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Antimicrobial and Antioxidant Activity of Anacardium occidentale L. Flowers in Comparison to Bark and Leaves Extracts

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Journal of Biosciences and Medicines 2016年第4期4卷 87-99页

作者： Rubenice Amaral da Silva Silvana Amado Liberio flavia M. M. do Amaral flavia raquel fernandes do nascimento Luce Maria Brandão Torres Valério Monteiro Neto Rosane Nassar Meireles Guerra Laboratory of Immunophysiology Universidade Federal do Maranhao Campus do Bacanga Sao Luis Brazil Instituto Botanico de Sao Paulo Sao Paulo Brazil Departament of Pathology Universidade Federal do Maranhao Sao Luis Brazil Universidade Ceuma Sao Luís Brazil

Anacardium occidentale L., Anacardiaceae, is frequently used to treat infections. We evaluated the antimicrobial and antioxidant activity of extracts obtained from aerial parts of the plant in comparison with the extract prepared with the flowers. Ethanol extracts of the leaves (EEL), stem bark (EEB), and flowers (EEF) were prepared separately. The antimicrobial activity was evaluated by agar diffusion and broth dilution methods. The minimum bactericidal and fungicidal concentrations were determined against: Streptococcus mutans, Lactobacillus acidophilus, Staphylococcus aureus, MRSA, Enterococcus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, Salmonella choleraesuis, Candida albicans, and Candida tropicalis. The antioxidant activity of the extracts was evaluated based on their scavenger capacity of 2,2-diphenyl-1-picrylhydrazyle. The phytochemical profile was analyzed by colorimetric methods and by HPLC with UV detection. All extracts exhibited antioxidant and antimicrobial activity. Although, the EEF was the most effective since it inhibited the growth of all 14 microorganisms tested. Anacardic and galic acids were identified in all extracts as well phenolic compounds, triterpenes, flavones and xanthones. In conclusion, the extracts obtained from the aerial parts of A. occidentale, mainly the extract of flowers that was the most effective, are rich in bioactive metabolites that exert a potent antioxidant and antimicrobial effect. Taken together, the results indicate an important biotechnological potential of A. occidentale as a source of compounds with broad-spectrum antimicrobial and of antioxidant activity to be used in the food and cosmetics industry.

关键词： Anacardium occidentale Antimicrobial Agents Flowers Cashew Caju Antioxidant

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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： flavia Oliveira Monteiro da Silva Abreu Taysse Holanda Joice Farias do nascimento Henety nascimento Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros Júlio César Sousa Prado raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa

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Asian Journal of Andrology 2011年第5期13卷 747-753页

作者： Otacilio D Benvindo Nilberto RF nascimento Claudia F Santos Manasses C Fonteles Edilberto R Silveira Daniel E Uchoa Adriana R Campos Karina MA Cunha flavia A Santos Vietla S Rao Department of Physiology and Pharmacology Faculty of Medicine Federal University of Ceara PO Box 3157 60430-270 Fortaleza CE Brazil Superior Institute of Biomedicine Caara State University Fortaleza CE Brazil Detriment of Organic and Inorganic Chemistry Federal University of Ceara 60455-760 Fortaleza CE Brazil

Compounds with dual action on cyclic adenosine monophosphate （cAMP） and cyclic guanosine monophosphate （cGMP） may be a treatment option for erectile dysfunction, as they not only promote penile erection but also prevent the upregulation of phosphodiesterase-5. In this study, we examined the possible relaxant effect and mechanism of 17-nor-subincanadine E （SEC, 0.2-200 pmol I^-1）, a plant-derived alkaloid, in rabbit corpus cavernosum （RbCC） strips that had been precontracted by exposure to phenylephrine （10 pmol I^- 1） or a high concentration of K＋（60 mmol I^- 1） in vitro. In addition to SEC＇s effect on cAMP and cGMP levels, electrical field stimulation （EFS） in phenylephrine-precontracted RbCC and calcium chloride （1-100 mmol I^-1） evoked responses in depolarized RbCC were analysed. SEC relaxed the phenylephrine-precontracted RbCCs in a concentration-dependent manner. Atropine, guanethidine and N-co-nitro-L-arginine methyl ester （L-NAME） did not have any effect on the relaxation of RBCCs. When 1H-1,2,4oxadiazole[4,3-a] quinoxalin-1-one （ODQ） was added, it effectively blocked the relaxant response of SEC. Although SEC enhanced the maximal relaxation produced by sodium nitroprusside （SNP） and forskolin in phenylephrine-precontracted cavernosal smooth muscle, it caused a decrease in the maximal contractile response induced by calcium chloride in depolarized RbCCs. The relaxant effect of SEC was paralleled by an increase in the tissue levels of the Cyclic nucleotides cAMP and cGMP. We conclude that SEC promotes the relaxation of RbCC, possibly favouring cAMP and cGMP accumulation and calcium blockade. This novel mechanism could be useful for patients who do not benefit from phosphodiesterase inhibitors and for those with endothelial and nitrergic dysfunction, such as patients with diabetes, hypertension and dyslipidaemias.

关键词： 17-nor-subincanadine E cyclic nucleotides electrical field stimulation nitric oxide rabbit corpus cavernosum smoothmuscle relaxation

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Phytoplankton Productivity and Hydrology in an Impacted Estuarine Complex in Northeastern Brazil

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Open Journal of Ecology 2019年第10期9卷 458-477页

作者： Laisa Madureira da Silva Fernando Antonio do nascimento Feitosa Manuel de Jesus Flores Montes Amanda Yumi Otsuka flavia Saldanha-Correa Carlos Noriega Oceanography Department Federal University of Pernambuco—UFPERecifeBrazil Oceanographic Institute of the University of So Paulo University of So Paulo—USPSo PauloBrazil

The aim of the current study was to evaluate the productive capacity of the phytoplankton community and other environmental variables in the estuarine area of Suape;while considering the constant morphological, sedimentological and hydrological changes, the site has been facing due to the implementation and expansion of an industrial and port complex. The study comprised 6 campaigns: 3 in the dry season and 3 in the rainy season. Water samples were collected from the surface layer of the internal and external portions of the estuarine bay during low spring tides. The salinity ranged from 32.20 to 37.10, the water temperature ranged from 26.60°C to 29.40°C, and the oxygen saturation rate ranged from 58.5% to 114.5%. There was significant seasonal variation. The nitrite concentration was higher during the rainy season, whereas the ammonia concentration was higher during the dry season;the higher ammonia concentration helped increase chlorophyll-a levels and rates of primary productivity, which ranged from 0.02 - 2.45 mg·m−3 and from 0.34 to 4.32 mg·C·m−3·h−1, respectively. Chlorophyll-a a-containing biomass, and this reflected the low nutrient content in the water and indicated that the area was free from eutrophication processes. The decrease of rainfall during the sampling months and the anthropogenic changes in the environment led to reduced continental contributions, increased marine interference, nutrient dilution and loss of phytoplankton production capacity in Suape Bay, which severely damaged other trophic links in the ecosystem.

关键词： Estuarine Area Phytoplankton Primary Productivity Chlorophyll a Suape Bay

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