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Geo-Spatial Information Science 2019年第4期22卷 223-236,I0001页

作者： Antonio Annis fernando nardi Water Resources Research and Documentation Centre(WARREDOC) University for Foreigners of PerugiaPerugiaItaly Department of Civil and Environmental Engineering(DICEA) University of FlorenceFlorenceItaly Institute of Water and Environment(InWE) Florida International UniversityMiamiFLUSA

Crowdsourced data can effectively observe environmental and urban ecosystem *** use of data produced by untrained people into flood forecasting models may effectively allow Early Warning Systems(EWS)to better perform while support decision-making to reduce the fatalities and economic losses due to inundation *** this work,we develop a Data Assimilation(DA)method integrating Volunteered Geographic Information(VGI)and a 2D hydraulic model and we test its *** proposed framework seeks to extend the capabilities and performances of standard DA works,based on the use of traditional in situ sensors,by assimilating VGI while managing and taking into account the uncertainties related to the quality,and the location and timing of the entire set of observational *** November 2012 flood in the Italian Tiber River basin was selected as the case *** show improvements of the model in terms of uncertainty with a significant persistence of the model updating after the integration of the VGI,even in the case of use of few-selected observations gathered from social *** will encourage further research in the use of VGI for EWS considering the exponential increase of quality and quantity of smartphone and social media user worldwide.

关键词： Crowdsourced data VGI data assimilation(DA) flood forecasting 2D hydraulic modelling

On-surface synthesis of covalent coordination polymers on micrometer scale

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Nano Research 2017年第3期10卷 933-940页

作者： Mathieu Koudia Elena nardi Olivier Siri Mathieu Abel Aix Marseille UniversitY CNRS IM2NP UMR 7334 13397 Marseille France Aix Marseille UniversitY CNRS CINaM UMR 7325 13288 Marseille France

On-surface synthesis under ultrahigh vacuum provides a promising strategy to control matter at the atomic level, with important implications for the design of new two-dimensional materials having remarkable electronic, magnetic, or catalytic properties. This strategy must address the problem of limited extension of the domains due to the irreversible nature of covalent bonds, which prevents the ripening of defects. We show here that extended materials can be produced by a controlled co-deposition process. In particular, co-deposition of quinoid zwitterion molecules with iron atoms on a Ag（111） surface held at 570 K allows the formation of micrometer-sized domains based on covalent coordination bonds. This work opens up the construction of micrometer-scale single-layer covalent coordination materials under vacuum conditions.

关键词： on-surface synthesis scanning tunnelingmicroscopy (STM) two-dimensional polymer covalent organic frameworks

Multidisciplinary treatment of rectal cancer in 2014: Where are we going?

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World Journal of Gastroenterology 2014年第32期20卷 11249-11261页

作者： Andrea Vignali Paola De nardi Department of Surgery San Raffaele Scientific Institute Vita Salute University

In the present review we discuss the recent developments and future directions in the multimodal treatment of locally advanced rectal cancer, with respect to staging and re-staging modalities, to the current role of neoadjuvant chemo-radiation and to the conservative and more limited surgical approaches based on tumour response after neoadjuvant combined therapy. When initial tumor staging is considered a high accuracy has been reported for T pre-treatment staging, while preoperative lymph node mapping is still suboptimal. With respect to tumour re-staging, all the current available modalities still present a limited accuracy, in particular in defining a complete response. The role of short vs long-course radiotherapy regimens as well as the optimal time of surgery are still unclear and under investigation by means of ongoing randomized trials. Observational management or local excision following tumour complete response are promising alternatives to total mesorectal excision, but need further evaluation, and their use outside of a clinical trial is not *** preoperative selection of patients who will benefit from neoadjuvant radiotherapy or not, as well as the proper identification of a clinical complete tumour response after combined treatment modalities,will influence the future directions in the treatment of locally advanced rectal cancer.

