检索结果-南通市图书馆

Immunogenic effects of chemotherapyinduced tumor cell death

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2018年第3期5卷 194-203页

作者： Yi-Jun Wang Rochelle fletcher Jian Yu Lin Zhang UPMC Hillman Cancer Center PittsburghPA15213USA Department of Pharmacology and Chemical Biology University of Pittsburgh School of MedicinePittsburghPA15213USA Department of Pathology University of Pittsburgh School of MedicinePittsburghPA 15213USA

Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity,but also results from the restoration of immunosurveillance,which has been largely neglected in the past preclinical and clinical *** immune response can be primed by immunogenic cell death(ICD),a type of cell death characterized by cell-surface translocation of calreticulin(CRT),extracellular release of ATP and high mobility group box 1(HMGB1),and stimulation of type I interferon(IFN)*** we summarize recent studies showing conventional chemotherapeutics as ICD inducers,which are capable of modulating tumor infiltrating lymphocytes(TILs)and reactivating antitumor immunity within an immuno-suppressive *** immunological effects of conventional chemotherapy are likely critical for better prognosis of cancer ***,combination of ICD-inducing chemotherapeutics with immunotherapy is a promising approach for improving the clinical outcomes of cancer patients.

关键词： Antitumor immunity Autophagy Conventional chemotherapy ER stress Immunogenic cell death Immunosurveillance

Utilization of access to colorectal cancer screening modalities in low-income populations after medicaid expansion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2023年第9期15卷 1653-1661页

作者： Gerald fletcher Joan Culpepper-Morgan Alvaro Genao Eric Alatevi Department of Gastroenterology NYC Health+Hospitals/HarlemNew YorkNY 10037United States Department of Gastroenterology NYC Health+Hospitals/Harlem506 Lenox AveNew YorkNY 10037United States

BACKGROUND Colorectal cancer(CRC)remains a relevant public health *** research suggests that racial,economic and geographic disparities impact *** the expansion of Medicaid eligibility as a key component of the Affordable Care Act(ACA),there is a dearth of information on the utilization of newly gained access to CRC screening by low-income *** study investigates the impact of the ACA’s Medicaid expansion on utilization of the various CRC screening modalities by low-income *** working hypothesis is that Medicaid expansion will increase access and utilization of CRC screening by low-income *** To investigate the impact of the Affordable Care Act and in particular the effect of Medicaid expansion on access and utilization of CRC screening modalities by Medicaid state expansion status across the United *** This was a quasi-experimental study design using data from the Behavioral Risk Factor Surveillance System,a large health system survey for participants across the United States and with over 2.8 million *** period of the study was from 2011 to 2016 which was dichotomized as pre-ACA Medicaid expansion(2011-2013)and post-ACA Medicaid expansion(2014-2016).The change in utilization of access to CRC screening strategies between the expansion periods were analyzed as the dependent *** analyses included stratification of the access by ethnicity/race,income,and education *** A greater increase in utilization of access to CRC screening was observed in Medicaid expansion states than in nonexpansion states[+2.9%;95%confidence interval(95%CI):2.12,3.69].Low-income participants showed a+4.02%(95%CI:2.96,5.07)change between the expansion periods compared with higher income groups+3.19%(1.70,4.67).Non-Hispanic Whites and Hispanics[+3.01%(95%CI:2.16,3.85)vs+5.51%(95%CI:2.81,8.20)]showed a statistically significant increase in utilization of access but not in Non-Hispanic Blac

关键词： Medicaid expansion Colorectal cancer screening Low-income Disparities Minorities Affordable care act

Can changes in midsole bending stiffness of shoes affect the onset of joint work redistribution during a prolonged run?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2022年第3期11卷 293-302页

作者： Sasa Cigoja Jared R.fletcher Benno M.Nigg Human Performance Laboratory Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Health and Physical Education Mount Royal UniversityCalgaryAB T3E 6K6Canada

