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The efficacy and safety of pramipexole er versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study

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Translational Neurodegeneration 2014年第1期3卷 80-88页

作者： Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the pramipexole er study team Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine ShanghaiChina Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina The Second Affiliated Hospital of Soochow University SuzhouChina Qilu Hospital affiliated to Shandong University JinanChina Nanjing Brain Hospital NanjingChina West China Hospital affiliated to Sichuan University ChengduChina First Affiliated Hospital of China Medical University ShenyangChina Boehringer Ingelheim International Trading(Shanghai)Co LtdShanghaiChina Boehringer Ingelheim Pharmaceuticals IncRidgefieldCTUSA Boehringer Ingelheim France S.A.S ReimsFrance Department of Neurology Ruijin Hospital affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina 不详

Objective:To evaluate the non-inferiority of pramipexole extended-release(er)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group ***:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-*** received treatment with pramipexole er(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total ***:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for er and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole er and IR was *** incidence of adverse events(AEs)was 68.8%in the er arm and 73.6%in the IR arm with few severe AEs(er:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole er was non-inferior to pramipexole *** safety profiles of pramipexole er and IR were *** results were based on comparable mean daily doses and durations of treatment for both formulations.

关键词： Parkinson’s disease pramipexole er pramipexole IR Non-inferiority Unified Parkinson’s Disease Rating Scale(UPDRS) Safety

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Prospects of the Multi-channel Photometric Survey Telescope in the Cosmological Application of Type Ia Supernovae

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Research in Astronomy and Astrophysics 2024年第4期24卷 183-191页

作者： Zhenyu Wang Jujia Zhang Xinzhong er Jinming Bai Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China International Centre of Supernovae Yunnan Key LaboratoryKunming 650216China South-Western Institute for Astronomy Research Yunnan UniversityKunming 650500China

The Multi-channel Photometric Survey Telescope(Mephisto)is a real-time,three-color photometric system designed to capture the color evolution of stars and transients *** telescope system can be crucial in cosmological distance measurements of low-redshift(low-z,z■0.1)Type Ia supernovae(SNe Ia).To optimize the capabilities of this instrument,we perform a comprehensive simulation study before its official operation is scheduled to *** considering the impact of atmospheric extinction,weather conditions,and the lunar phase at the observing site involving the instrumental features,we simulate light curves of SNe Ia obtained by *** best strategy in the case of SN Ia cosmology is to take the image at an exposure time of 130 s with a cadence of 3 *** this condition,Mephisto can obtain hundreds of high-quality SNe Ia to achieve a distance measurement better than 4.5%.Given the on-time spectral classification and monitoring of the Lijiang 2.4 m Telescope at the same observatory,Mephisto,in the whole operation,can significantly enrich the well-calibrated sample of supernovae at low-z and improve the calibration accuracy of high-z SNe Ia.

关键词： (stars:)supernovae:general (cosmology:)cosmological parameters telescopes

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Gentiana macrophylla Pall.:a review of the basic source,traditional use,chemical components,pharmacological activities and quality control

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Traditional Medicine Research 2024年第12期9卷 13-30页

作者： Qi-er Mu Yi-Sa A Yan-Qiu Bai Chu-La Sa College of Mongolian Medicine Inner Mongolian Medical UniversityJinshan Economic and Technological Development ZoneTumote Left BannerHohhot 010110China

Gentiana macrophylla Pall.(***),whose genus and family belong to the Gentianaceae and *** main distribution centers of *** resources were the Loess Plateau and the eastern Qinghai-Tibet Plateau in ***,as a traditional medicine,has a long history and was used in different ethnic *** roots were used in traditional Chinese medicine,which had the effect of anti-inflammatory,anti-rheumatism,antiviral,promote blood circulation,eliminate swelling and pain,while its flowers were used in traditional Mongolian medicine,which had the effect of removing“Xieriwusu”(“Xieriwusu”means rheumatism),antiviral,reducing *** previous studies,it could be found that there were more than forty components isolated and identified from *** main chemical components were iridoids,flavonoids,triterpenoids,steroids,phenylpropanoids,and *** terpenoid components represented by gentiopicroside and Loganic acid were the main components of the root of ***,which had anti-inflammatory,antioxidant,hepatoprotective,analgesic,antibacterial and promote gastrointestinal tract *** flower mainly contains isoorientin and isovitexin as the representative of *** have anti-tumor,liver protection,heart protection,inhibition of acetylcholinesterase and inhibition of *** could be seen from previous studies that the research on *** was mainly focused on the root,and the flower was rarely *** was reported that the experimental data of the anti-inflammatory and anti-tumor effects of *** flowers show that its curative effect was very ***,the flowers of the flower of *** can be used as potential medicinal parts for *** that flavonoids are mostly found in flowers and exhibit a range of functions,it is possible to investigate the flowers in order to learn more about ***’s potential medical *** on botanical books,Chi