关键词： Rectal cancer Cancer staging Cancer restaging Neoadjuvant chemoradiation Response Treatment Local control Local excision Complete pathologic response Rectal cancer surgery

Endoluminal vacuum-assisted therapy to treat rectal anastomotic leakage:A critical analysis

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World Journal of Gastroenterology 2022年第14期28卷 1394-1404页

作者： Andrea Vignali Paola De nardi Department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy Department of Surgery Vita-Salute UniversityMilano 20132Italy

Endoluminal vacuum-assisted therapy(EVT)has been introduced recently to treat colorectal anastomotic leaks in clinically stable non-peritonitic *** application has been mainly reserved to low colorectal and colo-anal *** main advantage of this new procedure is to ensure continuous drainage of the abscess cavity,to promote and to accelerate the formation of granulation tissue resulting in a reduction of the abscess *** reported results are promising allowing a higher preservation of the anastomosis when compared to conventional treatments that include trans-anastomotic tube placement,percutaneous drainage,endoscopic clipping of the anastomotic defect or stent ***,despite this procedure is gaining acceptance among the surgical community,indications,inclusion criteria and definitions of success are not yet standardized and extremely heterogeneous,making it difficult to reach definitive conclusions and to ascertain which are the real benefits of this new ***,long-term and functional results are poorly *** present review is focused on critically analyzing the theoretical benefits and risks of the procedure,short-and long-term functional results and future direction in the application of EVT.

关键词： Anastomotic leakage Rectal surgery Endoluminal vacuum therapy Endosponge Complications

New approach to anal cancer:Individualized therapy based on sentinel lymph node biopsy

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World Journal of Gastroenterology 2012年第44期18卷 6349-6356页

作者： Paola De nardi Michele Carvello Carlo Staudacher Surgical Department San Raffaele Scientific Institute20132 MilanItaly

Oncological treatment is currently directed toward a tailored therapy *** cell carcinoma of the anal canal could be considered a suitable platform to test new therapeutic strategies to minimize treatment *** of care for patients with anal canal cancer consists of a combination of radiotherapy and *** treatment has led to a high rate of local control and a 60% cure rate with preservation of the anal sphincter,thus replacing surgical abdominoperineal *** node metastases represent a critical independent prognostic factor for local recurrence and *** and iliac lymph nodes are usually included in the radiation field,whereas the inclusion of inguinal regions still remains controversial because of the subsequent adverse side *** lymph node biopsies could clearly identify inguinal node-positive patients eligible for therapeutic groin irradiation.A sentinel lymph node navigation procedure is reported here to be a feasible and effective method for establishing the true inguinal node status in patients suffering from anal canal *** on the results of sentinel node biopsies,a selective approach could be proposed where node-positive patients could be selected for inguinal node irradiation while node-negative patients could take advantage of inguinal sparing irradiation,thus avoiding toxic side effects.

关键词： Anal carcinomal Lymphnode metastasis Sen-tinel lymphnode Tumor staging

Relation between skeletal muscle volume and prognosis in rectal cancer patients undergoing neoadjuvant therapy

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 423-433页

作者： Paola De nardi Alessandro Giani Giulia Maggi Marco Braga Department of Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilano 20132Italy Department of Surgery School of MedicineUniversity of Milano-BicoccaMilan ItalyMonza 20900Italy Department of Oncologic Surgery Policlinico CasilinoRome 00169Italy Department of Surgery San Gerardo HospitalUniversity Milano BicoccaMonza 20900Italy

The prognostic role of body composition indexes,and specifically sarcopenia,has recently been explored in different cancer ***,conflicting results have been *** in cancer type,cancer stage or oncological treatments,as well as different methodology and definition of sarcopenia,could be accounted for different conclusions retrieved from *** focusing on colorectal cancer,it clearly appears that colon and rectal cancers are often treated as a single entity though they have different behaviors and ***,patients with advanced rectal cancer represent a peculiar group of patients that according to current guidelines are treated with neoadjuvant chemotherapy and radiotherapy followed by radical *** review was restricted to a homogeneous group of patients with advanced lower rectal cancer and the aim of exploring whether there is a correlation between skeletal muscle depletion and *** was searched for articles related to patients with advanced rectal cancer undergoing neoadjuvant chemo-radiotherapy(NCRT)followed by radical surgery,in whom muscle mass and/or change in muscle mass during neoadjuvant treatment were *** full-text articles were selected and included in the present *** main findings of our review were:(1)The majority of the studies defined sarcopenia as muscle mass alone over muscle strength or physical performance;(2)There was a great deal of heterogeneity in the definition and measures of sarcopenia,in the definition of cut-off values,and in the method to measure change in muscle mass;(3)There was not full agreement on the association between sarcopenia at baseline and/or after chemoradiotherapy and prognosis,and only few studies found a significance in the multivariate analysis;and(4)It seems that a loss in skeletal muscle mass during NCRT is associated with the worst outcomes in terms of disease-free *** conclusion,analysis of muscle mass might provid

