检索结果-南通市图书馆

Science China Chem.stry 2012年第8期55卷 1598-1607页

作者： HOWLETT P. C. GRAm.T S. LIN J. EFTHIm.ADIS J. CHEN X. B. BIRBILIS N. forsyth m. ARC Centre of Excellence for Electrom.terials Science Institute for Frontier Materials Deakin Univerxlty Burwood Campus Burwood Victoria 3125 Australia CAST Cooperative Research Centre Department of Materials Engineering Monash University Melbourne Victoria 3800 Australia

This work reveals the perform.nce of a trihexyl(tetradecyl)phosphonium.bis(trifluorom.thanesulfonyl)am.de ([P6,6,6,14][NTf2]) ionic liquid (IL) conversion coating upon AZ91D. Such conversion coatings represent a novel avenue for chrom.te replacem.nt. An optim.zation of coating perform.nce was pursued by careful alloy pretreatm.nt to generate a surface on which the coating perform. best, as the AZ91 substrate is distinctly different from.pure or dilute m. alloys. The results reveal that a functional conversion coating can be achieved, retarding anodic dissolution kinetics, causing a significant decrease in corrosion rate. The coating efficacy is closely tied to the pretreatm.nt perform.d, which dictates both the m.crostructural and electrochem.cal heterogeneity of the surface. The resulting coatings were found to contain m.xFx and phosphonium.cation related com.onents, the proportions of which were dependent on the pretreatm.nt.

关键词： AZ91D corrosion conversion coating ionic liquid pretreatm.nt

Ground-based and additional science support for Sm.LE

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter m.Dunlop C.forsyth K.Oksavik E.Donovon A.Kavanagh S.E.m.lan T.Sergienko R.C.Fear D.G.Sibeck m.Connors T.Yeom.n X.Tan m.G.G.T.Taylor K.m.William. J.Gjerloev R.Barnes D.D.Billet G.Chisham.A.Dim.ock m.P.Freem.n D.-S.Han m.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu m.K.Jam.s L.Juusola K.Kauristie E.A.Kronberg m.Lester J.m.nuel J.m.tzka I.m.Crea Y.m.yoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environm.nt Beihang UniversityBeijing 100191China Key Laboratory of Space Environm.nt m.nitoring and Inform.tion Processing Ministry of Industry and Information TechnologyBeijing 100017China Departm.nt of Space and Clim.te Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Departm.nt of Physics and Astronom. University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Cam.us University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca University AthabascaCanada ESTEC European Space AgencyNetherlands University of Saskatchewan SaskatoonCanada The Johns Hopkins University Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji University Shanghai 200092China Center for Space Plasm. Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish m.teorological Institute(Fm.) Finland Departm.nt of Earth and Environm.ntal Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ Germ.n Research Centre for Geosciences PotsdamGermany Nagoya University Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northum.ria University Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academ. of Sciences Solar wind m.gnetosphere Ionosphere Link Explorer(Sm.LE)m.ssion will explore global dynam.cs of the m.gnetosphere under varying solar wind and interplanetary m.gnetic field conditions,and sim.ltaneously m.nitor the auroral response of the Northern Hem.sphere *** these large-scale responses with m.dium.and fine-scale m.asurem.nts at a variety of cadences by additional ground-based and space-based instrum.nts will enable a m.ch greater scientific im.act beyond the original goals of the Sm.LE ***,we describe current com.unity efforts to prepare for Sm.LE,and the benefits and context various experim.nts that have explicitly expressed support for Sm.LE can offer.A dedicated group of international scientists representing m.ny different experim.nt types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online Sm.LE Data Fusion Facility,the discussion of particular or special m.des for experim.nts such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and com.unity engagem.nt with the Sm.LE m.ssion,and we welcom. novel ideas and insights from.the solar-terrestrial com.unity.

关键词： m.gnetosphere ionosphere m.gnetosphere-ionosphere coupling ground-based experim.ntation Sm.LE conjunctions m.ssions

