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Acta Mathematica Scientia 2008年第1期28卷 7-16页

作者： e.A.Youness Tarek emam Department of Mathematics Faculty of ScienceTanta UniversityTantaEgypt Department of Mathematics Faculty of Education in SuezSuez Canal UniversitySuezEgypt

The authors of this article are interested in characterization of efficient solutions for special classes of problems. These classes consider semi-strong e-convexity of involved functions. Sufficient and necessary con... 详细信息

关键词： Multi-objective optimization problems semi-strong e-convex efficient solutions properly efficient solutions

Multidisciplinary approach for patients with esophageal cancer

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World Journal of Gastroenterology 2012年第46期18卷 6737-6746页

作者： Victoria M Villaflor Marco e Allaix Bruce Minsky fernando A Herbella Marco G Patti Department of Medicine Section Hematology/Oncology University of Chicago Medicine Department of Surgery University of Chicago Medicine Radiation Oncology University of Chicago Medicine

Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations.

关键词： esophageal Cancer Multimodality therapy Multidisciplinary therapy Chemoradiotherapy esophageal resection esophagectomy

横向磁场直线开关磁阻电机及其控制系统(英文)

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中国电机工程学报 2007年第33期27卷 22-29页

作者：葛宝明赵楠 Aníbal T.de Almeida fernando J.T.e.Ferreira 北京交通大学电气工程学院北京市海淀区100044 科英布拉大学电气工程系

研究了基于横向磁场直线开关磁阻电机(transverse flux linear switched reluctance motor,TFLSRM)、全数字控制器与新型位置传感器的直线电机驱动系统,建立了TFLSRM数学模型。新型位置传感器利用了TFLSRM次极边极形,无需在次极安装任... 详细信息

研究了基于横向磁场直线开关磁阻电机(transverse flux linear switched reluctance motor,TFLSRM)、全数字控制器与新型位置传感器的直线电机驱动系统,建立了TFLSRM数学模型。新型位置传感器利用了TFLSRM次极边极形,无需在次极安装任何元件,改善了系统可靠性。为改善系统性能,在电流环进行了从牵引力到平均电流的非线性转换,在速度环采用离散时间趋近率控制。基于DSP设计了控制器,测试了新型位置传感器与所提驱动系统的动、静态性能。实验结果验证了新型位置传感器与TFLSRM驱动系统的优良性能。

关键词：数字控制直线开关磁阻电机位置传感器横向磁场电机

Age as a predictor of clinical outcomes and determinant of therapeutic measures for emergency medical services treated cardiogenic shock

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Journal of Geriatric Cardiology 2023年第1期20卷 1-10页

作者： Xiaoman Xiao Jason e Bloom emily Andrew Luke P Dawson Ziad Nehme Michael Stephenson David Anderson Himawan fernando Samer Noaman Shelley Cox William Chan David M Kaye Karen Smith Dion Stub Department of Cardiology Alfred Health55 Commercial RoadMelbourneAustralia Baker Heart and Diabetes Institute 75 Commercial RoadMelbourneAustralia Department of Cardiology Western HealthFurlong RoadSt AlbansAustralia Ambulance Victoria 31 Joseph StreetBlackburnAustralia School of Public Health and Preventive Medicine Monash University553 St Kilda RoadMelbourneAustralia Department of Paramedicine Monash UniversityMcMahons RoadFrankstonAustralia

BACKGROUND The impact of age on outcomes in cardiogenic shock(CS)is poorly described in the pre-hospital *** assessed the impact of age on outcomes of patients treated by emergency medical services(eMS).MeTHODS This population-based cohort study included consecutive adult patients with CS transported to hospital by *** linked patients were stratified into tertiles by age(18-63,64-77,and>77 years).Predictors of 30-day mortality were assessed through regression *** primary outcome was 30-day all-cause *** A total of 3523 patients with CS were successfully linked to state health *** average age was 68±16 years and 1398(40%)were *** patients were more likely to have comorbidities including pre-existing coronary artery disease,hypertension,dyslipidemia,diabetes mellitus,and cerebrovascular *** incidence of CS was significantly greater with increasing age(incidence rate per 100,000 person years 6.47[95%CI:6.1-6.8]in age 18-63 years,34.34[32.4-36.4]in age 64-77 years,74.87[70.6-79.3]in age>77 years,Pere was a step-wise increase in the rate of 30-day mortality with increasing age *** adjustment,compared to the lowest age tertile,patients aged>77 years had increased risk of 30-day mortality(adjusted hazard ratio=2.26[95%CI:1.96-2.60]).Older patients were less likely to receive inpatient coronary *** Older patients with eMS-treated CS have significantly higher rates of short-term *** reduced rates of invasive interventions in older patients underscore the need for further development of systems of care to improve outcomes for this patient group.