关键词： Gentiana macrophylla Pall. basic source chemical component pharmacological activity quality control

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教育强国建设进程中教师队伍建设的战略与路径——习近平总书记关于教师的重要论述的逻辑与理论体系

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民族教育研究 2024年第2期35卷 43-51页

作者：薛二勇李健北京师范大学中国教育政策研究院北京100875 北京师范大学国际与比较教育研究院北京100875

教师队伍建设是教育强国建设的基础性和战略性支撑。围绕什么是好老师、如何认识教师、采用什么方法、通过什么路径建设教师队伍的问题,习近平总书记提出了一系列新观点新思想,构成了新时代建设高素养专业化创新型教师队伍的战略思路和... 详细信息

教师队伍建设是教育强国建设的基础性和战略性支撑。围绕什么是好老师、如何认识教师、采用什么方法、通过什么路径建设教师队伍的问题,习近平总书记提出了一系列新观点新思想,构成了新时代建设高素养专业化创新型教师队伍的战略思路和实践遵循。本体论上,从教师本身角度,教师要做“四有好老师”;从学生发展角度,教师要做“四个引路人”;从品质提升角度,教师要具备“教育家精神”。认识论上,教师作为立教之本、兴教之源,要做到经师和人师的统一,是“中国梦”得以实现的“筑梦人”与“大先生”。方法论上,坚持把师德师风作为教师第一标准、教师首先要明道信道、以“四个统一”协同育人、加强思想政治教师队伍建设。实践论上,教育优先发展中优先建设教师队伍、教师队伍建设中优先建设乡村教师、提高教师职业待遇、在教师群体中加强党的组织建设。

关键词：习近平总书记教育强国教师队伍教育思想教育战略

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新时代提升高等学历继续教育教学质量的路径研究

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广州开放大学学报 2024年第2期24卷 31-38,108页

作者：邬庆儿广州开放大学广东广州510091

在数字化、网络化的新时代背景下,终身学习理念被越来越多地强调,社会也要求人才具备更高的专业水平和更广的知识视野。高等学历继续教育以在线教育等新的教学方式,使得学习过程更加灵活、便利,其不仅成为了实现终身学习的重要平台,也... 详细信息

在数字化、网络化的新时代背景下,终身学习理念被越来越多地强调,社会也要求人才具备更高的专业水平和更广的知识视野。高等学历继续教育以在线教育等新的教学方式,使得学习过程更加灵活、便利,其不仅成为了实现终身学习的重要平台,也成为满足现代人学习需求的重要途径,这使得高等学历继续教育教学质量的提升成为必然。本研究总结了高等学历继续教育的发展历程,分析了发展现状,明确当前存在的问题和原因,提出改革教学方法、优化课程设置、加强教师队伍建设、完善管理制度、丰富学习资源,提高学习者参与度等策略,为推动高等学历继续教育的健康发展和教学质量的提升提供有益思考和建议。

关键词：新时代高等学历继续教育教学质量提升路径

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Characteristics of American Scholars’Research on Chinese Medical Classics and Their Contributions

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Chinese Journal of Integrative Medicine 2020年第8期26卷 629-632页

作者： WANG er-liang CHEN Xiao School of Basic Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China

Chinese medical classics are important carriers for the inheritance,innovation and development of academic thoughts of Chinese medicine(CM),containing rich thoughts on diagnosis and treatment as well as therapeutic principles of *** international exchange of CM has a very long *** the development of society,Western scholars in modern times are deepening their researches on Chinese medical *** would provide a new way for promoting CM in Western countries to investigate researches made by famed American scholars and their academic viewpoints.

关键词： Chinese medicine classics international exchange American scholar

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Experimental Studies of Electrostatic Fluctuations and Turbulent Transport in the Boundary of J-TEXT Tokamak Using Reciprocating Probe

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Plasma Science and Technology 2012年第12期14卷 1041-1047页

作者： CHEN Zhipeng SUN Yue WANG Zhijiang YANG Zhoujun DING Yonghua ZHUANG Ge J-TEXT team State Key Laboratory of Advanced Electromagnetic Engineering and Technology Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Geospace Environment Chinese Academy of Sciences University of Science & Technology of China Hefei 230026 China