关键词： Advanced rectal cancer Sarcopenia Neoadjuvant treatment Chemoradiotherapy Surgery Muscle mass change Prognosis Survival Review

Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis

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Stroke & Vascular Neurology 2022年第1期7卷 6-12页

作者： Anthony Larson Valentina nardi Waleed Brinjikji John Benson Giuseppe Lanzino Luis Savastano Department of Radiology Mayo ClinicRochesterMinnesotaUSA Neurosurgery Mayo ClinicRochesterMinnesotaUSA

Objective To systematically analyse prior reports of carotid endarterectomy(CEA)performed in cases of≤50%carotid stenosis in order to understand patient tolerance and potential *** A systematic review and descriptive analysis was performed in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** English-language search was performed of online databases using librarian-selected search *** were reviewed for relevance which included mention of carotid endarterectomy and *** or retrospective observational cohort studies that reported series of patients who underwent endarterectomy for minimal(≤50%)luminal stenosis with reported outcomes were *** Six studies(which included our institutional series)with a total of 143 patients met the inclusion *** weighted mean age at the time of CEA was 72.3 years;113(79.0%)were male.55.8%of patients with available data had recurrent ipsilateral ischaemic events despite medical *** patients out of 129 with available perioperative data(1.6%)had perioperative MRI findings of acute ischaemic stroke,both within the hemisphere contralateral to the side of *** the 138 patients with available follow-up(mean,36 months),none had recurrent ipsilateral ischaemic *** Endarterectomy for symptomatic carotid disease causing≤50%stenosis may be a potentially beneficial strategy to prevent stroke *** with robust methodology are needed to draw more definitive conclusions in terms of the safety and efficacy of endarterectomy for minimal stenosis with vulnerable features relative to intensive medical therapy.

关键词： carotid stenosis analysis

Intra-abdominal myositis ossificans-a clinically challenging disease:A case report

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World Journal of Orthopedics 2023年第5期14卷 362-368页

作者： Gabriele Carbone Valentina Andreasi Paola De nardi Department of Gastrointestinal Surgery IRCCS San Raffaele HospitalMilan 20132Italy

BACKGROUND Myositis ossificans(MO)is an uncommon disorder characterized by heterotopic ossification within soft *** a few cases of intra-abdominal MO(IMO)have been described in the *** could be difficult to understand and a wrong diagnosis could lead to an improper *** SUMMARY We herein report the case of IMO in a healthy 69-year-old *** patient presented with an abdominal mass in the left lower quadrant.A computed tomography scan showed an inhomogeneous mass with multiple *** patient underwent radical excision of the *** findings were compatible with *** months later the patient showed a recurrence causing hemorrhagic shock due to intractable intralesional *** patients eventually died within three months since *** The case described could be classified as post-traumatic MO that developed close to the previously fractured iliac *** subsequent surgical procedure was ineffective and the disease rapidly *** misleading intraoperative diagnosis led to improper surgical treatment with a dramatic evolution.

