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r.le of N-for.yl peptide r.ceptor.2 in ger.inal matr.x hemor.hage:an intr.nsic r.view of a hematoma r.solving pathway

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Neur.l r.gener.tion r.sear.h 2024年第2期19卷 350-354页

作者： Jer.y flores Jiping Tang Depar.ment of Physiology&Phar.acology Loma Linda University School of MedicineLoma LindaCAUSA

Ger.inal matr.x hemor.hage is one of the leading causes of mor.idity,mor.ality,and acquir.d infantile hydr.cephalus in pr.ter. infants in the United States,with little pr.gr.ss made in its clinical *** clots have been shown to elicit secondar. br.in injur. after.ger.inal matr.x hemor.hage,by disr.pting nor.al cer.br.spinal fluid cir.ulation and absor.tion after.ger.inal matr.x hemor.hage causing post-hemor.hagic hydr.cephalus *** evidence suggests that r.pid hematoma r.solution is necessar. to impr.ve neur.logical outcomes after.hemor.hagic *** ar.icles have demonstr.ted the beneficial effects of stimulating the polar.zation of micr.glia cells into the M2 phenotype,as it has been suggested that they play an essential r.le in the r.pid phagocytosis of the blood clot after.hemor.hagic models of str.ke.N-for.yl peptide r.ceptor.2(FPr.),a G-pr.tein-coupled r.ceptor.has been shown to be neur.pr.tective after.***2 activation has been associated with the upr.gulation of phagocytic macr.phage clear.nce,yet its mechanism has not been fully *** liter.tur. suggests that FPr. may play a r.le in the stimulation of scavenger.r.ceptor.*** r.ceptor.CD36 plays a vital r.le in micr.glia phagocytic blood clot clear.nce after.ger.inal matr.x ***2 has been shown to phosphor.late extr.cellular.signal-r.gulated kinase 1/2(Er.1/2),which then pr.motes the tr.nscr.ption of the dual-specificity pr.tein phosphatase 1(DUSP1)*** this r.view,we pr.sent an intr.nsic outline of the main components involved in FPr. stimulation and hematoma r.solution after.ger.inal matr.x hemor.hage.

关键词： AnxA1 FPr. GMH hematoma r.solution hemor.hagic str.ke M1 M2 micr.glia polar.zation micr.glia phagocytosis

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Competencies in Computer.Secur.ty and r.solution of Technological Pr.blems in Higher.Education Students

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Jour.al of Computer.and Communications 2024年第4期12卷 171-185页

作者： Esteban Pér.z flores Alejandr. Aldr.tte Malacar. Sandr. r. Mur.llo Cano Vittor.o Zanella Palacios Facultad de Ciencias Administr.tivas Universidad Aut&#243noma de Baja California Mexicali M&#233xico Decanato de Ingenier.#237 as Universidad Popular Aut&#243noma Del Estado de Puebla Puebla M&#233xico

Star.ing fr.m the impor.ance of pr.ser.ing our.infor.ation and pr.tecting our.devices against attacks on their.vulner.bilities, this ar.icle aims to establish the level of knowledge in computer.secur.ty and pr.blem-solving of students at a univer.ity in nor.hwest Mexico. This r.sear.h has a quantitative appr.ach wher. the Eur.pean Fr.mewor. of Digital Competencies for.Citizenship was used as a r.fer.nce to identify and establish the level of the competencies that wer. evaluated. The IKANOS Test was used as a data collection tool. The r.sults show that students know the impor.ance of keeping their.devices safe and how valuable the infor.ation found on them is. On the other.hand, the r.sults also show a consider.ble per.entage of students who do not have the knowledge and ar. at a basic level of knowledge to solve technical pr.blems with their.devices.

关键词： Digital Liter.cy Cyber.ecur.ty DigComp Digital Skills Data Pr.tection

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r.mediation of amide pesticide-polluted soils by combined solar.zation and ozonation tr.atment

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Pedospher. 2024年第3期34卷 641-651页

作者： Isabel GAr.IDO Car.en MMAr.INEZ Pilar.flores Pilar.HELLIN Fulgencio CONTr.r.S Jose FENOLL Depar.ment of Sustainability and Quality Gr.up of Fr.it and Vegetable Pr.ducts Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

