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中华烧伤杂志 2018年第10期34卷 659-661页

作者：陈璧空军军医大学西京医院全军烧伤中心、烧伤与皮肤外科西安710032

我从事烧伤医学工作60年，其中3年多在农村基层工作，包括参加巡回医疗队、抗洪救灾、野营拉练、开门办学等。这些经历不仅使我在缺医少药的艰苦条件下树医德、长医术，更使我能根据实际条件，创新求精、造福病患。

关键词：烧伤救死扶伤缺医少药创新求精

Design and Simulation of Flow Field for Bone Tissue Engineering Sca old Based on Triply Periodic Minimal Surface

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Chinese Journal of Mechanical Engineering 2019年第2期32卷 193-202页

作者： Zhen Wang Chuanzhen Huang Jun Wang Peng Wang Shisheng bi Ch Asad Abbas Centre for Advanced Jet Engineering Technologies (Ca JET ) Key Laboratory of High-efciency and Clean Mechanical Manufacture (Ministry of Education) School of Mechanical Engineering Shandong University School of Mechanical and Manufacturing Engineering The University of New South Wales (UNSW )

A novel method was proposed to design the structure of a bone tissue engineering scafold based on triply periodic minimal *** this method,reverse engineering software was used to reconstruct the surface from point cloud *** method overcomes the limitations of commercially available software packages that prevent them from generating models with complex surfaces used for bone tissue engineering ***,the fluid feld of the scafolds was simulated through a numerical method based on fnite volume and the cell proliferation performance was evaluated via an in vitro *** cell proliferation and the mass flow evaluated in a bioreactor further verifed the flow feld simulated using computational fluid *** result of this study illustrates that the pressure value drops rapidly from 0.103 pa to 0.011 pa in the y-axis direction and the mass flow is unevenly distributed in the *** mass flow in the side outlets is observed to be approximately 24.3 times higher thanthe ***,although the mean value of wall shear stress is signifcantly more than 0.05 pa,there is stil a large area with a suitable shear stress below 0.05 pa where most cells can proliferate *** result shows that th inlet velocity 0.0075 m/s is suitable for cell proliferation in the *** study provides an insight into the design analysis,and in vitro experiment of a bone tissue engineering scafold.

关键词： Bone tissue engineering Porous sca old Flow field Reverse engineering Cell proliferation

Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1070-1079页

作者： Xiaoxiao luo Qirui bi Dongdong Huang Yun li Changliang Yao Jianqing Zhang Wenlong Wei Jiayuan li Zhenwei li Jingxian Zhang Shen Ji Yurong Wang De-an Guo School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing211198China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China NMpa Key laboratory for Quality Control of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Pheretima,also called“earthworms”,is a well-known animal-derived traditional Chinese medicine that is extensively used in over 50 Chinese patent medicines(CPMs)in Chinese Pharmacopoeia(2020 edition).However,its zoological origin is unclear,both in the herbal market and *** this study,a strategy for integrating in-house annotated protein databases constructed from close evolutionary relationship-sourced RNA sequencing data from public archival resources and various sequencing algorithms(restricted search,open search,and de novo)was developed to characterize the phenotype of natural peptides of three major commercial species of Pheretima,including Pheretima aspergillum(pa),Pheretima vulgaris(PV),and Metaphire magna(MM).We identified 10,477 natural peptides in the pa,7,451 in PV,and 5,896 in MM *** specific signature peptides were screened and then validated using synthetic peptides;these demonstrated robust specificity for the authentication of pa,PV,and ***,all marker peptides were successfully applied to identify the zoological origins of Brain Heart capsules and Xiaohuoluo pills,revealing the inconsistent Pheretima species used in these *** conclusion,our integrated strategy could be used for the in-depth characterization of natural peptides of other animal-derived traditional Chinese medicines,especially non-model species with poorly annotated protein databases.