关键词： assessed services shock

Growth phenology adjusts to seasonal changes in water availability in coexisting evergreen and deciduous mediterranean oaks

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Forest ecosystems 2023年第5期10卷 535-546页

作者： Filipe Campelo Alvaro Rubio-Cuadrado fernando Montes Michele Colangelo Cristina Valeriano J.Julio Camarero Department of Life Sciences University of CoimbraCalçada Martim de FreitasCoimbra3000-456Portugal Departamento de Sistemas y Recursos Naturales Escuela Tecnica Superior de Ingeniería de MontesForestal y Del Medio NaturalUniversidad Politecnica de MadridCiudad Universitaria S/n28040MadridSpain Instituto Pirenaico de ecología(IPe-CSIC) Avda.Montanana 1005E-50192ZaragozaSpain Departamento de Dinamica y Gestion Forestal Instituto de Ciencias Forestales(ICIFOR-INIA-CSIC)Ctra.La Coruna Km 7.528040MadridSpain Scuola di Scienze Agrarie ForestaliAlimentari e AmbientaliUniversita Della BasilicataViale Dell’Ateneo Lucano 1085100PotenzaItaly

Different leaf(evergreen *** habit)and xylem(***-porous wood)traits represent contrasting strategies to face seasonal changes in water availability and ***,how contrasting leaf and xylem habits of coexisting tree species affect stem wood formation and tree-ring development remains poorly ***,we investigated the spatio-temporal patterns of wood formation in two deciduous oaks(Quercus faginea and Quercus petraea)and two evergreen oaks(Quercus ilex and Quercus suber)coexisting in seasonally dry Mediterranean forests along an aridity gradient in *** hypothesized that growth responses to drought and intra-and inter-annual growth patterns would differ between functional *** simulated intra-and interannual growth using a modified version of the Vaganov-Shashkin(VS)process-based,growth *** VS model simulations were used to estimate growth changes under a high emission scenario(RCP 8.5)for the current distribution of the study oak species and to forecast their future performance under warm(4.8℃)conditions in the Iberian *** simulations indicate that climate warming would induce a shortening of the ringgrowth season and a reduction of radial growth in evergreen and deciduous Mediterranean oaks,particularly in dry sites from southern and eastern Iberia currently occupied by *** and *** oaks may better recover after dry periods than deciduous oaks by resuming growth after the summer *** soil water availability in spring would be more detrimental to growth of deciduous ***-based growth models should be refined and validated to better forecast changes in tree growth as a function of climate.

关键词： Process-based growth model Quercus ilex Quercus suber Quercus faginea Quercus petraea Tree-ring growth

Inocula selection in microbial fuel cells based on anodic biofilm abundance of Geobacter sulfurreducens

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Chinese Journal of Chemical engineering 2016年第3期24卷 379-387页

作者： Guotao Sun Diogo de Sacadura Rodrigues Anders Thygesen Geoffrey Daniel Dinesh fernando Anne S.Meyer Center for BioProcess engineering Department of Chemical and Biochemical EngineeringTechnical University of Denmark Department of Forest Products Swedish University of Agricultural Sciences

Microbial fuel cells （MFCs） rely on microbial conversion of organic substrates to electricity. The optimal perfor- mance depends on the establishment of a microbial community rich in electrogenic bacteria. Usually this micro- bial community is established from inoculation of the MFC anode chamber with naturally occurring mixed inocula. In this study, the electrochemical performance of MFCs and microbial community evolution were eval- uated for three inocula including domestic wastewater （DW）, lake sediment （LS） and biogas sludge （BS） with varying substrate loading （Lsub） and external resistance （Rext） on the MFC. The electrogenic bacterium Geobacter sulfurreducens was identified in all inocula and its abundance during MFC operation was positively linked to the MFC performance. The IS inoculated MFCs showed highest abundance （18% ± 1%） of G. sulfurreducens, maximum current density [Imax = （690 ± 30） mA.m 2] and coulombic efficiency （Ce = 29% ±1%） with acetate as the substrate./max and Ce increased to （1780 ± 30） mA.m-2 and 58%± 1%, respectively, after decreasing the Rext from 1000 Ωto 200 Ω, which also correlated to a higher abundance ofG. sulfurreducens （21% ±0.7%） on the MFC anodic biofilm. The data obtained contribute to understanding the microbial community response to Lsub and Roy, for of timizing electricity eneration in MFCs.