As the basic of a deeper investigation on the turbulent transport, the fluctuation property in the boundary of the newly-reconstructed Joint Texas Experimental Tokamak （J- TEXT） is studied experimentally using the reciprocating Langmuir four-tip probe, which has been built and operated as the primary diagnostic tool in the boundary of J-TEXT tokamak. In this paper, spatial profiles of the plasma-edge parameters are obtained, such as electron temperature, plasma density, plasma potential, poloidal electric field and their fluctuations. The results indicate the existence of a er ×BT shear layer at the vicinity of last closed flux surface （LCFS）, with the fluctuations suppressed in varying degrees. The turbulence-induced particle and energy fluxes can be calculated by the local plasma parameters above. Convection dominates the cross-field turbulent transport in boundary plasma. Electrostatic fluctuations properties are also studied in detail with the help of numerical analysis. Statistical analysis on density fluctuation shows that, the intermittency can affect the turbulence in the scrape-off layer （SOL）.

关键词： electrostatic fluctuations anomalous transport J-TEXT reciprocating Lang- muir probe

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“微生物学”课程劳动教育资源的挖掘与运用

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微生物学通报 2024年第4期51卷 1246-1260页

作者：倪海燕邹龙黄运红付学琴陈青龙中儿江西师范大学生命科学学院江西南昌330022 枣庄学院生命科学学院山东枣庄277160

以专业课程为载体创新劳动教育的实践路径,让学生“劳力并劳心”,是新时代加强大学生劳动教育的新要求。本文结合微生物学课程特性与学生发展的需求阐述了在专业课程中开展劳动教育的重要性,并重新制定了课程劳动教育的内容和目标。课... 详细信息

以专业课程为载体创新劳动教育的实践路径,让学生“劳力并劳心”,是新时代加强大学生劳动教育的新要求。本文结合微生物学课程特性与学生发展的需求阐述了在专业课程中开展劳动教育的重要性,并重新制定了课程劳动教育的内容和目标。课程团队依据马克思主义劳动观的塑造和劳动素养与创造能力的提升两大路径深度挖掘了微生物学课程中蕴含的劳动教育资源,并采用多种教学模式和方法开展课程劳动教育的教学探索。实践表明,改革后学生的学习兴趣和求知欲、专业认同感、责任感和使命感都明显增强,学生不断夯实自己的专业知识和技能,劳动素养和创造性劳动能力也得到明显提升,学习效果显著,初步达到了较好的课程劳动教育育人成效。

关键词：微生物学课程劳动教育教学改革

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左心室辅助装置植入患者围手术期行家庭参与式护理的实践

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中华急危重症护理杂志 2024年第8期5卷 721-724页

作者：何晓娣兰美娟陈媛儿沈航朱贤浙江大学医学院附属第二医院护理部杭州市310009 浙江大学医学院附属第二医院心脏大血管外科杭州市310009

总结6例左心室辅助装置植入患者围手术期家庭参与式护理经验。护理要点:组建专案小组,选择合适的家庭照护责任人参与术前状态优化和心理支持、术后危重期鼓励家属参与ICU谵妄预防;出院准备期以家庭照护培训为重点,分阶段完成机械辅助装... 详细信息

总结6例左心室辅助装置植入患者围手术期家庭参与式护理经验。护理要点:组建专案小组,选择合适的家庭照护责任人参与术前状态优化和心理支持、术后危重期鼓励家属参与ICU谵妄预防;出院准备期以家庭照护培训为重点,分阶段完成机械辅助装置管理、抗凝管理、症状管理、感染防控、日常生活管理五大模块的培训内容。6例患者皆顺利完成手术,家庭照护责任人全程参与围手术期护理,出院前掌握目标知识和技能,出院后家庭照护效果满意,居家期间随访无仪器设备故障及其他并发症,无非计划二次入院。

关键词：左心室辅助装置家庭参与式护理围手术期护理危重病护理

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Optical properties of one-dimensional soft photonic crystals with ferrofluids

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Frontiers of physics 2013年第1期8卷 1-19页

作者： Chun-Zhen Fan er-Jun Liang Ji-Ping Huang School of Physical Science and Engineering and Key Laboratory of Materials Physics of Ministry of Education of China Zhengzhou University Zhengzhou 450052 China State Key Laboratory of Surface Physics and Department of Physics Fudan University Shanghai 200433 China

We review the recent theoretical study on the optical properties of one-dimensional soft photonic crystals (1D SPCs) with ferrofluids. The proposed structure is composed of alternating ferrofluid layers and dielectric layers. For the ferrofluid, single domain ferromagnetic nanoparticles can align to a chain under the stimuli of an external magnetic field, thus changing the microstructure of the system. Meanwhile, nonlinear optical responses in ferrofluids are also briefly reviewed.

关键词： soft photonic crystals ferrofluids band gap

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