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心理学报 2008年第10期40卷 1124-1134页

作者： Gordon T. Harold Katherine H. Shelton frances rice Jacky Boivin Dale Hay Marianne Van Den Bree Anita Thapar School of Psychology Cardiff UniversityUnited Kingdom Department of Psychological Medicine School of MedicineCardiff UniversityUnited Kingdom

本文介绍一个可以用于研究遗传与环境互动的新颖方法。此研究收集了上千个4～10岁儿童的数据。这些儿童的出生都借助于不同的辅助受孕技术（Assisted Reproductive Technologies），包括试管婴儿、精子捐赠、卵子捐赠、胚胎捐赠及代孕... 详细信息

本文介绍一个可以用于研究遗传与环境互动的新颖方法。此研究收集了上千个4～10岁儿童的数据。这些儿童的出生都借助于不同的辅助受孕技术（Assisted Reproductive Technologies），包括试管婴儿、精子捐赠、卵子捐赠、胚胎捐赠及代孕技术。本项目通过妇科（助孕）医院收集被试的行为数据，包括家庭互动、养育方式、父母婚姻质量、家庭成员的心理健康及经济状况等。本文选择性地介绍一些分析的结果，以彰显这种设计在分离遗传和产前产后环境对儿童发展的贡献。首先，我们比较了“助孕”儿童与“自然孕”儿童在父母冲突、父母对子女敌意以及儿童抑郁症状之间关系的异同。其次，我们比较了这两组儿童在父母抑郁症状、家庭关系质量以及儿童抑郁症状之间关系的异同。再次，本文介绍了这一可分离遗传与环境因素的研究设计。最后，我们讨论了这一设计对发展心理病干预及预防的意义。

关键词：辅助受孕技术家庭关系遗传与环境互动

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Genetic mapping of QTL for agronomic traits and grain mineral elements in rice

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The Crop Journal 2019年第4期7卷 560-572页

作者： Gwen Iris Descalsota-Empleo Amery Amparado Mary Ann Inabangan-Asilo frances Tesoro James Stangoulis Russell Reinke B.P.Mallikarjuna Swamy Strategic Innovation Platform International Rice Research Institute (IRRI) Metro Manila 1226 Philippines Department of Plant Breeding and Genetics College of Agriculture University of Southern Mindanao Kabacan 9407 Cotabato Philippines College of Science and Engineering Flinders University Adelaide 5001 Australia

Malnutrition is one of the prevailing health problems worldwide, affecting a large proportion of the populations in rice-consuming countries. Breeding rice varieties with increased concentrations of elements in the grain is considered the most cost-effective approach to alleviate malnutrition. Development of molecular markers for high grain concentrations of essential elements, particularly Zn, for use in marker-assisted selection (MAS) can hasten breeding efforts to develop rice varieties with nutrient-dense grain. We performed QTL mapping for four agronomic traits: days to 50% flowering, plant height, number of tillers, grain yield, and 13 grain elements: As, B, Ca, Co, Cu, Fe, K, Mg, Mn, Mo, Na, P, and Zn, in two doubled-haploid populations derived from the crosses IR64 × IR69428 and BR29 × IR75862. These populations were phenotyped during 2015DS and 2015WS at IRRI, Los Ba os, The Philippines, and genotyped them with a 6 K SNP chip. Inclusive composite interval mapping revealed 15 QTL for agronomic traits and 50 QTL for grain element concentration. Of these, eight QTL showed phenotypic variance of >25% and 11 QTL were consistent across seasons. There were seven QTL co-localization regions containing QTL for more than two traits. Twenty five epistatic interactions were detected for two agronomic traits and seven mineral elements. Several DH lines with high Fe and Zn in polished rice were identified. These lines can be used as donors for breeding high-Zn rice varieties. Some of the major QTL can be further validated and used in MAS to improve the concentrations of nutritive elements in rice grain.

关键词： rice Quantitative trait loci Biofortification Mineral elements DH Epistasis

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Precision health: A nursing perspective

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International Journal of Nursing Sciences 2020年第1期7卷 5-12页

作者： Mei R.Fu Emma Kurnat-Thoma Angela Starkweather Wendy A.Henderson Ann K.Cashion Janet K.Williams Maria C.Katapodi Karin Reuter-rice Kathleen T.Hickey Veronica Barcelona de Mendoza Kathleen Calzone Yvette P.Conley Cindy M.Anderson Debra E.Lyon Michael T.Weaver Pamela K.Shiao Rose E.Constantino Shu-Fen Wung Marilyn J.Hammer Joachim G.Voss Bernice Coleman William F.Connell School of Nursing Boston CollegeChestnut HillMAUSA National Institute of Nursing Research National Institutes of HealthBethesdaMDUSA School of Nursing and Health Studies Georgetown UniversityWashingtonDCUSA School of Nursing University of ConnecticutStorrsCTUSA School of Nursing The University of IowaIowa CityIAUSA Nursing Science University of BaselBaselSwitzerland School of Nursing Duke UniversityDurhamNCUSA School of Nursing Columbia UniversityNew YorkNYUSA School of Nursing Yale UniversityOrangeCTUSA National Cancer Institute Center for Cancer ResearchGenetic BranchBethesdaMDUSA School of Nursing University of PittsburghPittsburghPAUSA College of Nursing The Ohio State UniversityOHUSA University of Florida Gainesville FLUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugusta UniversityAugustaGAUSA College of Nursing The University of Arizona TucsonAZUSA Dana-Farber Cancer Institute 450 Brookline AvenueLW523BostonMAUSA frances Payne Bolton School of Nursing Case Western Reserve UniversityClevelandOHUSA Nursing Research and Development Cedars-Sinai Medical CenterLos AngelesUSA

