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测量技术助力实现脱碳目标

流程工业 2024年第5期 19-21页

作者： florian Kraftschik Frederik Effenberger Endress+Hauser集团

在工业领域,能源转型目标非常明确:使用可再生资源,保证可持续能源供给。即减少化石燃料燃烧产生的二氧化碳排放,甚至实现零排放。工业脱碳技术对测量技术提出了严格且具体的要求。本文概述了过程自动化专家Endress+Hauser如何为这项事... 详细信息

在工业领域,能源转型目标非常明确:使用可再生资源,保证可持续能源供给。即减少化石燃料燃烧产生的二氧化碳排放,甚至实现零排放。工业脱碳技术对测量技术提出了严格且具体的要求。本文概述了过程自动化专家Endress+Hauser如何为这项事业贡献自己的力量。化工行业的能源转型充满挑战,必须抓紧时间积极应对。化石燃料燃烧会产生大量的二氧化碳气体,对环境造成污染,替代需求非常迫切;然而,二氧化碳依然是众多化工生产的基础原材料。可以说,我们面临的能源转型任务复杂而艰巨。

关键词：基础原材料二氧化碳气体可持续能源可再生资源自动化专家能源转型二氧化碳排放化工行业

炎性因子与冠状动脉旁路移植术后心房颤动的相关性研究进展

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心肺血管病杂志 2024年第6期43卷 663-666页

作者： florian Osmanaj 华琨杨秀滨首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所结构性心脏病外科中心100029

心脏外科术后心房颤动(postoperative atrial fibrillation,POAF)发病率为10%~65%[1],其中CABG术患者POAF发病率高达45%,与术后脑卒中风险增加及较高的晚期死亡率相关[2]。POAF发展是多种因素共同作用结果,许多增强和促进炎症的过程均... 详细信息

心脏外科术后心房颤动(postoperative atrial fibrillation,POAF)发病率为10%~65%[1],其中CABG术患者POAF发病率高达45%,与术后脑卒中风险增加及较高的晚期死亡率相关[2]。POAF发展是多种因素共同作用结果,许多增强和促进炎症的过程均有助于增加POAF风险。

关键词：冠状动脉旁路移植术心脏手术术后心房颤动发病机制

奈妥匹坦帕洛诺司琼预防化疗引起的恶心呕吐:从临床试验到日常临床实践

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中国实用医药 2024年第1期19卷 159-174页

作者： Matti Aapro Karin Jordan florian Scotté Luigi Celio Meinolf Karthaus Eric Roeland Genolier Cancer Centre Clinique de GenolierGenolierSwitzerland Department Haematology Oncology and Palliative CareErnst von Bergmann Klinikum PotsdamPotsdamGermany Department of Medicine V HematologyOncology and RheumatologyUniversity Hospital HeidelbergHeidelbergGermany Interdisciplinary Cancer Course Department Gustave Roussy Cancer InstituteVillejuifFrance Medical Oncology Unit ASST del GardaDesenzano del Garda(BS)Italy Department of Hematology Oncology and Palliative CareKlinikum NeuperlachMunichGermany Department of Hematology Oncology and Palliative CareKlinikum HarlachingMunichGermany Oregon Health and Sciences University Knight Cancer InstitutePortlandORUSA

化疗引起的恶心呕吐(CINV)是众多抗癌药物治疗中常见的不良事件,不仅会对患者生活质量带来负面影响,还有可能影响化疗效果。目前,指南建议的止吐方案可以预防大部分癌症患者的CINV。但临床医师并不能始终遵循指南建议,患者也常常难以坚... 详细信息

