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血清几丁质酶-3样蛋白1与血液透析患者预后关系的研究

Advances in Reproductive Sciences（生殖科学） 2023年第4期

作者： Marie Florence N’Guessan bi Bali Sery foua Jonas Vanié bi N’Gbesso Amos Ekissi Youzan Ferdinand Djohan Founzégué Amadou Coulibaly Allico Joseph Djaman

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中国血液净化 2024年第7期23卷 500-504页

作者：毕书红高月明苏春燕王悦唐雯何莲张爱华北京大学第三医院肾内科北京100191 首都医科大学宣武医院肾内科北京100053

目的探讨血清几丁质酶-3样蛋白1(chitinase 3-like protein 1,CHI3l1)与血液透析患者全因死亡和心脑血管疾病死亡之间的关系。方法本研究为前瞻性队列研究,病例来自2014年9月北京大学第三医院肾内科维持性血液透析患者。测定基线血CHI3l... 详细信息

目的探讨血清几丁质酶-3样蛋白1(chitinase 3-like protein 1,CHI3l1)与血液透析患者全因死亡和心脑血管疾病死亡之间的关系。方法本研究为前瞻性队列研究,病例来自2014年9月北京大学第三医院肾内科维持性血液透析患者。测定基线血CHI3l1水平,并根据中位数将患者分为高CHI3l1组和低CHI3l1组,随访9年。用Kaplan-Meier生存分析高CHI3l1组和低CHI3l1组患者生存率的差异,用限制性立方样条(restricted cubic spline,RCS)曲线描述CHI3l1与全因死亡率的剂量反应关系,用多因素COX比例风险模型分析患者全因死亡或心脑血管疾病死亡的独立危险因素。结果共纳入109例患者,随访时间为80.0(38.2,113.2)个月。Kaplan-Meier生存分析显示高CHI3l1组患者全因死亡率高于低CHI3l1组(χ^(2)=4.720,P=0.030),2组患者心脑血管疾病死亡率无明显差异(χ^(2)=1.954,P=0.162)。当CHI3l1≥199.8 ng/ml时,全因死亡率随着CHI3l1水平的增加有明显增加(HR=1.747,95%CI:1.035~2.947,P=0.037)。COX回归分析结果显示:年龄增加(HR=1.029,95%CI:1.001~1.056,P=0.040)、长透析龄(HR=2.251,95%CI:1.310~3.868,P=0.003)、收缩压高(HR=1.022,95%CI:1.008~1.036,P=0.002)、血肌酐低(HR=0.135,95%CI:0.064~0.283,Pl1仍然是患者全因死亡的独立危险因素(HR=1.963,95%CI:1.010~3.813,P=0.047)。结论高CHI3l1组患者全因死亡率高于低CHI3l1组患者,血CHI3l1可能是血液透析患者全因死亡的独立预测指标。

关键词：血清几丁质酶-3样蛋白1 血液透析预后全因死亡心脑血管疾病

体力活动与膝或髋关节置换术老年患者术后谵妄的关系

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中华麻醉学杂志 2024年第8期44卷 922-926页

作者：孔荐邱云飞徐钐凌王元龙化树慧林亚男李传董瑞巩红岩林旭王彬毕燕琳山东第二医科大学麻醉学院潍坊261053 青岛市第八人民医院麻醉科青岛266071 滨州医学院第二临床医学院烟台264003 青岛市市立医院麻醉科青岛266071

目的评价体力活动(pa)与膝或髋关节置换术老年患者术后谵妄(POD)的关系。方法基于围术期神经认知障碍和生物标志物生活方式队列,属于巢式病例对照研究。收集2022年8月至2023年8月在青岛市市立医院于脊椎-硬膜外麻醉下行择期膝或髋关节... 详细信息

目的评价体力活动(pa)与膝或髋关节置换术老年患者术后谵妄(POD)的关系。方法基于围术期神经认知障碍和生物标志物生活方式队列,属于巢式病例对照研究。收集2022年8月至2023年8月在青岛市市立医院于脊椎-硬膜外麻醉下行择期膝或髋关节置换术老年患者病历资料,依据是否发生POD将其分为POD组(n=89)和非POD组(n=221)。术前抽取外周血标本,脊椎-硬膜外麻醉穿刺成功后抽取脑脊液(CSF)2 ml,采用ElISA法测定β淀粉样蛋白42(Aβ_(42))、总tau蛋白(t-tau)及磷酸化tau蛋白(p-tau)浓度。logistics回归法筛选POD的影响因素,进行CSF生物标志物的中介效应分析。结果logistic回归校正高血压、糖尿病、饮酒史、受教育年限和MMSE评分等多项混杂因素后,结果显示,CSF Aβ_(42)浓度升高(OR=0.997,P=0.006)、Aβ_(42)/t-tau比值升高(OR=0.642,P=0.003)、Aβ_(42)/p-tau比值升高(OR=0.872,P=0.001)和pa(OR=0.374,P=0.001)为老年患者POD的保护因素,t-tau浓度升高(OR=1.006,P=0.001)和p-tau浓度升高(OR=1.030,P=0.011)是膝或髋关节置换术老年患者POD的危险因素。中介效应显示,pa与老年患者POD的关系由Aβ_(42)浓度(20%)、t-tau浓度(16%)、Aβ_(42)/t-tau比值(23%)和Aβ_(42)/p-tau比值(28%)介导。结论pa是膝或髋关节置换术老年患者POD的保护因素,其可能通过CSF生物标志物发挥中介效应预防POD发生。

