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Multi-mechanical waves against Alzheimer’s disease pathology:a systematic review

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Translational Neurodegeneration 2021年第3期10卷 459-486页

作者： Francisca Monteiro Ioannis Sotiropoulos Óscar Carvalho Nuno Sousa filipe S.silva Center for Microelectromechanical Systems(CMEMS) University of MinhoCampus Azurém4800-058 GuimarãesPortugal Life and Health Sciences Research Institute(ICVS) Medical SchoolUniversity of MinhoCampus Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Biosciences&Applications NCSR“Demokritos” AthensGreece

Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people *** inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this *** vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented *** of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory ***,there is a huge variety of treatment specifcations,and in many cases,conficting results are *** this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 *** studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older *** the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated ***,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.

关键词： Alzheimer’s disease Auditory stimulation Mechanical vibrations Ultrasounds Whole-body vibration

Increasing the detail of European land use/cover data by combining heterogeneous data sets

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International Journal of Digital Earth 2020年第5期13卷 602-626页

作者： Konštantín Rosina filipe Batista e silva Pilar Vizcaino Mario Marín Herrera Sérgio Freire Marcello Schiavina European Commission Joint Research Centre(JRC)IspraItaly

Data on land use and land cover(LULC)are a vital input for policy-relevant research,such as modelling of the human population,socioeconomic activities,transportation,environment,and their *** Europe,CORINE Land Cover has been the only data set covering the entire continent consistently,but with rather limited spatial *** data sets have provided much better detail,but either have covered only a fraction of Europe(*** Atlas)or have been thematically restricted(*** High Resolution Layers).In this study,we processed and combined diverse LULC data to create a harmonised,ready-to-use map covering 41 *** doing so,we increased the spatial detail(from 25 to one hectare)and the thematic detail(by seven additional LULC classes)compared to the CORINE Land ***,we decomposed the class‘Industrial and commercial units’into‘Production facilities’,‘Commercial/service facilities’and‘Public facilities’using machine learning to exploit a large database of points of *** overall accuracy of this thematic breakdown was 74%,despite the confusion between the production and commercial land uses,often attributable to noisy training data or mixed land *** learnt from this exercise are discussed,and further research direction is proposed.

关键词： Data fusion land use land cover machine learning points of interest

Directional derivative-based method for quasi-stationary voltage support analysis of single-infeed VSC-HVDC units

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High Voltage 2020年第5期5卷 511-522页

作者： Arcadio Perilla Jose Luis Rueda Torres Elyas Rakhshani Roni Irnawan filipe Faria da silva Mart van der Meijden Claus Leth Bak Alex Alefragkis Anna Lindefelt Electrical Sustainable Energy Department Delft University of TechnologyMekelweg 42628 CDDelftThe Netherlands 2Department of Energy TechnologyAalborg UniversityPontoppidanstraede 1119220AalborgDenmark 3TenneT TSO B.VArnhemThe Netherlands 4EnerginetFredericiaDenmark

This study presents an investigation of the impact of the quasi-stationary voltage support provided by a voltage source converter(VSC)connected to a single point of a power *** on the directional derivative concept,an analytical method is developed to quantify the sensitivities of the AC bus voltage with respect to the VSC reactive power control *** on a real case study,it is shown that the method applies to VSC units that are part of VSC-HVDC systems,which can operate in a point-to-point or multi-terminal ***-domain simulations are performed to verify the findings from the application of the analytical method on a reduced size power system.

关键词： stationary method system.

Quantum hydrodynamics of a single particle

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Light(Science & Applications) 2020年第1期9卷 1199-1205页

作者： Daniel Gustavo Suarez-Forero Vincenzo Ardizzone Saimon filipe Covre da silva Marcus Reindl Antonio Fieramosca Laura Polimeno Milena De Giorgi Lorenzo Dominici Loren N.Pfeiffer Giuseppe Gigli Dario Ballarini Fabrice Laussy Armando Rastelli Daniele Sanvitto CNR NANOTEC Institute of NanotechnologyCampus EcotekneVia Monteroni73100 LecceItaly Dipartimento di Ingegneria dell’Innovazione Universita del SalentoCampus Ecoteknevia Monteroni73100 LecceItaly Institute of Semiconductor and Solid State Physics Johannes Kepler UniversityAltenbergerstr.69Linz 4040Austria Dipartimento di Matematica e Fisica E.De Giorgi Universita del SalentoCampus Ecoteknevia MonteroniLecce 73100Italy PRISM Princeton Institute for the Science and Technology of MaterialsPrinceton UniversityPrincetonNJ 08540USA Faculty of Science and Engineering University of WolverhamptonWulfruna StreetWolverhampton WV11LYUK Russian Quantum Center Novaya 100143025 SkolkovoMoscow RegionRussia

Semiconductor devices are strong competitors in the race for the development of quantum computational *** this work,we interface two semiconductor building blocks of different dimensionalities with complementary properties:(1)a quantum dot hosting a single exciton and acting as a nearly ideal single-photon emitter and(2)a quantum well in a 2D microcavity sustaining polaritons,which are known for their strong interactions and unique hydrodynamic properties,including ultrafast real-time monitoring of their propagation and phase *** the present experiment,we can thus observe how the injected single particles propagate and evolve inside the microcavity,giving rise to hydrodynamic features typical of macroscopic systems despite their genuine intrinsic quantum *** the presence of a structural defect,we observe the celebrated quantum interference of a single particle that produces fringes reminiscent of wave *** this behavior could be theoretically expected,our imaging of such an interference pattern,together with a measurement of antibunching,constitutes the first demonstration of spatial mapping of the self-interference of a single quantum particle impinging on an obstacle.