Purpose This study aimed to investigate if changing the midsole bending stiffness of athletic footwear can affect the onset of lower limb joint work redistribution during a prolonged *** Fifteen trained male runners(10-km time of<44 min)performed 10-km runs at 90%of their individual speed at lactate threshold(i.e.,when change in lactate exceeded 1 mmol/L during an incremental running test)in a control and stiff shoe condition on 2 *** limb joint kinematics and kinetics were measured using a motion capture system and a force-instrumented *** were acquired every 500 *** Prolonged running resulted in a redistribution of positive joint work from distal to proximal joints in both shoe *** to the beginning of the run,less positive work was performed at the ankle(approximately 9%;p≤0.001)and more positive work was performed at the knee joint(approximately 17%;p≤0.001)at the end of the *** running in the stiff shoe condition,the onset of joint work redistribution at the ankle and knee joints occurred at a later point during the *** A delayed onset of joint work redistribution in the stiff condition may result in less activated muscle volume,because ankle plantar flexor muscles have shorter muscles fascicles and smaller cross-sectional areas compared to knee extensor *** active muscle volume could be related to previously reported decreases in metabolic cost when running in stiff *** results contribute to the notion that footwear with increased stiffness likely results in reductions in metabolic cost by delaying joint work redistribution from distal to proximal joints.

关键词： Fatigue Footwear Mechanics Performance Running

Peripancreatic collections in acute pancreatitis: Correlation between computerized tomography and operative fi ndings

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第34期16卷 4291-4296页

作者： Santhi Swaroop Vege Joel G fletcher Rupjyoti Talukdar Michael G Sarr Miles and Shirley Fiterman Center for Digestive Diseases Rochester MN 55905 United States Department of Radiology Mayo Clinic Rochester MN 55905 United States Department of Surgery Mayo Clinic Rochester MN 55905 United States

AIM: To evaluate the ability of contrast-enhanced computerized tomography (CECT) to characterize the nature of peripancreatic ***: Twenty five patients with peripancreatic collections on CECT and who underwent operative intervention for severe acute pancreatitis were retrospectively studied. The collections were classified into (1) necrosis without frank pus; (2) necrosis with pus; and (3) fluid without necrosis. A blinded radiologist assessed the preoperative CTs of each patient for necrosis and peripancreatic fluid collections. Peripancreatic collections were described in terms of volume, location, number, heterogeneity, fluid attenuation, wall perceptibility, wall enhancement, presence of extraluminal gas, and vascular ***: Fifty-four collections were identif ied at operation, of which 45 (83%) were identif ied on CECT. Of these, 25/26 (96%) had necrosis without pus, 16/19 (84%) had necrosis with pus, and 4/9 (44%) had fluid without necrosis. Among the study characteristics, fluid heterogeneity was seen in a greater proportion of collections in the group with necrosis and pus, compared to the other two groups (94% vs 48% and 25%, P = 0.002 and 0.003, respectively). Among the wall characteristics, irregularity was seen in a greater proportion of collections in the groups with necrosis with and without pus, when compared to the group with fluid without necrosis (88% and 71% vs 25%, P = 0.06 and P < 0.01, respectively). The combination of heterogeneity and presence of extraluminal gas had a specif icity and positive likelihood ratio of 92% and 5.9, respectively, in detecting pus. CONCLUSION: Most of the peripancreatic collections seen on CECT in patients with severe acute pancreatitis who require operative intervention contain necrotic tissue. CECT has a somewhat limited role in differentiating the different types of collections.

关键词： Contrastenhanced computerized tomogra-phy Correlation Pancreatic necrosis Pancreatitis Peripancreatic fluid collection Surgery

CLE peptide-mediated signaling in shoot and vascular meristem development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Biology 2017年第6期12卷 406-420页

作者： Thai Q. Dao Jennifer C. fletcher Plant Gene Expression Center United States Department of Agriculture-Agricultural Research Service Albany CA 9471 O USA Department of Plant and Microbial Biology University of California Berkeley Berkeley CA 94720 USA

