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Massive abdominal muscle atrophy during prolonged mechanical ventilation: Implications for tracheostomy removal

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Journal of Intensive Medicine 2024年第1期4卷 133-135页

作者： Pascal Beuret Florian Michelin Audrey Tientcheu Laurane Chalvet Benedicte Philippon-jouve Jean-Charles Chakarian Xavier Fabre Service de Réanimation et Soins continus Centre Hospitalier de RoanneRoanneFrance

Introduction Maintaining the functional integrity of respiratory muscles is crucial for critically ill patients to be weaned from mechanical ventilation and decannulated if *** of the diaphragm is frequent in patients under mechanical ventilation and has been associated with a longer duration of weaning.[1,2]Studies on expiratory muscles are *** recent studies demonstrated the feasibility and reproducibility of ultrasound in measuring the thickness of abdominal muscles,[3,4]with one study showing abdominal muscle atrophy in 22%of mechanically ventilated critically ill patients during the first week of mechanical ventilation.[4]

关键词： critically mechanical abdominal

Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa

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Asian Journal of Andrology 2019年第6期21卷 570-576页

作者： Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel Univ Rennes CHU RennesLaboratoire de Biologie de la Reproduction-CECOSInsermEH ESPIrset(Institut de recherche en santeenvironnement et travail)-UMR_S 1085Rennes F-35000France Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences194223 St-PetersburgRussia Univ Rennes Biosit Platform-MRICRennes 35000France Univ Rennes CHU RennesDepartment of Gynecology Obstetric and Human ReproductionRennes 35000France Univ Rennes CHU RennesDepartment of CytogeneticIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes 35000France Univ Rennes InsermEH ESPIrset(Institute for Environmental and Occupational Health)-UMR_S 1085Rennes F-35000France University of Poitiers-CHU Poitiers STIM ERL 7003 CNRSPoitiers 86021France

Autophagy is invoIved in spermatogenesis by regulating germ cell *** catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged *** is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in *** aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid *** samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron *** protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm ***3 was also detected in the midpiece of cryptorchid sperm *** substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid *** electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid *** degraded mitochondria were frequently discerned in autophagic *** conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to *** work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological ***,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men.

关键词： autophagy cryptorchidism mitophagy spermatozoa

Spinal alignment evolution with age:A prospective gait analysis study

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World Journal of Orthopedics 2017年第3期8卷 256-263页

作者： Sébastien Pesenti Benjamin Blondel Emilie Peltier Elke Viehweger Vincent Pomero Guillaume Authier Stéphane Fuentes Jean-Luc jouve Pediatric orthopedics Timone Enfants Aix-Marseille University Institute of Movement Sciences (CNRS UMR 7287) Gait Analysis Laboratory Hopital Timone Enfants Aix-Marseille University Spine Unit Hopital de la Timone Spine unit Timone Aix-Marseille University Neurosurgery Timone Enfants Aix-Marseille University

AIM To describe,using gait analysis,the development of spinal motion in the growing *** Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis(9m-walk).Various kinematic parameters were recorded and analyzed such as thoracic angle(TA),lumbar angle(LA)and sagittal vertical axis(SVA).The kinetic parameters were the net reaction moments(N.m/kg)at the thoracolumbar and lumbosacral *** TA and LA curves were not statistically correlated to the age(respectively,P=0.32 and P=0.41).SVA increased significantly with age(P<0.001).Moments in sagittal plane at the lumbosacral junction were statistically correlated to the age(P=0.003),underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with *** in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age(P=0.0002and P=0.0006),revealing that transversal mechanical constraints decrease with *** The kinetic analysis showed that during growth,a decrease of torsional constraint occurs while an increase of sagittal constraint is *** changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition,allowing stabilization despite lower limbs *** the acquisition of mature gait,the spine will mainly undergo constraints in the sagittal plane.

关键词： Sagittal balance Spine biomechanics Gait analysis Thorcic kyphosis Spine growth

Small bowel entrapment and ureteropelvic junction disruption associated with L3 Chance fracture-dislocation

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World Journal of Clinical Cases 2016年第9期4卷 264-268页

作者： Sebastien Pesenti Benjamin Blondel Alice Faure Emilie Peltier franck Launay Jean-Luc jouve Pediatric Orthopaedics Hopital d'Enfants de la TimoneAix Marseille University Spine Unit Aix Marseille University Pediatric Surgery H?pital NordAix-Marseille University

