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Geo-Spatial Information Science 2019年第4期22卷 223-236,I0001页

作者： Antonio Annis fernando Nardi Water Resources Research and Documentation Centre(WARREDOC) University for Foreigners of PerugiaPerugiaItaly Department of Civil and Environmental Engineering(DICEA) University of FlorenceFlorenceItaly Institute of Water and Environment(InWE) Florida International UniversityMiamiFLUSA

Crowdsourced data can effectively observe environmental and urban ecosystem *** use of data produced by untrained people into flood forecasting models may effectively allow Early Warning Systems(EWS)to better perform while support decision-making to reduce the fatalities and economic losses due to inundation *** this work,we develop a Data Assimilation(DA)method integrating Volunteered Geographic Information(VGI)and a 2D hydraulic model and we test its *** proposed framework seeks to extend the capabilities and performances of standard DA works,based on the use of traditional in situ sensors,by assimilating VGI while managing and taking into account the uncertainties related to the quality,and the location and timing of the entire set of observational *** November 2012 flood in the Italian Tiber River basin was selected as the case *** show improvements of the model in terms of uncertainty with a significant persistence of the model updating after the integration of the VGI,even in the case of use of few-selected observations gathered from social *** will encourage further research in the use of VGI for EWS considering the exponential increase of quality and quantity of smartphone and social media user worldwide.

关键词： Crowdsourced data VGI data assimilation(DA) flood forecasting 2D hydraulic modelling

O_(3) based advanced oxidation for ibuprofen degradation

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Chinese Journal of Chemical Engineering 2022年第2期35卷 277-284页

作者： Vitória M.Almeida Carla A.Orge M.fernando R.Pereira O.SaloméG.P.Soares Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials (LSRE-LCM)Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias4200-465 PortoPortugal

The degradation of the anti-inflammatory ibuprofen(IBP)was evaluated by several advanced oxidation *** was treated by single ozonation and oxidation with hydrogen peroxide(H_(2)O_(2)),as well as a combination of these *** order to improve the efficiency,the presence of catalysts such as original carbon nanotubes,labelled as CNT,and iron oxide supported on carbon nanotubes,named as Fe/CNT sample,was *** evolution of IBP degradation,mineralization and toxicity of the solutions was *** formation of intermediates was also *** the non-catalytic processes,IBP was faster removed by single ozonation,whereas no significant total organic carbon(TOC)removal was *** with H_(2)O_(2) did not present satisfactory *** ozone and H_(2)O_(2) were combined,a higher mineralization was attained(70%after 180 min of reaction).On the other hand,in the catalytic processes,this combined process allowed the fastest IBP *** terms of mineralization degree,the presence of Fe/CNT increases the removal rate in the first hour of reaction,achieving a TOC removal of 85%.Four compounds were detected as *** treated solutions presented lower toxicity than the initial solution,suggesting that the released intermediates during applied processes are less toxic.

关键词： Advanced oxidation processes Catalysts Emerging pollutants Ibuprofen

Overview of the anterolateral complex of the knee

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World Journal of Clinical Cases 2022年第24期10卷 8474-8481页

作者： Ignacio Garcia-Mansilla Juan Pablo Zicaro Ezequiel fernando Martinez Juan Astoul Carlos Yacuzzi MatiasCosta-Paz Knee Surgery Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina

In the last few years,much more information on the anterolateral complex of the knee has become *** has now been demonstrated how it works in conjunction with the anterior cruciate ligament(ACL)controlling anterolateral rotatory *** studies have shown that the anterolateral complex(ALC)has a role as a secondary stabilizer to the ACL in opposing anterior tibial translation and internal tibial *** is of utmost importance that surgeons comprehend the intricate anatomy of the entire anterolateral aspect of the *** most studies have only focused on the anterolateral ligament(ALL),the ALC of the knee consists of a functional unit formed by the layers of the iliotibial band combined with the anterolateral joint *** interest has also been given to imaging evaluation using magnetic resonance and several studies have targeted the evaluation of the ALC in the setting of ACL *** are inconsistent with a lack of association between magnetic resonance imaging evidence of injury and clinical *** ACL reconstruction may not always reestablish knee rotatory stability in patients with associated ALC *** such cases,additional procedures,such as anterolateral reconstruction or lateral tenodesis,may be *** are several techniques available for ALL *** options include the iliotibial band,gracilis or semitendinosus tendon autograft,or allograft.