关键词： Pheretima Natural peptides label-free peptidomics Proteogenomics Animal derived medicine

Plasma Membrane localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice

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Molecular Plant 2010年第5期3卷 917-926页

作者： Fang Chen Ming-Jun Gao Yan-Song Miao Yue-Xing Yuan Mu-Yang Wang Qun li bi-Zeng Mao li-Wen Jiang Zu-Hua He National Key laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Present address: Department of Molecular Cellular and Developmental Biology Yale University New Haven CT 06511 USA Department of biology and Molecular biotechnology Program The Chinese University of Hong Kong Shatin New Territories Hong Kong China Present address: Department of Emergency Medicine Thomas Jefferson University Philadelphia PA 19107 USA biotechnology Institute Zhejiang University Hanghzou 310029 China

The rice pattern recognition receptor （PRR） XA21 confers race-specific resistance in leaf infection by bacterial blight Xathornonas oryzae pv. oryzae （Xoo）, and was shown to be primarily localized to the endoplasmic reticulum （ER） when expressed with its native promoter or overexpressed in the protoplast. However, whether the protein is still ER- localization in the intact cell when overexpressed remains to be identified. Here, we showed that XA21, its kinase-dead mutant XA21PK736EP and the triple autophosphorylation mutant XA21PS686AJT688AJS699A GFP fusions were primarily localized to the plasma membrane （PM） when overexpressed in the intact transgenic rice cell, and also localized to the ER in the transgenic protoplast. The transgenic plants constitutively expressing the wild-type XA21 or its GFP fusion displayed racespecific resistance to Xoo at the adult and seedling stages. XA21 and XA21PK736EP could be internalized probably via the SCAMP-positive early endosomal compartment in the protoplast, suggesting that XA21 might be endocytosed to initiate resistance responses during pathogen infection. We also established a root infection system and demonstrated that XA21 also mediated race-specific resistance responses to Xoo in the root. Our current study provides an insight into the nature of the XA21-mediated resistance and a practical approach using the root cell system to further dissect the cellular signaling of the PRR during the rice-Xoo interaction.

关键词： Rice XA21 pattern recognition receptor bacterial bight cellular localization internalization root infection race-specific resistance.

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古代于阗的一种织物——白氎

中国经济史研究 2018年第3期 162-170页

作者：毕波中国人民大学国学院

根据汉文传世文献记载,古代于阗的衣物用料种类多样,如丝、毛等均在和田出土的汉文、于阗文及其他胡语文书有所印证。不过,玄奘所记于阗棉织物"白氎",在出土文书中却一直未见其踪。本文指出,"白氎"可能对应的就是于阗语文书中的pe'mīna... 详细信息

根据汉文传世文献记载,古代于阗的衣物用料种类多样,如丝、毛等均在和田出土的汉文、于阗文及其他胡语文书有所印证。不过,玄奘所记于阗棉织物"白氎",在出土文书中却一直未见其踪。本文指出,"白氎"可能对应的就是于阗语文书中的pe'mīnai thau。根据其词源为*pa2ma-"羊毛",学者最初将这一于阗语词汇释作"毛布",即一种毛织物。近年来又有学者将其释作"",即一种丝织物。本文指出,尽管该词源自于"羊毛",但可能并不能按通常情况理解为毛织物,"毛"可能是用以表示棉织物毛茸茸的特征,正如"氎"构字虽然亦有"毛",但可以确定是指棉织物。现有材料表明,于阗在7世纪中叶前后似乎尚未开始种植棉花,当时的于阗很可能和汉地相类似,称棉布为"毛布",故而采用词源为"羊毛"的词造出了和汉文"毛布"同样的词pe'mīnai-thau。

关键词：于阗织物白氎出土文书

Roles of NAMPT and NAD decline in patho⁃genesis of parkinson disease in mice

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中国药理学与毒理学杂志 2021年第9期35卷 652-653页

作者： CHEN Cong SHEN Chen GAO Tong-yao WANG Tong lU Yun-bi ZHANG Wei-ping Zhejiang University School of Medicine Hangzhou 310043China