Agr.cultur. has a close r.lationship with natur.,but it can also be the sour.e of negative and per.anent envir.nmental *** use of pesticides in moder. agr.cultur. is a common pr.ctice,but their.side effects on the envir.nment cannot be *** this study,we evaluated a combination of solar.zation and ozonation techniques for.the elimination of six amide pesticides(boscalid,chlor.ntr.nilipr.le,cyflufenamid,fluopyr.m,napr.pamide,and pr.pyzamide)in *** exper.ments wer. per.or.ed with four.differ.nt soils to assess the efficiency of this methodology at differ.nt soil temper.tur.s and ozone dosages under.labor.tor. conditions,and then a gr.enhouse pot exper.ment was conducted under.contr.lled conditions dur.ng *** days after.the onset of the exper.ments,higher.degr.dation per.entages of amide pesticides wer. obser.ed in ozonized soils than in other.tr.ated soils,par.icular.y when ozone was applied at 10 cm soil *** r.sults show that the utilization of ozonation,along with solar.zation,r.pr.sents a valid method for.degr.ding r.sidues of the studied pesticides and suggest that this combined technology may be a pr.mising tool for.r.mediating pesticide-polluted soils.

关键词： inter.ediate ozone pesticide degr.dation pesticide r.sidue polyethylene film r.mediation technique

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Polyoxidovanadates a new ther.peutic alter.ative for.neur.degener.tive and aging diseases

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Neur.l r.gener.tion r.sear.h 2024年第3期19卷 571-577页

作者： Sonia Ir.is Gonzalez-Cano Gonzalo flores Jor.e Guevar. Julio Cesar.Mor.les-Medina Samuel Tr.viño Alfonso Diaz Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico Depar.ment of Biochemistr. Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal r.pr.duction r.sear.h Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natur.l phenomenon char.cter.zed by a pr.gr.ssive decline in physiological integr.ty,leading to a deter.or.tion of cognitive function and incr.asing the r.sk of suffer.ng fr.m chr.nic-degener.tive diseases,including car.iovascular.diseases,osteopor.sis,cancer.diabetes,and *** is consider.d the major.r.sk factor.for.Par.inson’s and Alzheimer.s disease ***,diabetes and insulin r.sistance constitute additional r.sk factor. for.developing neur.degener.tive ***,no tr.atment can effectively r.ver.e these neur.degener.tive ***,some antidiabetic dr.gs have opened the possibility of being used against neur.degener.tive *** the pr.vious fr.mewor.,Vanadium species have demonstr.ted a notable antidiabetic *** r.sear.h gr.up evaluated polyoxidovanadates such as decavanadate and metfor.inium-decavanadate with pr.ventive and cor.ective activity on neur.degener.tion in br.in-specific ar.as fr.m r.ts with metabolic *** r.sults suggest that these polyoxidovanadates induce neur.nal and cognitive r.stor.tion *** r.view aims to descr.be the ther.peutic potential of polyoxidovanadates as insulin-enhancer.agents in the br.in,constituting a ther.peutic alter.ative for.aging and neur.degener.tive diseases.

关键词： Alzheimer.s disease antidiabetic br.in cognition diabetes insulin neur.degener.tion neur.inflammation oxidative str.ss Vanadium species

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A Hybr.d Model for.Impr.ving Softwar. Cost Estimation in Global Softwar. Development

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Computer., Mater.als & Continua 2024年第1期78卷 1399-1422页

作者： Mehmood Ahmed Nor.ini B.Ibr.him Wasif Nisar.Adeel Ahmed Muhammad Junaid Emmanuel Sor.ano flores Divya Anand Faculty of Computer.Science and Infor.ation Technology Universiti Tun Hussein Onn Malaysia Parit RajaBatu Pahat86400Malaysia Depar.ment of Computer.Science COMSATS University Wah Cantt CampusIslamabad47010Pakistan Depar.ment of Infor.ation Technology The University of HaripurKhyber Pakhtunkhwa22620Pakistan Engineer.ng r.sear.h Innovation Gr.up Universidad Europea del AtlanticoSantander39011Spain

Accur.te softwar. cost estimation in Global Softwar. Development(GSD)r.mains challenging due to r.liance on histor.cal data and exper. *** models,such as the Constr.ctive Cost Model(COCOMO II),r.ly heavily on histor.cal and accur.te *** addition,exper. judgment is r.quir.d to set many input par.meter.,which can intr.duce subjectivity and var.ability in the estimation ***,ther. is a need to impr.ve the cur.ent GSD models to mitigate r.liance on histor.cal data,subjectivity in exper. judgment,inadequate consider.tion of GSD-based cost dr.ver. and limited integr.tion of moder. technologies with cost *** study intr.duces a novel hybr.d model that syner.izes the COCOMO II with Ar.ificial Neur.l Networ.s(ANN)to addr.ss these *** pr.posed hybr.d model integr.tes additional GSD-based cost dr.ver. identified thr.ugh a systematic liter.tur. r.view and fur.her.vetted by industr. *** ar.icle compar.s the effectiveness of the pr.posedmodelwith state-of-the-ar.machine lear.ing-basedmodels for.softwar. cost *** the NASA 93 dataset by adopting twenty-six GSD-based cost dr.ver. r.veals that our.hybr.d model achieves super.or.accur.cy,outper.or.ing existing *** findings indicate the potential of combining COCOMO II,ANN,and additional GSD-based cost dr.ver. to tr.nsfor. cost estimation in GSD.