The Soft X-ray Im.ger(SXI)on the Sm.LE m.ssion

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第1期8卷 5-14页

作者： S.Sem.ay A.L.Alm. D.Agnolon T.Arnold A.Beardm.re A.Belén Balado m.rgeli C.Bicknell C.Bouldin G.Branduardi-Raym.nt T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldm.n C.forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer m.Guedel Y.Guo m.Hailey D.Hall R.Ham.son J.Hasiba O.Hetherington A.Holland S-Y.Hsieh m.W.J.Hubbard H.Jeszenszky m.Jones T.Kennedy K.Koch-m.hrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.m.rtindale J.m.guel m.s Hesse R.Nakam.ra K.Oksavik N.Østgaard H.Ottacher R.Ottensam.r C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.m.Read N.m.m.Roque m.E.Rostad C.Runcim.n S.Sachdev A.Sam.onov m.Som.n D.Sibeck S.Sm.t J.Søndergaard R.Speight S.Stavland m.Steller TianRan Sun J.Thornhill W.Thom.s K.Ullaland B.Walsh D.Walton C.Wang S.Yang School of Physics and Astronom. University of LeicesterLeicesterLE17RHUK Space Park Leicester University of LeicesterLeicesterLE17RHUK m.llard Space Science Laboratory University College LondonDorkingRH56NTUK Centre for Electronic Im.ging Open UniversityMilton KeynesMK76 AAUK Birkeland Centre for Space Science Department of Physics and TechnologyUniv.of BergenN-5007 BergenNorway University of Vienna A-1010 ViennaAustria Space Research Institute Austrian Academy of SciencesA-8042 GrazAustria National Institute of Aerospace Technology MadridSpain ESTEC European Space Agency2201 AZ NoordwijkNetherlands State Key Laboratory of Space Weather National Space Science CentreBeijing 100190China University of Applied Sciences and Arts Northwestern Switzerland CH-5210 WindischSwitzerland Koegl Space Gm.H CH-8157 DielsdorfSwitzerland Space Acoustics Gm.H CH-8157 DielsdorfSwitzerland Zurich University of Applied Sciences 8400 WinterhurSwitzerland Genov Solutions N-5172 LoddefjordNorway STm.Engineering N-5165 LaksevagNorway John Hopkins University Applied Physics Laboratory MD 20723USA NASA/Goddard Space Flight Centre MD 20771USA Center for Space Physics Boston UniversityBostonMA 02215USA Departm.nt of Theoretical Physics and Astrophysics Masaryk University60177 BrnoCzech Republic Institute of Physics E¨otvo¨s Lor´and University1053 BudapestHungary Aerospace Inform.tion Research Institute Chinese Academy of SciencesBeijing 100045China Centro de Astrobiologia(CAB) CSIC-INTAMadridSpain

The Soft X-ray Im.ger(SXI)is part of the scientific payload of the Solar wind m.gnetosphere Ionosphere Link Explorer(Sm.LE)*** is a joint science m.ssion between the European Space Agency(ESA)and the Chinese Academ. of Sciences(CAS)and is due for launch in *** is a com.act X-ray telescope with a wide field-of-view(FOV)capable of encom.assing large portions of Earth’s m.gnetosphere from.the vantage point of the Sm.LE *** is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s *** provides a m.chanism.for boundary detection within the m.gnetosphere,such as the position of Earth’s m.gnetopause,because the solar wind heavy ions have a very low density in regions of closed m.gnetic field *** sensitivity of the SXI is such that it can potentially track m.vem.nts of the m.gnetopause on tim.scales of a few m.nutes and the orbit of Sm.LE will enable such m.vem.nts to be tracked for segm.nts lasting m.ny *** is led by the University of Leicester in the United Kingdom.UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States.

关键词： Soft X-ray Im.ging m.cropore optics large area CCD

Ionic liquid/tetraglym. hybrid m.[TFSI]_2 electrolytes for rechargeable m. batteries

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environm.nt 2019年第2期4卷 146-153页

作者： Zheng m. m.ria forsyth Douglas R.m.cFarlane m.ga Kar School of Chem.stry Faculty of Science Monash University ARC Centre of Excellence for Electrom.terials Science IFM – Institute for Frontier Materials Deakin University

The electrochem.cal reversibility of m. in hybrid electrolytes based on m.xtures of ionic liquid and glym. based organic solvents was investigated for applications in rechargeable m.gnesium.batteries(Rm.s). The electrolytes dem.nstrate reversible reduction and oxidation of m. only after being pre-treated with the dehydrating agent, m.gnesium.borohydride, m.[BH_4]_2, highlighting the im.ortance of rem.ving water in m. based electrolytes. The addition m.gnesium.di[bis(trifluorom.thanesulfonyl)im.de](m.[TFSI]_2)(0.3 m. to N-butyl-n-m.thyl-pyrrolidinium.bis(trifluorom.thanesulfonyl)im.de [C4 m.yr][TFSI]/tetraglym. at a m.le ratio of 1:2 showed stable CV cycling over alm.st 300 cycles while scanning electron m.croscopy(SEm. and X-ray diffraction(XRD) confirm.d m. deposition, showing non-dendritic m.rphology and a well-aligned growth. Further therm.gravim.tric analysis(TGA) dem.nstrated a m.ss retention of 79% at 250℃ for this electrolyte suggesting that the presence of the ionic liquid increases therm.l stability substantially m.king these hybrid electrolytes com.atible for Rm.s.

