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院内泌尿系感染病原菌及耐药性研究

中华医院感染学杂志 2008年第4期18卷 592-593页

作者：武怀书额尔敦卡索赵立强解放军253医院感染控制科内蒙古呼和浩特010051

目的调查院内尿路感染病原菌的现状及体外耐药性,为临床医生提供诊断和治疗依据。方法对2004年1月-2006年1月住院患者尿液培养中分离出的213株病原菌进行鉴定和体外耐药性试验。结果泌尿系感染菌株以大肠埃希菌(eCO)为主,占34.3%;其次... 详细信息

目的调查院内尿路感染病原菌的现状及体外耐药性,为临床医生提供诊断和治疗依据。方法对2004年1月-2006年1月住院患者尿液培养中分离出的213株病原菌进行鉴定和体外耐药性试验。结果泌尿系感染菌株以大肠埃希菌(eCO)为主,占34.3%;其次为表皮葡萄球菌(SeP)、肠球菌属(eCN)、产气肠杆菌(eAe)、铜绿假单胞菌(PAe)、真菌;肠杆菌科对抗菌药物耐药率均较严重;革兰阳性球菌耐药率也相当严重。结论泌尿系感染最主要病原菌为大肠埃希菌,由于病原菌耐药率呈上升趋势,合理使用抗菌药物,重视病原菌的培养和药敏,是预防医院感染的重要措施。

关键词：泌尿系感染病原菌抗菌药物耐药性

单辊快速凝固法制备Co-Cu-Pb合金颗粒的结构与形成机制

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粉末冶金材料科学与工程 2016年第6期21卷 862-869页

作者：高卡郭晓琴张锐郑州航空工业管理学院航空材料河南省重点实验室郑州450015 郑州大学材料科学与工程学院郑州450001

摘要：分别以Co47.5Cu47.5Pb5和Co42.5Cu42.5Pb15三元偏晶合金作为母合金，采用单辊法急冷快速凝固制备Co—Cu—Pb三元难混溶合金颗粒，对颗粒的微观组织结构与尺寸进行观察与分析，并对不同结构颗粒的形成机制进行研究。结果表明：Co-C... 详细信息

摘要：分别以Co47.5Cu47.5Pb5和Co42.5Cu42.5Pb15三元偏晶合金作为母合金，采用单辊法急冷快速凝固制备Co—Cu—Pb三元难混溶合金颗粒，对颗粒的微观组织结构与尺寸进行观察与分析，并对不同结构颗粒的形成机制进行研究。结果表明：Co-Cu-Pb合金颗粒的直径为70～600μm，得到实心颗粒、空心颗粒及多层壳核结构3种不同结构的颗粒。Co-Cu-P合金颗粒发生包晶反应形成富Co（Cu）相的初生枝晶，富Pb相主要富集于枝晶间隙处。随辊面线速度从15m／s增大到30m／s，初生Co（Cu）相枝晶发生粗大枝晶→细小等轴晶的转变，合金颗粒的凝固组织显著细化，并且由于液态难混溶合金发生Marangoni运动，形成快速凝固多层壳核结构，最终获得均质化的Co-Cu-P合金凝固组织。

关键词：金属材料 Co-Cu-P合金颗粒快速凝固壳核结构组织形态形成机制

茜草属药用植物茜草大叶茜草和小红参的比较研究

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时珍国医国药 2017年第4期28卷 892-895页

作者：陈燕芳卞卡上海中医药大学穆拉德中药现代化研究中心上海201203 美国乔治华盛顿大学生物化学与分子生物学系华盛顿特区华盛顿20052

2015版《中国药典》规定茜草为茜草科茜草属多年生草本植物茜草Rubia cordifolia L.的干燥根及根茎。从考证商品药材茜草的原植物基源出发,对茜草、大叶茜草和小红参等3种茜草属药用植物的形态特征、药材性状及显微特征加以鉴定比较,结... 详细信息

2015版《中国药典》规定茜草为茜草科茜草属多年生草本植物茜草Rubia cordifolia L.的干燥根及根茎。从考证商品药材茜草的原植物基源出发,对茜草、大叶茜草和小红参等3种茜草属药用植物的形态特征、药材性状及显微特征加以鉴定比较,结合薄层层析和DNA条形码技术等方法学在茜草属药用植物鉴定中的应用,为茜草药材及其原植物的鉴别,以及同属药用植物的比较研究提供参考。

关键词：茜草大叶茜草小红参比较鉴别

CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation

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Cellular & Molecular Immunology 2023年第2期20卷 201-213页

