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Crohn's disease-related'gastrocnemius myalgia syndrome'successfully treated with infliximab:A case report

World Journal of Gastroenterology 2022年第7期28卷 755-762页

作者： Julien Catherine Hazim Kadhim frédéric lambot Claire Liefferinckx Virginie Meurant Lukas Otero Sanchez Institute for Medical Immunology UniversitéLibre de BruxellesGosselies 6041Belgium department of Internal Medicine C.U.B.Hôpital ErasmeBrussels 1070Belgium NeuroMyopathology Unit(Anatomic Pathology Service)and Reference Center for Neuromuscular Pathology CHU BrugmannUniversitéLibre de BruxellesBrussels 1020Belgium department of Internal Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium department of Gastroenterology Hepatopancreatology and Digestive OncologyC.U.B.Hôpital ErasmeBrussels 1070Belgium Laboratory of Experimental Gastroenterology UniversitéLibre de BruxellesBrussels 1070Belgium department of Emergency Medicine Centre Hospitalier Universitaire TivoliLa Louvière 7100Belgium

BACKGROUNd Extra-intestinal manifestations in inflammatory bowel diseases(IBd)are frequent and involve virtually all ***,the clinical characteristics and course of inflammatory myopathies in IBd remain poorly described and mostly related to orbital ***,alternative therapeutic strategies in non-responder patients to corticosteroid therapy must still be *** SUMMARY A 33-year-old woman with a history of unclassified colitis presented with acute bilateral calf *** admission,her clinical and biological examinations were ***,magnetic resonance imaging showed bilateral inflammatory changes in gastrocnemius muscles suggestive of *** biopsy confirmed the diagnosis of myositis and demonstrated an inflammatory infiltrate mainly located in the perimysial compartment including lympho-plasmocytic cells with the formation of several granulomatous structures while the endomysium was relatively *** combined clinical,biological and histomyopathological findings were concordant with the diagnosis of‘gastrocnemius myalgia syndrome’(GMS),a rare disorder associated with Crohn’s disease(Cd).Ileocolonoscopy confirmed Cd diagnosis and systemic corticosteroids(CS)therapy was started,resulting in a rapid clinical *** CS tapering,however,she experienced a relapse of GMS together with a severe active *** was started and allowed a sustained remission of both conditions at the latest follow-up(20 mo).CONCLUSION The GMS represent a rare Cd-associated inflammatory myopathy for which anti-tumour necrosis factor-αtherapy might be considered as an effective therapeutic option.

关键词： Crohn’s disease Extra-intestinal manifestation Gastrocnemius myalgia syndrome Granulomatous myositis Anti-tumour necrosis factor-αtherapy Case report

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