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A novel biodegradable polymer-coated sirolimus-eluting stent:1-year results of the helios registry

Chinese Medical Journal 2023年第15期136卷 1848-1854页

作者： Bo Zheng Yi Liu Ruining Zhang Wangwei Yang Fangju Su Rutao Wang Dapeng Chen Guidong Shen Yumin Qiu Lianmin Wang Chang Chen Zhongwei Wu Fei Li Jiayi Li Chengxiang Li Chao Gao Ling Tao for the helios investigators Department of Cardiology Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Cardiology Radboud UniversityNijmegenThe Netherlands Department of Cardiology National University of IrelandGalwayGalwayIreland Internal Medicine of Heart Centre General Hospital of Ningxia Medical UniversityYinchuanNingxia 750003China Department of Cardiology Ankang City Central HospitalAnkangShaanxi 725099China Department of Cardiovascular Cardio-cerebrovascular Hospital affiliated to Ningxia Medical UniversityYinchuanNingxia 750002China Department of Cardiology Mudanjiang Cardiovascular hospitalMudanjiangHarbin 157011China Department of Cardiology the First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong 515041China Department of Cardiology Western Central Hospital of Hainan ProvinceDanzhouHainan 571700China 不详

Background:The helios stent is a sirolimus-eluting stent with a biodegradable polymer and titanium oxide film as the *** study aimed to evaluate the safety and efficacy of helios stent in a real-world ***:The helios registry is a prospective,multicenter,cohort study conducted at 38 centers across China between November 2018 and December 2019.A total of 3060 consecutive patients were enrolled after application of minimal inclusion and exclusion *** primary endpoint was target lesion failure(TLF),defined as a composite of cardiac death,non-fatal target vessel myocardial infarction(MI),and clinically indicated target lesion revascularization(TLR)at 1-year ***-Meier methods were used to estimate the cumulative incidence of clinical events and construct survival ***:A total of 2998(98.0%)patients completed the 1-year *** 1-year incidence of TLF was 3.10%(94/2998,95%closed interval:2.54-3.78%).The rates of cardiac death,non-fatal target vessel MI and clinically indicated TLR were 2.33%(70/2998),0.20%(6/2998),and 0.70%(21/2998),*** rate of stent thrombosis was 0.33%(10/2998).Age≥60 years,diabetes mellitus,family history of coronary artery disease,acute myocardial infarction at admission,and device success were independent predictors of TLF at 1 ***:The 1-year incidence rates of TLF and stent thrombosis were 3.10%and 0.33%,respectively,in patients treated with helios *** results provide clinical evidence for interventional cardiologists and policymakers to evaluate helios *** trial registration:***,NCT03916432.

关键词： Percutaneous coronary interventions Titanium oxide film Sirolimus-eluting stent Target lesion failure helios

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