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Role of N-formyl peptide receptor 2 in germina. ma.rix hemorrha.e:a. intrinsic review of a.hema.oma.resolving pa.hwa.

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 350-354页

作者： Jerry flores Jiping Ta.g Depa.tment of Physiology&Pha.ma.ology Loma Linda University School of MedicineLoma LindaCAUSA

Germina. ma.rix hemorrha.e is one of the lea.ing ca.ses of morbidity,morta.ity,a.d a.quired infa.tile hydrocepha.us in preterm infa.ts in the United Sta.es,with little progress ma.e in its clinica. *** clots ha.e been shown to elicit seconda.y bra.n injury a.ter germina. ma.rix hemorrha.e,by disrupting norma. cerebrospina. fluid circula.ion a.d a.sorption a.ter germina. ma.rix hemorrha.e ca.sing post-hemorrha.ic hydrocepha.us *** evidence suggests tha. ra.id hema.oma.resolution is necessa.y to improve neurologica. outcomes a.ter hemorrha.ic *** a.ticles ha.e demonstra.ed the beneficia. effects of stimula.ing the pola.iza.ion of microglia.cells into the M2 phenotype,a. it ha. been suggested tha. they pla. a. essentia. role in the ra.id pha.ocytosis of the blood clot a.ter hemorrha.ic models of stroke.N-formyl peptide receptor 2(FPR2),a.G-protein-coupled receptor,ha. been shown to be neuroprotective a.ter ***2 a.tiva.ion ha. been a.socia.ed with the upregula.ion of pha.ocytic ma.ropha.e clea.a.ce,yet its mecha.ism ha. not been fully *** litera.ure suggests tha. FPR2 ma. pla. a.role in the stimula.ion of sca.enger receptor *** receptor CD36 pla.s a.vita. role in microglia.pha.ocytic blood clot clea.a.ce a.ter germina. ma.rix ***2 ha. been shown to phosphoryla.e extra.ellula.-signa.-regula.ed kina.e 1/2(ERK1/2),which then promotes the tra.scription of the dua.-specificity protein phospha.a.e 1(DUSP1)*** this review,we present a. intrinsic outline of the ma.n components involved in FPR2 stimula.ion a.d hema.oma.resolution a.ter germina. ma.rix hemorrha.e.

关键词： a.xa. FPR2 GMH hema.oma.resolution hemorrha.ic stroke M1 M2 microglia.pola.iza.ion microglia pha.ocytosis

Remedia.ion of a.ide pesticide-polluted soils by combined sola.iza.ion a.d ozona.ion trea.ment

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Pedosphere 2024年第3期34卷 641-651页

作者： Isa.el Ga.RIDO Ca.men MMa.TINEZ Pila. flores Pila. HELLIN Fulgencio CONTRERa. Jose FENOLL Depa.tment of Susta.na.ility a.d Qua.ity Group of Fruit a.d Vegeta.le Products Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

a.riculture ha. a.close rela.ionship with na.ure,but it ca. a.so be the source of nega.ive a.d perma.ent environmenta. *** use of pesticides in modern a.riculture is a.common pra.tice,but their side effects on the environment ca.not be *** this study,we eva.ua.ed a.combina.ion of sola.iza.ion a.d ozona.ion techniques for the elimina.ion of six a.ide pesticides(bosca.id,chlora.tra.iliprole,cyflufena.id,fluopyra.,na.ropa.ide,a.d propyza.ide)in *** experiments were performed with four different soils to a.sess the efficiency of this methodology a. different soil tempera.ures a.d ozone dosa.es under la.ora.ory conditions,a.d then a.greenhouse pot experiment wa. conducted under controlled conditions during *** da.s a.ter the onset of the experiments,higher degra.a.ion percenta.es of a.ide pesticides were observed in ozonized soils tha. in other trea.ed soils,pa.ticula.ly when ozone wa. a.plied a. 10 cm soil *** results show tha. the utiliza.ion of ozona.ion,a.ong with sola.iza.ion,represents a.va.id method for degra.ing residues of the studied pesticides a.d suggest tha. this combined technology ma. be a.promising tool for remedia.ing pesticide-polluted soils.

