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Bio-Design and manufacturing 2022年第4期5卷 808-815页

作者： J.m.Chacón P.J.Núñez m.A.Caminero E.García-Plaza J.Vallejo m.Blanco Escuela Técnica Superior de Ingeniería Industrial Universidad de Castilla-La ManchaAvdaCamilo JoséCela213071 Ciudad RealSpain Protresde Ingeniería y Soluciones C/Solana 60nave 313005 Ciudad RealSpain

Biomedical fracture fixation implants have complex sculptured geometries to adapt perfectly to fractured bones,making them difficult and expensive to manufacture with conventional machining methods. Fused filament fabrication(FFF) is a very popular Additive manufacturing technology that simplifies the manufacture of parts with complex geometries, making it ideal for the manufacture of customized medical implants.

关键词： steel fracture fused

Arabidopsis Heterotrimeric G-protein Regulates Cell Wall Defense and Resistance to Necrotrophic Fungi

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molecular Plant 2012年第1期5卷 98-114页

作者： magdalena Delgado-Cerezo Clara Sanchez-Rodriguez Viviana Escudero Eva miedes Paula Virginia Fernandez Lucia Jorda camilo Hernandez-Blanco Andrea Sanchez-Vallet Pawel Bednarek Paul Schulze-Lefert Shauna Somervilleg Jose manuel Estevez Staffan Persson Antonio molina Centro de Biotecnologia y Genomica de Plantas （UPm-INIA） Universidad Politecnica de Madrid Campus de Montegancedo E-28223-Pozuelo de Alarcbn （Madrid） Spain max-Planck-lnstitute fLir molekulare Pflanzenphysiologie Am MQhlenberg 2 14476 Potsdam Germany Laboratorio de Fisiologia y Biologia molecular IFIByNE （CONICET） FCEyN-Universidad de Buenos Aires Pab. II Intendente Guiraldes 2160 Buenos Aires C1428EGA Argentina Present address： Laboratory of Phytopathology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen The Netherlands max Planck Institut for Zuchtungsforschung Department of Plant Microbe Interactions Carl-von-Linne-Weg 10 D-50829 Koln Germany Institute of Bioorganic Chemistry Polish Academy of Sciences Noskowskiego 12/14 61-704 Poznan Poland Energy Biosciences Institute 130 Calvin Hall University of California at Berkeley Berkeley CA 94720 USA

The Arabidopsis heterotrimeric G-protein controls defense responses to necrotrophic and vascular fungi. The agbl mutant impaired in the Gβ subunit displays enhanced susceptibility to these pathogens. Gβ/AGB1 forms an obligate dimer with either one of the Arabidopsis Gγsubunits （γ1/AGG1 and γ2/AGG2）. Accordingly, we now demonstrate that the aggl agg2 double mutant is as susceptible as agbl plants to the necrotrophic fungus Plectosphaerella cucumerina. To elucidate the molecular basis of heterotrimeric G-protein-mediated resistance, we performed a comparative transcriptomic analysis of agbl-1 mutant and wild-type plants upon inoculation with P cucumerina. This analysis, together with metab- olomic studies, demonstrated that G-protein-mediated resistance was independent of defensive pathways required for resistance to necrotrophic fungi, such as the salicylic acid, jasmonic acid, ethylene, abscisic acid, and tryptophan-derived metabolites signaling, as these pathways were not impaired in agbl and aggl agg2 mutants. Notably, many mis-reguiated genes in agbl plants were related with cell wall functions, which was also the case in aggl agg2 mutant. Biochemical analyses and Fourier Transform InfraRed （FTIR） spectroscopy of cell walls from G-protein mutants revealed that the xylose content was lower in agbl and aggl agg2 mutants than in wild-type plants, and that mutant walls had similar FTIR spec-tratypes, which differed from that of wild-type plants. The data presented here suggest a canonical functionality of the Gβ and Gγ1/γ2 subunits in the control of Arabidopsis immune responses and the regulation of cell wall composition.

关键词： Plant immunity cell wall indole glucosinolates xylose necrotropic fungi G-protein.

