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Improvement of Survival in Patient with Primary Metastatic Breast Cancer over a 10-Year Periode: Prospective Analyses Based on Individual Patient Date from a Multicenter Data Bank

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Journal of Cancer Therapy 2013年第8期4卷 1306-1312页

作者： Jana Barinoff florian heitz Sherko Kuemmel Christine Dittmer Rita Hils Fatemeh Lorenz-Salehi Alexander Traut Andreas du Bois Agaplesion Markus Krankenhaus Frankfurt am Main Germany Dr. Horst-Schmidt Klinik Wiesbaden Germany Kliniken Essen Mitte Essen Germany

Approximately 6% of patients with breast cancer have distant metastases at the time of the initial diagnosis. The aim of this analysis was to examine the overall survival rate over time and to investigate the effect of new therapy options. Methods: This retrospective analysis was performed based on the data bank of the Clinic for Gynaecological Oncology/Dr. Horst Schmidt Klinik, Wiesbaden and the Clinic for Gynaecological Oncology and Senology/Kliniken Essen Mitte, Essen. The patients with primary metastatic breast cancer (pmBC) who were diagnosed and treated at the accredited breast cancer centres of these clinics were enrolled between 1998 and 2007. The date of diagnosis was used to define 2 specifically chosen 5-year periods: 1998-2002 and 2003-2007. The follow-up time was on average 76 months. The Breslow Test was used to evaluate changes in the median survival time and to detect factors associated with the increase in survival rates. Results: Two hundred sixteen patients with complete baselines were analysed. Ninety patients were diagnosed between 1998 and 2002, and 126 patients received their diagnosis of pmBC between 2003 and 2007. The tumour-biological factors were the same in both groups, whereas the therapeutic concepts were different—the later group (2003-2007) received more aromatase inhibitors, taxane-based chemotherapy and trastuzumab. This finding resulted in an increased median survival time from 31 months in the years 1998-2002 to 44 months in the group with the first diagnosis between 2003 and 2007. Conclusions: Primary metastatic breast cancer occurred at constant rates over last 10 years. The tumour findings did not change in the time between the two examined groups;however, the treatment options in the 2003-2007 group included newly approved therapies. The time period of the first diagnosis was detected as a risk factor for overall survival. Those patients diagnosed in the more recent time frame had a significantly improved survival rate. The es

关键词： Breast Cancer Primary Metastatic Breast Cancer Therapy of Metastatic Breast Cancer Survival of Metastatic Breast Cancer

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An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

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Journal of Bionic Engineering 2021年第2期18卷 375-386页

作者： Sebastian Lifka florian Hischen Johannes heitz Werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip

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