关键词： Myositis ossificans Post-traumatic Diagnosis Surgical treatment Prognosis Case report

Shoshonitic Magmatic Series and the High Ba-Sr Granitoids:A Review with Emphasis on Examples from the Neoproterozoic Dom Feliciano Belt of Southern Brazil and Uruguay

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Journal of Earth Science 2021年第6期32卷 1359-1373页

作者： Lauro Valentim Stoll nardi Maria de Fátima Bitencourt Luana Moreira Florisbal Dionatan Ferri Padilha Programa de Pós-Graduação em Geociências(PPGGEO) Universidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil Programa de Pós-Graduação em Geologia(PPGGeologia) Universidade Federal de Santa Catarina(UFSC)FlorianópolisBrazil

Fractional crystallization of parental magmas of shoshonitic or silica-saturated,ultrapotassic affinity,with variable amount of concurrent crustal assimilation,may result in granitic and syenitic *** plutonic members of the shoshonitic series are monzonites and quartz monzonites,whilst syenites and quartz syenites are the dominant plutonic products of the ultrapotassic *** magmas are commonly found in association with both series and are frequently part of coeval mingling/mixing *** and shoshonitic primary magmas,including lamprophyric ones,are derived from amphibole-phlogopite-bearing mantle sources produced by previous,subduction-related *** and intermediate rocks can be derived from such parental magmas,generally through AFC ***-like granitoids,which have not clear relation with intermediate or basic shoshonitic rocks,or are produced dominantly by crustal melting,should be named high-Ba-Sr *** study focuses mainly on Neoproterozoic shoshonitic and silica-saturated ultrapotassic rock associations formed in post-collisional settings from southern Brazil and *** source of magmas,their evolution,the role played by crustal contamination in modifying pristine geochemical signatures and their tectonic control are discussed based on elemental and Sr-Nd isotope *** main features of plutonic rocks related to the shoshonitic series are their potassic,silica-saturated alkaline character,predominance of monzonitic to syenitic compositions,high Sr and Ba contents,monotonous,light REE-enriched patterns,and moderate HFSE *** shoshonitic and high Ba-Sr granitoids within shear zones show lower alkali,LREE,HFSE,and Sr contents than those formed away from the main deformation *** rocks related to the extended silica-saturated ultrapotassic series are mostly syenites,alkalifeldspar granites and lamprophyres with K_(2)O/Na_(2)O ratios above *** t

关键词： shoshonitic-like rocks post-collisional magmatism K-rich granitoids

Prognostic role of ultrasonography staging in patients with anal cancer

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 732-740页

作者： Paola De nardi Giaime G Arru Giovanni Guarneri Iliyan Vlasakov Luca Massimino Gastrointestinal Surgery IRCCS San Raffaele Scientific InstituteMilan 20132Italy Vita-Salute University San Raffaele Milan 20132Italy Laboratory of Immunopathology in Gastroenterology Humanitas UniversityMilan 20132Italy

BACKGROUND Carcinomas of the anal canal are staged according to the size and extent of the disease;however,we propose including a novel ultrasound(US)staging system,based on depth of tumor *** this study the clinical American Joint Committee on Cancer(AJCC)staging guidelines and the US classificationss in patients with anal cancer were *** To evaluate the prognostic role of the US staging system in patients with anal *** The data of 48 patients with anal canal squamous cells carcinoma,observed at our University Hospital between 2007 and 2017,who underwent pre-treatment assessment with pelvic magnetic resonance imaging(MRI),total body computed tomography(CT)scan and endoanal US were retrospectively *** canal tumors were clinically staged according to AJCC,determined by MRI by measurement of the longest tumor diameter,and CT *** US was performed with a high multi-frequency(9-16 MHz),360°rotational mechanical probe;US classification was based on depth of tumor penetration through the anal wall,according to Giovannini’s *** patients were treated with definitive radiation combined with 5-fluorouracile and *** treatment patients were followed-up *** At baseline there were 30 and 32 T1-2,18 and 16 T3-4,31 and 19 N+patients classified according to the clinical AJCC and US staging system *** a mean follow-up of 98 months,38 patients(79.1%)are alive and 28(58.3%)are disease *** follow up 20 patients(41.6%)experienced *** univariate analysis,American Society of Anesthesiologists(ASA)score(P=0.00000001)and US staging(P=0.009)were significantly related to disease-free survival(DFS).When overall survival and DFS functions were compared,a statistically significant difference was observed for DFS survival when the US staging was applied with respect to the clinical AJCC *** combining the 2 significant prognostic variables,namely the US staging with the ASA s

关键词： Anal cancer Ultrasonography staging American Joint Committee on Cancer staging Prognosis Disease-free survival Staging