关键词： intermedia.e ozone pesticide degra.a.ion pesticide residue polyethylene film remedia.ion technique

Non-Da.cy Flow in Molding Sa.ds

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Open Journa. of a.plied Sciences 2024年第4期14卷 976-982页

作者： Miguel a. Ba.ron-Meza.Joa. Reyes-Mira.da.Da.iel flores-Sa.chez Depa.ta.ento de Ma.eria.es Universidad Autonoma Metropolitana Azcapotzalco Ciudad de Mexico Mexico

Da.cy’s la. is widely used to describe the flow in porous media.in which there is a.linea. rela.ionship between fluid velocity a.d pressure gra.ient. However, it ha. been found tha. for high numbers of Reynolds this la. cea.es to be va.id. In this work, the Ergun equa.ion is employed to consider the non-linea.ity of a.r velocity with the pressure gra.ient in ca.ting sa.ds. The contribution of non-linea.ity to the tota. flow in terms of a.va.ia.le defined a. a.non-Da.cy flow fra.tion is numerica.ly qua.tified. In a.dition, the influence of the sha.e fa.tor of the sa.d gra.ns on the non-linea. flow fra.tion is a.a.yzed. It is found tha. for va.ues of the Reynolds number less or equa. tha. 1, the contribution of non-linea.ity for spherica. pa.ticles is a.ound 1.15%.

关键词： Da.cy’s La. Molding Sa.ds Non-Da.cy Flow Reynolds Number Sha.e Fa.tor

Polyoxidova.a.a.es a.new thera.eutic a.terna.ive for neurodegenera.ive a.d a.ing disea.es

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 571-577页

作者： Sonia.Ira.s Gonza.ez-Ca.o Gonza.o flores Jorge Gueva.a.Julio Cesa. Mora.es-Medina.Sa.uel Treviño a.fonso Dia. Fa.ulty of Chemica. Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Depa.tment of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico a.ima. Reproduction Resea.ch Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

a.ing is a.na.ura. phenomenon cha.a.terized by a.progressive decline in physiologica. integrity,lea.ing to a.deteriora.ion of cognitive function a.d increa.ing the risk of suffering from chronic-degenera.ive disea.es,including ca.diova.cula. disea.es,osteoporosis,ca.cer,dia.etes,a.d *** is considered the ma.or risk fa.tor for Pa.kinson’s a.d a.zheimer’s disea.e ***,dia.etes a.d insulin resista.ce constitute a.ditiona. risk fa.tors for developing neurodegenera.ive ***,no trea.ment ca. effectively reverse these neurodegenera.ive ***,some a.tidia.etic drugs ha.e opened the possibility of being used a.a.nst neurodegenera.ive *** the previous fra.ework,Va.a.ium species ha.e demonstra.ed a.nota.le a.tidia.etic *** resea.ch group eva.ua.ed polyoxidova.a.a.es such a. deca.a.a.a.e a.d metforminium-deca.a.a.a.e with preventive a.d corrective a.tivity on neurodegenera.ion in bra.n-specific a.ea. from ra.s with meta.olic *** results suggest tha. these polyoxidova.a.a.es induce neurona. a.d cognitive restora.ion *** review a.ms to describe the thera.eutic potentia. of polyoxidova.a.a.es a. insulin-enha.cer a.ents in the bra.n,constituting a.thera.eutic a.terna.ive for a.ing a.d neurodegenera.ive disea.es.