关键词： Anterolateral complex Knee instability Anterolateral ligament Anterior cruciate ligament reconstruction

Predictive value of bleeding risk scores in elderly patients with atrial fibrillation and oral anticoagulation

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老年心脏病学杂志:英文版 2023年第9期20卷 684-692页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi Andrea Lizancos-Castro Jose A Parada-Barcia AndréGonzález-García Ana Ledo-Piñeiro Vanesa Noriega-Caro Carla Iglesias-Otero AndrésÍñiguez-romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain

BACKGROUND The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well *** goal of this study was to evaluate the predictive value of HASBLED,ORBIT and ATRIA for major bleeding(MB)and intracranial hemorrhage(ICH)in patients≥75 years with atrial fibrillation and oral anticoagulation(OAC).METHODS A retrospective unicenter study including patients≥75 years with atrial fibrillation(AF)and OAC.A total of 7613 patients≥75 years with AF and OAC included between 2014 and 2018(registry:NCT04364516).We analyzed the discriminative value of HASBLED,ATRIA and ORBIT scores for bleeding endpoints(major bleeding as primary endpoint and intracerebral hemorrhage as secondary).Cox regression was used to predict major bleeding with each scale and also for searching other variables potentially predictor of major *** discrimination was assessed using Harrell’s *** was assessed with goodness-of-fit test proposed by Gronnesby and *** During a mean follow up of 4.0 years(IQR:2.4–5.7 years),729 patients developed MB(2.61 per 100 patients/year)and 243 patients developed ICH(0.85 per 100 patients/year).Three scores showed a low discrimination for major bleeding,being ORBIT the best(HASBLED C statistic=0.557;ATRIA C statistic=0.568;ORBIT C statistic=0.595)and also a low discrimination for ICH(HASBLED C statistic=0.509;ATRIA C statistic=0.522;ORBIT C statistic=0.526).Among the variables that are part of the scores and other baseline characteristics,after multivariable adjustment only sex(male),dementia,prior admission for bleeding,anemia and liver disease were found as a predictors of *** In older patients under oral anticoagulation with atrial fibrillation,the risk scores HASBLED,ATRIA and ORBIT showed a weak discrimination for major bleeding and intracranial ***,other better alternatives should be evaluated for this purpose.

关键词： patients bleeding fibrillation

Extraintestinal manifestations of inflammatory bowel disease:Do they influence treatment and outcome?

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World Journal of Gastroenterology 2011年第22期17卷 2702-2707页

作者： fernando Tavarela Veloso Department of Gastroenterology Hospital S. Joao Faculdade de Medicina Al. Prof. Hernani Monteiro 4200-319 Porto Portugal

Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases that often involve organs other than those of the gastrointestinal tract. Immune-related extraintestinal manifestations (EIMs) are usually related to disease activity, but sometimes may take an independent course. Globally, about one third of patients develop these systemic manifestations. Phenotypic classification shows that certain subsets of patients are more susceptible to developing EIMs, which frequently occur simultaneously in the same patient overlapping joints, skin, mouth, and eyes. The clinical spectrum of these manifestations varies from mild transitory to very severe lesions, sometimes more incapacitating than the intestinal disease itself. The great majority of these EIMs accompany the activity of intestinal disease and patients run a higher risk of a severe clinical course. For most of the inflammatory EIMs, the primary therapeutic target remains the bowel. Early aggressive therapy can minimize severe complications and maintenance treatment has the potential to prevent some devastating consequences.

关键词：胃肠道治疗炎症外表 EIMS 肠道疾病溃疡性结肠炎免疫相关

Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation

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Journal of Molecular Cell Biology 2020年第9期12卷 738-740页

作者： Guo Yu Jie Fu Ana romo Baojie Li Huijuan Liu Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Basic Medical Science Xinxiang Medical UniversityXinxiang 453003China Laboratory of Stem Cells and Gene Therapy Instituto Tecnolo´gico de Chascomu´s(INTECH)CONICET-UNSAMChascomu´sBuenos AiresArgentina

Dear Editor,Abl1,when fused with BCR,expresses fusion protein BCR‒ABL that underlies the etiology of chronic myeloid leukemia and is therapeutically targeted by Imatinib Mesylate(Khatri et al.,2016).However,the function of proto-oncogene product Abl1 remains not fully *** non-receptor tyrosine kinase can be activated by growth factors,DNA damage,oxidative stress,and microbial pathogens(Wang,2014).Cell-based studies suggest that Abl1 phosphorylates proteins in DNA damage response(DDR)and other signaling pathways,promoting p53 expression as well as cell cycle arrest and apoptosis(Gonfloni et al.,2009).Abl1 deletion leads to runtedness,osteoporosis,and other developmental defects in ***,it has been reported that Abl1 kinase is activated in many solid tumors and Abl1 is implicated in EphB2-mediated intestinal adenoma growth and colorectal cancer(CRC)invasion and metastasis(Kundu et al.,2015;Sonoshita et al.,2015).However,a recent study showed that Abl1 expression is reduced in most CRC patient samples(Uhlen et al.,2015).Thus,the function of Abl1 in CRC initiation warrants further investigation.