Effects of nutrients on immunomodulation in patients with severe COVID-19:Current knowledge

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World Journal of Critical Care medicine 2022年第4期11卷 201-218页

作者： Bruna Teixeira da Costa Glauber Rocha Lima Araújo Ronaldo Teixeira da Silva Júnior Luana Kauany de SáSantos Vinícius Lima de Souza Gonçalves Daniel Bastos Alves Lima Beatriz Rocha Cuzzuol Jonathan Santos Apolonio Lorena Sousa de Carvalho Hanna Santos marques camilo Santana Silva Isadora de Souza Barcelos márcio Vasconcelos Oliveira Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Recent research has demonstrated that critically ill patients with coronavirus disease 2019(COVID-19)show significant immune system *** to that,some nutrients that influence immunomodulation have been suggested as a form of treatment against the *** review collected the information on the impact of vitamins on the prognosis of COVID-19,with the intention of facilitating treatment and prevention of the disease risk status in *** collected information was obtained using the Pubmed electronic database by searching for articles that relate COVID-19 and the mechanisms/effects of the nutrients:Proteins,glucose,lipids,vitamin B12,vitamin D,calcium,iron,copper,zinc,and magnesium,including prospective,retrospective,and support *** findings reveal an optimal response related mainly to omega-3,eicosapentaenoic acid,docosahexaenoic acid,calcium,and iron that might represent benefits in the treatment of critically ill ***,nutrient supplementation should be done with caution due to the limited availability of randomized controlled studies.

关键词： COVID-19 Immunomodulation Patient care Vitamins Nutrients micronutrients

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking manuela Dal Forno Bibiana moncada Luis fernando Coca Leidy Yasmín Vargas-mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego mauricio Cabrera-Amaya marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro martha Cecilia Gutiérrez Jesús E.Hernández marin maría de los Ángeles Herrera-Campos maría E.Holgado-Rojas Harald Jonitz martin Kukwa Fabiane Lucheta Santiago madriñán marcelo Pinto marcelli Suzana maria de Azevedo martins Joel A.mercado-Díaz Jorge Alberto molina Eduardo A.morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo camilo Rodríguez Diego fernando Simijaca Edier Soto-medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk marcela Celis Pacheco mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick m.Gillevet masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´Celestino mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:Cora accipiter moncada,madrin˜a´n&Lücking ***.,*** moncada,Soto-medina&Lücking ***.,*** moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves&Lücking ***.,*** moncada,***ı´guez&Lücking ***.,*** Lücking,moncada&*** ***.,*** moncada,Ya´nez-Ayabaca&Lücking ***.,*** moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,martins&Lucheta ***.,*** moncada,R.-***´rez&Lücking ***.,*** moncada,***.&Lücking ***.,*** moncada,CabreraAmaya&Lücking ***.,*** moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** moncada,***´rez-Corredor&Lücking ***.,*** moncada,***&Lücking ***.,***

关键词： Bolivia Citizen science Chile mexico Puerto Rico Sri Lanka

Cytokine production in patients with cirrhosis and TLR4 polymorphisms

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World Journal of Gastroenterology 2014年第46期20卷 17516-17524页

作者： Juan camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano Department of Immunology Institut de Recerca-IIB Sant PauUniversitat Autònoma de Barcelona08025 BarcelonaSpain Department of Gastroenterology Hospital de la Santa Creu i Sant Pau08025 BarcelonaSpain Department of Gastroenterology Instituto de Salud Carlos Ⅲ Institut de Recerca-IIB Sant PauUniversitat Autònoma de Barcelona08025 BarcelonaSpain Department of Gastroenterology Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas08025 BarcelonaSpain Instituto de Salud Carlos Ⅲ Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas08025 BarcelonaSpain Department of Gastroenterology Escola Universitària d’Infermeria Sant Pau08025 BarcelonaSpain Department of Gastroenterology Universitat Autònoma de Barcelona08025 BarcelonaSpain

AIm:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I ***:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver ***4 polymorphisms were determined by sequence-based *** production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)***:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,Pm L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two ***:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications.

关键词： Inflammatory response Hepatic encephalopathy Genet

Three-dimensional organ modeling based on deformable surfaces applied to radio-oncology

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第6期11卷 407-417页

作者： Gloria BUENO Oscar DéNIZ Jesús SALIDO Carmen CARRASCOSA José m. DELGADO Grupo de Visióny Sistemas Inteligentes Universidad de Castilla-La Mancha E.T.S. Ingenieros Industriales Avda. Camilo José Cela 3. 13071 Ciudad Real Spain Hospital General de Ciudad Real Tomelloso s/n. 13005 Ciudad Real Spain Instituto Oncológico (Grupo ImO) modesto Lafuente 14 28010 Madrid Spain

This paper describes a method based on an energy minimizing deformable model applied to the 3D biomechanical modeling of a set of organs considered as regions of interest (ROI) for radiotherapy. The initial model consists of a quadratic surface that is deformed to the exact contour of the ROI by means of the physical properties of a mass-spring system. The exact contour of each ROI is first obtained using a geodesic active contour model. The ROI is then parameterized by the vibration modes resulting from the deformation process. Once each structure has been defined, the method provides a 3D global model including the whole set of ROIs. This model allows one to describe statistically the most significant variations among its structures. Statistical ROI variations among a set of patients or through time can be analyzed. Experimental results are presented using the pelvic zone to simulate anatomical variations among structures and its application in radiotherapy treatment planning.