关键词： Ar.ificial neur.l networ.s COCOMO II cost dr.ver. global softwar. development linear.r.gr.ssion softwar. cost estimation

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Design,Synthesis,and Applications of Mesopor.us Covalent Or.anic Fr.mewor.s

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CCS Chemistr. 2024年第1期6卷 57-68页

作者： Niyati Ar.r. Cassandr. flores Milinda C.Senar.thna Chr.stina M.Thompson r.nald A.Smaldone Depar.ment of Chemistr. and Biochemistr. University of TexasDallasRichardsonTexas 75080

Covalent or.anic fr.mewor.s(COFs)ar. highly or.er.d and per.anently por.us or.anic polymer. that can be classified as two-dimensional or.*** tunable design and cr.stalline or.er.endow a r.nge of por. sizes,shapes,functions,and applications that differ.ntiate them fr.m other.*** COF por. sizes and shapes r.ly on the geometr. of the monomer. and dynamic covalent chemistr.,while the stacking of the sheets r.lies on noncovalent *** tunability allows for.post-modification or.the incor.or.tion of additional functional gr.ups for.the r.infor.ement by var.ous noncovalent *** limits of mesopor.us COFs ar. still being investigated,with the design r.les continuing to *** we r.por. a compr.hensive r.view of mesopor.us COFs,explor. str.tegies for.lar.e por. r.infor.ement,highlight str.ctur.l design and featur.s,elucidate their.var.ous functions and applications,discuss fundamental challenges faced that need to be addr.ssed,and pr.dict futur. dir.ctions.

关键词： covalent or.anic fr.mewor.s mesopor.us supr.molecular.chemistr. polymer. por. size

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Effect of Senescence r.tar.ants on the Quality of Per.ian Lime Fr.its

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Phyton-Inter.ational Jour.al of Exper.mental Botany 2024年第8期93卷 1805-1818页

作者： r.fael Ar.za-flores r.fael Ambr.z-Cer.antes Pedr. Cadena-Iñiguez Luis A.Gálvez-Mar.oquín Miguel A.Cano-Gar.ía National Institute of For.str. Agriculture and Livestock Research(INIFAP)South Pacific Regional CenterSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México National Institute of For.str. Agriculture and Livestock Research(INIFAP)Zacatepec Research StationZacatepecMorelos62780México National Institute of For.str. Agriculture and Livestock Research(INIFAP)Central Chiapas Research StationOcozocoautlaChis29140México National Institute of For.str. Agriculture and Livestock Research(INIFAP)Oaxaca Central Valley Research StationSanto Domingo Barrio BajoVilla de EtlaOaxaca68200México

The objective of this study consisted of evaluating the effect of the application of chitosan(Q),1-methylcyclopr.pene(1-MCP)under.two contr.lled temper.tur.s on some physical,physiological,and chemical par.meter. contr.buting to the quality of Per.ian lime Citr.s latifolia *** tr.atments wer. evaluated,r.sulting fr.m the combination of four.senescence r.tar.ant applications(Q,1-MCP,1-MCP+Q,and without application)on fr.its stor.d at two temper.tur.s(12/20℃.Epider.is color.luminosity,chr.maticity,and hue),fr.it appear.nce,r.spir.tion,weight loss,total juice content,total soluble solids,and titr.table acidity wer. r.gister.d dur.ng the *** r.sults indicate that the 1-MCP and Q combination favor.d fr.it posthar.est quality conditions such as r.ducing r.spir.tion r.te;maintaining fr.it good appear.nce,tur.idity,and br.ghter.fr.it chr.maticity;fr.its tr.ated with chitosan and stor.d at 12℃,favor.d total soluble *** the other.hand,Var.ables such as weight loss,juice content,acidity,phenols,flavonoids,antioxidant activity,and hue values wer. favor.d by a 12℃ stor.ng temper.tur. r.gar.less of the *** gener.l,the use of modified atmospher.s,senescence r.tar.ants,and r.fr.ger.tion as posthar.est methods,can incr.ase Per.ian lime shelf life.