作者： Ana Jordan-Paiz Glòria Martrus Fenja L.Steinert Max kaufmann Adrian F.Sagebiel Renée R.C.e.Schreurs Anne Rechtien Martin e.Baumdick Johannes M.Jung kimberly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer Jennifer Schroeder-Schwarz Johannes Bvan Goudoever Teunis B.H.Geijtenbeek Marcus Altfeld Steven T.Pals Daniel Perez Paul L.klarenbeek Christian Tomuschat Guido Sauter Ingo königs Udo Schumacher Manuel A.Friese Nathaniel melling konrad Reinshagen Madeleine J.Bunders Department of Virus Immunology Leibniz Institute of VirologyHamburg20251Germany University medical Center Hamburg-eppendorf Hamburg20246Germany Institute of Neuroimmunology and Multiple Sclerosis Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburg20251Germany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburg20246Germany Department of experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam1105 AZThe Netherlands I.Department of medicine University Medical Center Hamburg-EppendorfHamburg20246Germany Partner Site Hamburg-Lübeck-Borstel-Riems German Center for Infection Research(DZIF)Hamburg20246Germany University of Bordeaux Institut National de la Santéet de la Recherche MédicaleBordeaux Population Health Research Center UMR1219 and INRIA SISTM TeamBordeaux33000France Institute of Anatomy and experimental Morphology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Rheumatology and Clinical Immunology and Department of experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1007 MBThe Netherlands Amsterdam Rheumatology&Immunology Center Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatric Surgery University Medical Center Hamburg-EppendorfHamburg20246Germany Institute of Pathology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pediatric Surgery Altona Children’s HospitalHamburg22763Germany III.Department of medicine University M

Gastrointestinal infections are a major cause for serious clinical complications in *** induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human *** CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to *** findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to ***-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B *** together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.

关键词： TFH cells B cells Antibodies Intestine Pediatrics

Processing and characterization of lead-free ceramics on the base of sodium-potassium niobate

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Journal of Advanced Dielectrics 2018年第1期8卷 29-36页

作者： e.D.Politova N.V.Golubko G.M.ka.eva A.V.Mosunov N.V.Sadovskaya S.Yu.Stefanovich D.A.kiselev A.M.kislyuk P.k.Panda L.Ya.karpov Institute of Physical Chemistry Vorontsovo Pole 10Moscow 105064Russia National University of Science and Technology“MISiS”Leninskii pr.4 Moscow 119991Russia kotelnikov Institute of Radio engineering and electronics Russian Academy of Sciences(Fryazino Branch)pl.Vvedenskogo 1 FryazinoMoscow Region 141190Russia National Aerospace Laboratories kodihalli Bangalore 560017India

Lead-free sodium-potassium niobate-based piezoelectric materials are most intensively studied in order to replace the widely used Pb-based *** this work,the effects of modification of compositions by donor and acceptor dopants in the A-and B-sites of perovskite lattice on structure,dielectric,ferroelectric,and piezoelectric properties of ceramics from Morphotropic Phase Boundary in the(1-x)(k_(0.5)Na_(0.5))NbO_(3)-xBaTiO_(3) system and in compositions with x=0.05 and 0.06 additionally doped by Ni^(3+) cations have been studied.

关键词： (ka_(0.5)Na_(0.5))NbO_(3) BaTiO_(3) perovskite structure solid solutions phase transitions dielectric ferroelectric piezoelectric properties

evolutionary Transients in the Rice Transcriptome

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Genomics, Proteomics & Bioinformatics 2010年第4期8卷 211-228页

作者： Jun Wang Jianguo Zhang Ruiqiang Li Hongkun Zheng Jun Li Yong Zhang Heng Li Peixiang Ni Songgang Li Shengting Li Jingqiang Wang Dongyuan Liu Jason McDermott Ram Samudrala Siqi Liu Jian Wang Huanming Yang Jun Yu Gane ka-Shu Wong key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100029 China Beijing Genomics Institute at Shenzhen Shenzhen 518083 China Department of Biochemistry and Molecular Biology University of Southern Denmark DK-5230 Odense M Denmark Theoretical Life Research Center Fudan University Shanghai 200433 China Computational Genomics Group Department of Microbiology University of Washington Seattle WA 98195 USA Computational Biology and Bioinformatics Pacific Northwest National Laboratory Richland WA 99352 USA Department of Biological Sciences and Department of medicine University of Alberta Edmonton AB T6G 2E9 Canada

In the canonical version of evolution by gene duplication, one copy is kept unaltered while the other is free to evolve. This process of evolutionary experimentation can persist for millions of years. Since it is so short lived in comparison to the lifetime of the core genes that make up the majority of most genomes, a substantial fra.tion of the genome and the transcriptome may—in principle—be attributable to what we will refer to as ＂evolutionary transients＂, referring here to both the process and the genes that have gone or are undergoing this process. Using the rice gene set as a test case, we argue that this phenomenon goes a long way towards explaining why there are so many more rice genes than Arabidopsis genes, and why most excess rice genes show low similarity to eudicots.