Precision health refers to personalized healthcare based on a person's unique genetic,genomic,or omic composition within the context of lifestyle,social,economic,cultural and environmental influences to help individuals achieve well-being and optimal *** health utilizes big data sets that combine omics(*** sequence,protein,metabolite,and microbiome information)with clinical information and health outcomes to optimize disease diagnosis,treatment and prevention specific to each *** implementation of precision health requires interprofessional collaboration,community outreach efforts,and coordination of care,a mission that nurses are well-positioned to *** the surge of interest and attention to precision health,most nurses are not well-versed in precision health or its implications for the nursing *** on a critical analysis of literature and expert opinions,this paper provides an overview of precision health and the importance of engaging the nursing profession for its *** topics reviewed in this paper include big data and omics,information science,integration of family health history in precision health,and nursing omics research in symptom *** paper concludes with recommendations for nurse leaders in research,education,clinical practice,nursing administration and policy settings for which to develop strategic plans to implement precision health.

关键词： Nurses Genomics Omics Precision medicine Precision health

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Genetic mapping of QTL for agronomic traits and grain mineral elements in rice

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The Crop Journal 2019年第4期

作者： Gwen Iris Descalsota-Empleo Amery Amparado Mary Ann Inabangan-Asilo frances Tesoro James Stangoulis Russell Reinke B.P. Mallikarjuna Swamy Strategic Innovation Platform，International rice Research Institute (IRRI) Department of Plant Breeding and Genetics，College of Agriculture，University of Southern Mindanao College of Science and Engineering，Flinders University

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The Genomic Variation of 3,000 diverse rice (Oryza sativa L.)Accessions:Discoveries And Applications In rice Improvement

The Genomic Variation of 3,000 diverse Rice (Oryza sativa L....

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2018中国作物学会学术年会

作者：黎志康 Fan Zhang Whensheng Wang Ramil Mauleon Zhiqiang Hu Dmytro Chebotarov Shuaishuai Tai Zhichao Min Li Tianqing Zheng Roven Rommel Fuentes Locedie Mansueto Dario Copetti Millicent Sanciangco Kevin Christian Palis Jianlong Xu Chen Sun Hongliang Zhang Binying Fu Yongming Gao Xiuqin Zhao Fei Shen Xiao Cui Hong Yu Zichao Li Miaolin Chen Jeffery Detras Yongli Zhou Xinyuan Zhang Yue Zhao Dave Kudrna Chunchao Wang Rui Li Ben Jia Jinyuan Lu Xianchang He Zhaotong Dong Jiabao Xu Yanhong Li Miao Wang Jianxin Shi Jing Li Dabing Zhang Seunhee Lee Wushu Hu Alexander Poliakov Inna Dubchak Victor Jun Ulat frances Nikki Borja John Robert Mendoza Jauhar Ali Ming Yang Yongchao Niu Zhen Yue Ma.Elizabeth B.Naredo Jayson Talag Xueqiang Wang Jinjie Li Xiaodong Fang Ye Yin Jean-Christophe Glaszmann Jianwei Zhang Jiayang Li Ruaraidh Sackville Hamilton Rod A.Wing Chaochun Wei Jue Ruan Gengyun Zhang Kenneth L.Mcnally Nickolai Alexandrov Hei Leung Hei Institute of Crop Sciences Chinese Academy of Agricultural Sciences Shenzhen Institute for Innovative Breeding Chinese Academy of Agricultural Sciences International rice Research Institute School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai Center for Bioinformation Technology BGI Genomics BGI-Shenzhen Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Anhui Agricultural University Arizona Genomics Institute School of Plant SciencesUniversity of Arizona China Agricultural University Institute of Genetics and Developmental Biology Chinese Academy of Sciences Lawrence Berkeley National Laboratory

Asian cultivated rice(Oryza sativa L.) is the staple food for the half world population with rich within species *** analyses of the genome resequencing data of a core collection of 3,010 rice accessions revealed four important aspects of the genomic diversity within ***,over 42 million SNPs and >3 million small InDels were discovered against five reference ***,we discovered more than 90,000 structural(>100 bps) variations(SVs) when compared with the Geng reference genome,consisting primarily of small-sized deletions and translocations,plus many duplications and *** SVs accounted for significant portion of the rice genome and involved most(～80%) rice ***,we discovered >12,000 full-length novel protein-coding genes plus 9000+ novel genes of partial sequences that are absent in the Nipponbare reference *** rice pan genome consists of ～62%core genes/gene families that are present in all rice lines,and ～38%distributed genes that are present only some of rice ***,using large-effect SNPs and InDels of all loci in the PG,a rice functional haplotype database was *** SNP,PG and SV variation clearly resolve the 3,010 rice accessions into two major subspecies,Xian(indica) and Geng(japonica),plus Aus and Aro groups and multiple subpopulations within Xian and *** reduced diversity was found in genomic regions where over 1,000 agronomically important and domestication-related genes *** efforts have been taken to identify and mine genes/QTLs/alleles associated with a wide range of important traits in rice using the 3 k materials and SNP *** demonstrate how the results of the 3 k RGP could be used in rice improvement,genomic constitutions of 476 BC F introgression lines(ILs) from our breeding program were constructed using high-quality reference genomes of their 9 parents and the 3 k RGP *** compared with their recurrent parent,Huang-hua-

关键词： rice genome diversity population structure pan genomes genomics-based breeding by design

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