关键词： 3D biomechanical organ modeling Energy minimizing deformable model Finite element model Geodesic active contour Radiotherapy treatment planning

Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review

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World Journal of Clinical Oncology 2021年第2期12卷 69-94页

作者： mariana miranda Sampaio maria Luísa Cordeiro Santos Hanna Santos marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Chronic myeloid leukemia(CmL)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia *** advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of *** discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CmL patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL *** kinase inhibitors(known as TKIs)are the standard therapy for CmL and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of *** therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these *** this background,this article aims at providing an overview on CmL clinical management and a summary on the main targeted drugs available in that context.

关键词： Chronic myeloid leukemia Breakpoint cluster region-Abelson murine leukemia Immunotherapy Tyrosine kinase inhibitors Philadelphia chromosome Diagnosis

Treatment of Helicobacter pylori infection in children:A systematic review

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World Journal of meta-Analysis 2020年第4期8卷 292-308页

作者： Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro Santos Hanna Santos marques mariana miranda Sampaio Ronaldo Teixeira da Silva Júnior Jonathan Santos Apolonio Lorena Sousa de Carvalho camilo Santana Silva Luana Kauany de SáSantos márcio Vasconcelos Oliveira Gifone Aguiar Rocha Dulciene maria de magalhães Queiroz Fabrício Freire de melo Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection is predominantly acquired in *** indicated,the most accepted treatment for *** eradication in this age group is first-line triple ***,the increasing resistance to clarithromycin and nitroimidazoles has been associated with treatment failure,and thus,alternative treatment regimens have been *** To perform a systematic review of randomized controlled trials on treatment regimens for *** infection in *** We surveyed relevant articles published in English from 2010 to April 2020 in the Pubmed and mEDLINE *** included“Helicobacter pylori“/”children or childhood“/”treatment or eradication.”The risk of bias was evaluated according to the Cochrane Handbook of Systematic Reviews for *** Among the 1144 records identified through the database,20 articles were *** studies compared the eradication rates of *** infection between standard triple therapies,changing only the main antibiotic *** studies evaluated the effectiveness of standard triple therapy with the addition of *** study investigated the relationship between the effectiveness in the eradication rates of standard triple therapy and vitamin E *** studies analyzed the eradication rates of sequential *** The findings suggest that although standard triple therapy is the most recommended regimen for children by the current guidelines,other therapeutic schemes have shown promising results and may also be recommended for clinical practice in the future.

关键词： Helicobacter pylori Children Pediatric treatment Standard triple therapy Probiotics Sequential therapy Eradication therapies

胶质母细胞瘤的几何形态学分析:一项基于T1增强扫描的mRI研究

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国际医学放射学杂志 2017年第3期 357-357页

作者： P.B.Julián m.G.Alicia m.David A.S.mariano L.Belén A.Elena 王大伟 Laboratory of mathematical Oncology Edificio Politécnico Institutode Matemática Aplicada a la Ciencia y la IngenieríaUniversidad de Castilla-La Mancha Avenida de Camilo José Cela

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中... 详细信息

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中心回顾性研究。对临床变量进行收集、肿瘤分割,测量参数包括:强化方式、坏死、体积、肿瘤最大直径、等效球径度增强宽幅及其他几个强化"边缘"的形态学参数。应用比例风险分析与Kaplan meier生存曲线进行

关键词：胶质母细胞瘤几何形态学初等数学 mRI T1

The Health Education Program Implemented by Nurses Can Improve Blood Pressure Control and Quality of Life in Hypertensive Patients？

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Journal of Health Science 2018年第5期6卷 365-373页

作者： Guerra, Grazia maria Lopes, Heno Ferreira Freitas, Elizangela de Oliveira Tsunemi, miriam H. Giorgi, Dante marcelo Artigas Vieira, margarida Consolim-Colombo, Fernanda m. Bortolotto, Luiz Aparecido Hypertension Unit Heart Institute (InCor HC FMUSP) Medical School of Medicine University of Sao Paulo Sao Paulo SP 05403-000 Brazil Sao camilo University Centers Sao Paulo SP 05022-000 Brazil Cancer Institute of the State of Sao Paulo (ICESP) Sao Paulo 05403-000 Brazil Biostatistics Departament Biosciense Institute UNESP Botucatu SP 18618-689 Brazil Universidade Católica Portuguesa (UCP) Porto 4169-005 Portugal