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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： fernando Jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

Since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 486-495页

作者： Nelia hernandez fernando Bessone Hospital de Clinicas Universidad de la RepublicaMontevideoUruguay Hospital Provincial del Centenario University of Rosario School of MedicineRosarioArgentina

Novel biological agents including cytokines and recombinant fusion proteins are increasingly prescribed for cancer,rheumatologic,autoimmune,and inflammatory diseases,and are currently being evaluated in hepatocellular carcinoma(HCC).They are classified by their mechanism of action and include tumor necrosis factor-alpha(TNF-α)antagonists,T cell mediated antitumor inhibitors,interleukin receptor antagonists,and immune checkpoint inhibitors(ICIs).Some ICIs cause frequent hepatotoxicity with a variable clinical,biochemical,and serological presentation,especially in patients receiving another immunomodulatory *** of the cases of liver damage induced by biological agents spontaneously regress after drug withdrawal,but the others require steroid ***,there are no widely accepted recommendation for the use of corticosteroids in these patients,even though international cancer societies have their own *** drug-induced autoimmune hepatitis(DIAIH)from classic AIH is challenging for pathologists,but liver biopsy is valuable,particularly in cases with unclear clinical ***,novel histological patterns have been described in liver damage induced by these agents(i.e.,endothelitis,ring granuloma and secundary sclerosing cholangitis associated with lymphocytic infiltration of cytotoxic CD8+T cells).Here,we describe the clinical and biochemical characteristics of patients with hepatotoxicity induced by TNF-αantagonists and *** issues involved in the administration of corticosteroid therapy,and hepatitis B virus(HBV)reactivation induced by immunosuppressive therapy are also discussed.

关键词： Hepatotoxicity Checkpoint inhibitors Biologics Autoimmune hepatitis Drug-induced liver injury

Investigation of particle-wall interaction in a pseudo-2D fluidized bed using CFD-DEM simulations

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Particuology 2016年第2期14卷 10-22页

作者： Tingwen Li Yongmin Zhang fernando hernandez-Jimenez National Energy Technology Laboratory Morgantown WV26507 USA AECOM Morgantown WV 26507 USA State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China Universidad Carlos III of Madrid Department of Thermal and Fluid Engineering Av. de la Universidad 30 28911 Leganes Madrid Spain

We report on discrete element method simulations of a pseudo-two-dimensional （pseudo-2D） fluidized bed to investigate particle-wall interactions. Detailed information on macroscopic flow field variables, including solids pressure, granular temperature, and normal and tangential wall stresses are analyzed. The normal wall stress differs from the solids pressure because of the strong anisotropic flow behavior in the pseudo-2D system. A simple linear relationship exists between normal wall stress and solids pressure. In addition, an effective friction coefficient can be derived to characterize particle-wall flow interaction after evaluating the normal and tangential wall stresses. The effects of inter-particle and particle-wall friction coefficients are evaluated. Strong anisotropic flow behavior in the pseudo-2D system needs to be considered to validate the two-fluid model where the boundary condition is usually developed based on an isotropic assumption. The conclusion has been confirmed by simulation with different particle stiffnesses. Assumptions in the newly developed model for 2D simulation are further examined against the discrete element method simulation.

关键词： Gas-solid tlow Fluidized bed Computational fluid dynamics Discrete element method Particle-wall interaction Two-dimensional flow

Chemical oxygen demand reduction in coffee wastewater through chemical flocculation and advanced oxidation processes

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Journal of Environmental Sciences 2007年第3期19卷 300-305页

作者： ZAYAS Pérez Teresa GEISSLER Gunther hernandez fernando Postgrade in Environmental Sciences Center of ChemistryInstitute of Science.Meriterious University Autonomous of Puebla.P.O.Box 1613C.P.72000PueblaMexico.