化疗引起的恶心呕吐(CINV)是众多抗癌药物治疗中常见的不良事件,不仅会对患者生活质量带来负面影响,还有可能影响化疗效果。目前,指南建议的止吐方案可以预防大部分癌症患者的CINV。但临床医师并不能始终遵循指南建议,患者也常常难以坚持医师处方的治疗。因此需要采取一些提高指南依从性的方法。奈妥匹坦帕洛诺司琼(NEPA)是首个也是唯一一个固定剂量复方止吐药,由奈妥匹坦(口服)/福奈妥匹坦(静脉给药)与帕洛诺司琼(PALO)组成。NEPA可以联合地塞米松组成三联止吐方案,这是用于高致吐性化疗(HEC)患者和部分中致吐性化疗(MEC)患者预防CINV的推荐方案。因此,NEPA止吐治疗操作简单便捷,可能有助于提高指南依从性。本综述对CINV进行了概括,评价了在临床试验和真实实践中积累的NEPA止吐效果及安全性方面的证据,同时也评价了在关键临床试验之外的环境下,即日常临床环境中使用NEPA进行止吐的初步证据。此外,本文还评述了化疗期间使用NEPA控制恶心症状和提高患者生活质量,这是癌症患者管理中面临的两个大挑战。

关键词：奈妥匹坦帕洛诺司琼化疗引起的恶心呕吐 NK1受体拮抗剂 5-羟色胺-3受体拮抗剂生活质量止吐方案

Modeling public holidays in load forecasting: a German case study

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Journal of Modern Power Systems and Clean Energy 2018年第2期6卷 191-207页

作者： florian ZIEL Fakultat fur Wirtschaftswissenschaften insb.Okonomik erneuerbarer EnergienUniversitat Duisburg-Essen

We address the issue of public or bank holidays in electricity load modeling and forecasting. Special characteristics of public holidays such as their classification into fixed-date and weekday holidays are discussed in detail. We present state-of-the-art techniques to deal with public holidays such as removing them from the data set,treating them as Sunday dummy or introducing separate holiday dummies. We analyze pros and cons of these approaches and provide a large load forecasting study for Germany that compares the techniques using standard performance and significance measures. Finally, we give general recommendations for the treatment of public holidays in energy forecasting to suggest how the drawbacks particular to most of the state-of-the-art methods can be mitigated. This is especially useful, as the incorporation of holiday effects can improve the forecasting accuracy during public holidays periods by more than 80%, but even for non-holidays periods, the forecasting error can be reduced by approximately 10%.

关键词： Public holidays Bank holidays Special day effects Forecasting Electricity load Holiday dummy

Using the DEM-CFD method to predict Brownian particle deposition in a constricted tube

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Particuology 2014年第4期12卷 94-106页

作者： florian Chaumeil Martin Crapper School of Engineering The University of EdinburghEdinburgh EH9 3JLUnited Kingdom

Modelling of the agglomeration and deposition on a constricted tube collector of colloidal size particles immersed in a liquid is investigated using the discrete element method （DEM）. The ability of this method to represent surface interactions allows the simulation of agglomeration and deposition at the particle scale. The numerical model adopts a mechanistic approach to represent the forces involved in colloidal suspensions by including near-wall drag retardation, surface interaction and Brownian forces. The model is implemented using the commercially available DEM package EDEM 2.3~, so that results can be repli- cated in a standard and user-friendly framework. The effects of various particle-to-collector size ratios, inlet fluid flow-rates and particle concentrations are examined and it is found that deposition efficiency is strongly dependent on the inter-relation of these parameters. Particle deposition and re-suspension mechanisms have been identified and analyzed thanks to EDEM＇s post processing capability. One-way coupling with computational fluid dynamics （CFD） is considered and results are compared with a two- way coupling between EDEM 2.3 and FLUENT 12.1. It is found that two-way coupling requires circa 500% more time than one-way coupling for similar results.

关键词： Discrete element method DEM Colloids Agglomeration Deposition Simulation

Analysis of stresses at the center of transversely isotropic Brazilian disk

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 618-629页

作者： Ali Aminzadeh florian Amann Institute of Geology of the Czech Academy of Sciences PragueCzech Republic Chair of Engineering Geology RWTH Aachen UniversityAachenGermany

