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急性脑卒中患者溶栓治疗后神经功能无改善：预测指标及其与预后的关系

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美国医学会杂志（中文版） 2005年第5期24卷 271-276页

作者： Gustavo Saposnik Bryan Young Brian Silver Silvia Di Legge fiona webster Vadim Beletsky Vivek Jain 孙伟平（译）黄一宁（校） Stroke Program Department of Clinical Neurological Sciences London Health Sciences Centre University of Western Ontario London Department of Neurology Henry Ford Hospital Detroit Mich 不详

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其... 详细信息

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其与3个月时不良预后的关系。设计、地点和参试者：对一所大学医院1999年1月至2003年3月连续收治的接受rt—PA治疗的急性脑卒中患者进行前瞻性队列研究。参试者来源于安大略省一个主要城市的2个学术中心和7个县的33家附属医院。主要观察指标：神经功能无改善定义为在24小时时国立卫生研究院卒中量表评分较基线水平改善≤3分。3个月时不良预后定义为改良Rankin量表评分3～5分或死亡。结果：216例接受rt—PA治疗的急性卒中患者中，111例（51．4％）在发病24小时神经功能无改善。在校正年龄、性别和卒中严重程度因素后，人院时基线血糖水平（血糖〉144mg／dL[8mmol／L]的优势比[OR]，2．89；95％CI，1．40～5．99）、皮层受累（OR，2．66；95％CI，1．36～5．20）以及治疗开始时间（治疗每延迟1分钟的OR，1．01；95％CI，1．0～1．02）是24小时神经功能无改善的独立预测指标。3个月时，43例患者（20．2％）死亡；在170例幸存者中，75例患者（44％）预后不良。在校正年龄、性别和卒中严重程度因素后，24小时神经功能无改善是不良预后（OR，12．9；95％CI，5．7—29．6）和死亡的独立预测指标（OR，7．5；95％C1，2．9～19．6）。24小时神经功能无改善的患者住院时间延长（14．5天比9．6天，P=0．02）。结论：对于接受溶栓治疗的急性脑卒中患者，24小时神经功能无改善与3个月时预后不良和死亡相关。高血糖、开始溶栓治疗时间和皮层受累是24小时神经功能无改善的预测指标。

关键词：独立预测指标脑卒中患者急性脑卒中神经功能不良预后溶栓治疗治疗后组织型纤溶酶原激活物前瞻性队列研究国立卫生研究院

S-Shaped Fused Azacorannulene Dimer:Structural and Redox Properties

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CCS Chemistry 2023年第5期5卷 1108-1117页

作者： Weifan Wang fiona Hanindita Richard D.webster Shingo Ito Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371

Because of their unique structural and chemical properties,buckybowl molecules have attracted considerable attention in a wide range of scientific *** importance and utility of buckybowl molecules significantly increases once they acquire largerπ-surface area and/or *** fusion of buckybowl molecules has emerged as a new strategy to extend theπ-surface of polycyclic aromatic compounds;however,theπ-extension of heteroatom-embedded buckybowls by the fusion strategy is still *** we report the synthesis and propeties of a fused azacorannulene dimer bearing a C62N2 core(1a),which can also be regarded as a double aza[5]*** to the steric repulsion between two azapentabenzocorannulene moieties,this molecule shows a rigid S-shaped structure where the two azacorannulene bowls face in opposite *** chemical oxidation of 1a resulted in the formation of the corresponding radical cation(1a^(+))and dication(1a^(2+)),providing an important insight into their *** fusion of heteroatom-embedded buckybowls provides a powerful way to synthesizeπ-extended polycyclic aromatic molecules.

关键词： azacorannulenes buckybowl dimer redox chemistry structure elucidation cycloadditions

The HIPERC Project:the Use of Nb for High Performance and Economy in Steel for Linepipe and General Structural Use

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Journal of Iron and Steel Research International 2011年第S1期18卷 690-695页

作者： webster Stephen Drewett Lyn Consultant UK Tata Steel RD&T Swinden Technology CentreRotherhamUK

The HIPERC study was a European research project involving several steel companies and research organisations which examined the effects of alloying elements and processing conditions in low carbon (<0.09 wt %),niobium containing (0.05%-0.12 wt.%) ***-scale heats and pilot rolling trials simulating air and water-cooled plate production as well as hot-rolled strip production were made and the effects of C,Mn,Ni,Cu,Cr,Mo,Nb,Ti and B on transformation characteristics and temperatures of recrystallisation *** equations for the characterisation of microstructure,tensile and impact properties and for the weldability of these steels were *** were manufactured and processed into plate and coil-plate by three steel companies and pipe produced from both *** from these,plus thicker plate for structural use,were determined and these compared well with the values predicted from the regression *** project has shown that excellent combinations of strength,toughness and weldability can be obtained for a wide variety of *** benefits were seen and recommendations on altering the limits for niobium in Euronorms have been proposed.

