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Ovarian cancer recurrence:“is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?”

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Cancer Drug Resistance 2022年第2期5卷 451-458页

作者： Tanja Pejovic Katherine fitch Gordon Mills Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA. Department of Obstetrics&Gynecology Oregon Health&Science UniversityPortlandOR 97239USA.

PolyADP ribose polymerase inhibitors(PARPi)have transformed the treatment of ovarian *** in high-grade serous ovarian cancer(HGSOC),a disease characterized by homologous recombination deficiency(HRD),PARPi have had a rapid and profound impact on the disease course,as well as biologic and biomarker definitions of HGSOC,thereby creating a paradigm shift in the approach to *** this review,we discuss the role of PARPi in the maintenance treatment of HGSOC,its effect on platinum sensitivity,and cross-resistance between platinum and PARP inhibitors.

关键词： PARP inhibitors olaparib niraparib ovarian cancer maintenance therapy

Implementation of an analogue model of a memristor based on a light-dependent resistor

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Chinese Physics B 2012年第10期21卷 500-507页

作者：王晓媛 Andrew L.fitch Herbert H.C.Iu Victor Sreeram 齐维贵 School of Electrical Engineering Harbin Institute of Technology School of Electrical Electronicand Computer EngineeringThe University of Western Australia 35 Stirling HighwayCrawleyWA 6009Australia

In this paper,an analogue model of a memristor using a light-dependent resistor(LDR) is *** model can be simplified into two parts:a control circuit and a variable *** can be used to easily verify theoretical presumptions about the switching properties of *** LDR-based memristor model can also be used in both simulations and experiments for future research into memristor *** paper includes mathematical models,simulations,and experimental results.

关键词： analogue model light-dependent resistor memristor simulator

Soil resource availability and its effect on the ecophysiology and establishment of Stipa pulchra

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Journal of Plant Ecology 2019年第4期12卷 603-614页

作者： Robert L.fitch Erin J.Questad Edward G.Bobich Department of Biological Sciences California State Polytechnic UniversityPomona3801 West Temple Avenue PomonaCA 91768USA

Aims The objectives of this study were to(i)determine the importance of soil moisture and soil nitrogen availability as resource requirements for the establishment of Stipa pulchra,(ii)to examine how changes in slope within a local habitat can affect the accumulation of soil moisture and soil nitrogen and(iii)to measure the physiological re-sponses of *** among such slope *** The field experiment occurred in the San JoséHills of Southern California on the California State Polytechnic University,Pomona *** were established within three different slope loca-tions(shallow,moderate and steep)within four separate *** nitrogen treatments(ambient,addition and removal)were replicated within each slope location for all four canyons,and five *** plants were planted in each *** nitrogen accumula-tion and soil moisture,as well as other abiotic variables,were meas-ured across the varied slope locations and nitrogen *** measured the cover,stress,and reproduction of *** plants for 2 years and used a mesocosm experiment to determine how ***-chra responds to varying water and nitrogen *** Findings Stipa pulchra had a strong positive response to the wettest watering treatment and a weak response to nitrogen addition in the meso-cosm *** the field experiment,*** responded positively in moderate slope locations and did not respond to ni-trogen treatments,possibly due to *** patterns of soil moisture were driven by slope,soil compaction and solar *** nitrogen accumulation did not vary among slope *** restoration of ***,priority should be placed on managing soil moisture availability and determining suitable edaphic factors.

关键词： establishment ecophysiology slope soil moisture soil properties nitrogen deposition

Androgenic-anabolic steroids and the Olympic Games

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Asian Journal of Andrology 2008年第3期10卷 384-390页

作者： Kenneth D. fitch School of Human Movement and Exercise Science Faculty of Life and Health Sciences University of Western AustraliaNedlands 6009 Australia

Androgenic-anabolic steroids （AAS） have been misused by athletes at the Olympic Games, both before and after they were prohibited in sport in 1974. Systematic doping with AAS occurred in the German Democratic Republic （GDR） from 1965 to 1989 which assisted that country to win many medals at Olympic Games, especially in female events. Currently, AAS are the most frequent category of prohibited substances detected in the urine of athletes both globally and at the last two Summer Olympic Games. Scientific confirmation that AAS are effective in enhancing sports performance was difficult because ethical approval was difficult for research involving male subjects taking massive doses of androgens as some athletes and bodybuilders did. Methods to detect AAS have evolved gradually over the past three decades and currently, despite an impressive array of sophisticated analytical equipment and methods, anti-doping authorities and analytical scientists continue to face challenges as have occurred from the use by athletes of designer AAS during the past few years. The future development and use of selective androgen receptor modulators （SARMs） can be anticipated to pose problems in the years ahead. Endocrinologists should be aware that on occasions, replacement testosterone （T） therapy may be authorized in sport as a therapeutic use exemption （TUE） and these circumstances are discussed.

