in vitro cellular *** evaluation of serum HBV DNA and HCV RNA amounts has revealed that complex virological profiles may be present in coinfected *** HBV/HCV infection has been associated to a severe course of the liver disease and to a high risk of developing hepatocellular *** the clinical importance,solid evidence and clear guidelines for treatment of this special population are still *** review summarizes the available data on the virological and clinical features as well as the therapeutic options of the dual HBV/HCV infection,and highlights the aspects that need to be better clarified.

关键词： Hepatitis B virus/hepatitis C virus coinfection Chronic hepatitis Viral interaction Cirrhosis Hepatocellular carcinoma Antiviral therapy

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Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1040-1042页

作者： francesca Fagiani Michele Catanzaro Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Scuola Universitaria Superiore IUSS Pavia P.zza Vittoria1527100 PaviaItaly

An elegant paper by Yuan et al.,recently published in Science,provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： al acute respiratory

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Fekete-Gauss Spectral Elements for Incompressible Navier-Stokes Flows:The Two-Dimensional Case

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Communications in Computational Physics 2013年第5期13卷 1309-1329页

作者： Laura Lazar Richard Pasquetti francesca Rapetti Lab.J.A.Dieudonne UMR 7351 CNRS UNSUniversite de Nice-Sophia Antipolis06108 Nice Cedex 02France

Spectral element methods on simplicial meshes,say TSEM,show both the advantages of spectral and finite element methods,i.e.,spectral accuracy and geometrical *** present a TSEM solver of the two-dimensional(2D)incompressible Navier-Stokes equations,with possible extension to the 3D *** uses a projection method in time and piecewise polynomial basis functions of arbitrary degree in *** so-called Fekete-Gauss TSEM is employed,i.e.,Fekete(***)points of the triangle are used as interpolation(***)*** the sake of consistency,isoparametric elements are used to approximate curved *** resolution algorithm is based on an efficient Schur complement method,so that one only solves for the element boundary ***,the algebraic system is never assembled,therefore the number of degrees of freedom is not *** accuracy study is carried out and results are provided for classical benchmarks:the driven cavity flow,the flow between eccentric cylinders and the flow past a cylinder.

关键词： Spectral elements simplicial meshes Fekete-Gauss approximation Navier-Stokes equations projection methods domain decomposition

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Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules

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Translational Neurodegeneration 2022年第1期11卷 161-177页

作者： francesca Natale Salvatore Fusco Claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro Cuore00168 RomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS 00168 RomeItaly.

Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of *** them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,representing the most disabling symptom on both personal and social *** molecular mechanisms underlying the onset and progression of dementia are still poorly understood,and include secretory factors potentially affecting differentiated neurons,glial cells and neural stem cell *** the last decade,much attention has been devoted to exosomes as novel carriers of information exchanged among both neighbouring and distant *** vesicles can be generated and internalized by different brain cells including neurons,neural stem cells,astrocytes,and microglia,thereby affecting neural plasticity and cognitive functions in physiological and pathological ***,we review data on the roles of exosomes as carriers of bioactive molecules potentially involved in the pathogenesis of neurodegenerative disorders and detectable in biological fluids as biomarkers of *** also discuss the experimental evidence of the therapeutic potential of stem cell-derived vesicles in experimental models of neurodegeneration-dependent cognitive decline.

关键词： Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline

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Prediction of Weyl semimetal and antiferromagnetic topological insulator phases in Bi_(2)MnSe_(4)

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npj Computational Materials 2019年第1期5卷 867-873页

作者： Sugata Chowdhury Kevin F.Garrity francesca Tavazza Materials Measurement Laboratory National Institute for Standards and TechnologyGaithersburgMD 20899USA

Three-dimensional materials with strong spin–orbit coupling and magnetic interactions represent an opportunity to realize a variety of rare and potentially useful topological phases with broken time-reversal *** this work,we use first principles calculations to show that the recently synthesized material Bi_(2)MnSe_(4) displays a combination of spin–orbit-induced band inversion,also observed in non-magnetic topological insulator Bi2PbSe4,with magnetic interactions,leading to several topological *** bulk form,the ferromagnetic phase of Bi_(2)MnSe_(4) has symmetry protected band crossings at the Fermi level,leading to either a nodal line or Weyl semimetal,depending on the direction of the *** to the combination of time reversal symmetry plus a partial translation,the ground state layered antiferromagnetic phase is instead an antiferromagnetic topological *** surface of this phase intrinsically breaks time-reversal symmetry,allowing the observation of the half-integer quantum anomalous Hall ***,we show that in thin film form,for sufficiently thick slabs,Bi_(2)MnSe_(4) becomes a Chern insulator with a band gap of up to 58 *** combination of properties in a stoichiometric magnetic material makes Bi_(2)MnSe_(4) an excellent candidate for displaying robust topological behavior.

关键词： topological insulator symmetry

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Does kinship affect spatial organization in a small and isolated population of a solitary felid: The Eurasian lynx?

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Integrative Zoology 2016年第5期11卷 334-349页

作者： Krzysztof SCHMIDT francesca DAVOLI Rafał KOWALCZYK Ettore RANDI Mammal Research Institute Polish Academy of SciencesBiałowieżaPoland Laboratory of Genetics Institute for Environmental Protection and ResearchOzzano EmiliaItaly Aalborg University Department of BiotechnologyChemistry and Environmental EngineeringAalborgDenmark

Social organization in wild carnivores is mostly determined by patterns of family bonds,which may shape the degree of relatedness among individuals in the *** studied kinship in a small and isolated population of a solitary carnivore,the Eurasian lynx(Lynx lynx)to evaluate its effect on spatial distribution of *** investigated the relationship between spatial location and pair-wise kinship among 28 lynx individuals identified in 2004-2011 by telemetry,non-invasive sampling and genotyping with the use of 12 autosomal microsatellites in the Białowieża Primeval Forest,*** average relatedness of the lynx population was relatively low(Lynch and Ritland’s R=0.03).Females were significantly more related to each other than males with other *** inferred pedigree showed that the population was dominated by only 2 familial *** did not find significant correlations between the relatedness and the extent of home range overlap or the straight-line distances between the home ranges’central *** results suggest that the dynamics of kinship in this solitary felid may not differ from the random mating processes described in social *** the chances of random mating could be limited to a few resident males and females,the presence of unrelated floaters may provide a“breeding buffer”that may prevent an increase of relatedness and likely inbreeding in the pop*** system is likely to fail in preserving genetic diversity in small,highly isolated populations;therefore,restoring habitat connectivity is crucial to ensure sufficient immigration from neighboring populations.

关键词： genetic variability inbreeding mating system relatedness social organization

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Lingo-1: a novel target in therapy for Alzheimer's disease?

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Neural Regeneration Research 2016年第1期11卷 88-89页

作者： francesca Fernandez-Enright Jessica L.Andrews Illawarra Health and Medical Research Institute Centre for Medical and Molecular Bioscience Faculty of Science Medicine and Health University of Wollongong School of Psychology Faculty of Social Sciences University of Wollongong

Unraveling the causes underlying Alzheimer’s disease（AD）is certainly one of the greatest challenges of this century for *** advances in medicine and technology,the world is experiencing a demographic shift towards a growing elderly *** this increasingly ageing population,the number of individuals being affected by AD is *** has a significant negative impact on the lives of the individuals with the disorder,as well as creating a significant social andeconomic burden for society.

关键词： lives advances neuronal demographic challenges elderly creating amyloid underlying processed

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