关键词： Lake sediment Coulombic efficiency Denaturing gradient gel electrophoresis Geobacter sulfurreducens Anode polarisation resistance

Damage-associated molecular patterns in inflammatory bowel disease:From biomarkers to therapeutic targets

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World Journal of Gastroenterology 2018年第41期24卷 4622-4634页

作者： Hayandra Ferreira Nanini Claudio Bernardazzi fernando Castro Heitor Siffert Pereira de Souza Servico de Gastroenterologia e Laboratorio Multidisciplinar de Pesquisa Departamento de Clinica MedicaHospital Universitario Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroRJ 21941-913Brazil D’Or Institute for Research and education(IDOR) Rua Diniz Cordeiro 30BotafogoRio de JaneiroRJ 22281-100Brazil

The chronic inflammatory process underlying inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, derives from the interplay of several components in a genetically susceptible host. These components include environmental elements and gut microbiota a dysbiosis. For decades, immune abnormalities have been investigated as critically important in IBD pathogenesis, and attempts to develop effective therapies have predominantly targeted the immune system. Nevertheless, immune events represent only one of the constituents contributing to IBD pathogenesis within the context of the complex cellular and molecular network underlying chronic intestinal inflammation. These factors need to be appreciated within the milieu of nonimmune components. Damage-associated molecular patterns (DAMPs), which are essentially endogenous stress proteins expressed or released as a result of cell or tissue damage, have been shown to act as direct proinflammatory mediators. excessive or persistent signalling mediated by such molecules can underlie several chronic inflammatory disorders, including IBD. The release of endogenous DAMPs amplifies the inflammatory response driven by immune and non-immune cells and promotes epigenetic reprogramming in *** effects determine pathologic changes,which may sustain chronic intestinal inflammation and also underlie specific disease *** addition to highlighting the potential use of DAMPs such as calprotectin as biomarkers,research on DAMPs may reveal novel mechanistic associations in IBD pathogenesis and is expected to uncover putative therapeutic targets.

关键词： Damage-associated molecular patterns environmental factors epigenetics Inflammatory bowel disease Therapeutic targets

Rectification of oxygen transfer through the rat colonic epithelium

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World Journal of Gastrointestinal Pathophysiology 2017年第2期8卷 59-66页

作者： fernando D Saraví Graciela e Carra Daniel A Matus Jorge e Ibánez Institute of Physiology Faculty of Medical SciencesNational University of Cuyo Department of Surgery Faculty of Medical SciencesNational University of Cuyo Mario H. Burgos Institute of Histology and embryology CONICETFaculty of Medical SciencesNational University of Cuyo

AIM To assess whether higher sensitivity of colonic epithelium to hypoxia at the serosal side is associated with oxygen transfer *** Rats were fed either with normal chow or a lowsodium diet. Tissues were mounted as flat sheets in a modified, airtight Ussing chamber with oxygen meters in each hemichamber. Mucosal samples from normal diet animals were studied under control conditions, in low-chloride solution and after adding chloride secretion inhibitors and chloride secretagogues. Samples from sodium-deprived rats were studied before and after ouabain addition. In separate experiments, the correlation between short-circuit current and oxygen consumption was analyzed. Finally, hypoxia was induced in one hemichamber to assess the relationship between its oxygen content and the oxygen pressure differencebetween both hemichambers. ReSULTS In all studied conditions, oxygen consumption was larger in the serosal hemichamber than in the mucosal one(P = 0.0025 to P ent showed significant correlation with both total oxygen consumption(r = 0.765; P = 0.009) in normoxia and oxygen consumption in the serosal hemichamber(r = 0.754; P = 0.011) during mucosal hypoxia, but not with oxygen consumption in the mucosal hemichamber. When hypoxia was induced in the mucosal hemichamber, an oxygen pressure difference of 13 k Pa with the serosal hemichamber was enough to keep its oxygen content constant. However, when hypoxia was induced in the serosal hemichamber, the oxygen pressure difference with the mucosal hemichamber necessary to keep its oxygen content constant was 40 k Pa(P erosal oxygen supply is more readily available to support short-circuit current. This may be partly due to a rectifying behavior of transepithelial oxygen transfer.

关键词： Colonic epithelium Hypoxia Oxygen diffusion Short-circuit current Ussing chamber

Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?

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World Journal of Stem Cells 2015年第2期7卷 408-417页

作者： Martha L Arango-Rodriguez fernando ezquer Marcelo ezquer Paulette Conget Center for Regenerative Medicine School of Medicine Clínica Alemana Universidad del Desarrollo

Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration.

关键词： Cancer Infection Mesenchymal stem cells Therapy Biosafety

RATIO OF CHARMeD BARYON TO MeSON IN e^(+)e^(-) ANNIHILATION

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Chinese Physics Letters 1990年第3期7卷 109-112页

作者： CHeN e-sheng WU Qian Department of Physics Shandong UniversityJinan 250100

A method to determine the value of the ratio of charmed baryon to meson in e^(+)e^(-) annihilation is *** the data of CLeO,HRS and MARK Ⅱ groups,we obtain f≡B_(c)/M_(c)=0.21±0.05,0.24±0.08 and 0.33±0.05,for √s=5... 详细信息

关键词： annihilation meson charm