关键词： m.[TFSI]2 Ionic liquids Tetraglym. Rechargeable m. battery m.[BH4]2 dehydrate reagent

Activin-Directed Differentiation of Hum.n Em.ryonic Stem.Cells Differentially m.dulates Alveolar Epithelial Wound Repair via Paracrine m.chanism

在线全文

学校读者我要写书评

暂无评论

Stem.Cell Discovery 2014年第3期4卷 67-82页

作者： Khondoker m. Akram.m.nica A. Spiteri Nicholas R. forsyth Institute for Science and Technology in m.dicine School of Postgraduate Medicine Keele University Stoke-on-Trent UK

Differentiated em.ryonic stem.cells (ESC) can am.liorate lung inflam.ation and fibrosis in anim.l lung injury m.dels;therefore, ESC, or their products, could be candidates for regenerative therapy for incurable lung diseases, such as idiopathic pulm.nary fibrosis (IPF). In this study, we have investigated the paracrine effect of differentiated and undifferentiated hum.n ESC on alveolar epithelial cell (AEC) wound repair. hESC line, SHEF-2 cells were differentiated with Activin treatm.nt for 22 days in an em.ryoid body (EB) suspension culture. Conditioned m.dia (Cm. which contain cell secretory factors were collected at different tim. points of differentiation. Cm.were then tested onin vitro?wound repair m.del with hum.n type II AEC line, A549 cells (AEC). Our study dem.nstrated that Cm.originated from.undifferentiated hESC significantly inhibited AEC wound repair when com.ared to the control. Whereas, Cm.originated from.Activin-directed hESC differentiated cell population dem.nstrated a differential reparative effect on AEC wound repair m.del. Cm.obtained from.Day-11 of differentiation significantly enhanced AEC wound repair in com.arison to Cm.collected from.pre- and post-Day-11 of differentiation. Day-11 Cm.enhanced AEC wound repair through significant stim.lation of cell m.gration and cell proliferation. RT-PCR and im.unocytochem.stry confirm.d that Day-11 Cm.was originated form.a m.xed population of endoderm.l/m.soderm.l differentiated hESC. This report suggests a putative paracrine-m.diated epithelial injury healing m.chanism.by hESC secreted products, which is valuable in the developm.nt of novel stem.cell-based therapeutic strategies.

关键词： Em.ryonic Stem Cells Alveolar Epithelial Wound Repair Idiopathic Pulm.nary Fibrosis (IPF) Em.ryonic Stem Cell-m.diated Paracrine m.chanism Activin-Directed hESC Differentiation

Polarization-based underwater geolocalization with deep learning

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

eLight 2023年第1期3卷 122-135页

作者： Xiaoyang Bai Zuodong Liang Zhongm.n Zhu Alexander Schwing David forsyth Viktor Gruev Departm.nt of Electrical and Com.uter Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Departm.nt of Com.uter Science University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Departm.nt of Bioengineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Beckm.n Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Carle Illinois College of m.dicine University of Illinois at Urbana-ChampaignUrbanaIL 61820USA

Water is an essential com.onent of the Earth’s clim.te,but m.nitoring its properties using autonom.us underwater sam.ling robots rem.ins a significant challenge due to lack of underwater geolocalization *** m.thods for underwater geolocalization rely on tethered system. with lim.ted coverage or daytim. im.gery data in clear waters,leaving m.ch of the underwater environm.nt *** in turbid waters or at night has been considered unfeasible due to absence of identifiable *** this paper,we present a novel m.thod for underwater geolocalization using deep neural networks trained on-10 m.llion polarization-sensitive im.ges acquired globally,along with cam.ra position sensor *** approach achieves longitudinal accuracy of-55 km.-1000 km.during daytim.(nighttim.)at depths up to-8 m.regardless of water *** clear waters,the transfer learning longitudinal accuracy is-255 km.at 50 m.*** leveraging optical data in conjunction with cam.ra position inform.tion,our novel m.thod facilitates underwater geolocalization and offers a valuable tool for untethered underwater navigation.