关键词：体力活动关节成形术,置换,膝关节成形术,置换,髋老年人谵妄

基于免疫原理的PID控制参数整定方法(英文)

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机床与液压 2013年第18期41卷 104-108页

作者：毕波重庆交通大学国际学院重庆400074

PID控制系统的技术性能取决于系统控制器的控制参数。针对控制参数整定过程中各个技术指标之间的要求难以兼容的难题,提出了一种基于免疫原理的PID控制器参数整定方法。讨论了协调各技术指标关系的目标函数,描述了人体免疫系统与控制系... 详细信息

PID控制系统的技术性能取决于系统控制器的控制参数。针对控制参数整定过程中各个技术指标之间的要求难以兼容的难题,提出了一种基于免疫原理的PID控制器参数整定方法。讨论了协调各技术指标关系的目标函数,描述了人体免疫系统与控制系统的对应关系,构建了基于免疫原理的控制参数整定模型,研究了具体的免疫控制算法。以二阶大滞后过程为控制对象,采用不同整定方法的仿真实验响应对比研究显示,基于免疫方法整定的控制参数,其系统响应时间快,系统调节时间短,系统超调量小,技术指标之间兼容性能比较好。研究结果表明,所提出方法是一种优化的PID控制参数整定算法。

关键词：免疫原理 PID控制器控制参数参数整定方法

THE REFINED CRYSTAl STRUCTURE OF THE NEUROPHYSIN-OXYTOCIN COMPlEX AT 2.8 RESOlUTION

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THE REFINED CRYSTAL STRUCTURE OF THE NEUROPHYSIN-OXYTOCIN CO...

皮胶原纤维固载Zr(IV)对水体中苯羧酸的吸附特性

Sixteenth Congress of the International Union of Crystallography

作者： John P.Rose bi-Cheng Wang Departments of Crystallography and biological Sciences University of PittsburghPittsburghPA 15260 USA.

＜正＞The posterior pituitary produces two important regulatory hormones, oxytocin and *** is known to mediate uterine contraction and milk ejection and has recently been shown to play an important role in sexual behavior and response,as well as bonding between parent and *** plays an important role in influencing kidney function,blood pressure and body *** hormones are nonapeptides and are found in concentrations as high as 0.1 M in the neurosecretory granules of the posterior pituitary complexed in a 1:1 ratio with a class of small（11 KD） disufide-rich

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四川大学学报（工程科学版） 2010年第3期42卷 189-194,200页

作者：顾迎春廖学品石碧四川大学制革清洁技术国家工程实验室四川成都610065

制备皮胶原纤维固载Zr(IV)吸附剂(ZlCF),并考察ZlCF对水体中苯甲酸(BA)、邻苯二甲酸(o-pa)、对苯二甲酸(p-pa)和间苯二甲酸(m-pa)的吸附特性。研究表明:这4种苯羧酸的吸附平衡同时符合langmuir和Freundlich方程,但随着它们的羧基数量和... 详细信息

制备皮胶原纤维固载Zr(IV)吸附剂(ZlCF),并考察ZlCF对水体中苯甲酸(BA)、邻苯二甲酸(o-pa)、对苯二甲酸(p-pa)和间苯二甲酸(m-pa)的吸附特性。研究表明:这4种苯羧酸的吸附平衡同时符合langmuir和Freundlich方程,但随着它们的羧基数量和位置的不同,其吸附容量也随之变化。总体看,ZlCF对所研究的苯羧酸均具有较大的吸附容量。当苯羧酸溶液(10ml)的初始浓度为6mmol/l、吸附温度为293K时,ZlCF(0.05g)对BA、o-pa、m-pa和p-pa的吸附容量分别达0.4616、0.5892、0.4912和0.3138mmol/g。吸附动力学研究表明:BA的吸附符合拟一级速率方程,边界层扩散为主控步骤;而o-pa、m-pa和p-pa的吸附符合拟二级速率方程,化学吸附为主控步骤。

关键词：皮胶原固载金属吸附剂固载Zr(IV) 苯羧酸吸附

upaR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis

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Cellular & Molecular Immunology 2018年第2期15卷 171-181页

作者： Yan liu Yun Feng pan You-qiu Xue lin-kai Fang Xing-hua Guo Xin Guo Meng liu bi-yao Mo Meng-ru Yang Fang liu Yun-ting Wu Nancy Olsen Song Guo Zheng Division of Rheumatology Department of Internal MedicineThe Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou510630China Department of Clinical Immunology The Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou510630China Division of Rheumatology Department of Internal MedicineThe Second People’s Hospital of Guangdong ProvinceGuangzhou510310China Division of Neurology Department of Internal MedicineThe Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou510630China Division of Rheumatology Department of MedicinePenn State Milton S.Hershey Medical CenterHershey17033PAUSA