关键词： evolutionary transients rice gene duplication

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具有迷向S-曲率的指数度量

重庆大学学报（自然科学版） 2007年第7期30卷 134-137页

作者：孙建凯程新跃重庆大学数理学院重庆400030 重庆工学院数理学院重庆400050

研究了Finsler几何中一类特殊(α,β)-度量-指数度量F=αeks的S-曲率性质。笔者通过把指数度量的S-曲率与其特殊S-曲率的表达式进行比较,采用代数方程公式运算的方法,分析方程因式指数的变化,得到了指数度量具有迷向S-曲率的充要条件:... 详细信息

研究了Finsler几何中一类特殊(α,β)-度量-指数度量F=αeks的S-曲率性质。笔者通过把指数度量的S-曲率与其特殊S-曲率的表达式进行比较,采用代数方程公式运算的方法,分析方程因式指数的变化,得到了指数度量具有迷向S-曲率的充要条件:指数度量具有迷向S-曲率当且仅当它具有迷向平均Berwald曲率。此时,该度量的S-曲率为零,且是弱Berwald度量。结论表明:对于这类特殊的(α,β)-度量来说,它的曲率性质较简单,即它有迷向S-曲率等价于它有迷向平均Berwald曲率,等价于它具有为零的S-曲率。

关键词：指数度量 S-曲率迷向S-曲率迷向平均Berwald曲率 (α,β)-度量

early Holocene climate signals from stable isotope composition of ice wedges in the Chara Basin,northern Transbaikalia,Russia

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Geoscience Frontiers 2018年第2期9卷 471-483页

作者： Yurij k.Vasil’chuk Alla C.Vasil’chuk Julia V.Stanilovskaya Geography and Geology Departments Lomonosov Moscow State UniversityMoscowRussia Sergeev environmental Geoscience Institute of the Russian Academy of Sciences Russia

Stable isotope composition of syngenetic and epigenetic ice wedges, radiocarbon age, and pollen spectra of the surrounding deposits were studied during long term investigations at the "Belyi klyuch" site on the first(6-8 m height) terrace of the Chara River(720 m.a.s.l.) in northern Transbaikalia to assess climatic conditions during ice-wedge formation. It was revealed that Holocene ice wedges had been formed from 10 to 7.5 ka 14 C BP. The isotope composition(δ^(18)O, δ~2 H) of relict ice wedges is the lightest and amounts-23‰ and-185‰, correspondingly. The isotopic compositions of ice lenses from sandy loam above ice wedges are-15.7‰, and-133‰; of small ice wedge in peat and sand are-15.3‰ and-117.9‰, *** of the ice wedge isotope composition has yielded that mean winter temperatures during cold stages of Holocene optimum were lower than today, during warm stages they were close to modern ones. During the coldest stages of Holocene optimum the total annual freezing index varied from-5100 to-5700 ℃ degree days, i.e. 300-600 ℃ degree days colder than during extremely severe modern winters. The total annual thawing index varied from 1300 to 1800 ℃ degree days, which was slightly higher than modern ones.

关键词： Holocene Ice wedge Stable isotopes Southern permafrost areas Northern Transbaikalia

Different cell kinetic changes in rat stomach cancer after treatment with celecoxib or indomethacin: Implications on chemoprevention

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World Journal of Gastroenterology 2005年第1期11卷 41-45页

作者： JunYu Bao-DongTang Waik.Leung ka-FaiTo AlfaH.C.Bai Zhi-RongZeng Po-kiMa MinnieY.Y.Go Pin-JinHu JosephJ.Y.Sung Departmentofmedicine&Therapeutics PrinceofWalesHospitalTheChineseUniversityofI-longKongShatinHongKongChina DepartmentofGastroenterology TheFirstAffiliatedHospitalSunYat-SenUniversityofMedicalSciencesGuangzhou510080GuangdongProvinceChina DepartmentofAnatomical&CellularPathology PrinceofWalesHospitalTheChineseUniversityofHongKongShatinHongKongChina

AIM: mechanisms underlying the chemopreventive effects of cyclooxygenase (COX) inhibitors remain elusive. We have previously shown that celecoxib but not indomethacin could prevent carcinogen-induced gastric cancer development in Wistar rats. This chemopreventive effect appeared to be independent of COX-2 and prostaglandin (PG) e2 suppression since the lowest PGe2 was obtained in indomethacin *** study compared the cell kinetic changes in stomachs of rats after treatment with celecoxib (5, 10, 20 mg/(kg·d)) or indomethacin (3 mg/(kg·d)) to gain more insights into the chemopreventive ***: The apoptosis and proliferation indexes in gastric tumor, adjacent non-cancer tissues and normal gastric tissues were determined. Apoptosis was quantified by apoptotic nuclei counting and TUNeL, whereas proliferation was determined by ki67 ***: Treatment with either celecoxib or indomethacin inhibited gastric tumor proliferation by more than 65% (P＜0.02). However, celecoxib caused a dose-dependent increase in apoptosis (P＜0.05) which was not seen in indomethacin-treated tumors (P = 0.54). The highest apoptosis to proliferation ratio was seen in tumors treated with celecoxib at 10 mg/(kg·d). Treatment with this dose of celecoxib was associated with the lowest incidence of gastric cancer ***: Our findings suggest that the difference in chemopreventive effects of indomethacin and celecoxib in this animal model of gastric carcinogenesis is largely due to the differential cell kinetic changes, which does not correlate with the degree of COX-2 and PG suppression.

关键词： Stomach cancer Celecoxib Indomethacin Cell kinetics