关键词： a.zheimer’s disea.e a.tidia.etic bra.n cognition dia.etes insulin neurodegenera.ion neuroinfla.ma.ion oxida.ive stress Va.a.ium species

a.sessment of Wa.er Qua.ity in High-Pressure Peruvia. a.thropic Sectors of La.e Titica.a.Using a.Ca.ibra.ed Index

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Journa. of Geoscience a.d Environment Protection 2024年第8期12卷 97-114页

作者： Stive flores-Gómez a.ilson Ben Da.Costa.Edua.do a. Lobo Gra.ua.e Progra. in Environmenta. Technology University of Santa Cruz do Sul (UNISC) Santa Cruz do Sul Brazil

The world’s la.es a.e in the process of degra.a.ion, with loss of wa.er qua.ity a. a.result of a.thropic influences. This resea.ch a.med to eva.ua.e wa.er qua.ity in high-pressure Peruvia. a.thropic sectors of La.e Titica.a.using a.ca.ibra.ed index. The study considered ten importa.t ba.s with influence from urba. sectors. In ea.h ba., surfa.e wa.ers were monitored for six yea.s, considering physica., chemica. a.d microbiologica. pa.a.eters. Wa.er qua.ity wa. a.sessed using the NSF Wa.er Qua.ity Index (NSF-WQI) a.d the one ca.ibra.ed for La.e Titica.a.(WQIT). Compa.ing the efficiency of these two indices, the WQIT showed a.va.ia.ion from modera.ely polluted ba.s to ba. qua.ity ba.s, such a. Desa.ua.ero a.d Yunguyo. These two ba.s were cla.sified a. hypereutrophic, therefore, the uses a.tributa.le to this condition a.e only irriga.ion a.d energy production. a.plying the NSF-WQI, the results were not a.le to identify this significa.ive difference, a. a.l ba.s were cla.sified a. modera.e qua.ity wa.ers. This result indica.es tha. the WQIT ca.ibra.ion wa. a.equa.e, a. it a.lows inferring a.d estima.ing the wa.er qua.ity of La.e Titica.a.with grea.er precision. a.cording to Peru’s wa.er qua.ity sta.da.d for ca.egory 4, esta.lished for the conserva.ion of the country’s la.es, the pa.a.eters tha. exceeded the sta.da.d va.ues were PO4-P (0.035 mg∙L−1) a.d BOD5 (5 mg∙L−1) in a.l ba.s, a.d TC (1000 MPN mL−1) in Yunguyo ba.. These high va.ues indica.e eutrophica.ion processes, one of the ma.n problems in the study a.ea. The WQIT ca.ibra.ed for La.e Titica.a.ca. be used a. a. efficient tool to a.sess wa.er qua.ity in high a.dea. lentic wa.erbodies in South a.erica.

关键词： a.dea. La.es Wa.er Qua.ity a.sessment Eutrophica.ion Wa.er Qua.ity Index (WQIT)

a.Hybrid Model for Improving Softwa.e Cost Estima.ion in Globa. Softwa.e Development

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Computers, Ma.eria.s & Continua 2024年第1期78卷 1399-1422页

作者： Mehmood a.med Nora.ni B.Ibra.im Wa.if Nisa. a.eel a.med Muha.ma. Juna.d Emma.uel Soria.o flores Divya.a.a.d Fa.ulty of Computer Science a.d Informa.ion Technology Universiti Tun Hussein Onn Malaysia Parit RajaBatu Pahat86400Malaysia Depa.tment of Computer Science COMSATS University Wah Cantt CampusIslamabad47010Pakistan Depa.tment of Informa.ion Technology The University of HaripurKhyber Pakhtunkhwa22620Pakistan Engineering Resea.ch Innova.ion Group Universidad Europea del AtlanticoSantander39011Spain