Urokinase-type plasminogen activator receptor(upaR),is a multifunctional receptor on cell surface,widely present in endothelial cells,fibroblasts,and a variety of malignant *** studies have suggested that upaR overexpressed on synovial tissues or in synovial fluid or plasma in patients with rheumatoid arthritis(RA).However,there are limited researches regarding the role of upaR on fibroblast-like synoviocytes of rheumatoid arthritis(RA-FlSs)and its underlying ***,our studies show that the expression of upaR protein was significantly higher in fibroblast-like synoviocytes(FlSs)from RA than those from osteoarthritis or traumatic injury *** gene silencing significantly inhibited RA-FlSs cell proliferation,restrained cell transformation from the G0/G1 phase to S phase,aggravated cell apoptosis,interfered with RA-FlSs cell migration and invasion,and reduced activation of the PI3K/Akt signaling pathway,which may be associated withβ*** supernatants from upaR gene-silenced RA-FlSs markedly inhibited the migration and tubule formation ability of the HUVECs(a human endothelial cell line).Therefore,we demonstrate that upaR changes the biological characteristics of RA-FlSs,and affects neoangiogenesis of synovial tissues in patients with *** of these may be associated with theβ1-integrin/PI3K/Akt signaling *** results imply that targeting upaR and its downstream signal pathway may provide therapeutic effects in RA.

关键词： angiogenesis cell viability fibroblast-like synoviocytes rheumatoid arthritis upaR

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高炉下部气体动力学条件与产量优化

钢铁研究学报 2007年第7期19卷 9-13页

作者：熊玮毕学工武汉科技大学钢铁冶金及资源利用省部共建教育部重点实验室湖北武汉430081

从高炉下部气体动力学条件出发,建立了反映高炉重要操作参数和最大产量之间对应关系的产量优化模型。模型计算结果表明,炉腹和死料堆焦炭的平均粒度增加5 mm,产量约提高20%;渣比下降100 kg/t,产量约提高8%;炉渣粘度下降0.1 pa.s,产量约... 详细信息

从高炉下部气体动力学条件出发,建立了反映高炉重要操作参数和最大产量之间对应关系的产量优化模型。模型计算结果表明,炉腹和死料堆焦炭的平均粒度增加5 mm,产量约提高20%;渣比下降100 kg/t,产量约提高8%;炉渣粘度下降0.1 pa.s,产量约提高4%;炉顶压力增加50 kpa,产量约提高6%;富氧增加1%或提高风温100℃,产量约提高2%。如果维持合适的理论燃烧温度不变,高煤比时提高富氧率对产量提高的作用比煤比小时更大。结合合理的上部调剂手段,提高未燃煤粉在炉内的利用率,在大喷煤比下将大型高炉的利用系数提高到3.0 t/(m3.d)的水平是完全可能的。

关键词：高炉气体动力学产量优化数学模型

Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial

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Chinese Journal of Cancer Research 2021年第4期33卷 490-499页

作者： Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng bi liangjun Zhu Zengqing Guo Jin Yan bing Hu Min Tao Shujun Yang Suzhan Zhang lu Wen Ruihua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Chinese PLA General HospitalBeijing 100853China Department of Medical Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Xinjiang Medical University Cancer HospitalUrumqi 830000China Department of Medical Oncology Foshan First People’s HospitalFoshan 528010China Department of Medical Oncology Shandong Cancer HospitalJinan 250117China Department of Medical Oncology West China Hospital of Sichuan UniversityChengdu 610041China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Fujian Cancer HospitalFuzhou 350014China Department of Surgical Oncology Sichuan Cancer HospitalChengdu 610041China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Medical Oncology Henan Cancer HospitalZhengzhou 450003China Department of Medical Oncology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology Shanxi Provincial Cancer HospitalTaiyuan 030009China

Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in ***,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with *** observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC ***:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across *** patients received different chemotherapeutic regimens combined with *** efficacy and safety data in the intention-to-treat study population were ***:A total of 611 patients were included in the efficacy *** median overall survival and median progression-free survival was 18.00 and 10.05 months,*** objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety *** 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher *** incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and *** in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acce

关键词： Metastatic colorectal cancer bevacizumab chemotherapy efficacy safety

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RFID在图书馆界引发的标签革命

农业网络信息 2007年第5期 136-138,140页

作者：蔡志华苏帕莎张弼湖南农业大学图书馆湖南长沙410128

科技的进步,信息技术的发展,正在给人类生活带来前所未有的变化。就标签领域来说,也许人们不会忘记条码时代给我们带来的便利,但是时至今日,当人们还沉浸在过去的辉煌时,一种新的标签技术-RFID(电子标签)正在悄然兴起。它的优于条码的... 详细信息

科技的进步,信息技术的发展,正在给人类生活带来前所未有的变化。就标签领域来说,也许人们不会忘记条码时代给我们带来的便利,但是时至今日,当人们还沉浸在过去的辉煌时,一种新的标签技术-RFID(电子标签)正在悄然兴起。它的优于条码的特征必然会在图书馆带来广泛的应用。

关键词： RFID 条形码技术电子标签应用