关键词： steel niobium linepipe structural property

IDeATe @ Hunt Library

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图书馆建设 2017年第2期 40-41页

作者： Keith webster 美国卡内基梅隆大学图书馆

Good evening!Thank you for your invitation!Today I will mainly talk about my perspectives on maker spaces especially on academic *** change is that the real thing is not simply about creating opportunities for students but for librarians to build academic *** the program language I'm talking about is IDeA Te.I will also talk about a few words

关键词：英语阅读理解图书馆

Does disruptive camouflage conceal edges and features？

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Current Zoology 2015年第4期61卷 708-717页

作者： Richard J. webster Department of Biology Carleton University Ottawa K1S 5B6 Canada

Camouflage is ubiquitous in the natural world and benefits both predators and prey. Amongst the range of conceal- ment strategies, disruptive coloration is thought to visually fragment an animal＇s＇ outline, thereby reducing its rate of discovery. Here, I propose two non-mutually exclusive hypotheses for how disruptive camouflage functions, and describe the visual me- chanisms that might underlie them. （1） The local edge disruption hypothesis states that camouflage is achieved by breaking up edge information. （2） The global feature disruption hypothesis states camouflage is achieved by breaking up the characteristic features of an animal （e.g., overall shape or facial features）. Research clearly shows that putatively disruptive edge markings do increase concealment; however, few tests have been undertaken to determine whether this survival advantage is attributable to the distortion of features, so the global feature disruption hypothesis is under studied. In this review the evidence for global feature disruption is evaluated. Further, I address if object recognition processing provides a feasible mechanism for animals＇ features to influence concealment. This review concludes that additional studies are needed to test if disruptive camouflage operates through the global feature disruption and proposes future research directions [Current Zoology 61 （4）： 708-717, 2015].

关键词： Antipredator Background matching Contour Crypsis Camouflage Disruptive coloration Edge detection Objectrecognition

The Stanley Neuropathology Consortium Integrative Database (SNCID) for Psychiatric Disorders

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Neuroscience Bulletin 2019年第2期35卷 277-282页

作者： Sanghyeon Kim Maree J.webster Stanley Brain Research Laboratory Stanley Medical Research Institute

The Stanley Medical Research Institute(SMRI)is a nonprofit organization with a primary mission to fund research on the cause and treatment of severe mental *** SMRI also supports a brain bank as part of the mission to facilitate research into mental *** SMRI brain bank distributes postmortem samples from individuals with serious mental illness,free of charge,to scientists around the *** SMRI brain bank is recognized for the unique way it is set up,organized,and *** of demographically-matched groups of patients with schizophrenia,bipolar disorder(BP),or major depression(DEP)and unaffected controls are organized such that all researchers applying for tissue received samples from the same cohort.

关键词： SNCID for Psychiatric Disorders DRD RNA

Characterization of Yield Stress Development of Cement Paste by Electrical Resistivity

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Journal of Wuhan University of Technology(Materials Science) 2017年第6期32卷 1361-1367页

作者： Mbujje Joel webster 魏小胜 ZHOU Kongjin School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Silicate Wuhan University of Technology Wuhan 430070 China

Yield stress development of cement paste is potentially governed by percolation of 3-dimensional links formed by hydration products on the surface of the particles. It rises steadily at a gradual rate before a sudden increase in rate of growth. In this study, a method was proposed to predict the yield stress development based on the diameter of spread（D） of mini slump cone test and gradient from electrical resistivity measurement（Km）. To evaluate the significance of（D） and（Km） in terms of yield stress, they were quantitatively compared to the initial yield stress（τ0） and rate of yield stress growth（K） obtained from a rheometer. A mathematical relationship between the yield stress of cement paste, diameter of spread and electrical resistivity characteristic gradient was developed. The equation developed can be used as an alternative method to estimate yield stress of cement paste.