This article presents the stresses at the center of a Brazilian disk(BD)for transversely isotropic *** is shown that the solution of stresses at the center of an anisotropic disk is a function of the disk radius and the magnitude of applied load,as well as the material orientation with respect to the load axis and two dimensionless ratios with specific physical meanings and *** two dimensionless parameters are the ratios of Young’s modulus and apparent shear modulus,although the ratio of apparent shear modulus will be eliminated if the Saint-Venant assumption is *** finite element simulations are carried out to find the stresses at the disk center concerning the material orientation and the two dimensionless ***,an approximate formula obtained from analytical results,previously proposed in the literature for solving the tensile and compressive stresses at the disk center,is re-written and simplified based on these new *** results of the approximate formula fitted to the analytical results are compared to those obtained from numerical solutions,suggesting a good agreement between the numerical and analytical *** approximate equation for the shear stress at the disk center is also formulated based on the numerical ***,the influence of the assumptions for simplification of the proposed formula for the tensile,compressive,and shear stresses at the disk center is discussed,and simple and practical equations are proposed as estimations for the stresses at the center of the BD specimen for low to moderate anisotropic *** highly anisotropic rocks,the reference plots can be used for more accuracy.

关键词： Brazilian test Transverse isotropy Rock anisotropy Anisotropic disk Tensile stress Shear stress

Malaria modeling: In vitro stem cells vs in vivo models

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World Journal of Stem Cells 2016年第3期8卷 88-100页

作者： florian Noulin Department of Microbiology and Molecular Genetics The Kuvin Center for the Study of Infectious and Tropical Diseases IMRIC The Hebrew University-Hadassah Medical School

The recent development of stem cell research and the possibility of generating cells that can be stably and permanently modified in their genome open a broad horizon in the world of in vitro modeling. The malaria field is gaining new opportunities from this importantbreakthrough and novel tools were adapted and opened new frontiers for malaria research. In addition to the new in vitro systems, in recent years there were also significant advances in the development of new animal models that allows studying the entire cell cycle of human malaria. In this paper, we review the different protocols available to study human Plasmodium species either by using stem cell or alternative animal models.

关键词： Malaria Stem cells In vitro models Animal models Humanized mice

Optimal trajectory design accounting for the stabilization of linear time-varying error dynamics

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Chinese Journal of Aeronautics 2022年第7期35卷 55-66页

作者： Patrick PIPREK Haichao HONG florian HOLZAPFEL Institute of Flight System Dynamics Technical University of MunichGarching D-85748Germany

This study is dedicated to the development of a direct optimal control-based algorithm for trajectory optimization problems that accounts for the closed-loop stability of the trajectory tracking error dynamics already during the ***,the trajectory is designed such that the Linear Time-Varying(LTV)dynamic system,describing the controller’s error dynamics,is stable,while additionally the desired optimality criterion is optimized and all enforced constraints on the trajectory are *** is achieved by means of a Lyapunov stability analysis of the LTV dynamics within the optimization problem using a time-dependent,quadratic Lyapunov function *** care is taken with regard to ensuring the correct definiteness of the ensuing matrices within the Lyapunov stability analysis,specifically considering a numerically stable formulation of these in the numerical *** developed algorithm is applied to a trajectory design problem for which the LTV system is part of the path-following error dynamics,which is required to be *** main benefit of the proposed scheme in this context is that the designed trajectory trades-off the required stability and robustness properties of the LTV dynamics with the optimality of the trajectory already at the design phase and thus,does not produce unstable optimal trajectories the system must follow in the real application.

关键词： LTV error dynamics LTV stability Optimal control-based LTV stabilization Path-following error controller Trajectory generation Trajectory optimization

Saturated Hydraulic Conductivity from Field Measurements Compared to Pedotransfer Functions in a Heterogeneous Arable Landscape

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Journal of Earth Science 2010年第6期21卷 923-930页

作者： florian Winter Markus Disse Institute of Hydro Sciences Universitt der Bundeswehr München

A high degree of uncertainty with regard to soil parameterisation limits the significance of physically-based simulation of distributed flood control measures, which affect the runoff generation process, such as land-use changes or differing soil tillage practices. In this study, the soil measurement data from the hillslope scale at the Scheyern research farm were compared to demonstrate this uncertainty. To account for the spatial variability of soils in the investigation area of Scheyern, different approaches were applied to estimate soil hydraulic properties and saturated hydraulic conductivity, and were compared to field measurements

关键词： hydraulic conductivity pedotransfer function hood infiltrometer uncertainty distributed flood control measures.