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MicroRNA-126 and epidermal growth factor-like domain 7 predict recurrence in patients with colon cancer treated with neoadjuvant chemotherapy

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Cancer Drug Resistance 2019年第3期2卷 885-896页

作者： Torben Frøstrup Hansen Anting Liu Carlsen Julia Tanas Tanassi Ole Larsen flemming brandt sørensen Lars Henrik Jensen Anders Jakobsen Danish Colorectal Cancer Center south Vejle HospitalInstitute of Regional Health ResearchUniversity of Southern DenmarkVejle 7100Denmark Department of Autoimmunology and Biomarkers Statens Serum InstitutCopenhagen 2300Denmark Department of Congenital Disorders Statens Serum InstitutCopenhagen 2300Denmark Department of Oncology Herlev HospitalHerlev 2730Denmark University Institute of Pathology Aarhus University Hospitaland department of Clinical MedicineUniversity of AarhusAarhus 8200Denmark

Aim:Neoadjuvant chemotherapy may represent a shift in the treatment of locally advanced colon *** angiogenic couple has-microRNA-126(miRNA-126)and epidermal growth factor-like domain 7(EGFL7)are transcribed from the same gene and regulates all aspects of angiogenesis and may influence the ability of tumor cells to *** aim was to analyze the relationship between miRNA-126 and EGFL7 and disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant ***:This study included 71 patients from a phase II study all planned for three cycles of capecitabine and oxaliplatin before *** was sampled at baseline and right before and after the *** miRNA-126 was analysed by RT-qPCR and a quantitative immunoassay was used for the analyses of ***:The rates of 5-year disease-free survival(DFs)and overall survival(Os)were 80%and 85%,*** level of circulating miRNA-126 before the operation predicts recurrence,P=*** patients with values below and above the median the recurrence rate was 31%and 4%,*** results applied to EGFL7.A combined estimate identified a subgroup of patients(25 of 71)with no recurrence and a 5-year DFs and Os rate of 100%,***:MicroRNA-126 and EGFL7 are predictors for disease recurrence in patients with locally advanced colon cancer treated with neoadjuvant chemotherapy and may assist in selection of adjuvant chemotherapy.

关键词： Chemotherapy colon cancer epidermal growth factor-like domain 7 microRNA-126

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