a.cura.e softwa.e cost estima.ion in Globa. Softwa.e Development(GSD)rema.ns cha.lenging due to relia.ce on historica. da.a.a.d expert *** models,such a. the Constructive Cost Model(COCOMO II),rely hea.ily on historica. a.d a.cura.e *** a.dition,expert judgment is required to set ma.y input pa.a.eters,which ca. introduce subjectivity a.d va.ia.ility in the estima.ion ***,there is a.need to improve the current GSD models to mitiga.e relia.ce on historica. da.a.subjectivity in expert judgment,ina.equa.e considera.ion of GSD-ba.ed cost drivers a.d limited integra.ion of modern technologies with cost *** study introduces a.novel hybrid model tha. synergizes the COCOMO II with a.tificia. Neura. Networks(a.N)to a.dress these *** proposed hybrid model integra.es a.ditiona. GSD-ba.ed cost drivers identified through a.systema.ic litera.ure review a.d further vetted by industry *** a.ticle compa.es the effectiveness of the proposedmodelwith sta.e-of-the-a.tma.hine lea.ning-ba.edmodels for softwa.e cost *** the Na.a.93 da.a.et by a.opting twenty-six GSD-ba.ed cost drivers revea.s tha. our hybrid model a.hieves superior a.cura.y,outperforming existing *** findings indica.e the potentia. of combining COCOMO II,a.N,a.d a.ditiona. GSD-ba.ed cost drivers to tra.sform cost estima.ion in GSD.

关键词： a.tificia. neura. networks COCOMO II cost drivers globa. softwa.e development linea. regression softwa.e cost estima.ion

Design,Synthesis,a.d a.plica.ions of Mesoporous Cova.ent Orga.ic Fra.eworks

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CCS Chemistry 2024年第1期6卷 57-68页

作者： Niya.i a.ora.Ca.sa.dra.flores Milinda.C.Sena.a.hna.Christina.M.Thompson Rona.d a.Sma.done Depa.tment of Chemistry a.d Biochemistry University of TexasDallasRichardsonTexas 75080

Cova.ent orga.ic fra.eworks(COFs)a.e highly ordered a.d perma.ently porous orga.ic polymers tha. ca. be cla.sified a. two-dimensiona. or *** tuna.le design a.d crysta.line order endow a.ra.ge of pore sizes,sha.es,functions,a.d a.plica.ions tha. differentia.e them from other *** COF pore sizes a.d sha.es rely on the geometry of the monomers a.d dyna.ic cova.ent chemistry,while the sta.king of the sheets relies on noncova.ent *** tuna.ility a.lows for post-modifica.ion or the incorpora.ion of a.ditiona. functiona. groups for the reinforcement by va.ious noncova.ent *** limits of mesoporous COFs a.e still being investiga.ed,with the design rules continuing to *** we report a.comprehensive review of mesoporous COFs,explore stra.egies for la.ge pore reinforcement,highlight structura. design a.d fea.ures,elucida.e their va.ious functions a.d a.plica.ions,discuss funda.enta. cha.lenges fa.ed tha. need to be a.dressed,a.d predict future directions.

关键词： cova.ent orga.ic fra.eworks mesoporous supra.olecula. chemistry polymers pore size

Effect of Senescence Reta.da.ts on the Qua.ity of Persia. Lime Fruits

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Phyton-Interna.iona. Journa. of Experimenta. Bota.y 2024年第8期93卷 1805-1818页

作者： Ra.a.l a.iza.flores Ra.a.l a.briz-Cerva.tes Pedro Ca.ena.Iñiguez Luis a.Gálvez-Ma.roquín Miguel a.Ca.o-Ga.cía Na.iona. Institute of Forestry Agriculture and Livestock Research(INIFAP)South Pacific Regional CenterSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México Na.iona. Institute of Forestry Agriculture and Livestock Research(INIFAP)Zacatepec Research StationZacatepecMorelos62780México Na.iona. Institute of Forestry Agriculture and Livestock Research(INIFAP)Central Chiapas Research StationOcozocoautlaChis29140México Na.iona. Institute of Forestry Agriculture and Livestock Research(INIFAP)Oaxaca Central Valley Research StationSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México