关键词： fly ash electrical resistivity rheology yield stress

A Prepandemic Warning!

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China CDC weekly 2020年第29期2卷 551-552页

作者： Robert G.webster Department of Infectious Diseases St.Jude Children’s Research Hospital

The goal of scientists is to provide knowledge that will benefit *** scientific paper(1)published in the Proceedings of the National Academy of Sciences(online on June 29,2020)has the potential of warning the global community of a future pandemic of *** the current focus on the coronavirus disease 2019(COVID-19)pandemic caused by the COVID-19 virus is fully merited because of its catastrophic impact on public health and global economics,it is important not to forget that an influenza pandemic can be even more debilitating.

关键词： forget demic disease.

The Structure of Low Frequency Phenomena in the Tropics and Its Interaction with the Extratropics

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Advances in Atmospheric Sciences 1992年第1期9卷 1-16页

作者： Peter J.webster 董敏 Department of Meteorology The Pennsylvania Stale University PA 16802 USA Academy of Meteorological Science State Meteorological Administration Beijing 100081 PRChe structure of planetary scale low freonency phenomena in the tropics is studied and an attempt is made to determine its influence and interactions with phenomena at higher latitudes.In the tropics it is found that the majority of the variance in the zonal wind structure is made up in wave numbers I and 2. During warm events in the Pacific Ocean when the Southern Oscillation Index is negative almost all of the variance resides in the gravest mode which undergoes a 40° eastward phase shift. Meanwhile the second logitudinal mode almost disappears. On the other hand the meridional wind field possesses maximum amplitude at higher wave numbers. However near the equatorthe amplitude is small with extreme values occurring in the subtropics. The difference in scale and the location of cxtrcma of the meridional and zonal wind components indicate that the tropical atmosphere is responding to two different driving mechanisms.Correlation analyses between variations of the zonal wind at reference points along the equator with variations of component elsewhere show that there are strong logitudinal connections. The strongest correlations between the tropics and higher latitudes exist in the region of the equatorial westerlies. In fact stronger correlations occur between variations in U anywhere along the equator and the middle latitudes to the north and south of the equatorial westerlies than to the latitudes immediately to the north and south of the reference points. We interpret this "remote" correlation pattern as indicating a two-stage teleconnection process which emphasizes the importance of the equatorial tropical westerlies of the Pacific Ocean as a "corridor" of communication between the low and high latitudes. The regionality of the correlations confirms to some extent recent theoretical development regarding trapped equatorial modes. Finally

The structure of planetary scale low freonency phenomena in the tropics is studied, and an attempt is made to determine its influence and interactions with phenomena at higher *** the tropics, it is found that the majority of the variance in the zonal wind structure is made up in wave numbers I and 2. During warm events in the Pacific Ocean, when the Southern Oscillation Index is negative, almost all of the variance resides in the gravest mode which undergoes a 40° eastward phase shift. Meanwhile, the second logitudinal mode almost disappears. On the other hand, the meridional wind field possesses maximum amplitude at higher wave numbers. However, near the equator,the amplitude is small with extreme values occurring in the subtropics. The difference in scale and the location of cxtrcma of the meridional and zonal wind components indicate that the tropical atmosphere is responding to two different driving *** analyses between variations of the zonal wind at reference points along the equator with variations of component elsewhere show that there are strong logitudinal connections. The strongest correlations between the tropics and higher latitudes exist in the region of the equatorial westerlies. In fact, stronger correlations occur between variations in U anywhere along the equator and the middle latitudes to the north and south of the equatorial westerlies than to the latitudes immediately to the north and south of the reference points. We interpret this 'remote' correlation pattern as indicating a two-stage teleconnection process which emphasizes the importance of the equatorial tropical westerlies of the Pacific Ocean as a 'corridor' of communication between the low and high latitudes. The regionality of the correlations confirms, to some extent, recent theoretical development regarding trapped equatorial modes. Finally, time lagged correlations from plus and minus six months between variations of U and OLR indicate that the interactio

关键词： In The Structure of Low Frequency Phenomena in the Tropics and Its Interaction with the Extratropics