Multicellular organisms rely on the transmission of information between cells to coordinate various biological processes during growth and development. Plants, like animals, utilize small peptide ligands as signaling molecules to transmit information between cells. These polypeptides typically act as extracellular messengers that are perceived by membrane-bound receptors, which then transduce the signal into the recipient cell to modify downstream gene transcription. The CLAVATA3/EMBRYO SURROUNDING REGION-RELATED (CLE) proteins represent one of the largest and best understood families of small polypeptides in plants. Members of the CLE family play critical roles in mediating cell fate decisions during plant development, particularly within the unique meristem structures that contain stem cell reservoirs acting as sources of cells for continuous organ formation. Here we review the roles of CLE family members in regulating the activity of the shoot apical meristems that generate the aerial parts of the plants, and of the vascular meristems that produce the sugar- and water-conducting tissues. A systematic literature search was performed using the Google Scholar and PubMed search engines. The keywords “CLE”, “CLV3”, “TDIF”, “meristem”, and “plant stem cells” were used as search terms. The 95 retrieved articles, dating from 1992, were organized by topic and their key findings incorporated into the text. We summarize our current understanding of how the CLE peptide CLV3 orchestrates the activity of shoot apical meristems, describing its expression, processing and movement, as well as its intracellular signal transduction pathways, key target genes and downstream gene regulatory networks. We also discuss the roles of CLE peptide signaling in the vascular meristems to promote procambial cell proliferation and suppress xylem differentiation. Signaling pathways mediated by CLE peptides are critical for stem cell maintenance and differentiation in shoot apical and vascular me

关键词： CLE CLV3 TDIF WUS stem cells procambium

The Roles of Different CLE Domains in Arabidopsis CLE Polypeptide Activity and Functional Specificity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2010年第4期3卷 760-772页

作者： Ling Meng Kenneth C. Ruth Jennifer C. fletcher Lewis Feldman Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Plant Gene Expression Center USDA-UC Berkeley 800 Buchanan Street Albany CA 94710 USA

The CLE （CLVATA3/ESR-related） family of plant polypeptide signaling molecules shares a conserved 14-aminoacid （aa） motif, designated the CLE motif, which recent studies suggest is sufficient for CLE function in vitro. In this study, we report that Arabidopsis CLE proteins can function in a tissue-specific manner and confirm some CLE factors can act through different receptors. Using domain swapping, we show for the first time that the CLE motif likely determines much of the functional tissue-specificity of the proteins in planta. However, we also provide evidence in support of the new view that sequences outside the CLE motif （14 aa） contribute to CLE function and functional specificity in vivo. Additionally, we report that deletion of the putative signal peptide from different CLE proteins completely inactivates CLE function in vivo, whereas exchanging the CLE signal peptides with a conventional signal peptide from a rice glycine-rich cell wall protein also influences CLE function. We thus propose that the CLE motif itself determines its functional tissue-specificity by dic- tating the direct recognition and interaction of each CLE peptide with its optimal receptor（s）, whereas the receptor（s） may be available in a tissue-specific manner. On the other hand, the sequences outside the CLE motif may influence CLE function by affecting the processing of CLE peptides, resulting in a change in the availability and/or abundance of CLE peptides in specific tissues and/or cells.

关键词： Arabidopsis cell signaling CLE meristem polypeptide protein domain.

Climate drives differences in the germination niche of a globally distributed invasive grass

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2020年第2期13卷 195-203页

作者： Rebecca A.fletcher Kayla M.Varnon Jacob N.Barney Virginia Tech School of Plant and Environmental Sciences675 Old Glade RdBlacksburgVA 24061USA