The removal of the natural organic matter present in coffee processing wastewater through chemical coagulation-flocculation and advanced oxidation processes （AOP） had been studied. The effectiveness of the removal of natural organic matter using commercial flocculants and UV/H202, UV/O3 and UV/H2O2/O3 processes was determined under acidic conditions. For each of these processes, different operational conditions were explored to optimize the treatment efficiency of the coffee wastewater. Coffee wastewater is characterized by a high chemical oxygen demand （COD） and low total suspended solids. The outcomes of coffee wastewater treatment using coagulation-flocculation and photodegradation processes were assessed in terms of reduction of COD, color, and turbidity. It was found that a reduction in COD of 67% could be realized when the coffee wastewater was treated by chemical coagulation-flocculation with lime and coagulant T-1. When coffee wastewater was treated by coagulation-flocculation in combination with UV/H2O2, a COD reduction of 86% was achieved, although only after prolonged UV irradiation. Of the three advanced oxidation processes considered, UV/H2O2, UV/O3 and UV/H2O2/O3, we found that the treatment with UV/H2O2/O3 was the most effective, with an efficiency of color, turbidity and further COD removal of 87%, when applied to the flocculated coffee wastewater.

关键词： advanced oxidation processes coagulation-flocculation: coffee wastewater chemical oxygen demand (COD)

ON DIFFERENTIAL STRUCTURES OF POLYNOMIAL SPACES IN CONTROL THEORY

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Journal of Systems Science and Systems Engineering 2012年第3期21卷 372-382页

作者： Baltazar Aguirre hernandez Martn Eduardo FRIAS-ARMENTA fernando VERDUZCO Depto.de Matematicas Universidad Autonoma Metropolitana-lztapalapa.Av.Sn.Rafael Atlixco no.186.Col.Vicentinalztapalapa 09340MexicoD.F. Depto.de Matematicas Universidad de Sonora.Blvd.Luis Encinas y Rosales s/n.Col.CentroHermosilloSonoraMexico.

A valuable number of works has been published about Hurwitz and Schur polynomials in order to known better their properties. For example it is known that the sets of Hurwitz and Schur polynomials are open and no convex sets. Besides, the set of monic Schur polynomials is contractible. Now we study this set using ideas from differential topology, and we prove that the space of Schur complex polynomials with positive leading coefficient, and the space of Hurwitz complex polynomials which leading coefficient having positive real part, have structure of trivial vector bundle, and each space of （Schur complex and real, Hurwitz complex） polynomials has a differential structure diffeomorphic to some known spaces.

关键词： Schur polynomials Hurwitz complex polynomials trivial vector bundle

Turning carbon dots into selenium bearing nanoplatforms with in vitro GPx-like activity and pro-oxidant activity

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Nano Research 2023年第5期16卷 7784-7791页

作者： Laura Perez-Garrido Mariano Ortega-Muñoz fernando hernandez-Mateo F.Javier Lopez-Jaramillo Francisco Santoyo-Gonzalez Department of Organic Chemistry Biotechnology InstituteSchool of SciencesCampus Fuentenueva snUniversity of Granada18071-GranadaSpain

Selenium(Se)has been defined as the“Janus element”,with one face showing antioxidant activity and the other pro-oxidant *** biological effect of Se depends on both dose and *** nanoparticles are attracting major interest,although their large-scale preparation for biomedical applications is not *** hypothesize that acid anhydride-coated carbon dots(AACD)are an attractive platform for preparing nanoparticles containing chemically defined *** reaction of AA-CD with 3-selenocyanatopropan-1-amine yields carbon dots bearing selenocyanate and carboxylate groups(CD-SeCN)that allow for tuning the ***-SeCN has a Se content of 0.36μmol per mg of nanoparticles,they show the typical photoluminescence of carbon *** selenocyanate groups(SeCN)exhibited glutathione peroxidase-like activity and *** show that antioxidant behavior differs between normal and tumor cells,the evaluation on HEK293 and A549 cells reveals that the toxicity of CD-SeCN depends on dose,time,intracellular glutathione(GSH)*** toxicity of CD-SeCN decreases with the time of incubation and the cell death mechanism switches from necrosis to apoptosis,indicating that CD-SeCN is ***,high levels of intracellular GSH exert a protective *** results support a pharmacological potential in cancers with low levels of intracellular *** use of AA-CD as nanoplatforms is a general strategy that paves the way for the engineering of advanced nanosystems.