Paediatric Chance fracture are rare lesions but often associated with abdominal injuries. We herein present the case of a seven years old patient who sustained an entrapment of small bowel and an ureteropelvic disruption associated with a Chance fracture and spine dislocation following a traffic accident. Initial X-rays and computed tomographic(CT) scan showed a Chance fracture with dislocation of L3 vertebra, with an incarceration of a small bowel loop in the spinal canal and a complete section of the left lumbar ureter. Paraplegia was noticed on the initial neurological examination. A posterior L2-L4 osteosynthesis was performed firstly. In a second time she underwent a sus umbilical laparotomy to release the incarcerated jejunum loop in the spinal canal. An end-toend anastomosis was performed on a JJ probe to suture the left injured ureter. One month after the traumatism, she started to complain of severe headaches related to a leakage of cerebrospinalis fluid. Three months after the traumatism there was a clear regression of the leakage. One year after the trauma, an anterior intervertebral fusion was done. At final follow-up, no neurologic recovery was noticed. In case of Chance fracture, all physicians should think about abdominal injuries even if the patient is asymptomatic. Initial abdominal CT scan and magnetic resonance imaging provide in such case crucial info for management of the spine and the associated lesions.

关键词： Chance fracture Uretero-pelvic disruption Small bowel injuries Seatbelt Dural tear

老年性眉毛和前额的治疗:肉毒杆菌毒素剂量效应的研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 11-12页

作者： Levy J.L. Pons F. jouve E. 罗素菊 Centre Laser Dermatologique 3 Bd Lord Duveen13008 MarseilleFrance

Objective:To determine if clinical use of two different doses of botulinum exotoxin A(BTX-A)injections to the forehead area result in wrinkle reduction and modifications of eyebrow ***:Prospective *** Private practice,Dermatologic Laser Centre,Marseille,***:Twenty-four adult patients treated with BTX-A(Vistabel)-injections for forehead ***:Of the 24 patients,12 received BTX-A injections of 5 U only and 12 received injections of 10 U into the forehead,with or without treatment of the lateral *** eyebrow position,forehead height and number of forehead lines determine the number of injection *** were evaluated before injection and every 2 months after treatment during next 8 ***:In the two groups of 12 patients,we found no significant change between the two *** each time after injections(every 2 months until 8 months),both groups showed a statistically significant improvement except at 8 *** groups exhibited the same results on standardized photos and on 3D skin ***:The two doses of BTX-A injections into the forehead gave the same *** duration of the effect is similar along 8 *** study emphasizes the role of low doses of BTX-A injections to obtain good clinical results without freezing aspect.

关键词：肉毒杆菌毒素剂量效应肉毒杆菌外毒素激光治疗中心注射点私人诊所法国马赛临床疗效持续时间

Postural spinal balance defined by net intersegmental moments: Results of a biomechanical approach and experimental errors measurement

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World Journal of Orthopedics 2015年第11期6卷 983-990页

作者： Benjamin Blondel Elke Viehweger Bertrand Moal Patrick Tropiano Jean-Luc jouve Virginie Lafage Raphael Dumas Stéphane Fuentes Gérard Bollini Vincent Pomero Laboratoire d’analyse du mouvement Spine UnitUniversité Aix-Marseille Ecole Doctorale 463 Sciences du Mouvement HumainUniversité Aix-Marseille Department of Spine Surgery Hospital for Joint DiseasesNew-York University Université de Lyon IFSTTAR LBMC Université Lyon 1 LBMC

AIM: To describe initial results and experimental error measurement of a protocol analyzing Human posture through sagittal intersegmental moments. METHODS: Postural analysis has been recently improved by development of three-dimensional radiographic imaging systems. However, in various situations such as global sagittal anterior malalignment interpretation of radiographs may not represent the real alignment of the subject. The aim of this study was to present initial results of a 3D biomechanical protocol. This protocol isobtained in a free standing position and characterizes postural balance by measurement of sagittal intersegmental net moments. After elaboration of a specific marker-set, 4 successive recordings were done on two volunteers by three different operators during three sessions in order to evaluate the experimental error measurement. A supplementary acquisition in a "radiographic" posture was also obtained. Once the data acquired, joint center, length, anatomical frame and the center of mass of each body segment was calculated and a mass affected. Sagittal net intersegmental moments were computed in an ascending manner from ground reaction forces at the ankles, knees, hips and the lumbosacral and thoraco-lumbar spinal junctions. Cervicothoracic net intersegmental moment was calculated in a descending ***: Based on average recordings, clinical interpretation of net intersegmental moments(in N.m) showed a dorsal flexion on the ankles(8.6 N.m), a flexion on the knees(7.5 N.m) and an extension on the hips(8.5 N.m). On the spinal junctions, it was flexion moments: 0.34 N.m on the cervico-thoracic; 6.7 N.m on the thoraco-lumbar and 0.65 N.m on the lumbo-sacral. Evaluation of experimental error measurement showed a small inter-trial error(intrinsic variability), with higher inter-session and inter-therapist errors but without important variation between them. For one volunteer the "radiographic" posture was associated to significant changes compared

关键词： Posture Sagittal alignement Biomechanical evaluation Intersegmental net moments