OBJECTIVE Nicotinamide phos⁃phoribosyltransferase(NAMPT)is the key enzyme for the synthesis of nicotinamide ade⁃nine dinucleotide(NAD)in the salvaging *** is an essential co-enzyme of multiple enzymes involved in cell metabolism and important enzymes such as *** level of both NAMPT and NAD decreases upon aging,which may cause neuronal ***,the roles of NAMPT and NAD in par⁃kinson disease(PD)remain *** study was to explore the roles of NAMPT and NAD decline in the pathogenesis of PD in *** Floxed nampt gene C57Bl/6J mice,including Namptwt/wt,Namptflox/wt and Namptflox/flox,were *** rAAV-hSyn-Cre-WPRE pa or rAAV-TH-Cre-WPRE pa adeno-associated virus(AAV)was used to conditioning knockout nampt gene in neurons or dopaminergic neurons,*** 2,4,6,and 8 weeks after AAV injection,the motor deficits of mice were evaluat⁃*** and immunohistochem⁃istry were used to evaluate the neuronal *** electron microscope was used to evaluate the axonal *** The knockout of nampt gene induced dopaminer⁃gic neuron loss in substantia nigra at 4 weeks but not 2 weeks after AAV *** 8 weeks after AAV injection,the Namptflox/flox mice showed a significantly decrease in motor activity in an open-field than Namptwt/wt and Namptflox/wt *** some Namptflox/flox mice showed spin behav⁃ior at 6-8 weeks after AAV *** dopa⁃minergic neurons in substantia nigra and ventral tegmental area are more susceptible to the knockout of nampt gene than the non-dopaminer⁃gic *** electron microscope examine showed degenerative changes of the myelin in striatum at 4 weeks after AAV injection for the Namptflox/flox *** orally supplementary of NAD precursor,nicotinamide ribose,improved the motor activity and decreased neuronal injury for the nampt gene knockout ***⁃SION Decline of NAMPT and NAD in dopaminer⁃gic neurons is a risk for developing PD,and NA

关键词： nicotinamide phosphoribosyltrans⁃ferase nicotinamide adenine dinucleotide myelin dopaminergic neurons

Manipulating active layer morphology of molecular donor/polymer acceptor based organic solar cells through ternary blends

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Science China Chemistry 2018年第8期61卷 1025-1033页

作者： Zijian Zhang Zicheng Ding David J.Jones Wallace W.H.Wong bin Kan Zhaozhao bi Xiangjian Wan Wei Ma Yongsheng Chen Xiaojing long ChuANDong Dou Jun liu lixiang Wang State Key laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China School of Chemistry Bio21 Institute the University of Melbourne Parkville Victoria 3010 Australia Key laboratory for Functional Polymer Materials and Centre for Nanoscale Science and Technology Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Key laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China University of the Chinese Academy of Sciences Beijing 100049 China

The development of molecular donor/polymer acceptor blend(MD/pa)-type organic solar cells(OSCs) lags far behind other type OSCs. It is due to the large-size phase separation morphology of MD/pa.lend, which results from the high crystallinity of molecular donors. In this article, to suppress the crystallinity of molecular donors, we use ternary blends to develop OSCs based on one polymer acceptor(P-BNBP-f BT) and two molecular donors(DR3 TBDTT and BTR) with similar chemical *** ternary OSC exhibits a power conversion efficiency(PCE) of 4.85%, which is higher than those of the binary OSCs(PCE=3.60% or 3.86%). To our best knowledge, it is the first report of ternary MD/pa-type OSCs and this PCE is among the highest for MD/pa-type OSCs reported so far. Compared with the binary blends, the ternary blend exhibits decreased crystalline size and improved face-on orientation of the donors. As a result, the ternary blend exhibits improved and balanced charge mobilities, suppressed charge recombination and increased donor/acceptor interfacial areas, which leads to the higher shortcircuit current density. These results suggest that using ternary blend is an effective strategy to manipulate active layer morphology and enhance photovoltaic performance of MD/pa-type OSCs.

关键词： organic solar cells molecular donor polymer acceptor blend morphology ternary blend

苏州生态景观林土壤有机碳储量及活性组分的垂直分布特征

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安徽农业大学学报 2024年第2期51卷 312-318页