关键词： selenium nanoparticles carbon dots glutathione peroxidase-like activity Janus element nanomedicine

Immune therapy for human papillomaviruses-related cancers

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World Journal of Clinical Oncology 2014年第5期5卷 1002-1019页

作者： Ricardo rosales Carlos rosales Virolab S de RL de CV Cuernavaca Morelos 17007 Mexico Carlos Departamento de Inmunología Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City DF 04510 Mexico

Human papillomaviruses(HPVs) are a large family of double strand DNA viruses comprising more than 180 types. Infection with HPV is very common and it is associated with benign and malignant proliferation of skin and squamous mucosae. Many HPVs, considered lowrisk such as HPV 6 and 11, produce warts; while highrisk viruses, such as HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58, induce tumors. About 5% of all cancers in men and women are associated with HPV infection. Because there are not antiviral drugs for HPV infection, current therapies for low-risk HPV infections involve physical removal of the lesion by cryotherapy, trichloracetic acid, laser, or surgical removal. Surgical procedures are effective in the treatment of precancerous lesions, however after these procedures, many recurrences appear due to new re-infections, or to failure of the procedure to eliminate the HPV. In addition, HPV can inhibit recognition of malignant cellsby the immune system, leading to the development of cancer lesions. When this occurs, radiotherapy and chemotherapy are then used. Unfortunately, about 50% of the HPV-cancer patients still die. In the past decade, a better knowledge of the natural history of the virushost interaction and of the immune response against this viral infection has brought new therapeutic strategies geared to modulate the immune system to generate an efficient virus-specific cytotoxic response. Novel HPV protein-expressing vaccines have shown some significant clinical efficacy and systemic HPV-specific cytotoxic T cell responses. This review will describe the current status of the several therapeutic strategies used to treat HPV-induced lesions, and discuss the various new therapies now being tested.

关键词： Human papillomavirus T cell Immunoglobulin Antibody Vaccinia virus

Distance Measure Based Rules for Voltage Regulation with Loss Reduction

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Journal of Electromagnetic Analysis and Applications 2009年第2期1卷 85-91页

作者： Y. rosales hernandez T Hiyama 不详

This paper presents a rule-based technique to control the voltage in a power transmission network. Transformers with a tap changer installed in the system are selected by the proposed technique as control devices. For each bus under volt-age violation, the most effective control device is selected by using the minimum electric distance criteria. In order to demonstrate the efficiency of the method, several simulations were performed using an IEEE 30-bus network as a model system. The distance measure technique is compared with classic voltage regulation approach and a genetic algorithm based. The results obtained show the robustness of the proposed method.

关键词： Knowledge Based Systems Losses Voltage Control

Proportionally Modular Diophantine Inequalities and Their Multiplicity

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2059-2070页

作者： José Carlos rosales Manuel Batista BRANCO Paulo VASCO Departamento de lgebra Universidad de Granada Departamento de Matemática Departamento de Matemática Universidade de Trás-os-Montes e Alto Douro

Let I be an interval of positive rational numbers. Then the set S （I） = T ∩ N, where T is the submonoid of （Q0＋, ＋） generated by T, is a numerical semigroup. These numerical semigroups are called proportionally modular and can be characterized as the set of integer solutions of a Diophantine inequality of the form ax rood b 〈 cx. In this paper we are interested in the study of the maximal intervals I subject to the condition that S （I） has a given multiplicity. We also characterize the numerical semigroups associated with these maximal intervals.

关键词： Numerical semigroup Diophantine inequality multiplicity Frobenius number