The objective of this study consisted of eva.ua.ing the effect of the a.plica.ion of chitosa.(Q),1-methylcyclopropene(1-MCP)under two controlled tempera.ures on some physica.,physiologica.,a.d chemica. pa.a.eters contributing to the qua.ity of Persia. lime Citrus la.ifolia.*** trea.ments were eva.ua.ed,resulting from the combina.ion of four senescence reta.da.t a.plica.ions(Q,1-MCP,1-MCP+Q,a.d without a.plica.ion)on fruits stored a. two tempera.ures(12/20℃.Epidermis color(luminosity,chroma.icity,a.d hue),fruit a.pea.a.ce,respira.ion,weight loss,tota. juice content,tota. soluble solids,a.d titra.a.le a.idity were registered during the *** results indica.e tha. the 1-MCP a.d Q combina.ion fa.ored fruit postha.vest qua.ity conditions such a. reducing respira.ion ra.e;ma.nta.ning fruit good a.pea.a.ce,turgidity,a.d brighter fruit chroma.icity;fruits trea.ed with chitosa. a.d stored a. 12℃,fa.ored tota. soluble *** the other ha.d,Va.ia.les such a. weight loss,juice content,a.idity,phenols,fla.onoids,a.tioxida.t a.tivity,a.d hue va.ues were fa.ored by a.12℃ storing tempera.ure rega.dless of the *** genera.,the use of modified a.mospheres,senescence reta.da.ts,a.d refrigera.ion a. postha.vest methods,ca. increa.e Persia. lime shelf life.

关键词： Citrus la.ifolia qua.ity conserva.ion orga.ic a.terna.ives

Urba. Soil Compa.tion Remedia.ion by Sha.low Tilla.e a.d Compost in Hydroseeded La.n

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Open Journa. of Soil Science 2024年第7期14卷 399-415页

作者： Ja.es Jihoon Ka.g a.a. flores Engil Isa.ora.Pujol Pereira.Jungseok Ho School of Ea.th Environmental and Marine Sciences University of Texas Rio Grande Valley Edinburg Texas USA Environmenta. Hea.th a.d Sa.ety University of Texas Health San Antonio San Antonio Texas USA Depa.tment of Civil Engineering University of Texas Rio Grande Valley Edinburg Texas USA

Construction a.tivities often involve remova. of topsoil a.d compa.tion of the exposed soil by hea.y equipments. Such compa.ted soils with low orga.ic ma.ter ca. lea. to low infiltra.ion a.d poor vegeta.ion esta.lishment. The objective of this study wa. to investiga.e the effica.y of tilla.e (sha.low till) a.d compost on soil physica. a.d biologica. properties in a.hydroseeded la.n a. a.post-construction best ma.a.ement pra.tice for soil compa.tion remedia.ion. The experimenta. site received a.tota. of four la.d trea.ments in five replica.ed tria.s a.d it wa. hydroseeded with common Bermuda.gra.s: 1) No Tilla.e + Compost (NT-C), 2) No Tilla.e + No Compost (NT-NC;control), 3) Tilla.e + Compost (T-C), a.d 4) Tilla.e + No Compost (T-NC). Bulk density (BD), infiltra.ion ra.e (IR), a.d wet a.grega.e sta.ility (Wa.) in ea.h plot were mea.ured to a.sess soil physica. properties while soil orga.ic ma.ter (SOM) a.d enzyme a.tivity (β-glucosida.e, a.id-phospha.a.e, a.d a.ka.ine-phospha.a.e) were mea.ured for soil biologica. properties. Over a.15-months of monitoring period, the sha.low tilla.e loosened the soil initia.ly, but its effect on BD without compost wa. diminished to control plot level (NT-NC) within 4 months a.ter hydroseeding. Both tilla.e a.d compost led to a. increa.e in IR, a.d it rema.ned higher tha. control by 2 - 3 times throughout the observa.ion period. The Wa. a.d β-glucosida.e a.tivity decrea.ed in tilled plot unless there wa. compost a.plica.ion. Turfgra.s showed greener lea.es a.d a.grega.ed roots in the compost-a.ended plots (NT-C a.d T-C). Our results suggest tha. compost a.plica.ion pla.s a.key role in improving soil physica. a.d biologica. properties in hydroseeded la.ns from construction sites.

关键词： Compa.tion Compost Infiltra.ion Soil Orga.ic Ma.ter Soil Enzyme Tilla.e Wet a.grega.e Sta.ility