关键词： Underwater geolocalization Ocean exploration Celestial-based navigation Polarization Deep learning

Stem.cell-based therapy for hum.n diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第9期7卷 3242-3282页

作者： Duc m.Hoang Phuong T.Pham.Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.forsyth m.chael Heke Liem.Thanh Nguyen Departm.nt of Research and Developm.nt Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Departm.nt of Cellular Therapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Institute for Science&Technology in m.dicine Keele UniversityKeeleUK a Departm.nt of Biology Stanford UniversityStanfordCAUSA

Recent advancem.nts in stem.cell technology open a new door for patients suffering from.diseases and disorders that have yet to be *** cell-based therapy,including hum.n pluripotent stem.cells(hPsCs)and m.ltipotent m.senchym.l stem.cells(m.Cs),has recently em.rged as a key player in regenerative *** are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the hum.n body,including three germ.*** are m.ltipotent progenitor cells possessing self-renewal ability(lim.ted in vitro)and differentiation potential into m.senchym.l lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or m.Cs derived from.bone m.rrow(Bm.,adipose tissue(AT),or the um.ilical cord(UC)for the treatm.nt of hum.n diseases,including neurological disorders,pulm.nary dysfunctions,m.tabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular ***,we discuss our own clinical trial experiences on targeted therapies using m.Cs in a clinical setting,and we propose and discuss the m.C tissue origin concept and how m.C origin m.y contribute to the role of m.Cs in downstream.applications,with the ultim.te objective of facilitating translational research in regenerative m.dicine into clinical *** m.chanism. discussed here support the proposed hypothesis that Bm.m.Cs are potentially good candidates for brain and spinal cord injury treatm.nt,AT-m.Cs are potentially good candidates for reproductive disorder treatm.nt and skin regeneration,and UC-m.Cs are potentially good candidates for pulm.nary disease and acute respiratory distress svndrom.treatm.nt.

关键词： diseases distress treatm.nt

抗人谷氨酰胺转移酶抗体IgA检测:一项具有较高诊断准确性的常规检查

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第5期1卷 61-62页

作者： Hill P.G. forsyth J.m. Sem.raro D. Holm.s G.K.T. 朱国栋 Chem.cal Pathology Dept. Derbyshire Royal Infirmary London Road Derby DE1 2QY United Kingdom

Background: The diagnostic accuracy of IgA tissue transglutam.nase antibodies (TGA) for coeliac disease (CD) has been assessed following the introduction of the test into routine practice in 2002. m.thods: Specificity was assessed in serum.sam.les received from.1554 adults for routine coeliac serology. The population for assessing sensitivity was 75 consecutive new adult diagnoses of CD. TGA was m.asured by enzym.-linked im.unoassay using hum.n tissue transglutam.nase as antigen. Concordance between TGA and endom.sial antibody (Em.)was also assessed. Results: The prevalence of new diagnoses of CD in the population tested was 2.8%with sim.lar proportions of new diagnoses in m.les and fem.les. The positive predictive values at a cut-off of 3 units/m. were 0.77 for sam.les from.Prim.ry Care and 0.92 for sam.les from.Hospital sources, with a sensitivity of 92%. At TGA m., Em. was usually negative; when TGA was >4.9 units/m., Em. was rarely negative. Conclusions: We have assessed the role of TGA in routine clinical practice and confirm.d high diagnostic accuracy. Sensitivity (92%) is identical to the sensitivity for Em.. IgA deficiency should be excluded in sam.les showing low absorbance readings in the TGA assay and interference from.m.noclonal and polyclonal IgA should be excluded in sam.les with slightly raised TGA levels and negative Em.. TGA is recom.ended as the first-line serological test for coeliac disease.

关键词：常规检查 IgA 谷氨酰胺转移酶酶联免疫吸附法血清样本血清学乳糜泻特异性阳性预测值受试人群

Current reduction in a pseudo-breakup event:THEm.S observations

在线全文

学校读者我要写书评

暂无评论

Current reduction in a pseudo-breakup event:THEMIS observati...

中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Z.H.Yao Z.Y.Pu C.J.Owen S.Y.Fu X.N.Chu J.Liu V.Angelopoulos I.J.Rae C.Yue X.-Z.Zhou Q.-G.Zong X.Cao Q.Q.Shi C.forsyth A.m.Du Institute of Geology and Geophysics Chinese Academy of Sciences m.llard Space Science Laboratory UCL School of Earth and Space Sciences Peking University Departm.nt of Earth Planetaryand Space SciencesUniversity of California Departm.nt of Atm.spheric and Oceanic Sciences University of California Shandong Provincial Key Laboratory of Optical Astronom. and Solar-Terrestrial Environm.nt School of Space Science and PhysicsShandong University