关键词： quantum particle hydrodynamic

Nest Site Selection of Loggerhead and Leatherback Sea Turtles at the Eastern Coast of Inhaca Island, Mozambique

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Journal of Life Sciences 2016年第5期10卷 260-268页

作者： Vera Cristina de Menezes Julien Almeida Tomas Guissamulo Armindo filipe da silva Adriano AfonsoMacia Junior Department of Biological Sciences University Eduardo Mondlane P. O. Box 257 Maputo Mozambique Natural History Museum University Eduardo Mondlane P. O. Box 257 Maputo Mozambique Department of Mapping Sciences National Statistics Institute Maputo P. O. Box 493 Maputo Mozambique

Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells

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World Journal of Gastroenterology 2008年第9期14卷 1411-1414页

作者： Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth filipe Santos-silva Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology University of Porto Porto 4200-465Portugal Medical Faculty University of Porto Porto 4200-465Portugal Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical CenterOmaha 68198-6805United States Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal

AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa.

关键词：幽门杆菌胃上皮细胞多态性胃疾病

Short mucin 1 alleles are associated with low virulent H pylori strains infection

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World Journal of Gastroenterology 2007年第12期13卷 1885-1886页

作者： Bárbara Peleteiro Nuno Lunet filipe Santos-silva Leonor David Céu Figueiredo Henrique Barros Department of Hygiene and Epidemiology Medical Faculty University of Porto Portugal Institute of Molecular Pathology and Immunology of the University of Porto Portugal

TO THE EDITOR We read with interest the article published by Nguyen et al[1] in the World Journal of Gastroenterology,

关键词：短粘蛋白1 等位基因低毒力幽门螺杆菌感染相关性遗传多态性

Scalp Melanoma Treated with Ipilimumab in Elderly Patient： A Complete Response to Treatment--Case Report

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Journal of Pharmacy and Pharmacology 2017年第1期5卷 1-4页

作者： Juliana Ramos Chaves filipe Rocha da silva Lucas Ivanilson Guedes Henriques silva Thiago Farias Camara Luis Eduardo Wemeck de Carvalho Jonathan Souza Sarraf Oncologica Brasil--Education and Research Belem-PA 66053-000 Brazil Mecicine Faculty Universidade do Estado do Para Belem-PA 66087-670 Brazil Medicine Faculty Centro Universitario do Estado do Para Belem-PA 66613-903 Brazil Medicine Faculty Universidade Federal do Para Belem-PA 66075-110 Brazil

Neurocognitive Disorders in Patients with HIV Infection with Virologic Suppression for More than 10 Years

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World Journal of AIDS 2017年第1期7卷 59-66页

作者： André filipe dos Santos-silva Joana Margarida Almeida Alves Isabel Ramos Maria del Cármen Piñ eiro-Calvo Cláudia Sousa Maria do Rosário Serrã o António Carlos Eugénio Megre Sarmento Infectious Diseases Department S&atilde o Joã o Hospital Centre Oporto Portugal Faculty of Medicine of the University of Oporto Oporto Portugal Psychiatry and Mental Health Department S&atilde o Joã o Hospital Centre Oporto Portugal Neurology Department S&atilde o Joã o Hospital Centre Oporto Portugal

Background: HIV-associated neurocognitive disorder (HAND) may appear in patients with viral and immunological response to treatment and remain unnoticed during the initial stage of the infection. The goal of this study is to evaluate the development and/or progression of HAND in patients with undetectable viral load for more than ten years. Methods: We included adult HIV-infected patients who were under antiretroviral treatment and had undetectable plasma viral load for more than ten years (blips were included). These patients had already been subjected to neurocognitive evaluation five years previously. Demographic, clinical and analytical data were analysed. For the neurocognitive evaluation, the WAIS-III subtests (digit symbol coding and symbol search), trail making test (TMT) A and B, Stroop test and categorical verbal fluency (animals) tests were used. SPSS??version 22.0 for Windows was used for statistical analysis. Results: In this re-evaluation, performed 4.76 (±1.82) years after the first one, 9 (36%) patients showed deficits in processing speed (WAIS-III and TMT A), 8 (32%) executive function (TMT B and Stroop) and 12 (48%) verbal fluency. There were significant statistical differences between the past and current executive function tests (p = 0.029 and p = 0.01), highlighting worsening of deficits. No differences were found for the other tests. No association was found between deficit progression and the studied variables. Conclusions: Although not generally noticed on regular appointments, in this small population, worsening of executive function deficits (mental flexibility and divided attention) was found. Classical risk factors for HAND did not appear to interfere in its progression. Speed of information processing and categorical verbal fluency remained stable.

关键词： HIV HAND Dementia Impairment