关键词： doping androgenic-anabolic steroids history Olympic Games detection designer steroids therapeutic use exemption

Coverage probability of cellular networks using interference alignment under imperfect CSI

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Digital Communications and Networks 2016年第4期2卷 162-166页

作者： Raoul F. Guiazon Kai-Kit Wong Michael fitch Department of Electronic and Electrical Engineering University College London WCIE 7JE UK BTMobility Group Martlesham Heath Suffolk IP5 3RE UK

Interference alignment （IA） is well understood to approach the capacity of interference channels, and believed to be crucial in cellular networks in which the ability to control and exploit interference is key. However, the achievable performance of IA in cellular networks depends on the quality of channel state information （CSI） and how effective IA is in practical settings is not known. This paper studies the use of IA to mitigate inter-cell interference of cellular networks under imperfect CSI conditions. Our analysis is based on stochastic geometry where the structure of the base station （BS） locations is considered by a Poisson point process （PPP）. Our main contribution is the coverage probability of the network and simulation results confirm the accuracy.

关键词： Interference alignment Beamforming Coverage probability Channel errors Stochastic geometry

维普期刊数据库

Let＇s Get Physical -China＇s Fitness Industry Boom

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China International Business 2009年第11期 44-46页

作者： LAURA fitch

Jiao Yang was in her mid-20s the first time she stepped into a gym. It was around five or six years ago, she isn＇t sure exactly, though she does remember why she joined her local club in Beijing：＂It＇s known for i... 详细信息

关键词：健身房行业中国俱乐部价格

Electron Transfer of <i>Shewanella oneidensis</i>MR-1 at Clay-Modified ITO Electrode

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American Journal of Analytical Chemistry 2019年第10期10卷 459-475页

作者： Reem Alshehri Alanah fitch Department of Chemistry and Biochemistry Loyola University Chicago Chicago USA Department of Chemistry Taibah University Al-Ula KSA

The electrode material is an important aspect for the efficiency and costs in the microbial fuel cells (MFCs). Enhancing of current production and bacteria attachment to the electrode are essential goals for developing the performance of MFCs. In this study, the role of the structural iron present in clays in enhancing the electron transfer of Shewanella oneidensis MR-1 was investigated. Two types of clay containing different amounts of iron situated in the octahedral sites were used to modify ITO (indium tin oxide) electrodes, namely nontronite NAu-1, and montmorillonite (Wyoming) SWy-1. Synthetic montmorillonite SYn-1 which is iron-free clay was used for comparison. The interaction between the bacterial cells and the clays was studied by potential-step chronoamperometry, cyclic voltammetry, confocal microscopy, and scanning electron microscopy (SEM). The obtained results showed that the current densities generated upon ITO electrode modification using the NAu-1 and SWy-1 iron-containing clays were 19 and 3 times higher than that produced using the bare ITO electrode. No current density was obtained when utilizing the synthetic montmorillonite SYn-1 clay. SEM and confocal microscopy observations confirmed the increased coverage percentage of the bacterial cells attached to the clay-modified electrodes compared to the bare ITO.

关键词： Shewanella oneidensis MR-1 Clay Modified ITO Electrode Microbial Fuel Cell

e-Automation,an Architecture for Distributed Industrial Automation Systems

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International Journal of Automation and computing 2004年第1期1卷 17-25页

作者： D.P.Buse J. fitch Department of Electrical Engineering and Electronics The University of Liverpool Liverpool L69 3GJ UKNetwork Strategy National Grid Company plc National Grid House Kirby Corner Road Coventry CV4 8JY UK

Due to the complexity of modern industrial systems, a conventional automation system is not capable of providing sufficient information management and high-level intelligent approaches, as achieving these functionalities requires the support of comprehensive data management and coordination between system devices and heterogenous information. This paper proposes the concept of e-Automation, in which computer networking and distributed intelligence agent technologies are applied to industrial automation systems, and presents a hardware and software architecture that implements this concept. An open infrastructure based on multi-agent systems is employed in the proposed architecture of e-Automation, which aims to allow the implementation of diverse tasks and to permit greater configurability than can be obtained from a traditional system. To evaluate our proposed e-Automation concept, this paper presents a case study of substation information management which adopts the proposed e-Automation architecture in power system domain.

关键词： Intelligent agents multi agent system distribute system e Automation monitoring system real time control

维普期刊数据库

Metal Ions Impact on <i>Shewanella Oneidensis</i>MR-1 Adhesion to ITO Electrode and the Enhancement of Current Output

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American Journal of Analytical Chemistry 2019年第9期10卷 428-443页

作者： Aisha Alshahrani Alanah fitch John Al-Bazi Department of Chemistry and Biochemistry Loyola University Chicago Chicago IL USA Department of Chemistry Al Baha University Al Baha KSA Department of Chemistry Northeastern Illinois University Chicago IL USA

The goal of this study is to enhance the efficiency of bacterial extracellular electron transfer (EET) in Shewanella oneidensis MR-1 by enhancing adhesion to the electrode surface. Our results clearly show a major difference in attachment and behavior of S. oneidensis MR-1 for Ca2+, Pb2+, Cd2+, and Mg2+ compared to the control. The final microbial coverage, as measured by confocal microscopy and cathodic peak charge in cyclic voltammetry (Qpc), increases with increasing metal ion concentrations. We found the cells attached to the electrode increased more with the addition of metal ion concentrations in the following order of metals: Ca2+ > Pb2+ > Cd2+ > Mg2+ compared to the control. The effect of metal ions on metabolism of the bacteria was tested by the riboflavin production and glucose consumption. Metabolic activity mirrored the same order of the activity as the electrochemical results.

关键词： Shewanella oneidensis MR-1 Metal Ions Extracellular Electron Transfer Glucose Riboflavin Adhesion