作者：姚新华唐建毕雷雷唐盛兰夏秀丽顾海波袁在翔关庆伟苏州市林业站苏州215128 南京林业大学生物与环境学院南方现代林业协同创新中心南京210037

为探究生态景观林类型对土壤有机碳(SOC)固持的影响,选择苏州市香樟人工林(Cinnamomum camphora plantation)、喜树人工林(Camptotheca acuminata plantation)、水杉人工林(Metasequoia glyptostroboides plantation)、栾树人工林(Koelreuteria paniculata plantation)和池杉人工林(Taxodium distichum *** plantation)5种生态景观林为研究对象,测定分析了各林分的0~20 cm、20~40 cm、40~60 cm和60~80 cm、80~100 cm 5个土壤层次有机碳、可溶性有机碳(DOC)、微生物生物量碳(MBC)以及易氧化有机碳(EOC)的含量与储量。结果表明:(1)各土层有机碳含量及储量分别在3.34~18.91 g·kg^(-1)和12.98~66.99 t·hm^(-2)之间,并且在不同林分之间差异显著,尤其是表层土壤有机碳;并且,香樟和喜树人工林0~100 cm土壤有机碳储量要显著高于其余3种林分。(2)不同生态景观林土壤可溶性有机碳、微生物生物量碳和易氧化有机碳差异显著,且具有明显的表聚效应;在不同林分之间,栾树和水杉人工林0~100 cm土壤可溶性有机碳与微生物生物量碳的储量最高,喜树和香樟人工林0~100 cm土壤易氧化有机碳储量最高。(3)试验地土壤有机碳及其活性组分主要与全氮、全磷极显著正相关,与容重极显著负相关。生态景观林类型显著影响0~100 cm土壤有机碳及活性组分的含量和储量;相较于水杉、栾树和池杉人工林,香樟和喜树人工林更有利于试验区土壤有机碳固持。

关键词：土壤有机碳活性有机碳生态景观林土壤层次垂直分布

Asymetrie temporelle dans la plasticite associative dependante de Pordre temporel entre activites

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Asymetrie temporelle dans la plasticite associative dependan...

PREpaRATION OF NANO-CRYSTAllINE Fe-Cu THIN FIlMS AND THEIR MAGNETIC PROPERTIES

首届全国功能神经影像学和神经信息学研讨会

作者： Guo qiang bi (Departement de la NeurobioJogie, Universite de Pittsburgh, ecole de Medecine, rue de 200 lothrop, E1451 BST, Pittsburgh, pa 15213, Etats-Unis)

＜正＞ Activity-dependent synaptic modification is critical for the development and function of the nervous system. Recent experimental discoveries suggest that both the extent and the direction of modification may depend on the precise timing of pre-and postsynaptic action potentials （spikes）. This phenomenon, termed spike timing-dependent plasticity （STDP）, provides a new, quantitative interpretation of Hebb’s rule and raises intriguing questions regarding the fundamental processes of cellular signaling. In this article, we summarize previous results obtained in a hippocampal culture system, where an asymmetric window of spike timing was found for paired pre- and postsynaptic spiking to induce STDP. We also discuss our recent studies using a "triplet-spiking" paradigm that reveals nonlinear, temporally asymmetric integration of STDP.

关键词： Hebb Synaptic plasticity Spike timing STDP Temporal integration Hippocampal culture

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Acta Metallurgica Sinica(English letters) 2002年第1期15卷 109-112页

作者： X.F. bi S.K. Gong H.B. Xu K.I Department of Materials Science and Engineering Beijing University of Aeronautics and AstronauticsBeijing 100083 China Research Institute of Electrical Communication Tohoku University Japan

Fe-Cu thin films of 0.2 mum in thickness with different Cu contents wereprepared by using r.f. magnetron sputtering onto glass substrate. The effect of sputteringparameters, including Ar gas pressure and input rf power, on the structure and magnetic propertieswas investigated. It was found that when the power is lower than 70W, the structure of the filmsremained single bcc-Fe phase with Cu solubility of up to 50at. percent. TEM observations for thebcc-Fe phase showed that the grain size was in the nanometer range of less than 20nm. The coercivityof Fe- Cu films was largely affected by not only Ar gas pressure but also rf power, and reachedabout 2.5Oe in the pressure of 0.67-6.67pa and in the power of less than 100W. In addition,saturation magnetization, with Cu content less than 60at. percent, was about proportional to thecontent of bcc-Fe. When Cu content was at 60at. percent, however, saturation magnetization was muchsmaller than its calculation value.

关键词： Fe-Cu thin film magnetic property sputtering condition nano-crystalline