Aims Exotic invasive species are often exposed to strong selection pressures in their new ranges that can often lead to substantial intraspecific *** differentiation in the timing of life history events in response to climate gradients is thought to be an important mechanism facilitating the range expansion of many invasive *** seed producing plants,the timing of seed germination determines the first environmental conditions experienced by newly emerged germinates,and can have important implications for the successful colonization,establishment and spread of invasive plants—though the role of germination in the success of invasive plants remains poorly *** We assessed the variation in seed germination dynamics among 10 populations of the invasive plant Johnsongrass(Sorghum halepense)across its North American distribution,capturing both a temperature and precipitation gradient,and whether that variation is associated with home *** were exposed to a wide range of temperatures(11–48℃)and two water availability *** Findings We found that Johnsongrass seeds germinated across a wide range of temperatures,but there was substantial variation among populations in the proportion of seeds that germinated in response to both temperature and water *** indicates that as Johnsongrass expanded its range from warmer climates into cooler climates,there was a concurrent shift in the germination temperature niche to cooler *** results suggest that the germination of Johnsongrass seeds has adapted to home climate allowing this invader to maximize germination throughout its range,and that this may be an important contributing factor to its invasion into new environments.

关键词： adaptation among-population variation Johnsongrass Sorghum halepense temperature water availability

Cultivated Land Changes and Their Driving Forces——A Satellite Remote Sensing Analysis in the Yellow River Delta,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2004年第1期14卷 93-102页

作者： ZHAOGeng-Xing G.LIN J.J.fletcher C.YUILL CollegeofResourcesandEnvironment ShandongAgriculturalUniversityTaian271018（China） RegionalResearchInstitute WestVirginiaUniversityMorgantownWV26505-6300（USA）

Taking Kenli County in the Yellow River Delta, China, as the study area and using digital satellite remote sensing techniques, cultivated land use changes and their corresponding driving forces were explored in this study. An interactive interpretation and a manual modification procedure were carried out to acquire cultivated land information. An overlay method based on classification results and a visual change detection method which was supported by land use maps were employed to detect the cultivated land changes. Based on the changes that were revealed and a spatial analysis between cultivated land use and related natural and socio-economic factors, the driving forces for cultivated land use changes in the study area were *** results showed a decrease in cultivated land in Kenli County of 5321.8 ha from 1987 to 1998, i.e.,an average annual decrement of 483.8 ha, which occurred mainly in the central paddy field region and the northeast dry land region. Adverse human activities, soil salinization and water deficiencies were the driving forces that caused these cultivated land use changes.

关键词： cultivated land driving force satellite remote sensing the yellow riverdelta

The measurement and modification of hypoxia in colorectal cancer:overlooked but not forgotten

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 132-144页

作者： Teddy fletcher Alex J.Thompson Hutan Ashrafian Ara Darzi Department of Surgery and Cancer Queen Elizabeth the Queen Mother WingSt Mary’s HospitalImperial College LondonLondonUK The Hamlyn Centre Institute of Global Health InnovationImperial College LondonLondonUK

Tumour hypoxia is the inevitable consequence of a tumour’s rapid growth and disorganized,inefficient *** compensatorymechanisms employed by tumours,and indeed the absence of oxygen itself,hinder the ability of all *** clinical consequence is poorer overall survival,disease-free survival,and locoregional *** this,clinicians have been attenuating the effect of hypoxia,primarily with hypoxicmodification or with hypoxia-activated prodrugs,and notable success has been ***,in the case of colorectal cancer(CRC),there is a general paucity of knowledge and evidence surrounding themeasurement andmodification of hypoxia,and this is possibly due to the comparative inaccessibility of such *** specifically review the role of hypoxia in CRC and focus on the current evidence for the existence of hypoxia in CRC,themajority of which originates from indirect positron emission topography imaging with hypoxia selective radiotracers;the evidence correlating CRC hypoxia with poorer oncological outcome,which is largely based on themeasurement of hypoxia inducible factor in correlation with clinical outcome;the evidence of hypoxicmodification in CRC,of which no direct evidence exists,but is reflected in a number of indirectmarkers;the prognostic andmonitoring implications of accurate CRC hypoxia quantification and its potential in the field of precision oncology;and the present and future imaging tools and technologies being developed for themeasurement of CRC hypoxia,including the use of blood-oxygenlevel-dependentmagnetic resonance imaging and diffuse reflectance spectroscopy.

关键词： hypoxia colorectal neoplasm prognostication neoadjuvant chemoradiotherapy