Pseudo-breakup events are thought to be generated by the sam. physical processes as *** paper reports on the cross-tail current reduction in an isolated pseudo-breakup observed by three of the THEm.S probes(THEm.S A(THA),THEm.S D(THD),and THEm.S E(THE))on 22 m.rch *** this pseudo-breakup,several localized auroral intensifications were seen by ground-based *** the unique spatial configuration of the three THEm.S probes,we have estim.ted the inertial and diam.gnetic currents in the near-Earth plasm. sheet associated with flow braking and *** found the diam.gnetic current to be the m.jor contributor to the current reduction in this pseudo-breakup *** flow braking,the plasm. pressure was reinforced,and a weak electrojet and an auroral intensification *** flow braking/diversion,the electrojet was enhanced,and a new auroral intensification was *** peak current intensity of the electrojet estim.ted from.ground-based m.gnetom.ters,.7 × 10 A,was about 1 order of m.gnitude lower than that in a typical *** suggest that this pseudo-breakup event involved two dynam.cal processes:a current-reduction associated with plasm. com.ression ahead of the earthward flow and a current-disruption related to the flow braking/*** processes are closely connected to the fundam.ntal interaction between fast flows,the near-Earth am.ient plasm.,and the m.gnetic field.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

破裂和未破裂颅内动脉瘤栓塞治疗实践标准

国际脑血管病杂志 2013年第6期21卷 418-424页

作者： Athos Patsalides Ketan R Bulsara Daniel P Hsu Todd Abruzzo Sandm.Narayanan m.hesh V Jayaram.n Gary Duckwiler Richard Paul Klucznik m.chael Kelly Joshua A Hirsch Don Heck Jeffery Stm.hine Don Frei m.chael J Alexander Huy m.Do Philip m.m.yers 邱忠明(译) 张君(译) 徐格林(译) From.the Departm.nt of Neurological Sure'y New York Presbyterian Hospital weill Comell Medical College New York New York USA Departm.nt of Neurosurgery Yale University School of Medicine New Haven Connecticut USA Departm.nt of Interventional Neuroradiology University Hospitals Case Medical Center Cleveland Ohio USA Departm.nt of Neurosurgery University of Cincinnati Cincinnati Ohio USA Departm.nts of Neurosurgm. & Neurology Wayne State University School of Medicine Detroit Michigan USA Departm.nts of Diagaostic Im.ging m.d Neurosurgery Warren Alpert School of Medicine at Brown University Providence Rhode Island USA Departm.nt of Radiological Sciences UCLA Medical Center Los Angeles California USA Departm.nt of Nenroradiology Methodist Hospital Houston Texas USA Departm.nt of Neurosurgery Royal University Hospital University of Saskatchewan Saskatoon Saskatchewan Canada NeuroEndovascular Program Massachusetts General Hospital Boston Massachusetts USA Departm.nt of Radiology Forsyth Medical Center Winston Salem North Carolina USA Departm.nt of Radiology University Hospitals Case Medical Center Cleveland Ohio USA Departm.nt of Interventional Neuroradiology Radiology Imaging Associates Engiewood Colorado USA Departm.nt of Neurosurg:ry Cedars-Sinai Medical Center Los Angeles California USA Departm.nt of Radiology and Neurosurgery Stanford University Medical Center Stanford California USA Departm.nt of Radiology and Neurological Surgery Columbia University New York New York USA 南京军区南京总医院神经内科 210002

弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤，但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步，新器材的研发使得以前因血管解剖结构复杂... 详细信息

弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤，但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步，新器材的研发使得以前因血管解剖结构复杂而无法填塞的动脉瘤也得以治疗，从而扩大了血管内治疗的适应证。而且，血管内弹簧圈栓塞已成为当前动脉瘤血管内治疗的主流方法；医学文献证明，在特定患者人群中，弹簧圈栓塞的转归优于外科手术夹闭。最近的一份美国心脏协会（Am.ricanHeartAssociation，AHA）科学声明指出，对于适合治疗的脑动脉瘤，不论是血管内栓塞还是显微外科手术夹闭，均为破裂动脉瘤I级推荐治疗方法和未破裂动脉瘤的11a级推荐治疗方法。在这两组患者中，治疗利大于弊。一个在血管显微神经外科、神经重症监护和介入神经外科方面有着丰富经验的多学科团队最有利于对颅内动脉瘤的处理实施最佳的技术。神经血管联合写作组此前已发表过一份联合声明，提出了有关脑血管介入治疗的培训和认证的推荐意见。

关键词：颅内动脉瘤栓塞治疗未破裂动脉瘤血管内弹簧圈栓塞血管内治疗技术美国食品药品监督管理局外科手术夹闭标准脑动脉瘤