关键词： al. invasion damage

A glance at three-dimensional Alexandrov spaces

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Frontiers of Mathematics in China 2016年第5期11卷 1189-1206页

作者： fernando GALAZ-GARCIA Institut fur Algebra und Geometrie Karlsruher Institut fiir Technologie (KIT) Karlsruhe Germany

We discuss the topology and geometry of closed Alexandrov spaces of dimension three.

关键词： Alexandrov space group action 3-manifold

Morphology and distribution of Pronoctiluca (Dinoflagellata, incertae sedis) in the Pacific Ocean

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Acta Oceanologica Sinica 2013年第4期32卷 71-76页

作者： GóMEZ fernando Department of Biological Oceanography Institute of Oceanography University of S o Paulo

The diversity and distribution of Pronoctiluca, a marine dinoflagellate of enigmatic systematic position, was studied in the vicinity of the Kuroshio and Oyashio Currents, the Philippines, Celebes, Sulu and South China Seas, western and central equatorial and southeast Pacific Ocean. The abundance of Pronoctiluca was high- er, with a wide vertical distribution, in eutrophic temperate regions, whereas it was nearly absent in surface waters of oligotrophic tropical regions. Most of the specimens corresponded to P. spinifera. Pronoctiluca pelagica, covered by hyaline layers and with no flagella, is considered as an encysted form. The bipartition was only observed in P. acuta-P, spinifera forms, that together with the occurrence of intermediate forms between P. spinifera and P. pelagica suggest that they may correspond to developmental stages of a single species. Pronoctiluca is essential to understanding the evolutionary history of the alveolates.

关键词： Alveolata basal dinoflagellates Dinophyceae heterotrophic flagellate Noctilucales plankton

Surveillance of emerging SARS-CoV-2 variants by nanopore technology-based genome sequencing

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 313-320页

作者： J.I.Abeynayake G.P.Chathuranga M.A.Y.fernando M.K.Sahoo Department of Virology Medical Research InstituteP.O.Box:527Baseline RoadColombo 08Sri Lanka Department of Pathology Stanford University School of MedicinePalo AltoCaliforniaUnited States of America

Objective:To surveill emerging variants by nanopore technology-based genome sequencing in different COVID-19 waves in Sri Lanka and to examine the association with the sample characteristics,and vaccination ***:The study analyzed 207 RNA positive swab samples received to sequence laboratory during different *** N gene cut-off threshold of less than 30 was considered as the major inclusion *** RNA was extracted,and elutes were subjected to nanopore *** the sequencing data were uploaded in the publicly accessible database,***:The Omicron,Delta and Alpha variants accounted for 58%,22%and 4%of the variants throughout the *** than 1%were Kappa variant and 16%of the study samples remained *** variant was circulated among all age groups and in all the *** value and variants assigned percentage was 100%in Ct values of 10-15 while only 45%assigned Ct value over ***:The present study examined the emergence,prevalence,and distribution of SARS-CoV-2 variants locally and has shown that nanopore technology-based genome sequencing enables whole genome sequencing in a low resource setting country.

关键词： Emerging SARS-CoV-2 variants Laboratory surveillance Nanopore technology Genome sequencing Bioinformatics analysis and phylogeny Sociodemographic and sample cutoff(Ct)threshold Global sharing of genomic data/GISAID

放射性药物治疗芯片:微流控驱动的数字孪生在个体化癌症治疗中的展望

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科学通报:英文版 2023年第18期68卷 1983-1988页

作者： Hamid Abdollahi Babak Saboury Madjid Soltani Kuangyu Shi Carlos uribe Arman Rahmim Department of Radiology University of British ColumbiaVancouver V5Z 1M9Canada Department of Integrative Oncology BC Cancer Research InstituteVancouver V5Z 1L3Canada Department of Radiology and Imaging Sciences Clinical CenterNational Institutes of HealthBethesda 20892USA Department of Electrical&Computer Engineering University of WaterlooWaterloo N2L 3G1Canada Department of Nuclear Medicine InselspitalBern University HospitalUniversity of BernBern 3010Switzerland Computer Aided Medical Procedures and Augmented Reality Institute of InformaticsTechnical University of MunichMunich 80333Germany Functional Imaging BC CancerVancouver V5Z 4E6Canada Department of Physics&Astronomy University of British ColumbiaVancouver V6T 1Z1Canada

Radiopharmaceutical therapy(RPT)has shown great promise in the treatment of various ***,the current approach is a"one size fits all"model,which results in varied patient responses,and there is a need for personalized RPT(Fig.S1 online).This personalized approach requires a better understanding of the physics,biology,radiobiology,pharmacology,immunology,chemistry,and imaging involved in RPT[1].Multidisciplinary research using experimental,numerical,and simulation platforms would be key to accelerating progress in this area.

关键词：放射性药物癌症治疗微流控