关键词： Citr.s latifolia quality conser.ation or.anic alter.atives

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C19MC mir.A-520G induces SP100 antivir.l gene tr.nscr.ption and inhibits melanin pr.duction in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Mar.an T.Smallin Nino Mtchedlidze Isha Godwin Mar.o Napoli Nicole Hackel Manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhar. Jaden r.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao Michelle A.r.iser.Keir.n S.M.Smalley Elsa r.flores Andr.w S.Br.hl Depar.ment of Molecular.Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular.Medicine Pr.gr.m H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor.Biology Depar.ment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sar.oma Depar.ment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antivir.l pr.tein that r.str.cts the pr.ductive stage of human papillomavir.s(HPV)and multiple other.vir.ses,and vir.ses in tur. block sUMO-1-mediated stabilization of SP100 and pr.motes its degr.dation(Table S1).Inter.er.n(IFN)signaling could still pr.duce mor. SP100 thr.ugh tr.nscr.ption to counter.ct vir.ses.1 Vir.ses also disable the tr.nscr.ptional up-r.gulation of SP100 to achieve per.istent infection in hosts.

关键词： SP100 melanoma stabilization

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Low-Cost and Biodegr.dable Ther.oelectr.c Devices Based on van der.Waals Semiconductor. on Paper.Substr.tes

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Ener.y & Envir.nmental Mater.als 2024年第1期7卷 201-206页

作者： Gulsum Er.u Car.en Munuer. Feder.co J.Mompean Daniel Vaquer. Jor.e Quer.da João Elias F.S.r.dr.gues Jose A.Alonso Eduar.o flores Jose r.Ar.s Isabel J.Fer.er.Abdullah M.Al-Enizi Ayman Nafady Sr.thi Kur.akose Joshua O.Island Andr.s Castellanos-Gomez Mater.als Science Factor. Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Gr.up USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Depar.amento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIr. Gr.up Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabr.r. Universidad Autónoma de MadridMadrid E-28049Spain Depar.ment of Chemistr. College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Depar.ment of Physics and Astr.nomy University of Nevada Las VegasLas Vegas NV 89154USA

We pr.sent a method to fabr.cate handcr.fted ther.oelectr.c devices on standar. office paper.*** devices ar. based on thin films of WS_(2),Te,and BP(P-type semiconductor.)and TiS_(3)and TiS_(2)(N-type semiconductor.),deposited by simply r.bbing powder.of these mater.als against *** ther.oelectr.c pr.per.ies of these semiconducting films r.vealed maximum Seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for.WS_(2)and TiS_(3),***,Peltier.elements wer. fabr.cated by inter.onnecting the P-and N-type films with gr.phite electr.des.A ther.opower.value up to 6.11 mV K^(-1)was obtained when the Peltier.element wer. constr.cted with thr.e *** findings of this wor. show pr.of-of-concept devices to illustr.te the potential application of semiconducting van der.Waals mater.als in futur. ther.oelectr.c power.gener.tion as well as temper.tur. sensing for.low-cost disposable electr.nic devices.

关键词： paper.based electr.nics Seebeck effect semiconductor. ther.oelectr.cs van der.Waals mater.als

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Assessing a complex patient with both color.ctal cancer.and diver.iculitis of the sigmoid colon: A case r.por. and liter.tur. r.view

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Lapar.scopic, Endoscopic and r.botic Sur.er. 2024年第4期7卷 181-185页

作者： Luis A. Her.ández-flores Daniel Aillaud-De-Ur.ar.e Fabiola Per.z-Baca Ar.on Yu Diego Mar.nes-Copado Depar.ment of Color.ctal Sur.er. Houston Methodist Willowbrook Hospital Houston TX 77070 USA Har.ar. Medical School Boston MA 02115 USA Texas A&M Univer.ity College Station TX 77843 USA

Diver.icular.disease,including diver.iculitis,is a common disease;it accounts for.mor. than 165,000 annual admissions in the United States,1 with an incidence of 188/100,000 per.on-year.,2 being the most common gastr.intestinal(GI)diagnosis in the United States hospitals.3 Diver.iculitis is common in older.adults,but r.cently an incr.ase has been gr.atest in young adults.2 It commonly pr.sents with acute/subacute abdominal pain in the left lower.quadr.nt(LLQ),fever.change in bowel habits and ***,none of these featur.s ar. specific for.diver.iculitis,as clinical suspicion is only diagnostic in 41%of the patients.4,5 Multiple modifiable r.sk factor. have been identified,including high body mass index,incr.ased subcutaneous viscer.l fat,lack of physical activity and smoking.

关键词： colon diagnosis color.ctal

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